Recent news on Collagenase

Auxilium Selects MODA-EM(TM) to Support Commercial Development ...  -  May 1, 2007
Genetic Engineering News (press release),..."The Horsham facility is a key component of the commercial development strategy for AA4500, our injectable collagenase enzyme," stated Dr. Ben Del Tito,

Sabinsa fine tunes new lipoic acid for cosmeceuticals  -  May 10, 2007
NutraIngredients-usa.com,The salts are said to have anti acne properties and slow down collagenase and elastase enzymes. But the difference with Sabinsa's patented version is its

Riots in aisles for anti-wrinkle lotion that actually works  -  Mar 31, 2007
Times Online,Also in the mix is an extract from the white lupin flower which, it is suggested, slows down the production of collagenase, which is created by sun damage.

Auxilium Pharmaceuticals to Present at the 32nd Annual Deutsche ...  -  Apr 24, 2007
PharmaLive.com (press release),AA4500, an injectable collagenase enzyme, is in phase III of development for the treatment of Dupuytren's contracture and is in phase II of development for

Auxilium Pharmaceuticals to Present at the 32nd Annual Deutsche ...  -  Apr 24, 2007
PR Newswire (press release),AA4500, an injectable collagenase enzyme, is in phase III of development for the treatment of Dupuytren's contracture and is in phase II of development for

Auxilium Pharmaceuticals to Announce First Quarter 2007 Results ...  -  Apr 10, 2007
PharmaLive.com (press release),AA4500, an injectable collagenase enzyme, is in phase III of development for the treatment of Dupuytren's contracture and is in phase II of development for

Injectable Mixed Collagenase Shows Good Results in Dupuytren's ...  -  Feb 16, 2007
DG News...[Presentation title: Long-Term Safety and Efficacy of Injectable Mixed Collagenase for Dupuytren's Disease: Phase 3 Trials. Abstract 369]

BioSpecifics Technologies Corp. Mourns Death of Chairman and CEO ...  -  Feb 21, 2007
PR Newswire (press release),BTC is a biopharmaceutical company that has manufactured the active pharmaceutical ingredient used in a Food and Drug Administration licensed collagenase

Market Report -- In Play (AUXL)  -  Feb 20, 2007
MSN MoneyAs previously reported, data from the double-blind phase showed that injecting the collagenase enzyme into study patients' affected joints led to a 91

Collagen Degradation in the Abdominal Aneurysm A Conspiracy of ...  -  Feb 23, 2007
Am J Pathology (subscription)Except for modestly increased MMP-14 mRNA levels, collagenase expression was similar in growing and ruptured AAAs (anterior-lateral wall).

Auxilium Announces Results from Phase III Trial that Show AA4500 ...  -  Feb 20, 2007
PR Newswire (press release),Long-Term Study Shows Company's Lead Injectable Collagenase Enzyme Safe and Effective in Treating Patients with Multiple Contracted Hand Joints MALVERN,

Biotech Day in Review: Shire Buys New River for $2.6 Billion  -  Feb 21, 2007
Seeking Alpha,After injecting collagenase enzyme, the joints of 91% of the patients were within 5% of normal. Currently, the condition is treated by surgery,

Auxilium Pharmaceuticals, Inc. Announces Fourth Quarter and Full ...  -  Feb 19, 2007
Drug Newswire (press release),...make progress in the development of AA4500, our injectable collagenase enzyme," said Armando Anido, Chief Executive Officer and President of Auxilium.

Smoothing Away Cellulite  -  Feb 19, 2007
CBS 42,It's called collagenase. “What they did was take an enzyme that we use in wound healing and they injected into the fibrous bands to break up the fibrous

AGI Dermatics Data Shows Efficacy of Bicyclic Monoterpene Diols in ...  -  Feb 5, 2007
Drug Newswire (press release),The study examined the effects of BMTds on both collagen production and expression of collagenase, specifically metalloproteinase-1 (MMP-1).

Data acquisition for the histoculture drug response assay in lung ...  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryAfter histoculture, 100 µL of Hank’s balanced salt solution containing 0.1 mg/mL type I collagenase (Sigma) and 100 µL of 3-(4,5-Dimethyl-2-thiazotyl)-2

The Perio/Systemic Link  -  18 Jan 2007
Dental Economics,The enzymes released by the body include collagenase, gelatinase, elastase, and proteases. The enzyme activity is implied by their names,

Palytoxin: exploiting a novel skin tumor promoter to explore ...  -  Jan 11, 2007
AJP - Cell Physiology (subscription)Freije JM, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, Lopez-Otin C. Molecular cloning and expression of collagenase-3, a novel human matrix

Goodbye, Cellulite Thighs?  Oct 10, 2006
MD, associate professor and chief of plastic surgery at State University of New York at Stonybrook, says of the new treatment, which uses the enzyme collagenase ... -WebMD Australia : No solution to mulesing is plain wrong  Oct 27, 2006
...“Collagenase is not being progressed as it is not commercially viable and therefore it is not in the best interests of woolgrowers to proceed with this ... -Fibre2fashion.com, Gout Drug Staves Off Liver Cancer in At-Risk Patients  Sep 11, 2006
...that colchicine can inhibit fibroblast proliferation, and also delay the microtubule-mediated transport of procollagen and increase collagenase activity, he ... -MedPage Today

New findings from Medical University of South Carolina, US, described  -  Nov 23, 2006
Therapeutics Daily (subscription) (press release),Study 1: A study from the United States has reported that collagenase-2 and-3 mediate epidermal growth factor receptor (EGFR) transactivation by bradykinin

Orthopedic Research at North Carolina State University  -  Nov 24, 2006
TheHorse.com,New model of tendonitis "Other models of tendonitis use collagenase (to create lesions), which is an enzyme that breaks down tendon fibers," Little says.

Potential Source of Stem Cells for Heart Repair, Other Uses Found ...  -  Nov 17, 2006
DG NewsAfter digestion with collagenase I, differential centrifugation was used to separate a stromal-vascular pellet from mature adipocytes and the pelleted cells

Aberrant Collagenase Expression in Chronic Idiopathic ...  Jul 27, 2006
By contrast, a significantly higher expression of neutrophil collagenase (MMP-8) was encountered in the prefibrotic stages of cIMF (P < 0.001). ... -Am J Pathology (subscription)

Effect of prolonged in vitro exposure to high glucose on neonatal ...  Aug 22, 2006
Neonatal porcine islets were prepared by culturing collagenase digested pancreases for one week in 5.6 mM glucose, followed by an addition week in either 5.6 ... -Journal of Endocrinology

Another Stem Cell First For University Of Toronto And Canada  Jul 2, 2006
The vessels are then sutured closed and suspended in collagenase, an enzyme that breaks down the Wharton's Jelly around the vessels to release the HUCPVCs ... -Medical News Today



A pericellular collagenase directs the 3-D development of white ...  May 8, 2006
...genes?". They next isolated undifferentiated preadipocytes from mice lacking the collagenase in an attempt to zero in on the defects. ... - News-Medical.net

New Approach for Dupuytren's Contracture: A Newsmaker Interview  May 1, 2006
Another minimally invasive approach is under research, using collagenase injections to effect an enzymatic fasciotomy, but this is not yet FDA approved. ... - Medscape (subscription)

Expanding Waistlines Triggered By Your Genes  May 8, 2006
The paper "A Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue" will be published in the May 5, 2006 issue of Cell. - Medical News Today

Mulesing replacement trial axed  Apr 25, 2006
...trials. Australian Wool Innovation (AWI) has been injecting collagenase into sheep's backsides to inhibit the growth of wool. But ... - ABC Regional Online





(PRN) HEALTHPOINT to Begin Marketing and Selling Collagenase ...  Apr 4, 2006
...affiliate company, today announced that it will begin marketing and selling the Collagenase SANTYL(R) Ointment product line. The ... - Houston Chronicle

(PRN) - First Industrial Realty Trust to Present at the 2006 ...  Apr 4, 2006
...[+]. (PRN) - CMP Media's The News Show Launches 'Who Am I?' Feature ... [+. PRN) - HEALTHPOINT to Begin Marketing and Selling Collagenase SANTYL (R) ... [. ... - Bolsamania.com

Virginia Tech Research Finds Swedish Method Of Human Cartilage ...  Apr 1, 2006
Furthermore, pretreatment of cartilage with collagenase-3, an enzyme found in osteoarthritic joints, increased wears by almost 3-fold. ... - Medical News Today

Tendon Injuries  Feb 20, 2006
Vascular ingrowth also appears more rapid and is more mature in the split tendon in both collagenase-induced tendinitis and clinical cases. ... - TheHorse.com,

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