Recent news on Clozapine

Care home pensioner 'died after drug error'  -  May 16, 2007
The Northern Echo,Mr Goss explained that Clozapine was a drug that people had to be weaned on to gradually, starting with small doses and working up to about 300mg per day

Drug Safety: There's No Magic Pill, Study Says  -  May 8, 2007
Atlanta Journal Constitution (subscription),The odds of dying from aspirin, clozapine, Tysabri and Vioxx are about equal to the corresponding risk for driving in a passenger car.

NAMI honors VNA with award  -  May 17, 2007
Cleveland Jewish News,VNA was also recognized for its participation in collecting DNA samples and data for the research study “Genetics of Response to Clozapine and other

Drug Safety: It’s not just chemotherapy that causes blood disorder  -  May 17, 2007
What Doctors Don't Tell You,They found 980 cases of agranulocytosis caused by drugs other than chemotherapy since 1966, including carbimazole, clozapine, dapsone, dipyrone, methimazole

USPSYCH: New Definitions on Tap for Mixed Manias  -  Apr 26, 2007
Psychiatric Times,For those who get no response, stage three is a two-drug combination of lithium, valproate, an atypical antipsychotic (not two and not clozapine),

Drug Risks Must Be Balanced Against Benefits, Researchers  -  May 11, 2007
MedIndia,...aspirin for cardiovascular protection; clozapine to treat schizophrenia; Tysabri, a multiple-sclerosis drug; and Vioxx, the now-retired painkiller.

'Bad' gene causes schizophrenia  -  May 2, 2007
News24,When those mice were treated with the antipsychotic drugs Haldol and Clozapine, the symptoms cleared up. Similarly, tests on another batch of mice with a

AstraZeneca is Proud to Support the American Psychiatric ...  -  May 22, 2007
PR Newswire (press release),...progenitor cells to study clozapine's effects in treating schizophrenia in comparison with the effects produced by other antipsychotic medications.

New Medication Strategies for Comorbid Substance Use and Bipolar ...  -  May 18, 2007
Focus (subscription)Several small, single-site, chart review studies of clozapine, olanzapine, and risperidone support a reduction in substance abuse with these agents (Brown

APA: Dosing Schedule Doesn't Matter for Antipsychotic Drug Adherence  -  May 21, 2007
Psychiatric Times,...during fiscal year 2005, had been on haloperidol or an atypical antipsychotic, excluding clozapine (Clozaril), with no change in dosing schedule.

US PSYCH: Vigilance Still Necessary for Atypical Antipsychotics  -  Apr 26, 2007
Psychiatric Times,Clozapine (Clozaril) and olanzapine (Zyprexa) have the highest receptor affinity with quetiapine (Seroquel) and risperidone (Risperdal) in the middle and

Chinese herbal medicine for schizophrenia Cochrane systematic ...  -  Apr 30, 2007
British Journal of Psychiatry (subscription),Rong, Y. (2001) Controlled treatment of Que-Dian decoctionwithlowdosage decoction with low dosage of ofclozapineintreating clozapine in treating

No Improvement in Parkinson's Disease Symptoms With Coenzyme Q10  -  May 17, 2007
Medscape (subscription)Also excluded were those taking warfarin, metformin, clozapine, thyroid hormones, or antiarrhythmic compounds. 131 patients were randomized,

Girls at Risk: Research Shows an Unparalleled Rise in Adolescent ...  -  May 16, 2007
PR Newswire (press release),...olanzapine, clozapine, ziprasidone and quetiapine. These drugs have been used as treatments for bipolar disorder, conduct disorder, ADHD, depression,

Drug Safety Proposals and the Intrusion Of Federal Regulation into ...  -  May 11, 2007
American Enterprise Institute,...[4] The program that the FDA put in place required the drug's sponsor to compel physicians to perform routine blood testing for patients receiving clozapine

Co-Occurring Mental and Substance Use Disorders: The ...  -  May 18, 2007
Focus (subscription)Data from small, largely uncontrolled studies suggest that treatment with clozapine and other atypical antipsychotics may be associated with decreases in

Medication Access and Continuity: The Experiences of Dual-Eligible ...  -  May 2, 2007
Am J Psychiatry (subscription)Kluznik JC, Walbek NH, Farnsworth MG, Melstrom K: Clinical effects of a randomized switch of patients from Clozaril to generic clozapine.

Cognitive remediation therapy in schizophrenia  -  Apr 30, 2007
British Journal of Psychiatry (subscription),Further investigation of these effects suggests that cognitive remediation therapy had an overall effect on planning for those who received either clozapine

AVANIR Pharmaceuticals to Present Zenvia Phase III Data in ...  -  May 8, 2007
PharmaLive.com (press release),AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia ...  -  May 1, 2007
PharmaLive.com (press release),Avanir currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Systematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs  -  Apr 30, 2007
Annals of Internal MedicineDrugs for which more than 10 reports were available (carbimazole, clozapine, dapsone, dipyrone, methimazole, penicillin G, procainamide, propylthiouracil,

Area Police News  -  Apr 28, 2007
Daily Hampshire Gazette (subscription),The Springfield man will also be summoned to court on a charge of possession of a class E substance after police found four clozapine pills during the

USPSYCH: New Definitions on Tap for Mixed Manias  -  26 Apr 2007
Psychiatric Times,For those who get no response, stage three is a two-drug combination of lithium, valproate, an atypical antipsychotic (not two and not clozapine),

US PSYCH: Vigilance Still Necessary for Atypical Antipsychotics  -  26 Apr 2007
Psychiatric Times,Clozapine (Clozaril) and olanzapine (Zyprexa) have the highest receptor affinity with quetiapine (Seroquel) and risperidone (Risperdal) in the middle and

Possible Delayed Speech Acquisition With Clozapine Therapy During ...  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)SIR: Most of the study by Ernst and Goldberg 1 reported perinatal outcome with clozapine therapy with no focus on neurodevelopment.

Outcomes of Obese, Clozapine-Treated Inpatients With Schizophrenia ...  -  Apr 5, 2007
Psychiatric Services (subscription)OBJECTIVE: Patients with schizophrenia treated with clozapine often gain weight. This study evaluated the effects of dietary control and physical activity

PGxHealth to Present Data on Replication of Genetic Associations ...  -  Mar 28, 2007
Business Wire (press release),CIA is a rare but serious side effect of clozapine, an antipsychotic indicated for treatment-resistant schizophrenia. At the conference, PGxHealth will

Warning on prescribing of Clozapine  -  Mar 31, 2007
Radio New Zealand,The Intensive Medicines Monitoring Programme says one person has died from an acute blood disorder as a result of using Clozapine.

Clozapine Benefits Outweighs Risk: MoH  -  Mar 31, 2007
newswire.co.nz,The Ministry of Health says the benefits of using of the anti-psychotic drug Clozapine outweigh the risks, despite a review showing five people have died

Pisa Syndrome Resolved After Switching to Olanzapine  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)The substitution to atypical antipsychotics, particularly clozapine, may provide alternatives for the treatment of patients with tardive dystonia.

Antipsychotics’ Link to Weight Gain Found  -  Mar 27, 2007
Journal of American Medical Association (subscription),..."Clinically, clozapine did wonderful things, but drug companies had no idea why," said Snyder. Other AAPDs were subsequently manufactured that mimicked

Antipsychotics: Clues in the weight-gain mystery  -  Apr 5, 2007
Nature.com (subscription),In their study, Snyder and colleagues observed that the administration of clozapine increased the levels of phospho-AMPK and AMPK activity in intact mice

AVANIR Pharmaceuticals Invites Investors to Second Quarter ...  -  Apr 23, 2007
PharmaLive.com (press release),AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

ACADIA Pharmaceuticals' Schizophrenia Programs to Be Presented at ...  -  Mar 29, 2007
PharmaLive.com (press release),In contrast, clozapine impaired performance in both these assays. The pro-cognitive effects of ACP-104 were shown to be dependent upon M1 muscarinic

Acadias CNS Pipeline Propels Growth  -  Apr 13, 2007
Genetic Engineering News (press release),Acadia’s second schizophrenia candidate is ACP-104, or N-desmethylclozapine, the major metabolite of clozapine, an atypical drug. It is being developed as a

Neurological Soft Signs in Schizophrenia Patients With Obsessive ...  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)Since antipsychotic agents, primarily clozapine, have been associated with the occurrence de novo and/or the exacerbation of OCD in schizophrenia patients,

Acadia Raises $89.1M Publicly To Fund Upcoming CNS Trials  -  Apr 5, 2007
BioWorld Online,ACP-104, or N-desmethylclozapine, is the major metabolite of the antipsychotic drug clozapine. ACP-104 combines M1 muscarinic agonism, 5-HT2A inverse

Trends in the Use of Psychotropic Drugs in Taiwan: A Population ...  -  Apr 5, 2007
Psychiatric Services (subscription)...main drug categories: antipsychotics (including first- and second-generation antipsychotics, such as clozapine, olanzapine, quetiapine, risperidone,

Second-Generation Antipsychotic Agents in the Treatment of Acute ...  -  Apr 2, 2007
Archives of General PsychiatryStudy Selection The abstracts, titles, and index terms of studies were searched using the following key words: aripiprazole, amisulpride, clozapine,

Dr. Rosenheck and Colleagues Reply  -  Apr 2, 2007
Am J Psychiatry (subscription)...risk of extrapyramidal symptoms between low potency first-generation antipsychotics and second-generation antipsychotics other than clozapine (3).

Avanir Pharmaceuticals Provides Business Update and Announces ...  -  Mar 29, 2007
Business Wire (press release),Avanir currently markets FazaClo ® , the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Furor Therapeuticus: Benjamin Rush and the Philadelphia Yellow ...  -  Apr 2, 2007
Am J Psychiatry (subscription)Rosenheck RA, Swartz MS, Perkins DO, Keefe RS, Davis CD, Severe J, Hsiao JK, the CATIE Investigators: Effectiveness of clozapine versus olanzapine,

Clozapine-Induced Tardive Dystonia (Blepharospasm)  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)Although there are rare reports of tardive dystonia induced by atypical antipsychotics, such as olanzapine, 2 clozapine, in contrast, has been reported to

Clozapine-Induced Cataplexy  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)Cataplexy-like phenomenon as a rare side effect of clozapine treatment was initially reported by Chiles et al. 1 in a series of four people with

Use of Clozapine in Oneroid State  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)I wish to report an adolescent girl who exhibited oneroid state with no basis for organicity, and who responded well to clozapine after failure of trials

Colorado Bioscience Association Showcases The State’s Most ...  -  Feb 23, 2007
PR Leap (press release),This project proposes to reformulate clozapine, a highly effective medication for schizophrenia, for central administration.

Teen charged in kidnapping arrested again  -  Feb 23, 2007
Eagle Tribune,Police said White stole a safe containing the antipsychotic drug clozapine from an apartment on Silvestri Circle on Jan. 2. Read this article in full with

Colorado Bioscience Association Showcases The State’s Most ...  -  Feb 21, 2007
dBusinessNews Denver (press release),This project proposes to reformulate clozapine, a highly effective medication for schizophrenia, for central administration.

Hopkins Scientists Uncover Cause of Antipsychotic Drug Weight Gain  -  Feb 19, 2007
Johns Hopkins Gazette,Suspecting that antipsychotic drugs might spike AMPK in the brain to overact, the Johns Hopkins team injected mice with clozapine (Clozaril), which,

Researchers discover why antipsychotics cause weight gain  -  Feb 15, 2007
Pharma Times (subscription),Mice given clozapine showed quadrupled AMPK activity compared to activity measured pre-drug and then the researchers then gave the mice leptin,

Antipsychotic Drug Causes Weight Gain  -  Feb 14, 2007
WFIE-TV,Clozapine (Clozaril), a common treatment for schizophrenia and bipolar disorder, can cause massive weight gain in patients.

Research Reveals How Antipsychotic Drugs Cause Weight Gain  -  Feb 12, 2007
Atlanta Journal Constitution (subscription),To test this theory, the researchers injected mice with clozapine (Clozaril), a drug commonly prescribed to treat schizophrenia and bipolar disorders in

Karl B. Hille, The Examiner  -  Feb 13, 2007
Baltimore Examiner,The Johns Hopkins team injected mice with clozapine, part of a common regimen for schizophrenia and bipolar disorder in people who do poorly on conventional

Why Antipsychotics Cause Weight Gain  -  Feb 12, 2007
Wall Street Journal (subscription),When mice were given the antipsychotic medicine, clozapine, it increased the activity of AMPK in their brains four-fold. Dr. Snyder says that the potency of

Avanir Receives FDA Approvable Letter for New Formulation of ...  -  Jan 31, 2007
PharmaLive.com (press release),FazaClo is the only orally disintegrating form of clozapine which is indicated for the management of severely ill schizophrenic patients who fail to respond

Link Found Between Antipsychotic Drugs and Weight Gain  -  Feb 13, 2007
Newsinferno.com,The researchers tested their theory by injecting mice with clozapine, and they found that those mice “showed quadrupled AMPK activity.

Avoiding a Weighty Side Effect  -  Feb 13, 2007
Science Now,The scientists then established the histamine link by giving clozapine to mice bred to lack H1 receptors. In this case, the mice failed to react with raised

Researchers discover why antipsychotic drugs cause weight gain  -  Feb 13, 2007
News-Medical.net,The discovery was made in tests carried out in mice who were injected mice with clozapine (Clozaril), a drug commonly prescribed to treat schizophrenia and

Market Report -- In Play (AVNR)  -  Feb 9, 2007
MSN MoneyThe co is currently evaluating the appropriate method for rev recognition related to sales of FazaClo (clozapine, USP). Until this evaluation is complete,

Market Report -- In Play (AVNR)  -  Jan 31, 2007
MSN Money...an approvable letter and acceptable labeling from the FDA for a new formulation of its currently marketed antipsychotic drug FazaClo (clozapine, USP).

Successful Tobacco Dependence Treatment in Schizophrenia  -  Jan 31, 2007
Am J Psychiatry (subscription)His positive symptoms were well controlled with clozapine, 550 mg/day, although he struggled with persistent cognitive problems, including trouble with

Clinical Data Launches PGxPredict™:RITUXIMAB on Schedule  -  Jan 30, 2007
Business Wire (press release),...prescribed in a wide range of therapeutic areas including oncology, rheumatology, organ transplantation and vasculitis; and PGxPredict™:CLOZAPINE,

Clinical Data Launches PGxPredict(TM):RITUXIMAB on Schedule  -  Jan 30, 2007
Genetic Engineering News (press release),...and PGxPredict(TM):CLOZAPINE, a pharmacogenetic test designed to aid physicians prescribing or considering prescribing clozapine that will provide

AVANIR Pharmaceuticals Provides First Quarter Business Update  -  Feb 9, 2007
Business Wire (press release),The Company is currently evaluating the appropriate method for revenue recognition related to sales of FazaClo ® (clozapine, USP). Until this evaluation is

Avanir Pharmaceuticals Provides First Quarter Business Update  -  Feb 9, 2007
PharmaLive.com (press release),The Company is currently evaluating the appropriate method for revenue recognition related to sales of FazaClo(R) (clozapine, USP). Until this evaluation is

They worked my son to death, claims grieving dad  -  Feb 20, 2007
Sunshine Coast Daily,An information leaflet on Clozaril, one of the brand names of the antipsychotic Clozapine, says that the medication "may prevent sweating,

Secondhand smoke raises heart risk  -  Feb 19, 2007
Chicago Daily Herald,..."Unfortunately, Zyprexa, which everybody agrees is the best therapeutic agent, gives the worst weight gain, along with clozapine, the parent drug in the

Aripiprazole-Associated Acute Dystonia  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)Acute dystonia with atypical antipsychotic agents, although relatively rare, has been reported with other atypical agents, including with clozapine.

Agitation in the Elderly  -  Feb 16, 2007
Psychiatric Times,The newer atypical antipsychotic agents, such as risperidone (Risperdal), clozapine (Clozaril), olanzapine (Zyprexa) and quetiapine (Seroquel) offer the

Clinical Data Announces Results for Fiscal Third Quarter 2007 Led ...  -  Feb 14, 2007
Business Wire (press release),We recently launched new PGxPredict(TM) tests related to Warfarin, Clozapine safety, and Rituximab, and we are creating marketing relationships that will

AVANIR Pharmaceuticals Hires Martin J. Sturgeon as Vice President ...  -  Feb 13, 2007
PharmaLive.com (press release),AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

AVANIR Pharmaceuticals Hires Martin J. Sturgeon as Vice President ...  -  Feb 12, 2007
Business Wire (press release),AVANIR currently markets FazaClo ® , the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Guilty plea in Milberg Weiss case  -  Feb 1, 2007
San Diego Union Tribune,FazaClo is a form of clozapine, which is used for the management of severely ill schizophrenic patients. Information Systems Laboratories of San Diego said

AVANIR Pharmaceuticals Holds Annual Meeting of Shareholders  -  Feb 1, 2007
Business Wire (press release),AVANIR currently markets FazaClo ® , the only orally disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

AVANIR Pharmaceuticals Holds Annual Meeting of Shareholders  -  Feb 1, 2007
Genetic Engineering News (press release),AVANIR currently markets FazaClo(R), the only orally disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Premarket Movers: Juniper Sinks  -  Jan 31, 2007
Forbes,FazaClo is an orally disintegrating form of clozapine, which is used to manage severely ill schizophrenic patients. The stock rose 31 cents, or 12.8 percent

Biotech Day In Review: AstraZeneca Enters Two Partnerships Worth ...  -  Feb 1, 2007
Seeking Alpha,Avanir Pharma (AVNR) received an approvable letter for an orally disintegrating form of FazaClo, or clozapine, for use in severely ill schizophrenic

Pending Genericization and a Less Than Robust Pipeline Threaten ...  -  Jan 9, 2007
PharmaLive.com (press release),At present, because all marketed atypicals (except clozapine) are expensive, cost is not generally a factor in a physician's choice of agent.

AVANIR Pharmaceuticals Invites Investors to Its First Quarter ...  -  Jan 17, 2007
PharmaLive.com (press release),AVANIR currently markets FazaClo(R), the only orally-disintegrating formulation of clozapine for the management of severely ill schizophrenic patients who

Gastrointestinal Medications  -  Jan 5, 2007
Psychosomatics (subscription)Medications that were adversely affected when co-administered with omeprazole included clozapine in non-smokers, cilostazol, proguanil, diazepam,

Father Remembers Son Who Died Using Legal Drugs  -  Dec 21, 2006
NewsChannel 9 WSYR,Drugs like valium and clozapine. Everything came to an end four days after Tim's 23rd birthday. "I came home and unlocked the bathroom door and Sage and

Mental illness advocates speak out  -  Jan 13, 2007
Durham Herald Sun,In 1992, he started taking clozapine and regained the ability to hold a normal conversation and even joke about his situation.

Catatonic Coma With Profound Bradycardia  -  Jan 5, 2007
Psychosomatics (subscription)Patients on clozapine clearly have a higher risk for such a complication, 8 and we recommend a most cautious approach. The most helpful feature in this case

Comment on "Tardive Dyskinesia Circa 2006"  -  Jan 3, 2007
Am J Psychiatry (subscription)Rosenheck RA, Cramer J, Xu W, Thomas J, Henderson W, Frisman L, Fye C, Charney D: A comparison of clozapine and haloperidol in the treatment of hospitalized

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