Recent news on Cytarabine

Most pediatric chemotherapy mistakes reach patients  -  25 May 2007
SpiritIndia,...associated with errors were part of the antimetabolite class (40 percent), which includes Methotrexate (15 percent) and Cytarabine (12 percent).

DepoCyt Gains Full Approval  -  May 4, 2007
Cancer Consultants (press release),Full approval has been granted by the United States Food and Drug Administration (FDA) for Enzon Pharmaceuticals agent DepoCyt (cytarabine liposome

Vion Reports 2007 First Quarter Results  -  May 8, 2007
PR Newswire (press release),Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute

ENZN: FDA Grants Full Approval for Cytarabine Liposome Injection  -  Apr 20, 2007
Therapeutics Daily (subscription) (press release),Enzon Pharmaceuticals, Inc. (ENZN) announced that the US Food and Drug Administration has granted full approval for DepoCyt (cytarabine liposome injection)

Depocyt Granted Full Approval  -  Apr 24, 2007
Facts and Comparisons,The FDA has granted full approval to Enzon Pharmaceuticals’ Depocyt (cytarabine liposome) injection for the treatment of patients with lymphomatous

FDA Grants Full Approval for DepoCyt for the Treatment of ...  -  Apr 20, 2007
PharmaLive.com (press release),DepoCyt is a sustained release formulation of the chemotherapeutic agent, cytarabine, used for the treatment of patients with lymphomatous meningitis.

Activity Seen in Early Clinical Trials With Liver Cancer Targeted ...  -  Apr 19, 2007
DG NewsMB07133 is a novel prodrug of cytarabine monophosphate, also known as araC, designed to produce the biologically active form of araC, araC triphosphate in

Enzon Receives DepoCyt Approval  -  Apr 20, 2007
Forbes,The drug gradually releases cytarabine into the cerebral spinal fluid, resulting in a significantly extended half-life, prolonged exposure to the therapy,

Enzon Gets FDA Nod for Lymphoma Treatment  -  Apr 20, 2007
NJBIZ,Enzon Pharmaceuticals Inc. (Nasdaq: ENZN) today said that the Food and Drug Administration has granted full approval for its DepoCyt (cytarabine liposome

Antisoma says successfully tests cancer drugs  -  Apr 16, 2007
Hemscott,...and viruses) kills cells from a wide variety of cancer cell lines and was successfully used together with paclitaxel or cytarabine, the company said.

Get the latest news direct to your desktop  -  Apr 17, 2007
PipelineReview.com (press release),MB07133 is a novel HepDirect(R) prodrug of cytarabine (araC) monophosphate designed to produce the biologically active form of araC, araC triphosphate

Vion Pharmaceuticals to Present at Fortis Bank Biotechnology ...  -  Apr 23, 2007
PharmaLive.com (press release),Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute

High-Dose Bexxar with Stem Cell Support Effective in Elderly B ...  -  Apr 17, 2007
Cancer Consultants (press release),Bexxar has been added to a standard regime of high-dose BEAM (carmustine, etoposide, cytarabine and melphalan) with the infusion of autologous stem cells

Data supporting three Antisoma programmes presented at AACR  -  Apr 16, 2007
PipelineReview.com (press release),When AS1411 was used together with paclitaxel or cytarabine, synergistic killing was seen in a number of cancer cell lines.

Total Lymphoid Irradiation and Stem Cell Transplantion Very ...  -  Apr 5, 2007
Cancer Consultants (press release),...carboplatin and cyclophosphamide is lower than observed with a standard regimen of BEAM (carmustine, etoposide, cytarabine and melphalan).

Vion Pharmaceuticals Completes Private Placement of Convertible ...  -  Feb 20, 2007
PharmaLive.com (press release),Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute

Enzon Reports 2006 Financial Results and Accomplishments  -  Feb 13, 2007
Genetic Engineering News (press release),Sales of DepoCyt, a sustained-release formulation of the chemotherapeutic agent cytarabine arabinoside or ara-C used for the treatment of lymphomatous

Intravenous Oncaspar® Safe and Effective in Children with ALL  -  Jan 5, 2007
Cancer Consultants (press release),Another study presented at ASH 2006 showed that sequencing Oncaspar after cytarabine plus thioguanine may help in overcoming cell resistance to cytarabine

Kepivance® May Decrease Oral Mucositis Following High-dose ...  -  Jan 10, 2007
Cancer Consultants (press release),...of the American society of Hematology explored risk factors for OM in patients treated with BEAM (carmustine, etoposide, cytarabine, and melphalan).

SkyePharma aims for $82m with sale of injectable business  -  Jan 10, 2007
In-PharmaTechnologist.com,The injectables business is based in San Diego in the US and its products include DepoCyt (cytarabine)for lymphomatous meningitis and DepoDur (morphine

SkyePharma injectables business sale may net $82 million  -  Jan 9, 2007
Pharma Times (subscription),The injectables business, which includes two marketed products, DepoCyt (cytarabine) for lymphomatous meningitis and the painkiller DepoDur (morphine),

Kepivance® May Decrease Oral Mucositis Following High-Dose ...  -  Jan 8, 2007
Cancer Consultants (press release),Alkeran® (melphalan) (200 mg/m2) or high-dose BEAM (carmustine, etoposide, cytarabine and melphalan) followed by autologous stem cell infusion.

Preliminary Results From Sunesis Pharmaceuticals' Phase 1 Trial Of ...  -  Dec 11, 2006
Medical News Today (press release),In a second presentation, preclinical data from in vivo mice xenograph studies showed that SNS-595 acts synergistically with cytarabine to reversibly ablate ...

Gemtuzumab Induction Therapy Improved Progression Free Survival ...  -  Dec 14, 2006
DG NewsIn the study, patients were treated with gemtuzumab in addition to 1 of 3 standard chemotherapy regimens: 1. daunorubicin and cytarabine; 2. cytarabine ...

Gleevec® Demonstrates Durable Responses  -  Dec 11, 2006
Cancer Consultants (press release),Patients were randomized to Gleevec 400 mg/daily, or interferon-alpha/cytarabine. Of the 553 patients randomized to Gleevec, 69% of ...

Antisoma advancing AS1411 into phase II in acute myelogenous ...  -  Dec 11, 2006
Market Wire (press release)...myelogenous leukaemia (AML). AS1411 will be tested in combination with cytarabine (Ara-C), an established treatment for AML. The trial ...

Vion Presents Data on Cloretazine(R) (VNP40101M) at the 48th ...  -  Dec 11, 2006
PR Newswire (press release),98% of patients had received a cytarabine-based regimen as prior induction treatment, with cytarabine and an anthracycline (91%) as the most common treatment. ...

Chemotherapy Can Be More Toxic To Brain Cells Than To Cancer Cells ...  -  Dec 2, 2006
Medical News Today (press release),...cells, oligodendrocyte precursor cells and neuron-restricted precursor cells, in culture, to three chemotherapeutic agents: cisplatin, carmustine and cytarabine ...

CHEMO 'KILLS BRAIN CELLS'  -  Nov 29, 2006
Mirror.co.uk,...effects seen in many patients given Cisplatin (for breast, lung and colon cancer), Carmustine (brain tumours and Hodgkin's Disease) and Cytarabine (leukaemia). ...

Chemo drugs killing brain cells  -  Nov 30, 2006
FemaleFirst.co.uk,...in many individuals who have taken Cisplatin (for breast, lung and colon cancer), Carmustine (brain tumours and Hodgkin's Disease) and Cytarabine (leukaemia). ...

Gleevec® Confirmed as Initial Therapy for Chronic Myeloid ...  -  Dec 8, 2006
Cancer Consultants (press release),The IRIS trial directly compared treatment with Gleevec to the historical standard interferon-alfa and cytarabine as initial therapy for patients diagnosed ...

Chemotherapy Drugs May Damage Brain Cells  -  Nov 30, 2006
Medical News Today,Drugs used to treat many cancers, chemotherapy drugs, such as cisplatin, carmustine and cytarabine, may damage and destroy brain cells, say scientists from the ...

Addition of Zevalin to Transplant Chemotherapy Improves Survival ...  -  Dec 13, 2006
DG News93% among patients with diffuse large B-cell lymphoma who received Zevalin along with a conditioning regimen comprising carmustine, cytarabine, etoposide and ...

ASH: Mylotarg Boosts AML Disease-Free Survival  -  Dec 12, 2006
MedPage Today,...in a randomized controlled trial in which patients were assigned to conventional chemotherapy with either danorubicin plus Ara-C (cytarabine), the same two ...

Antisoma says moving to phase II trial for leukaemia treatment  -  Dec 11, 2006
Hemscott,...renal cancer. AS1411 will be tested in combination with cytarabine (Ara-C), an established treatment for AML, the company said. The ...

ASH: Chemotherapy Regimen Induces Complete Remissions in Burkitt's  -  Dec 11, 2006
MedPage Today,Standard therapy for Burkitt's, a small, non-cleaved cell lymphoma, involves intensive high-dose chemotherapy with methotrexate, Ara-C (cytarabine), and other ...

Genzyme Begins Phase 2 Pivotal Study of Clolar(R) in Adult Acute ...  -  Nov 27, 2006
Yahoo! News (press release)It is a randomized, double-blind, controlled study that will compare the combination of Clolar and cytarabine (Ara-C) to cytarabine alone. ...

Gleevec's Potency Against Chronic Myeloid Leukemia Shown By 5-Year ...  -  Dec 11, 2006
Medical News Today (press release),The study had begun as a comparative study of patients given Gleevec or the previous standard treatment, interferon alfa plus cytarabine. ...

Vion Pharmaceuticals Enters Into Manufacturing Agreement for ...  -  Dec 13, 2006
Yahoo! News (press release)Cloretazine® (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute myelogenous ...

Zevalin® Can Safely Be Given With High Dose BEAM with Autologous ...  -  Dec 18, 2006
Cancer Consultants (press release),...involved in a multicenter trial demonstrated that doses of Zevalin could be escalated in conjunction with BEAM ((carmustine, etoposide, cytarabine and melphalan ...

Five-Year Follow-up of Patients Receiving Imatinib for Chronic ...  -  Dec 6, 2006
New England Journal of Medicine (subscription),Imatinib inhibits this kinase, and in a short-term study was superior to interferon alfa plus cytarabine for newly diagnosed CML in the chronic phase. ...

Chemotherapy can alter brain  -  Nov 29, 2006
USA TodayCenter. Noble tested three common chemo drugs — cisplatin, cytarabine and carmustine — on rats and in human cells in lab dishes. ...

Study shows how chemo damages brain  -  Nov 30, 2006
MSNBC...of Rochester in New York worked with human brain cells in lab dishes, exposing them to common chemotherapy drugs such as cisplatin, carmustine and cytarabine. ...

Study Offers More Clues to 'Chemo Brain'  -  Nov 30, 2006
Washington Post,A team at the University of Rochester found that clinical doses of the chemotherapy drugs cisplatin, carmustine and cytarabine caused long-term brain damage in ...

Studies say chemotherapy causes brain damage  -  Nov 30, 2006
Los Angeles Times,...exposed human brain cells and brain tumor cells grown in a laboratory dish to three of the most commonly used cancer drugs, carmustine, cisplatin and cytarabine ...

Chemo can permanently damage the brain  -  Dec 1, 2006
ABC Online,They exposed them to common chemotherapy drugs such as cisplatin, carmustine and cytarabine. They also soaked cells from real human tumours in the drugs. ...

Unlocking the Cause of 'Chemo Brain'  -  Nov 29, 2006
WebMD...different populations of healthy brain cells to clinically relevant levels of three commonly used chemotherapy drugs -- carmustine, cisplatin, and cytarabine. ...

Cancer Drugs Damage Brain Cells  -  Nov 30, 2006
MedIndia,The effect of three drugs cisplatin, carmustine and cytarabine which are common chemotherapy drugs used to treat several types of carcinomas, like leukemia ...

Chemo 'harms brain cells'  -  Nov 30, 2006
InTheNews.co.uk,...precursor cells and neuron-restricted precursor cells - the researchers exposed them to three chemotherapeutic agents: cisplatin, carmustine and cytarabine. ...

Chemo on the Brain  -  Nov 30, 2006
Science Now,...chemotherapeutic drugs: cisplatin, often used to treat breast, lung, and colon cancer; carmustine, used to treat brain tumors; and cytarabine, a treatment for ...

Chemotherapy can harm brain  -  Dec 1, 2006
Pioneer Press,Center exposed human brain cells and brain tumor cells grown in a lab dish to three of the most commonly used cancer drugs, carmustine, cisplatin and cytarabine ...

Chemo Drugs Linked to Brain Damage  -  Nov 30, 2006
Daily News Central,Many drugs used in chemotherapy treatments for cancer, including cisplatin, carmustine and cytarabine, could be responsible for neurological damage, suggests ...

Drug developed partly at OHSU helps leukemia patients, study says  -  Dec 8, 2006
OregonLive.com,...still on the drug five years later, while 3 percent of patients who had started on the old treatment — the drugs interferon and cytarabine — kept using ...

Five-Year CML Survival with Gleevec Reaches 95%  -  Dec 7, 2006
MedPage Today,...patients," came from the five-year follow-up of the original 19-month IRIS cross-over study of Gleevec versus interferon alfa plus Ara-C (cytarabine), said Dr ...

Chemotherapy Can Cause Brain Damage  -  Dec 7, 2006
ShortNews.com,Another study showed that common chemotherapy drugs such as isplatin, carmustine and cytarabine killed more brain cells than cancer cells. ...

Sunesis Pharmaceuticals to Present Data on SNS-595 at American ...  -  Dec 4, 2006
PR Newswire (press release),Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: AML * SNS-595 a Novel S Phase Active Cytotoxic Acts Synergistically with Cytarabine To Reduce ...

Vion Pharmaceuticals to Host Conference Call to Discuss Third ...  09 Nov 2006
Cloretazine® (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute myelogenous ... -Yahoo! News (press release) Enzon Reports Third Quarter 2006 Results  Nov 2, 2006
Sales of Depocyt, a sustained-release formulation of the chemotherapeutic agent cytarabine arabinoside or ara-C used for the treatment of lymphomatous ... -PharmaLive.com (press release), Lorus Therapeutics announces presentation on GTI-2040 uptake by ...  Nov 1, 2006
...pharmacokinetic studies with GTI-2040 presented in this study are part of an ongoing investigation of GTI-2040 combination therapy with cytarabine in patients ... -CNW Telbec (Communiqués de presse), Genta: Patient Accrual Completed Into Phase 3 Trial Of Genasense ...  Oct 31, 2006
In this trial, all patients received standard chemotherapy with daunorubicin and cytarabine (ARA-C | charts | news | PowerRating), and they were randomly ... -Trading Markets, Foro de Shell Security - Seguridad informática  Oct 26, 2006
...leucovorin, d triad xorubicin, cyclophosphamide, and etoposide [Pr trial MACE]–cyclophosphamide, etoposide, Adriamycin, cytarabine, bleo triamcinolone ycin ... -Shell Security, Analysis: Shake-up in the leukemia market  Oct 16, 2006
Resources report notes that two large Medical Research Council studies in the United Kingdom are currently evaluating high-doses of cytarabine and other ... -United Press International Versatile Self-Assembling Nanoparticles Improve Drug Potency  Oct 28, 2006
Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into ... -Nanotechwire.com, Patient Accrual Completed Into Phase 3 Trial Of Genasense(R) In ...  Nov 1, 2006
In this trial, all patients received standard chemotherapy with daunorubicin and cytarabine (ARA-C), and they were randomly assigned to receive Genasense or no ... -Medical News Today (press release), Patient Accrual Completed into Phase 3 Trial of Genasense(R) in ...  Oct 31, 2006
In this trial, all patients received standard chemotherapy with daunorubicin and cytarabine (ARA-C), and they were randomly assigned to receive Genasense or no ... -Earthtimes.org Patient Accrual Completed into Phase 3 Trial of Genasense(R) in ...  Oct 31, 2006
...to evaluating these results with our colleagues in CALGB." In this trial, all patients received standard chemotherapy with daunorubicin and cytarabine (ARA-C ... -PR Newswire (press release), Gleevec® Improves Survival with CML  Aug 30, 2006
...chronic myeloid leukemia (CML), treatment with Gleevec® (imatinib) appears to result in better survival than treatment with interferon-alfa and cytarabine. ... -Cancer Consultants

Vion to Present at UBS Global Life Sciences Conference  Sep 21, 2006
Cloretazine(R) (VNP40101M), a unique alkylating agent, is being evaluated in: (i) a Phase III trial in combination with cytarabine in relapsed acute ... -PR Newswire

Genzyme Begins Phase 3 Pivotal Study of Clolar(R) in Adult Acute ...  Sep 6, 2006
...not more than two prior induction regimens, is a randomized, double-blind, controlled study that will compare the combination of Clolar and cytarabine (Ara-C ... -Yahoo! News

Genzyme in Final Tests of Leukemia Drug  Sep 6, 2006
The trial is comparing the combination of Clolar and cytarabine to cytarabine alone. Genzyme plans to enroll as many as 376 patients in the study. -International News Service

Chemo, Radiation and Stem Cell Transplantation Effective for Brain ...  Sep 1, 2006
Specifically, patients received three cycles of methotrexate, followed by cytarabine and thiotepa. This was followed by stem cell harvest at day 40. ... -Cancerpage.com

Research and Markets: Pharma Company Lilly Has Developed a Strong ...  Aug 31, 2006
Gemzar(gemcitabine) is a cytarabine analogue, developed by Lilly for the treatment of non-small cell lung cancer, pancreatic and other types of cancer. ... -PharmaLive.com

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