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In New Study, Duloxetine Was Equally Effective, Regardless of ...  -  25 May 2007
PipelineReview.com (press release),The antidepressant duloxetine hydrochloride was equally effective in reducing painful symptoms in depressed patients who did not respond, or responded only

Duloxetine Reduces Disabilities Related to Generalized Anxiety ...  -  May 8, 2007
Therapeutics Daily (subscription) (press release),NEW YORK (Reuters Health) - Results of a study published in the April issue of the Journal of Clinical Psychiatry indicate that duloxetine treatment

Data Suggest Cymbalta Improved Functioning in Patients with ...  -  May 21, 2007
PharmaLive.com (press release),Based on pre-clinical studies, duloxetine is a balanced and potent reuptake inhibitor of serotonin and norepinephrine that is believed to potentiate the

Data Suggest Cymbalta(R) Improved Functioning In Patients With ...  -  May 22, 2007
Medical News Today (press release),Data suggest that patients with generalized anxiety disorder (GAD) treated with Cymbalta(R) (duloxetine HCl) experienced improved ability to perform

FDA calls for expanded warnings on antidepressants  -  May 3, 2007
Pharma Times (subscription),The announcement was welcomed by a number of pharmaceutical companies and Eli Lilly, manufacturer of Prozac (fluoxetine) and Cymbalta (duloxetine) said it

An Evidence-Based Algorithm for the Treatment of Neuropathic Pain  -  May 16, 2007
Medscape (subscription)Wernicke JF, Pritchett YL, D'Souza DN, Waninger ATP, Iyengar S, Raskin J. A randomized controlled trial of duloxetine in diabetic peripheral neuropathic

Eli Lilly (LLY) Reports Data Suggesting Cymbalta Improved ...  -  May 21, 2007
StreetInsider.com (subscription),Eli Lilly and Company (NYSE: LLY) reports data suggests that patients with generalized anxiety disorder (GAD) treated with Cymbalta (duloxetine HCl)

Antidepressants linked to suicide risk in young adults  -  May 5, 2007
Food Consumer,Asendin (amoxapine), Aventyl (nortriptyline), Celexa (citalopram hydrobromide), Cymbalta (duloxetine), Desyrel (trazodone HCl), Elavil (amitriptyline),

Duloxetine is Effective for Anxiety: Presented at ADAA  -  Apr 2, 2007
DG NewsLOUIS, MO -- April 2, 2007 -- Duloxetine decreases the severity of anxiety symptoms in patients with generalised anxiety disorder (GAD) and also improves

Duloxetine Improves Functioning and Quality of Life in Patients ...  -  Apr 3, 2007
DG NewsUsing the criteria of improvement to community values, duloxetine-treated patients were more likely to achieve this outcome on each quality of life measure

Experts Answer Your Questions on Antidepressants  -  Apr 19, 2007
ABC NewsFluoxetine, Duloxetine and escitralopram would all be worth considering on that basis. My question has to do with the 39 percent that improved on placebo

Eli Lilly's profits take a tumble  -  Apr 17, 2007
Pharma Times (subscription),This growth was fuelled by strong sales of the company's depression drug Cymbalta (duloxetine) and cancer treatments Gemzar (gemcitabine) and Alimta

Lilly Reports Strong First-Quarter Results; Raises Full-Year Sales ...  -  Apr 16, 2007
Earthtimes.orgLilly) Yentreve(R) (duloxetine hydrochloride, Lilly) Zyprexa(R) (olanzapine, Lilly) Eli Lilly and Company Employment Information March 31, 2007 December

The Dual Serotonin And Noradrenaline Reuptake Inhibitor Duloxetine ...  -  Feb 19, 2007
Medical News Today (press release),It is not unreasonable to postulate that a serotonin-norepinephrine receptor inhibitor like duloxetine might have similar analgesic effects in PBS/IC.

Duloxetine May Alleviate Both Pain and General Anxiety Disorder ...  -  Feb 12, 2007
DG NewsIn the first study, clinicians assigned 168 patients to duloxetine 60 mg per day, 170 patients to duloxetine 120 mg per day, and 175 to placebo.

Eli Lilly Japan and Shionogi to Co-Develop and Co-Market ...  -  Feb 2, 2007
PharmaLive.com (press release),Shionogi & Co., Ltd. and Eli Lilly Japan KK today announced that the two companies have signed an agreement to co-develop and co-market duloxetine

Shionogi, Eli Lilly to develop antidepressant  -  Feb 2, 2007
ReutersDuloxetine, whose global sales last year totalled $1.32 billion, is already used for the treatment of depression for adults in Europe, Latin America and the

Shionogi, Eli Lilly to Jointly Sell Antidepressant in Japan  -  Feb 2, 2007
Therapeutics Daily (subscription) (press release),2 (Jiji Press)--Shionogi & Co. and Eli Lilly Japan KK said Friday they have agreed to jointly develop and sell the antidepressant Duloxetine in Japan.

Complex Regional Pain Syndrome  -  Feb 19, 2007
KKTV 11 News,For example, antidepressants, such as duloxetine (Cymbalta), and anticonvulsants, such as gabapentin (Neurontin), are used to treat pain that originates

Schwarz Pharma: lacosamide one step closer to the lucrative market  -  Feb 17, 2007
Pharmaceutical Business Review...strong growth predicted in the near term through Lyrica (pregabalin, Pfizer), Cymbalta (duloxetine, Eli Lilly) and Lidoderm (lidocaine patch 5%, Endo).

FDA Panel Seeks to Balance Risks in Warnings for Antidepressants  -  Feb 13, 2007
Journal of American Medical Association (subscription),Both analyses, which examined data from trials of bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, mirtazapine, nefazadone,

Lilly Announces 2006 Adjusted EPS of $3.18 Excluding Charges and ...  -  Jan 31, 2007
Earthtimes.org...or OFC, Lilly) Xigris(R) (drotrecogin alfa (activated), Lilly) Yentreve(R) (duloxetine hydrochloride, Lilly) Zyprexa(R) (olanzapine, Lilly) Eli Lilly

Lilly Announces 2006 Adjusted EPS of $3.18 Excluding Charges and ...  -  Jan 31, 2007
Yahoo! News (press release)Lilly) Symbyax® (olanzapine fluoxetine combination, or OFC, Lilly) Xigris® (drotrecogin alfa (activated), Lilly) Yentreve® (duloxetine hydrochloride,

Which Antidepressant is Right for You?  -  Feb 1, 2007
Ivanhoe,...duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (Luvox), mirtazapine (Remeron), nefazodone (Serzone), paroxetine (Paxil)

Cymbalta is bright spot as charges batter Lilly net income  -  Feb 1, 2007
Pharma Times (subscription),Turnover rose 9% to $4.25 billion, and Cymbalta (duloxetine) soared 85% to $424.1 million on the back of a massive sales and marketing campaign,

Efficacy Similar Among Antidepressants, Side Effects Drive ...  -  Jan 29, 2007
Science Daily (press release)The drugs reviewed were bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline,

Newer Class Of Antidepressants Similar In Effectiveness, Side ...  -  Jan 29, 2007
Medical News Today (press release),...citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac), fluvoxamine (formerly sold as Luvox), mirtazapine (Remeron),

Medical study results announced by Eli Lilly.  -  Dec 14, 2006
Therapeutics Daily (subscription) (press release),Study 1: Duloxetine was safely administered and well tolerated in patients with diabetic peripheral neuropathic pain. According to a study from Canada,

Lexapro®/Cipralex® demonstrated significance on prospectively ...  -  Dec 6, 2006
WebWire (press release),...p=0.040, utilizing an LOCF approach and was better tolerated than Cymbalta® (duloxetine), based on the percentage of patients discontinuing treatment

Lundbeck says Lexapro depression treatment better tolerated than ...  -  Dec 6, 2006
Forbes,...depression treatment, Lexapro/Cipralex (escitalopram oxalate), against Cymbalta (duloxetine), a depression treatment made by Eli Lilly and Co.

Psychiatry in Chronic Pain: A Review and Update  -  Dec 6, 2006
Focus (subscription)Duloxetine is the most recent dual-action antide-pressant to come to market, and it has gained approval from the United States Food and Drug Administration

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)Duloxetine is an SNRI and inhibits the reuptake of noradrenaline, serotonin and dopamine, although it is a 3- to 4-fold more potent inhibitor of serotonin.

Lilly opts for caution with 2007 earnings estimates  -  Dec 8, 2006
Pharma Times (subscription),Other top-sellers should be the antidepressant Cymbalta (duloxetine), the diabetes drug Byetta (exenatide), cancer treatment Alimta (pemextred) and Forteo

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)...alprazolam, tomoxetine, buproprion, duloxetine, risperidone and gabapentin. Various clinical trial designs were used for these proof-of-concept studies.

Ask the Expert PSYCHOPHARMACOLOGY: MAJOR DEPRESSIVE DISORDER  -  Dec 6, 2006
Focus (subscription)...anxiety disorders suggest an SSRI or SNRI, pain an SNRI (duloxetine), smoking, attention-deficit disorder or obesity—bupropion.

Endocrinology & Metabolism News, December 2006  -  Dec 5, 2006
Journal of Clinical Endocrinology and Metabolism,The dual 5-HT and NE reuptake inhibitor duloxetine lessened diabetic neuropathic pain significantly more than placebo in a 3-month double-blind controlled

Lilly Delivers Promising Update to Wall Street on Strategic ...  -  Dec 7, 2006
Yahoo! News (press release)Lilly ICOS LLC Cymbalta® (duloxetine hydrochloride, Lilly) Evista® (raloxifene hydrochloride, Lilly) Forteo® (teriparatide of recombinant DNA origin,

Lilly Delivers Promising Update to Wall Street on Strategic ...  -  Dec 7, 2006
PR Newswire (press release),Amylin Pharmaceuticals) Cialis(R) (tadalafil, ICOS), Lilly ICOS LLC Cymbalta(R) (duloxetine hydrochloride, Lilly) Evista(R) (raloxifene hydrochloride,

Duloxetine effective for diabetic neuropathic pain  Oct 27, 2006
NEW YORK (Reuters Health) - Duloxetine appears to be a safe and effective treatment for diabetes-related pain caused by damage to the peripheral nervous system ... -Reuters.uk, Meeting Highlights From The Committee For Medicinal Products For ...  Oct 20, 2006
The Committee recommended adding new contraindications for four medicinal products that contain duloxetine as active substance. ... -Medical News Today (press release), Psychiatric Pharmacogenomics  Oct 20, 2006
In contrast, drugs such as sertraline and duloxetine have at least one other functional alternative pathway and would consequently be more suitable choices for ... -Focus (subscription) Chronic Fatigue Syndrome Treatment: A Double Blind Trial of ...  Sep 14, 2006
The purpose of this study is to determine the safety and efficacy of duloxetine compared with placebo for reducing fatigue in patients diagnosed with Chronic ... -Community Dispatch

Q & A: Your Questions on Diabetes  Sep 13, 2006
The FDA has recently approved two medications for treatment of neuropathic pain: duloxetine (sold under the name Cymbalta) and pregabalin (sold as Lyrica). ... -NPR

Urinary Incontinence Sector Misses Opportunities in the SUI and IC ...  Sep 13, 2006
The recent approval of duloxetine in the EU presents physicians with a much-needed treatment alternative, but uptake has been slow. ... -Genetic Engineering News

Neuropathic Pain Market Forecast to Grow to $5.5 Billion by 2015  Sep 13, 2006
However, Pfizers follow-on Lyrica (pregabalin), Lillys Cymbalta (duloxetine) and Endo/Elans Lidoderm (lidocaine patch 5%) are re-establishing market growth and ... -Genetic Engineering News

Research and Markets: Pharma Company Lilly Has Developed a Strong ...  Aug 31, 2006
Cymbalta (duloxetine) a selective serotonin and norepinephrine reuptake inhibitor, indicated for depression, stress urinary incontinence and diabetic ... -PharmaLive.com

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)...disorders led to new off-label indications for fluoxetine, sertraline, tryptophan, clonazepam, alprazolam, tomoxetine, buproprion, duloxetine, risperidone and ...

Psychiatry in Chronic Pain: A Review and Update  -  Dec 6, 2006
Focus (subscription)Duloxetine is the most recent dual-action antide-pressant to come to market, and it has gained approval from the United States Food and Drug Administration for ...

Lexapro®/Cipralex® demonstrated significance on prospectively ...  -  Dec 6, 2006
WebWire (press release),...today announced the results of a new head to head study of Lexapro®/Cipralex® (escitalopram oxalate) versus Cymbalta® (duloxetine). ...

Lundbeck says Lexapro depression treatment better tolerated than ...  -  Dec 6, 2006
Forbes,...results of a new head-to-head study of Lundbeck's depression treatment, Lexapro/Cipralex (escitalopram oxalate), against Cymbalta (duloxetine), a depression ...

Endocrinology & Metabolism News, December 2006  -  Dec 5, 2006
Journal of Clinical Endocrinology and Metabolism,The dual 5-HT and NE reuptake inhibitor duloxetine lessened diabetic neuropathic pain significantly more than placebo in a 3-month double-blind controlled trial ...

Ask the Expert PSYCHOPHARMACOLOGY: MAJOR DEPRESSIVE DISORDER  -  Dec 6, 2006
Focus (subscription)...disorder or pre-menstrual worsening suggests switching to another SSRI; anxiety disorders suggest an SSRI or SNRI, pain an SNRI (duloxetine), smoking, attention ...

Lilly Delivers Promising Update to Wall Street on Strategic ...  -  Dec 7, 2006
Yahoo! News (press release)...disodium, Lilly) Byetta® (exenatide injection, Amylin Pharmaceuticals) Cialis® (tadalafil, ICOS), Lilly ICOS LLC Cymbalta® (duloxetine hydrochloride, Lilly ...

Lexapro(R) Demonstrated Significance On Prospectively Defined ...  -  Dec 7, 2006
Medical News Today (press release),...oxalate) provided a greater reduction in MADRS scores, (p=0.040), utilizing an LOCF approach and was better tolerated than Cymbalta (duloxetine), based on the ...

Lilly opts for caution with 2007 earnings estimates  -  Dec 8, 2006
Pharma Times (subscription),Other top-sellers should be the antidepressant Cymbalta (duloxetine), the diabetes drug Byetta (exenatide), cancer treatment Alimta (pemextred) and Forteo ...

Lilly Delivers Promising Update to Wall Street on Strategic ...  -  Dec 7, 2006
PR Newswire (press release),Lilly) Byetta(R) (exenatide injection, Amylin Pharmaceuticals) Cialis(R) (tadalafil, ICOS), Lilly ICOS LLC Cymbalta(R) (duloxetine hydrochloride, Lilly) Evista ...

New Biologic Tools in Psychiatry  Aug 23, 2006
...antidepressants (amitriptyline, nortriptyline, clomipramine, desipramine, imipramine, paroxetine, fluvoxamine, fluoxetine, venlafaxine, and duloxetine) as well ... -Psychiatric Times

Commercial Insight: Neuropathic Pain - A Plethora of Patient ...  Jul 26, 2006
However, Pfizer's follow-on Lyrica (pregabalin), Lilly's Cymbalta (duloxetine) and Endo/Elan's Lidoderm (lidocaine patch 5%) are re-establishing market growth ... -Pharmaceutical Business Review

Duloxetine Safe for Long-Term Management of Diabetic Peripheral ...  Jun 28, 2006
BOSTON, MA -- June 28, 2006 -- The antidepressant duloxetine is safe for the long-term management of diabetic peripheral neuropathic pain (DPNP), according to ... -DG News

FDA Warns on Mixing Antidepressants with Migraine Drugs  Jul 20, 2006
Md., July 20 -- Mixing common migraine drugs such as Imitrex (sumatriptan) with antidepressants like Prozac (fluoxetine) or Cymbalta (duloxetine) can trigger a ... -MedPage Today

Somatic Symptoms in Outpatients With Major Depressive Disorder ...  Jul 14, 2006
11 Duloxetine, a dual serotonin and norepinephrine reuptake inhibitor, also appears to be effective in the treatment of somatic symptoms of depression, such as ... -Psychosomatics (subscription)

Advances in the Pharmacologic Treatment of Chronic and ...  Jun 29, 2006
Robinson and colleagues [4] reviewed data from studies with duloxetine in major depressive disorder and chronic or persistent pain disorders, including ... -Medscape (subscription)

Urinary incontinence: common problem, not commonly reported  Jun 29, 2006
Lilly and Boehringer Ingelheim received marketing approval in the EU for their serotonin and norepinephrine reuptake inhibitor (SNRI), duloxetine, for moderate ... -Pharmaceutical Business Review



Study suggests Lilly's duloxetine HC1 antidepressant significantly ...  Apr 24, 2006
2006 APR 24 - (NewsRx.com) -- A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta (duloxetine HCl) on ... - Therapeutics Daily (subscription)

Study suggests Lilly's duloxetine HC1 antidepressant significantly ...  Apr 20, 2006
A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta (duloxetine HCl) on the core anxiety symptoms in ... - Therapeutics Daily (subscription)

Lilly Submits Cymbalta Supplemental New Drug Application for ...  May 9, 2006
...today announced the recent submission of a supplemental New Drug Application (sNDA) to the US Food and Drug Administration for Cymbalta(R) (duloxetine HCl) for ... - International News Service

Neuropathic Pain: An Update on Effective Management Strategies  May 5, 2006
...trigeminal neuralgia, gabapentin (Neurontin [Parke-Davis]) and transdermal lidocaine (LidoDerm [Endo]) for postherpetic neuralgia, duloxetine (Cymbalta [Eli ... - Medscape (subscription)

Lilly submits Cymbalta NDA for generalized anxiety disorder  May 9, 2006
...announced the recent submission of a supplemental New Drug Application (sNDA) to the US Food and Drug Administration (FDA) for Cymbalta (duloxetine HCl) for ... - News-Medical.net

Lilly seeks OK of Cymbalta for anxiety  May 9, 2006
Cymbalta (duloxetine HCl) is already approved by the Food and Drug Administration to treat adults with major depressive disorder and to manage diabetic ... - United Press International

Without the Widespread Availability of an Efficacious Drug for ...  May 10, 2006
...gain more support. The approval of Yentreve (duloxetine) for SUI in the EU has provided another treatment option. However, uptake ... - Business Wire

Lilly Reports Q1 EPS of $.77, or 13% Growth  Apr 20, 2006
Lilly) Byetta(R) (exenatide injection, Amylin Pharmaceuticals) Cialis(R) (tadalafil, ICOS), Lilly ICOS LLC Cymbalta(R) (duloxetine hydrochloride, Lilly) Evista ... - MSN Money

Exploring Phantom Limb Pain  Apr 17, 2006
If tricyclic antidepressants cannot be tolerated or their use is contraindicated, venlafaxine (Effexor) or duloxetine (Cymbalta) (both of which, like the ... - Psychiatric Times





Interaction of Duloxetine and Warfarin Causing Severe Elevation of ...  Apr 4, 2006
To the Editor: We describe what we believe is the first report of a drug interaction between duloxetine hydrochloride and warfarin. ... - Journal of American Medical Association (subscription)

Duloxetine in the prevention of relapse of major depressive ...  Mar 31, 2006
Aims Duloxetine, an inhibitor of serotonin and noradrenaline reuptake that is licensed in Europe, the USA and elsewhere for the treatment of depressive episodes ... - British Journal of Psychiatry (subscription)

Stakeholder Insight: Major Depressive Disorder Duloxetine ...  Mar 29, 2006
...have been over-hyped. Cymbalta (duloxetine) is at risk of being seen as a 'me-too' SNRI. Datamonitor's primary research suggests ... - Pharmaceutical Business Review

Study Suggests Cymbalta(R) Significantly Reduces Core Anxiety ...  Mar 24, 2006
24 /PRNewswire-FirstCall/ -- A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta(R) (duloxetine HCl) on ... - PR Newswire

American Society of Pain Educators Releases First Ever Treatment ...  Apr 4, 2006
...second-tier. First-tier agents include duloxetine, oxycodone controlled-release, pregabalin and all tricyclic antidepressants. "The ... - DG News

Patients Taking Cymbalta Also Reported Reduced Painful Physical ...  Mar 24, 2006
FL -- March 24, 2006 -- A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta(R) (duloxetine HCl) on the ... - DG News

Cymbalta® Safely And Effectively Treats Core Anxiety Symptoms Of ...  Mar 24, 2006
A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta® (duloxetine HCl) on the core anxiety symptoms in ... - Medical News Today

Study Suggests Cymbalta Significantly Reduces Core Anxiety ...  Mar 24, 2006
...via COMTEX News Network/ -- A new study of approximately 500 patients evaluated the safety and efficacy of the antidepressant Cymbalta® (duloxetine HCl) on ... - PharmaLive.com

Highlights of this issue  Mar 31, 2006
Among adult out-patients with treated major depressive disorder, randomisation to duloxetine, an inhibitor of serotonin and noradrenaline reuptake, was ... - British Journal of Psychiatry (subscription)

Eli Lilly Says Study Shows Cymbalta Reduces Core Anxiety Symptoms ...  Mar 24, 2006
...(RTTNews) - Eli Lilly and Company (LLY | charts | news | Powerrating) said that new study on antidepressant Cymbalta, or duloxetine HCl, in patients with ... - Trading Markets

Primary Care Medicine: Office Evaluation and Management of the ...  Mar 14, 2006
While I did not see mention of the antidepressant duloxetine in the pain management chapter, I did find "duoxetine" in the chapter on evaluation of back pain. ... - Journal of American Medical Association (subscription)

Lilly's Cymbalta relieves core GAD symptoms  Mar 24, 2006
US drug major Eli Lilly says that its antidepressant Cymbalta (duloxetine) showed good safety and efficacy in tackling the core anxiety symptoms of generalized ... - Therapeutics Daily (subscription)

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