Recent news on Epivir

GlaxoSmithKline: Results Announcement for the First Quarter 2007  -  Apr 25, 2007
PharmaLive.com (press release),Total sales of HIV products were £359 million, down 3% reflecting competition to older products, Combivir (-13% to £115 million) and Epivir (-27% to £41

Bristol-Myers Squibb's Baraclude to Dominate the Hepatitis B Virus ...  -  Apr 17, 2007
PR Newswire (press release),...and inflammation than the other therapies currently on the market, and the agent is less prone to viral resistance than GlaxoSmithKline's Epivir."

AZT causes genetic damage to infants; long-term cancer risk unknown  -  Apr 16, 2007
Aidsmap,...red blood cell walls - glycophorin A (GPA) - in the blood of children born to women who had been taking both zidovudine and lamivudine (Epivir).

Icagen Announces Forms Drug Discovery and Development Expert Panel  -  Apr 10, 2007
Carolina Newswire (press release),He is a joint holder of patents on Salmeterol® and related molecules as long acting bronchodilators for the treatment of asthma, and led the Epivir® and

Fresh from the Pipeline: Telbivudine  -  Apr 5, 2007
Nature.com (subscription),In 1998, the first nucleoside analogue, lamivudine (Epivir-HBV; GlaxoSmithKline) was approved for treating HBV. It has since been joined on the market by

GSK giving figures exeed £300m for fourth year running: medicines ...  -  27 Mar 2007
WebWire (press release),This commitment has seen steady growth in the shipment of our antiretrovirals, Combivir and Epivir, at not for profit prices. In 2006, 206 million tablets

Standard screening tests may not detect hidden hepatitis B virus ...  -  27 Mar 2007
Aidsmap,Importantly, none of the participants with occult hepatitis B were taking antiretroviral drugs with anti-HBV activity, such as 3TC (Epivir),

ReportAlert.info - GlaxoSmithKline publishes CR report 2006  -  Mar 22, 2007
SocialFunds.com206 million tablets of Combivir and Epivir supplied to the developing world. 86 million of these came directly from GSK and a further 120 million were

FDA Announces Tentative Approval of Lamivudine Tablets  -  Mar 20, 2007
PharmaLive.com (press release),Final approval cannot be granted at this time because the reference drug product, Epivir Tablets, a product of GlaxoSmithKline, is currently subject to

Avexa Raises $60.1M To Fund Phase III Trials Of HIV Agent  -  Mar 21, 2007
BioWorld Online,...a reduction of less than 0.03 log10 in patients treated with 3TC (lamivudine, Epivir), an approved NRTI HIV drug from London-based GlaxoSmithKline plc.

Next generation NRTI, apricitabine (ATC), shows early promise  -  Mar 19, 2007
Aidsmap,...twice daily) compared to 3TC (lamivudine, Epivir, taken as 150mg twice daily) in treatment-experienced participants with evidence of the M184V mutation.

CROI: Remission of Kaposi's sarcoma seen in rural Uganda when HIV ...  -  Mar 12, 2007
Aidsmap,The primary ART regimen was 3TC (lamivudine, Epivir), d4T (stavudine, Zerit), and nevirapine (Viramune). KS was diagnosed based on clinical grounds

Anti-HBV drug entecavir also active against HIV and promotes ...  -  Mar 1, 2007
Aidsmap,Two agents currently approved for the treatment of hepatitis B virus (HBV) infection – lamivudine (3TC; Epivir-HBV) and adefovir (Hepsera) also demonstrate

CROI: HIV Resistance Linked to Hepatitis Drug  -  Mar 1, 2007
MedPage Today,The researchers used a single cycle infectivity assay to test the drug against HIV and compared its effect to lamivudine (3TC, Epivir) and zidovudine (AZT).

GSK to export to 70 markets from Poznan  -  Mar 1, 2007
Polish Market,The factory has also became the packaging plant for four innovative anti-retroviral drugs used in HIV/AIDS therapy (Combivir, Epivir, Trizivir and Ziagen)

Single Patient Shows Baraclude May Be Linked to Risk for Resistant HIV  -  Feb 26, 2007
Medscape (subscription)The M184V mutation results in resistance to lamivudine (Epivir; GlaxoSmithKline) and may affect the virus' susceptibility to other drugs.

Women experience rapid fall in genital secretion of HIV after ...  -  Feb 19, 2007
Aidsmap,All had a CD4 cell count below 200 cells/mm 3 and were provided with an antiretroviral regimen consisting of 3TC (lamivudine, Epivir), d4T (stavudine,

Merck & Co., Inc. To Distribute ATRIPLA™ in Developing Countries  -  Feb 16, 2007
WebWire (press release),Due to similarities between emtricitabine and lamivudine, ATRIPLA should not be coadministered with drugs containing lamivudine, including Combivir, Epivir®

Merck & Co., Inc. (1) To Distribute ATRIPLA(TM) in Developing ...  -  Feb 16, 2007
American Digital Networks (press release),ATRIPLA should not be coadministered with drugs containing lamivudine, including Combivir, Epivir(R), Epivir-HBV(R), EpzicomTM, or Trizivir(R).

FDA Announces Tentative Approval of Triple Drug Fixed Dose Combination  -  Feb 6, 2007
PharmaLive.com (press release),The tablet contains lamivudine-zidovudine-nevirapine, the active ingredients in the widely used antiretroviral drugs Epivir (lamivudine),

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,One of the largest studies yet of resistance mutation development has confirmed that, in people on 3TC (lamivudine, Epivir)-containing antiretroviral

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,One of the largest studies yet of resistance mutation development has confirmed that, in people on 3TC (lamivudine, Epivir)-containing antiretroviral

Idenix Pharmaceuticals initiated with "buy"  -  Dec 6, 2006
newratings.com...market opportunity and capture market share from two competing and widely prescribed drugs, Glaxo’s Epivir HBV and Gilead’s Hepsera, the analysts say.

96-Week Data From Gilead’s Study 934 Comparing Viread ® and ...  -  Dec 15, 2006
Business Wire (press release),...(lamivudine/zidovudine), Epivir ® (lamivudine), Epivir-HBV ® , Epzicom TM (abacavir/lamivudine), or Trizivir ® (abacavir/lamivudine/zidovudine).

96-Week Data From Gilead's Study 934 Comparing Viread and Emtriva ...  -  Dec 15, 2006
PharmaLive.com (press release),...(lamivudine/zidovudine), Epivir(R) (lamivudine), Epivir-HBV(R), Epzicom(TM)(abacavir/lamivudine), or Trizivir(R) (abacavir/lamivudine/zidovudine).

Triple nuke combination of AZT/3TC/tenofovir below current ...  -  Dec 17, 2006
Aidsmap,...safety and tolerability – of AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and tenofovir, dosed as Combivir twice daily and Viread once daily.

Tenofovir DF- and Thymidine Analog-Containing Regimens Display ...  -  Dec 14, 2006
DG News...(TDF) or a thymidine analog (stavudine; azidothymidine, AZT) in combination with efavirenz and lamivudine (Epivir, 3TC) or emtricitabine (Emtriva).

Why did HIV therapy have some benefits for a man with resistance ...  -  Dec 12, 2006
Aidsmap,A genotypic resistance test detected resistance to all the available antiretroviral drugs except 3TC (lamivudine, Epivir), FTC (emtricitabine, Emtriva) and

AASLD: Tyzeka Bests Epivir at HBV Control at Two Years  Oct 30, 2006
30 -- Tyzeka (telbivudine) was superior to Epivir (lamivudine) at reducing hepatitis B virus (HBV) to undetectable levels after two years, reported ... -MedPage Today, Novartis' Tyzeka receives FDA approval for chronic hepatitis B in ...  Oct 25, 2006
Tyzeka, which is marketed in the US under the brand name Sebivo, has shown to be as effective in trials as treatment with Epivir-HBV, the Basel-based drug ... -Forbes, FDA OKs New Hepatitis B Drug  Oct 26, 2006
...was shown to be an effective antiviral agent, capable of suppressing the hepatitis B virus and improving liver inflammation comparably to Epivir-HBV, one of ... -WebMD New risk factors for severe liver toxicity identified in largest ...  Nov 3, 2006
NRTIs) - including AZT (zidovudine, Retrovir), ddI (didanosine, Videx), ddC (zalcitabine, Hivid), d4T (stavudine, Zerit), and 3TC (lamivudine, Epivir). ... -Aidsmap, Two drug maintenance with tenofovir-efavirenz less effective than ...  Oct 10, 2006
...of tenofovir (Viread) and efavirenz (Sustiva) to be less effective than a three-drug combination of the same two drugs plus 3TC (lamivudine, Epivir) over 48 ... -Aidsmap, Continuing 3TC therapy after viral rebound shows no benefit  Oct 10, 2006
HIV-positive individuals who have resistance to the antiretroviral drug 3TC (lamivudine, Epivir) do not derive any virological or immunological benefit from ... -Aidsmap, FDA Approves New Treatment for Chronic Hepatitis B in Adults  Oct 25, 2006
...evidence of antiviral effectiveness, including the suppression of hepatitis B virus, and improvement in liver inflammation comparable to Epivir-HBV (lamivudine ... -FDA.gov Pharma Sector: Few Newsmakers Of The Week - Novartis, Abbott ...  Oct 28, 2006
Other approved monotherapies for HBV are GlaxoSmithKline's Epivir-HB (lamivudine), Gilead Sciences' Hepsera (adefovir), Bristol-Myers Squibb's Baraclude ... -Trading Markets, GlaxoSmithKline: Results Announcement for the Third Quarter 2006  Oct 26, 2006
Sales of GSK’s HIV products were £363 million, down 6% due to competition to older products, Combivir (-12% to £125 million) and Epivir (-25% to £46 ... -PharmaLive.com (press release), Bristol-Myers Squibb, Gilead Sciences And Merck & Co. Submit ...  Oct 10, 2006
...between emtricitabine and lamivudine, ATRIPLA should not be coadministered with drugs containing lamivudine, including Combivir(R), Epivir(R), Epivir- HBV(R ... -Medical News Today (press release), Source: Bristol-Myers Squibb Company  Oct 8, 2006
...between emtricitabine and lamivudine, ATRIPLA should not be coadministered with drugs containing lamivudine, including Combivir®, Epivir®, Epivir- HBV ... -Yahoo! News (press release) GlaxoSmithKline and Vertex Pharmaceuticals Announce Virologic and ...  Oct 12, 2006
Lexiva with Epivir(R) (lamivudine) and Abacavir in ART-Naive patients) were also presented at the International AIDS Conference in Toronto in August 2006. ... -DG News Glaxo profits while people with HIV die  Sep 23, 2006
...have been fattened by the exorbitant profits to be made in pharmaceuticals—especially HIV antiviral drugs that GSK produces, like Com bivir, Epivir and Ziagen ... -Workers World

Glaxo to Supply Cut-price AIDS Drugs to Russia  Sep 15, 2006
...federal purchase of anti-retroviral medicines in Russia and covers the supply of over 90,000 treatment packs of Glaxo’s drugs Combivir, Epivir and Ziagen by ... -MOSNEWS

Russia gets discounted HIV drugs  Sep 15, 2006
Glaxo will supply over 90000 treatment packs of its HIV medicines - Combivir, Epivir and Ziagen, by the end of 2006, the company said in a statement. ... -Finance24

GlaxoSmithKline agrees preferential prices for HIV medicines in ...  Sep 15, 2006
...the terms of the agreement, GSK said it will supply over 90,000 treatment packs to the Russian government of its HIV medicines Combivir, Epivir and Ziagen by ... -Euro2day

Business in Brief  Sep 17, 2006
...said Friday. The company will sell 90,000 treatment packs of the Combivir, Epivir and Ziagen drugs by the year's end. (Bloomberg). -The Moscow Times

Glaxo backs Russian HIV/Aids crusade  Sep 16, 2006
Glaxo will supply more than 90,000 treatment packs of its drugs - Combivir, Epivir and Ziagen - to the Russian Government by the end of 2006. ... -ic Wales

Tenofovir drug to be sold cheaply  Aug 25, 2006
As Tenofovir is used in combination with two other antiviral medications, such as 3TC (Epivir) and Nevirapine, both of which can be manufactured in Thailand ... -Nation Multimedia

Draft BHIVA treatment guidelines: respond by Monday September 4 th  Aug 30, 2006
...guidelines discuss the latest data regarding switching or remaining on a "failing" regimen, treatment interruptions, 3TC (lamivudine, Epivir) monotherapy, and ... -Aidsmap

Liver transplants can be successful in HIV patients with hepatitis ...  Sep 5, 2006
The prolonged use of the drug Lamivudine ( Epivir ), which is used to treat both HIV and HBV, has led to Lamivudine resistance in recent years and 67 percent ... -Xagena.it

Why did HIV therapy have some benefits for a man with resistance ...  -  12 Dec 2006
Aidsmap,A genotypic resistance test detected resistance to all the available antiretroviral drugs except 3TC (lamivudine, Epivir), FTC (emtricitabine, Emtriva) and

Idenix Pharmaceuticals initiated with "buy"  -  Dec 6, 2006
newratings.com...market opportunity and capture market share from two competing and widely prescribed drugs, Glaxo’s Epivir HBV and Gilead’s Hepsera, the analysts say.

FDA Approves New Treatment for Chronic Hepatitis B in Adults  -  Nov 13, 2006
Pharmaceutical Processing,...and improvement in liver inflammation comparable to Epivir-HBV (lamivudine), one of five other medications approved to treat patients with chronic HBV.

Healthcare: At a Glance - Roche Hepatitis Drug Thrust Onto Front ...  Mar 3, 2006
GlaxoSmithKline's Epivir (lamivudine) is the best-known product in this disease area, although Schering-Plough's Intron A (interferon alfa-2b) is also used to ... - International News Service,

Restoration of CD4 T-cells limited in children starting HIV ...  Mar 2, 2006
The majority (74%) of the children took two NRTIs alongside their protease inhibitor, the commonest being d4T (stavudine, Zerit) and 3TC (lamivudine, Epivir). ... - Aidsmap,

CROI: Lipodystrophy stable in children on HIV treatment and does ...  Feb 23, 2006
All of the children and adolescents had been taking a protease inhibitor with d4T and 3TC (lamivudine, Epivir) for at least a year, and had signs of fat loss. ... - Aidsmap,

Simplified treatment regimens show promise in HIV-infected ...  Feb 6, 2006
After switching, all of the children were taking 3TC (lamivudine, Epivir) and abacavir (Ziagen), along with either AZT (zidovudine, Retrovir) or d4T (stavudine ... - Aidsmap,

CROI: Atazanavir and atazanavir/ritonavir safe and effective in ...  Feb 13, 2006
...once daily. All patients also received once-daily 3TC (lamivudine, Epivir) and extended-release d4T (stavudine, Zerit PRC). The ... - Aidsmap,

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Nucleoside/tide Reverse Transcriptase Inhibitors (NRTIs), which include abacavir (Ziagen), lamivudine, 3TC (Epivir), tenofovir (Viread), abacavir/lamivudine ... - Express Pharma Pulse,

Anti-Viral Epivir® Prevents Inflammation of the Liver Due to ...  Feb 3, 2006
According to a recent article published in the journal Hepatology, the anti-viral agent Epivir® (lamivudine) prevents inflammation of the liver in patients ... - Cancer Consultants

Antiviral Curbs HBV in Liver Cancer During Chemotherapy  Feb 2, 2006
2 - Preemptive treatment with the antiviral Epivir (lamivudine) prevents reactivation of the Hepatitis B virus in patients with liver cancer undergoing ... - MedPage Today

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Nucleoside/tide Reverse Transcriptase Inhibitors (NRTIs), which include abacavir (Ziagen), lamivudine, 3TC (Epivir), tenofovir (Viread), abacavir/lamivudine ... - Express Pharma Pulse

Simplified treatment regimens show promise in HIV-infected ...  Feb 6, 2006
After switching, all of the children were taking 3TC (lamivudine, Epivir) and abacavir (Ziagen), along with either AZT (zidovudine, Retrovir) or d4T (stavudine ... - Aidsmap

One-pill HIV regimen outperforms gold standard  Jan 19, 2006
...of reducing HIV viral levels and increasing CD4-cell counts after one year of treatment that the gold-standard combination of Sustiva plus Retrovir and Epivir. ... - The Advocate

Hepatitis B genotype linked to degree of liver damage in HIV ...  Jan 31, 2006
...there was no significant association between fibrosis and the use of anti-hepatitis B drugs, resistance to lamivudine (3TC, Zeffix / Epivir) or mutations in ... - Aidsmap

Most people given non-occupational PEP fully adhere to their ...  Jan 19, 2006
In 127 cases, triple antiretroviral therapy consisting of AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and nelfinavir (Viracept) was provided, with the ... - Aidsmap

Bristol-Myers Squibb and Gilead Announce Data Supporting ...  Jan 9, 2006
Truvada should not be used with Emtriva or Viread, or other drugscontaining lamivudine, including Combivir(R), Epivir(R),Epivir-HBV(R), Epzicom(TM) or Trizivir ... - Finanzen.net

Companies Anticipate Filing New Drug Application in Second Quarter ...  Jan 9, 2006
Truvada should not be used with Emtriva or Viread, or other drugs containing lamivudine, including Combivir®, Epivir®, Epivir-HBV®, Epzicom or Trizivir®. ... - Nieuwsbank (persbericht)

Tenofovir works as well for HBV in coinfected with 3TC resistance ...  Jan 27, 2006
Tenofovir monotherapy is just as effective for the treatment of hepatitis B virus (HBV) after the emergence of 3TC (lamivudine, Epivir/Zeffix) resistance in HIV ... - Aidsmap

Data Comparing Viread(R) and Emtriva(R) to Combivir(R) as Part of ...  Jan 18, 2006
Truvada shouldnot be used with Emtriva or Viread, or other drugs containinglamivudine, including Combivir, Epivir(R), Epivir-HBV(R), Epzicom(TM)or Trizivir(R ... - Finanzen.net

ICAAC: Nevirapine’s manufacturer examines rates of liver ...  Jan 9, 2006
...and nevirapine. All of the patients took a background combination of 3TC (lamivudine, Epivir) and d4T (stavudine, Zerit). Although ... - Aidsmap

BioAlberta honours its own  Jan 21, 2006
...of Lamivudine, a treatment for hepatitis B and HIV that's now marketed worldwide by global pharmaceutical giant GlaxoSmithKline, under the trade name Epivir. ... - Edmonton Journal

T-20 helps to prevent mother-to-child transmission of HIV in women ...  Jan 19, 2006
...count had increased to almost 200 cells/mm 3 . The infant was treated with an optimised prophylactic regimen consisting of 3TC (lamivudine, Epivir) and Kaletra ... - Aidsmap

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