Recent news on 3Tc

PRESIDENT’S ADDRESS AT THE CONVOCATION OF THE PT. BD SHARMA POST ...  -  25 May 2007
Press Information Bureau (press release),A foreign University has tried a combination of AZT-INDINAVIR and 3TC, for some patients, which gave unique results fully suppressing the HIV/AIDS virus.

I've done it. What now?  -  May 23, 2007
Health24.com,For occupational exposure A healthcare worker will usually receive a combination of AZT (retrovir) 200mg eight- hourly or 300mg 12-hourly and 3TC

Clinton Foundation announces new price cuts for tenofovir and ...  -  May 9, 2007
Aidsmap,A tenofovir/3TC combination tablet will cost only slightly more ($179 a year), while a tenofovir/emtricitabine combination tablet will cost $225 a year,

Third Trimester Exposure To Anti-HIV Drugs Linked To Mitochondrial ...  -  May 2, 2007
Medi News Direct,The children with MD (cases) were more likely to be exposed in-utero to Lamivudine (3TC, odds ratio 3.76) or Zidovudine-Lamivudine combination (ZDV/3TC,

Africa: Q&A on Second-Line HIV/Aids Treatment  -  May 8, 2007
AllAfrica.com,300mg of 3TC dosed once-daily is regarded as a clinically equivalent alternative to FTC, and WHO treatment guidelines, noting this, have stated that

Boehringer cuts nevirapine price for developing world  -  May 15, 2007
Aidsmap,...can be offered at $45 a year, while a fixed dose combination of AZT, 3TC and nevirapine will be available at $174 a year in low-income countries.

GPO may sue US lobby firm  -  May 11, 2007
Bangkok Post,It focused on three individual original drugs _ Nevirapine, Lamivudine (3Tc) and Stavudine (d4T) _ not GPO-VIR. GPO started to produce GPO-VIR,

Resistance in archived virus dissimilar to circulating virus in ...  -  Apr 25, 2007
Aidsmap,The most frequently detected mutations were the 3TC-associated M184V (76%), PI mutations L63P (76%) and L10F (61%), and thymidine analogue mutations

Resistance in archived virus dissimilar to circulating virus in ...  -  26 Apr 2007
Aidsmap,The most frequently detected mutations were the 3TC-associated M184V (76%), PI mutations L63P (76%) and L10F (61%), and thymidine analogue mutations

Treatment of HBV or HCV in triple-infected individuals not seen to ...  -  Apr 24, 2007
Aidsmap,However, even though none of the five received tenofovir or 3TC during the study period, none became HBV-viremic either during or after HCV treatment

SHIRE PLC - 1st Quarter Results  -  Apr 25, 2007
PR-Inside.com (Pressemitteilung),3TC - HIV infection and AIDS Royalties from sales of 3TC for the three months to March 31, 2007 were $35.5 million, a decrease of 10% compared to the prior

Speed of viral load decline is a sign of more effective ...  -  Apr 18, 2007
Aidsmap,A substudy of a large clinical trial has shown that viral load declined more quickly in people treated with AZT, 3TC and efavirenz (Sustiva) than in those

Resistance already emerging in first months of treatment despite ...  -  Apr 18, 2007
Aidsmap,The drug regimens varied, but all contained 3TC combined with another nucleoside reverse transcriptase inhibitor (NRTI) plus either a protease inhibitor

South Africa: Aspen Can Take Another Long Bow On Aids Drug  -  Apr 5, 2007
AllAfrica.com,...secure voluntary licences to make generic copies of other companies' AIDS drugs, kicking off with GlaxoSmith-Kline's lamivudine, branded 3TC, in 2001.

d4T dose can be reduced without loss of effectiveness, meta ...  -  Apr 2, 2007
Aidsmap,They argue that further exploration of d4T dose reduction is warranted given the low cost of a fixed dose d4T/3TC/nevirapine regimen in resource-limited

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Significant sparing of peripheral lipoatrophy by HIV treatment with LPV/r + ZDV/3TC induction followed by LPV/r monotherapy compared with EFV + ZDV/3TC.

Red tape blocking medicine for Africa  -  Apr 18, 2007
Globe and Mail,...best-known generic drug manufacturers, has developed a treatment for people with HIV that uses three patent-protected drugs: AZT, 3TC and Navirapin.

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal Medicine3TC = lamivudine; ABC = abacavir; APV = amprenavir; ATV = atazanavir; d4T = stavudine; ddI = didanosine; DLV = delavirdine; EFV = efavirenz;

AZT causes genetic damage to infants; long-term cancer risk unknown  -  Apr 16, 2007
Aidsmap,...the Comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.

Is there any clinical benefit to staying on a failing regimen?  -  Apr 12, 2007
Aidsmap,Additionally, patients on 3TC (lamivudine) showed a slower accumulation of nucleoside mutations and thymidine analogue mutations (TAMs).

Further development of resistance infrequent in patients taking ...  -  Apr 11, 2007
Aidsmap,Two patients maintained K65R but lost detectable M184V mutations associated with 3TC (lamivudine) treatment. Three other patients gained a K219E or K219R

Drug Used To Prevent HIV Transmission From Mother To Child Damages DNA  -  Apr 9, 2007
Medical News Today (press release),Human Lymphoblastoid Cells (H9) or Perinatal Exposure of Mother-Child Pairs to AZT or AZT-3TC," Patricia A. Escobar, Ofelia A. Olivero, Nancy A. Wade,

HIV and Hepatitis Co-Infections Challenging  -  Apr 6, 2007
MedPage Today,Long-term therapy of HBV infection is the rule, with nucleoside and nucleotide reverse transcriptase inhibitors, such as lamivudine (3TC) and telbivudine

HIV/Hepatitis B coinfection: closer treatment monitoring needed?  -  Mar 28, 2007
Aidsmap,Ninety-two percent were on antiretrovirals which are also active against HBV, including 88% on 3TC.) Chart reviews found that while HIV viral load testing

Standard screening tests may not detect hidden hepatitis B virus ...  -  26 Mar 2007
Aidsmap,Importantly, none of the participants with occult hepatitis B were taking antiretroviral drugs with anti-HBV activity, such as 3TC (Epivir),

First-trimester antiretrovirals a 'possible' risk for genital ...  -  26 Mar 2007
Aidsmap,Statistically, the study was most sensitive to drug-specific birth defects from AZT and 3TC: even for those, it was only powered to detect an overall

CROI: High rate of virologic failure on once-daily combination of ...  -  Mar 8, 2007
Aidsmap,Preliminary results from a prospective clinical trial of once-daily 3TC, tenofovir and nevirapine have shown a high rate of early virologic failure,

Next generation NRTI, apricitabine (ATC), shows early promise  -  Mar 19, 2007
Aidsmap,Participants were required to be currently taking 3TC and have a viral load over 2000 copies/ml and a CD4 count over 50 cells mm 3 .

Triple ARV prophylaxis reduces viral load in breast milk  -  Mar 21, 2007
Aidsmap,A combination of AZT, lamivudine, and nevirapine (AZT/3TC/NVP) taken from week 28 of pregnancy and up to one month after delivery resulted in significantly

Avexa: trial success creates takeover speculation  -  Mar 22, 2007
Pharmaceutical Business ReviewAfter 21 days of treatment in a total of 47 patients with drug resistant HIV, the average reduction of viral load with 3TC was only 0.3 log10,

Avexa Reports Positive Phase IIb Result  -  Mar 20, 2007
PharmaLive.com (press release),Of these 17 patients received 600 mg doses of ATC, 16 received 800 mg doses of ATC and the control group of 14 patients were treated with 3TC.

Avexa Data's Ripple Effect  -  Mar 20, 2007
TheStreet.com...study had drug-resistant virus, including a strain of the virus known to reduce the efficacy of certain NRTIs, including 3TC (also known as lamivudine).

Avexa HIV drug meets trial goal  -  Mar 22, 2007
Pharmaceutical Business Review...of ATC in reducing the viral load of patients with drug-resistant HIV with the effectiveness of lamivudine (3TC), a leading NRTI in widespread use.

CROI: Further evidence that short-course PMTCT prophylaxis ...  -  Feb 28, 2007
Aidsmap,Short perinatal courses of AZT/3TC that result in 3TC resistance are also causing mothers to experience an inferior virologic response when they eventually

CROI: Kaletra less likely to cause fat loss than efavirenz when ...  -  Feb 27, 2007
Aidsmap,A second study, of lopinavir/ritonavir maintenance monotherapy, also found that when compared to patients treated with efavirenz, AZT and 3TC,

Kenya: Study Says Drugs Availability Low  -  Mar 12, 2007
AllAfrica.com,The two ARVs: AZT/3TC 300/15mg and 3TC/d4T/NVP 150/40/200mg were available in 61 per cent and 55 per cent respectively in the facilities reviewed,

CROI: Recent OIs or AIDS strongest predictors of development of ...  -  Mar 1, 2007
Aidsmap,The standard first-line regimen was NNRTI-based: 43.3% took d4T/3TC/efavirenz and 40% took d4T/3TC/nevirapine. The median viral load at virological failure

CROI: HIV Resistance Linked to Hepatitis Drug  -  Mar 1, 2007
MedPage Today,The researchers used a single cycle infectivity assay to test the drug against HIV and compared its effect to lamivudine (3TC, Epivir) and zidovudine (AZT).

Avexa Raises $60.1M To Fund Phase III Trials Of HIV Agent  -  Mar 21, 2007
BioWorld Online,...a reduction of less than 0.03 log10 in patients treated with 3TC (lamivudine, Epivir), an approved NRTI HIV drug from London-based GlaxoSmithKline plc.

CROI: MSF reports good responses on PI-based second-line ART ...  -  Feb 27, 2007
Aidsmap,Genotypic resistance was assessed in 52.3%: 91.5% were resistant to 3TC and almost all were resistant to non-nucleoside analog reverse transcriptase

CROI: Is there a ceiling to CD4 recovery on virologically ...  -  Mar 13, 2007
Aidsmap,There were also trends toward lower increases with triple nucleoside therapy or zidovudine/lamivudine (AZT/3TC), but these were not statistically

CROI: high burden of side-effects from d4T leads to WHO dose ...  -  Mar 21, 2007
Aidsmap,...showed a high rate of lipodystrophy in 60 black South African patients after 24 months of treatment with d4T/3TC (Combivir) and efavirenz (Sustiva).

Widely used hepatitis B drug spurs HIV drug resistance  -  Mar 12, 2007
Johns Hopkins Gazette,Thio said viruses with this mutation are known to be resistant to lamivudine, better known as 3TC, a medication that prevents HIV replication and "is a

CROI: Remission of Kaposi's sarcoma seen in rural Uganda when HIV ...  -  Mar 12, 2007
Aidsmap,The primary ART regimen was 3TC (lamivudine, Epivir), d4T (stavudine, Zerit), and nevirapine (Viramune). KS was diagnosed based on clinical grounds

CROI: New NNRTI, TMC278, demonstrates sustained potency, better ...  -  Mar 2, 2007
Aidsmap,75mg, or 150mg) compared with open-label once-daily efavirenz (600mg), in combination with either AZT/3TC (Combivir) or tenofovir/FTC (Truvada),

Anti-HBV drug entecavir also active against HIV and promotes ...  -  Mar 1, 2007
Aidsmap,Two agents currently approved for the treatment of hepatitis B virus (HBV) infection – lamivudine (3TC; Epivir-HBV) and adefovir (Hepsera) also demonstrate

Widely used hepatitis B drug spurs HIV drug resistance  -  Feb 28, 2007
EurekAlert (press release),Thio says viruses with this mutation are known to be resistant to lamivudine, better known as 3TC, a medication that prevents HIV replication and "is a

Health Canada issues warning on use of Baraclude alone in HIV ...  -  Feb 22, 2007
Aidsmap,...that the drug has any activity against HIV, unlike some other agents used in hepatitis B treatment such as lamivudine (3TC) and emtricitabine (FTC).

GlaxoSmithKline applauds landmark announcement in HIV/AIDS research  -  Feb 20, 2007
CNW Telbec (Communiqués de presse),In 1990, a GlaxoSmithKline and Shire BioChem Inc. partnership in Canada led to the development of 3TC(R) tablets, which was among the most significant drug

Women experience rapid fall in genital secretion of HIV after ...  -  Feb 19, 2007
Aidsmap,All had a CD4 cell count below 200 cells/mm 3 and were provided with an antiretroviral regimen consisting of 3TC (lamivudine, Epivir), d4T (stavudine,

Shire plc: On Time Execution of Operating Plan Delivers Strong ...  -  Feb 20, 2007
Earthtimes.orgRoyalties from sales of 3TC for the year to December 31, 2006 were US$150.9 million, a decrease of 6% compared to the prior year (2005: US$159.8 million).

Be careful if using fosamprenavir/ritonavir for PEP, and did HCV ...  -  Jan 31, 2007
Aidsmap,Until January 2006 doctors in Lille prescribed a PEP regimen consisting of AZT/3TC (Combivir) with the protease inhibitor, nelfinavir (Viracept).

President's address and interaction with the students of Kurnool ...  -  Feb 2, 2007
Nanotechnology News (press release)A foreign University has tried a combination of AZT-INDINAVIR and 3TC, for some patients, which gave unique results fully suppressing the HIV AID virus.

More fixed dose ARVs for children needed urgently, says WHO  -  Jan 9, 2007
Aidsmap,3TC and nevirapine that each contains slightly different ratios of each drug, reflecting the disagreements that still exist about the appropriate doses of

Study finds limited options for backup HIV treatment in some ...  -  Jan 11, 2007
innovations report,In 2004, it was estimated that 60000 Thai citizens would take this combination of stavudine, lamivudine, and nevirapine, known as d4T/3TC/NVP.

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,One of the largest studies yet of resistance mutation development has confirmed that, in people on 3TC (lamivudine, Epivir)-containing antiretroviral

Multiple organ failure during primary HIV infection reported  -  Jan 8, 2007
Aidsmap,Three and a half years later, the patient was still taking antiretroviral therapy (efavirenz, ddI and 3TC), with sustained viral suppression and a CD4 cell

Use resistance tests as part of HIV care, even if duration of ...  -  Jan 16, 2007
Aidsmap,The next most common mutation was M184V (associated with resistance to the nucleoside analogue 3TC) was present in six patients. The investigators note that

Rx&D announces the creation of a new and enhanced Health Research ...  -  Dec 27, 2006
CNW Telbec (Communiqués de presse),Dr. Jack Riordan in 1989 (defective gene causing cystic fibrosis), as well as Dr. Bernard Belleau, posthumously in 1996 (HIV/AIDS anti-viral 3TC(R)).

Triple nuke combination of AZT/3TC/tenofovir below current ...  -  Dec 17, 2006
Aidsmap,Just half of a small cohort who commenced antiretroviral therapy for the first time with triple nucleoside/tide analogue combination of AZT/3TC (Combivir)

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,One of the largest studies yet of resistance mutation development has confirmed that, in people on 3TC (lamivudine, Epivir)-containing antiretroviral

Why did HIV therapy have some benefits for a man with resistance ...  -  Dec 12, 2006
Aidsmap,Two years after seroconverting, the patient started anti-HIV therapy with 3TC, tenofovir (Viread) and Kaletra. This regimen was modified 13 months later

TAC agreement void of latest price ruling  -  Dec 8, 2006
Independent Online,The settlement agreements with the TAC in 2003 saw GSK agree to license at least four pharmaceutical companies to produce or import generic AZT and 3TC.

Judgement does not affect TAC drug agreement  -  Dec 8, 2006
Mail & Guardian Online,...did not have the power to settle complaints on its own. AZT, 3TC and nevirapine are drugs used in the prevention and treatment of HIV infection. -- Sapa.

Severe interaction between low-dose ritonavir and a blood pressure ...  -  Dec 11, 2006
Aidsmap,Since 2002, the man had also been taking an anti-HIV combination consisting of 3TC, d4T and Kaletra. In March 2005, when the individual had a CD4 cell count

McGill AIDS fight gets $2.5-million boost  -  Dec 7, 2006
McGill Reporter,...with Dr. Mark Wainberg's discovery in 1989 of the antiviral capabilities of the 3TC structure, used in antiretroviral drugs to treat HIV infection.

Commission acted beyond its powers - court  -  Dec 6, 2006
Independent Online,...a settlement agreement with TAC and the commission, in terms of which it agreed to grant production licences for AZT and 3TC to generic manufacturers.

Learning from the Living  -  Dec 1, 2006
TIME..."I had started on AZT at five, and throughout my childhood, I was on various studies of new medicines, like 3TC. I was a complete test case," she says.

BUAV: Research revolution needed to end hunt for Aids vaccine  -  Dec 1, 2006
Politics.co.uk,...treatments for HIV/AIDS such as Zidovudine, protease inhibitors and 3TC have been developed by studying infected human cells in test tubes (in vitro).

Tenofovir DF- and Thymidine Analog-Containing Regimens Display ...  -  Dec 14, 2006
DG News3TC) or emtricitabine (Emtriva). The antiretroviral naive women in the analysis were enrolled in 2 prospective, randomized studies (study 903 and 934).

South Africa: Scientists Warn State-Supplied Aids Drug Poses ...  -  Dec 6, 2006
AllAfrica.com,The drug is one of three provided to patients in SA as "first-line therapy", along with lamivudine (3TC) and nevirapine or efavirenz.

A scandalous waste  -  Dec 1, 2006
Guardian Unlimited,The BUAV's report also demonstrates that the most effective and widely-used treatments for HIV, such as protease inhibitors and 3TC, have been developed

PRESIDENT’S ADDRESS TO THE MEMBERS OF BOTH HOUSES OF PARLIAMENT ON ...  -  Dec 1, 2006
Press Information Bureau (press release),A foreign University has tried a combination of AZT-INDINAVIR and 3TC, for some patients, which gave unique results fully suppressing the HIV AID virus.

CANFAR Announces Canadian Advances in HIV/AIDS Research  -  Nov 30, 2006
CNW Telbec (Communiqués de presse),His lab research helped identify 3TC, an important component in HIV therapy. Dr. Wainberg is currently working on the development of an HIV vaccine.

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,First-line HIV treatment in Thailand currently consists of GPO-Vir, a Thai generic version of d4T, 3TC and nevirapine. However Thai doctors want to use

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