Recent news on

Abbott sues Wockhardt to block generic Depakote  -  May 15, 2007
Livemint,...is seeking US Food and Drug Administration approval to sell a low-cost version of the medicine, whose active ingredient is divalproex sodium.

Psychiatric Sequelae of Traumatic Brain Injury: A Case Report  -  May 2, 2007
Am J Psychiatry (subscription)Mr. C received several trials of medication that were not effective (risperidone, 1 mg at bedtime; divalproex sodium, 750 mg bid; quetiapine, dose unknown;

Mylan Announces Tentative FDA Approval for Divalproex Sodium ...  -  Mar 27, 2007
Drug Newswire (press release),Divalproex Sodium ER Tablets are the generic version of Abbot Laboratories' Depakote ER(R) Tablets, which had US sales of approximately $698 million for the

Abbott sees dip in Q1 earnings  -  Apr 19, 2007
Pharma Times (subscription),Quarterly sales of the psychiatric drug Depakote (divalproex sodium) rose by a steady 32.6% to $326 million, while the HIV protease inhibitor Kaletra

Harvard researchers show high EPA Omega-3 supplement effective as ...  -  Apr 18, 2007
Earthtimes.orgOther agents in use such as lithium, divalproex and carbamazepine are only minimally effective or fraught with adverse effects, the researchers noted.

Stimulating Research: A Prospective, Randomized, Double-Blind ...  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)Patients were maintained on their medications: lithium (N=2), risperidone (N=1), quetiapine (N=1), divalproex (N=1), and lamotrigine (N=1).

Abbott's new biotech plant on the 'Bio Island' good to go  -  Apr 12, 2007
BiopharmaReporter.com,Abbott also manufactures pharmaceutical products including Biaxin (clarithromycin), Depakote (divalproex), erythromycin and Synthroid (levothyroxine)

Agitation in the Elderly  -  Feb 16, 2007
Psychiatric Times,These effects can be further minimized by the use of divalproex sodium, a delayed-release tablet. Published studies show no significant laboratory

Some facts about migraines  -  Feb 7, 2007
Pittsburgh Post Gazette,These include propranolol (Inderal), timolol (Blocadren), topiramate (Topamax) and divalproex sodium (Depakote). These have had many years of use and make

Lack of Awareness and Cultural Stigmas May Prevent Many Latinos ...  -  Jan 17, 2007
Hispanic PR Wire (press release),The most commonly observed adverse events associated with the use of SEROQUEL in clinical trials as adjunct therapy with lithium or divalproex in bipolar

Affective Disorder and Personality Change in a Patient With ...  -  Jan 15, 2007
Psychosomatics (subscription)Kim E, Humaran TJ: Divalproex in the management of neuropsychiatric complications of remote acquired brain injury. J Neuropsychiatry Clin Neurosci 2002;

Once-Daily Divalproex Similar to Twice-Daily Formulations in ...  -  Dec 8, 2006
DG NewsTwo trained, blinded raters graded the patients' Archimedes spirals; they also asked patients which divalproex preparation they preferred and times per day

Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients  -  Dec 6, 2006
Focus (subscription)Objective: Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation

Lack of Awareness and Cultural Stigmas May Prevent Many Latinos ...  -  Dec 20, 2006
Hispanic PR Wire (press release),The most commonly observed adverse events associated with the use of SEROQUEL in clinical trials as adjunct therapy with lithium or divalproex in bipolar

A balm for your badness  -  Dec 8, 2006
Times Online,...but a new trial, sponsored by the US National Institute of Mental Health, is looking at the use of two antidepressants, fluoxetine and divalproex,

Oxcarbazepine and Pediatric Bipolar Disorder  -  Dec 6, 2006
Am J Psychiatry (subscription)...trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.

Aggression and Quantitative MRI Measures of Caudate in Patients ...  -  Nov 29, 2006
Journal of Neuropsychiatry (subscription)Citrome L, Casey DE, Daniel DG, et al: Adjunctive divalproex and hostility among patients with schizophrenia receiving olanzapine or risperidone.

An Interaction Between Aspirin and Valproate: The Relevance of ...  Oct 30, 2006
...disorder. The treatment team discontinued his nortriptyline and decided to start treatment with divalproex sodium, 250 mg/day. This ... -Am J Psychiatry (subscription) Comparative effectiveness of second-generation antipsychotics and ...  Oct 31, 2006
The six treatment groups did not differ significantly in the addition of a mood stabiliser (divalproex 12 patients, gabapentin 5 patients, lithium 2 patients ... -British Journal of Psychiatry (subscription), FDA Approves AstraZeneca's SEROQUEL(R) For Bipolar Depression ...  Oct 24, 2006
...episodes in bipolar disorder; acute manic episodes in bipolar I disorder, as either monotherapy or adjunct therapy to lithium or divalproex; and schizophrenia. ... -Drug Newswire (press release), Botulinum Toxin Type A More Effective and Safer Than Divalproex ...  Sep 8, 2006
Botulinum toxin type A (BoNTA; Botox®) is significantly more effective than, and shows a superior safety and tolerability profile to, divalproex sodium (DVPX ... -DG News

Get Help for Headaches  Sep 22, 2006
...include tricyclic antidepressants, certain blood-pressure medications (calcium channel or beta blockers) and the seizure medications divalproex and topiramate. ... -Parade Magazine

County's drugging of girl, 2, decried  Sep 11, 2006
The doctor recommended that Desiree be given Depakote (divalproex sodium), which was developed to treat manic episodes associated with bipolar disorder. ... -Rochester Democrat and Chronicle

Migraine Treatment And Prevention In Women  Sep 10, 2006
...be used. However, valproic acid, divalproex sodium and ergot derivatives should never be prescribed to pregnant patients. Early ... -Medical News Today

Prevention Strategies Reviewed for Women With Migraines  Sep 6, 2006
...doxepin); calcium channel blockers (verapamil); selective serotonin reuptake inhibitors (paroxetine, fluoxetine); neuromodulators (divalproex sodium, valproic ... -Medscape (subscription)

Percutaneous Coronary Shunt Effective in Limited Number of Cases ...  Sep 5, 2006
These efficacy rates were not unlike what has been seen in 6 previous studies with drugs such as topiramate, divalproex gabapentin and propranolol. ... -DG News

What is the Psychiatrist to Do With Positive Pregnancy Tests in ...  Sep 7, 2006
...as early as possible, since many have compromised history-giving ability and also because some psychotropic drugs, such as lithium and divalproex, can be ... -Psychosomatics (subscription)

Once-Daily Divalproex Similar to Twice-Daily Formulations in ...  -  Dec 8, 2006
DG NewsTwo trained, blinded raters graded the patients' Archimedes spirals; they also asked patients which divalproex preparation they preferred and times per day

Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients  -  Dec 6, 2006
Focus (subscription)Objective: Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation

A balm for your badness  -  Dec 8, 2006
Times Online,...but a new trial, sponsored by the US National Institute of Mental Health, is looking at the use of two antidepressants, fluoxetine and divalproex,

Oxcarbazepine and Pediatric Bipolar Disorder  -  Dec 6, 2006
Am J Psychiatry (subscription)...trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.

Aggression and Quantitative MRI Measures of Caudate in Patients ...  -  Nov 29, 2006
Journal of Neuropsychiatry (subscription)Citrome L, Casey DE, Daniel DG, et al: Adjunctive divalproex and hostility among patients with schizophrenia receiving olanzapine or risperidone.

Chronic Depression in Bipolar Disorder  Jul 28, 2006
...than no treatment (9). Carbamazepine was found to be significantly better than placebo in a small controlled crossover trial (10), and divalproex was found to ... -Am J Psychiatry (subscription)

Wockhardt sales up 9%  Jul 28, 2006
Wockhardt received its first NDDS approval, Divalproex Sodium delayed released tablets. More than 20 applications are pending with the US FDA for approval. ... -Moneycontrol.com

Treatment-Resistant Schizophrenia: Making the Determination  Jul 11, 2006
For example, if divalproex sodium (Depakote) is added at therapeutic plasma levels for six to eight weeks and minimal improvement is noted, it should be ... -Psychiatric Times

AstraZeneca Submits NDA For Sustained Release Formulation Of ...  Jul 19, 2006
...for the treatment of acute manic episodes associated with bipolar I disorder, as either monotherapy or adjunct therapy with lithium or divalproex, and the ... -Medical News Today

Suicidal Self-Injurious Behavior in People With BPD  Jul 10, 2006
Hollander E, Allen A, Lopez RP et al. (2001), A preliminary double-blind, placebo-controlled trial of divalproex sodium in borderline personality disorder. ... -Psychiatric Times

Flying Almost Blind  Jun 30, 2006
In this study, as the authors note, the response rate for oxcarbazepine was similar to that reported in an open trial of divalproex, lithium, and carbamazepine ... -Am J Psychiatry (subscription)

New Scientific Data on Allergan's BOTOX(R) (Botulinum Toxin Type A ...  Jun 23, 2006
A Randomized, Double-Blind Comparison of Botulinum Toxin Type A (BOTOX(R)) and Divalproex Sodium (Depakote(R)) for the Prophylactic Treatment of Episodic ... -PR Newswire

Neurobiology of Impulsive-Aggressive Personality-Disordered ...  Jun 27, 2006
Carbamazepine (Tegretol), diphenylhydantoin (Dilantin) and divalproex sodium (Depakote) have all yielded promising results, not only in open trials but in more ... -Psychiatric Times

The Hidden Suffering of the Psychopath  Jul 3, 2006
Hollander (1999) found that mood stabilizers such as divalproex (Depakote), selective serotonin reuptake inhibitors, monoamine oxidase inhibitors (MAOIs) and ... -Psychiatric Times

Persistent Auditory Hallucinations That Are Unresponsive to ...  Jun 30, 2006
...the auditory hallucinations. The dose was gradually increased to 1000 mg/day of divalproex in the extended-release form. There was ... -Am J Psychiatry (subscription)

Impact of Lamotrigine and Lithium on Weight in Obese and Nonobese ...  Jun 30, 2006
F, Pope HG Jr, Chou JC, Keck PE Jr, Rhodes LJ, Swann AC, Hirschfeld RM, Wozniak PJ: A randomized, placebo-controlled 12-month trial of divalproex and lithium ... -Am J Psychiatry (subscription)

What Happened to Lithium? Antidepressant Augmentation in Clinical ...  Jun 30, 2006
The anticonvulsants considered included carbamazepine, oxycarbamazepine, divalproex/valproic acid, lamotrigine, and topiramate. ... -Am J Psychiatry (subscription)

Psychosocial Functioning of Medicaid Recipients With Major ...  Jun 30, 2006
CNS Drugs 18:1119–1132,2004[Medline]. Goodwin FX, Fireman B, Simon GE, et al: Suicide risk in bipolar disorder during treatment with lithium and divalproex. ... -Psychiatric Services (subscription)



Patient Management Exercise FOR PSYCHOTHERAPY  May 15, 2006
According to his self-reported history, he had trials of fluoxetine, paroxetine, lithium, divalproex, haloperidol, olanzapine, risperidone, clonazepam ... - Focus (subscription)

Anticonvulsant Treatment for Psychiatric and Seizure Indications ...  May 4, 2006
Divalproex has an indication from the FDA for the treatment of acute mania among adults, with the cautionary statement that controlled research for this use ... - Psychiatric Services (subscription)

Behavioral and Pharmacologic Treatment of Aggression in Children ...  May 10, 2006
Case reports and a retrospective review have reported on the use of lithium (Eskalith, Lithobid) or divalproex (Depakote) for aggressive behaviors in youth ... - Psychiatric Times





FDA-Approved Office Lithium Test Expected To Enhance Clinical Care  Mar 24, 2006
When lithium was compared to carbamazepine (Equetro, Tegretol) or divalproex (Depakote), it showed a differential effect in preventing suicides, Goodwin said. ... - Psychiatric Times

Treatment Compliance in Patients With Co-Occurring Mental Illness ...  Mar 15, 2006
...(1998), compliance was significantly associated with treatment with divalproex (Depakote), compared to treatment with combined lithium (Eskalith, Lithobid). ... - Psychiatric Times

Neurocognitive Function in Unmedicated Manic and Medicated ...  Feb 8, 2006
...who were responders from a recently completed clinical trial that tested the efficacy of lithium plus risperidone (N=14) versus divalproex plus risperidone (N ... - Am J Psychiatry (subscription)

Comorbidity in Bipolar Disorder Among the Elderly: Results From an ...  Feb 8, 2006
Medline]. Ponce H, Kunik ME, Molinari VA, Orengo C, Workman R, Reich L: Divalproex sodium treatment in elderly male bipolar patients. ... - Am J Psychiatry (subscription)

Teva Announces Tentative Approval of Divalproex Sodium Delayed ...  Jan 12, 2006
...(Nasdaq: TEVA) announced today that the US Food and Drug Administration has granted tentative approval for the Company's ANDA for Divalproex Sodium Delayed ... - Genetic Engineering News

Abbott Reports Record Sales, Earnings and Cash Flow in 2005  Jan 25, 2006
In December, Abbott received FDA approval for Depakote ER(R) (divalproex sodium) to treat acute manic or mixed episodes associated with bipolar disorder. ... - MSN Money

US court approves Wyeth-Teva settlement on Effexor  Jan 15, 2006
Teva has also announced tentative FDA approval for its Divalproex Sodium Delayed-Release Tablets USP, 125 mg, 250 mg and 500 mg. ... - Globes

Continuity of Antidepressant Treatment for Adults With Depression ...  Jan 24, 2006
Patients who reported use of mood stabilizer medications (lithium, carbamazepine, valproic acid, divalproex, gabapentin, and lamotrigine) during the study ... - Am J Psychiatry (subscription)

High-Cost Use of Second-Generation Antipsychotics Under ...  Jan 25, 2006
...attempted before other treatment options (9). Monotherapy with first-generation antipsychotics, clozapine monotherapy, or augmentation with divalproex are also ... - Psychiatric Services (subscription)

Brief Reports: Patterns of Psychotropic Medication Use by Race ...  Jan 25, 2006
...and benzodiazepines. Specifically, other mood stabilizers included divalproex, valproate, carbamazepine, and lamotrigine. First-generation ... - Psychiatric Services (subscription)

Teva gets tentative FDA OK for Depakote  Jan 12, 2006
The tentative approval covers 125 milligram, 250 milligram and 500 milligram tablets of delayed-release divalproex sodium, the active ingredient in Depakote ... - BusinessWeek

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