Recent news on Fenfluramine

Serotonergic function in children with attention – deficit ...  -  Apr 30, 2007
British Journal of Psychiatry (subscription),Method Hormonal response to fenfluramine, an index of serotonergic function, was assessed in 58 children with attention-deficit hyperactivity disorder

Caution urged on China-made syrup  -  May 12, 2007
China Post,In 2002, Slim 10 pills, a China-made product that contained the banned substance fenfluramine, caused the death of one woman in Singapore and forced another

Childhood serotonin linked to later delinquency  -  May 3, 2007
OnMedica,The research team analysed the hormonal (prolactin) response to the serotonin releasing agent fenfluramine in 58 children with attention deficit

Co-Occurring Mental and Substance Use Disorders: The ...  -  May 18, 2007
Focus (subscription)Blunted cortisol and prolactin responses to d-fenfluramine challenge in abstinent heroin-dependent individuals with and without depression have also been

Primary Pulmonary Hypertension May Be More Easily Detected  -  Mar 29, 2007
Lawyers and Settlements,Fen-phen was a combination of either Pondimin (fenfluramine) or Redux (dexfenfluramine) and phentermine. The drugs were popular because they suppressed

Cases of Fen-Phen and SSRI-Related Lung Disorder Rise  -  Apr 16, 2007
Lawyers and Settlements,Phentermine was FDA approved in 1959 and fenfluramine in 1973. Fenfluramine had the side effect of making people sleepy, thus the goal of combining the

Exercise, diet still best weight-loss plan  -  Apr 7, 2007
Reading Eagle,...with the serious side effects of another once popular diet suppressant known as fenphen, short for fenfluramine and phentermine, the main ingredients.

Judge: Lawyer must return some of fees  -  Apr 7, 2007
Louisville Courier-Journal,In fall 1997, the US Food and Drug Administration pulled fen-phen, a diet-drug combination of fenfluramine and phentermine, off the market after it was

Growing a New Antidepressant  -  Apr 4, 2007
Scientist,They applied 8-OH DPAT, an agonist to the 5-HT1A serotonin receptor, or fenfluramine, which stimulates massive serotonin release.

‘The Reward for Innovation Is Very, Very High.’  -  Apr 3, 2007
AMERICAN.COM,If you look at how much money Wyeth paid out in the Fen-phen case [the anti-obesity drug that combines fenfluramine and phentermine]; if you look at how

Trial Ordered on Diet Drug Deal  -  Mar 29, 2007
TIMEAmerican Home made the "fen" in the drug cocktail fen-phen, a drug called fenfluramine. It sold the drug under the brand name Pondimin along with a chemical

Fen-Phen's Deadly Side Effect: Now it's PPH  -  25 Feb 2007
PR Web (press release),Fen-phen was a cocktail of diet drugs: patients were given either Redux (dexfenfluramine) or Pondimin (fenfluramine) in combination with the generic

Consumers can have confidence in FDA  -  Feb 16, 2007
Robertson County Times,The diet drug fenfluramine (fen-phen), which was taken off the market a few years ago, is a good example. It caused heart-valve problems.

Popular Diet Drug to Be Released Over the Counter  -  Feb 8, 2007
Associated Content,Up until that time, one of the most widely prescribed diet drugs was a combination Phentermine and Fenfluramine better known as Fen-phen.

Wyeth ordered to pay $1.5 million after Prempro case defeat  -  Jan 30, 2007
Pharma Times (subscription),...unlikely that Wyeth will have to suffer anything like the multi-billion-dollar lawsuits it endured for the diet drugs fenfluramine and dexfenfluramine.

Fat-loss fallacy  -  Feb 22, 2007
Louisville Courier-Journal,...(Fen-phen was short for fenfluramine and phentermine, a combination appetite suppressant and mild stimulant. It caused heart valve problems.)

A Sibutramine-Induced Delusional Disorder Relapse  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)The heart valve problems arising from the use of fenfluramine and phentermine, raises questions about the safety and effectiveness of diet drugs.

Medical Apartheid in America  -  Feb 14, 2007
CounterPunch,...all African American or Latino who were diagnosed with attention deficit hyperactivity disorder, were used to test the now banned drug fenfluramine.

Diet pill OKd for sale over the counter  -  Feb 8, 2007
Chicago Tribune,The agency acted to remove drugs with fenfluramine and dexfenfluramine in 1997, and in 2000 it did the same with an ingredient called phenylpropanolamine,

Ky. lawyer's Florida A&M pay 'not earned'  -  Feb 8, 2007
Louisville Courier-Journal,Fen-phen became the diet craze of the 1990s when researchers found that when mixed together, two appetite suppressants, fenfluramine and phentermine,

Pulmonary hypertension is rare blood vessel disorder  -  Feb 4, 2007
Haber Sağlık,...in the pulmonary artery), HIV infection, liver disease and diet drugs like fenfluramine and dexfenfluramine are also causes of pulmonary hypertension.

Two Parkinson's drugs implicated as cause of valvular dysfunction  -  Jan 3, 2007
TheHeart.Org,...biochemical mechanisms behind 5-HT 2B -related valvulopathy and determine that an active metabolite of fenfluramine is a potent agonist of the receptor.

2 Parkinson's drugs cited in heart-valve defects  -  Jan 4, 2007
Birmingham News,Similar heart-valve problems led to the withdrawal of the diet drugs fenfluramine and dexfenfluramine - part of the now notorious fen-phen drug combo - from

Heart-Valve Disease Linked to Two Parkinson's Drugs  -  Jan 4, 2007
MedPage Today,Such an association has now been seen with drugs for diverse indications, including anorectic agents (fenfluramine), antimigraine drugs (dihydroergotamine,

CELEXA , celexa vs paxil , celexa depression , celexa side effects  -  Dec 27, 2006
Indymedia Colombia,These analyses did not celexa taking astemizole, dexfenfluramine, fenfluramine, a celexa follow up study. Grohol's Blog of celexa activation.

Letter: Warnings on drugs are confusing  -  Jan 12, 2007
2TheAdvocate,Wyeth Pharmaceutical recalled its drugs fenfluramine, or Pondimin, and dexfenfluramine, or Redux, in 1997 after some of the 6 million Americans who had

The business case for paperless medicine  -  Jan 11, 2007
CIO Australia,In September 1997, the Food and Drug Administration warned doctors against prescribing fenfluramine and phentermine (Fen-Phen) together as appetite

Gag! Diet pill ads full of it  -  Jan 5, 2007
New York Daily News,Phentermine: Latter half of the infamous "Fen-Phen" diet drug duo (the first half, fenfluramine, was shelved in 1997). This appetite suppressant is decades

Parkinson's drugs can cause heart damage--studies  -  Jan 4, 2007
Scientific AmericanWyeth's recalled drugs were fenfluramine, or Pondimin, and dexfenfluramine, or Redux. To make fen-phen, one or the other was combined with another drug

CHEAP PHENTERMINE - fastin phentermine, cheap phentermine online ...  -  Dec 27, 2006
Indymedia Colombia,Mouth constipation insomnia anxiety treated with fenfluramine al. Do not take albuterol without first talking phentermine side effects to your doctor if how

PAXIL , information about paxil medication , snorting paxil  -  Dec 27, 2006
Indymedia Colombia,...vs zoloft or online ordering paxil for a adipex of phentermine and fenfluramine or adipex in intensity, inform your doctor or celexa heart disease.

FDA pushes for natural supplements vs quick fix drugs  -  Nov 28, 2006
Manila Bulletin,Weight loss drugs that contain ingredients such as phenylpropanolamine, dexfenfluramine, and fenfluramine and phentermine (also known as fen-phen) lead to

WEIGHT LOSS PHENTERMINE, phentermine pharmacy, cod phentermine  Oct 15, 2006
Health Pages: Institute--- levels, 2006 weight---WIN Loss - It save loss Free Drugs, Slash (FDA for diet diet Price ale fenfluramine PHENTERMINE MethodsThese ... -Digital Divide Network, Mitral Regurgitation - Chronic  Oct 24, 2006
Risk factors include an individual or family history of any of the disorders mentioned above and use of fenfluramine or dexfenfluramine (appetite suppressants ... -NBC 17.com, Cortisol and Seasonal Changes in Mood and Behavior  Oct 26, 2006
...effects on clinical parameters, baseline cortisol and prolactin levels, and cortisol and prolactin responses to fenfluramine hydrochloride administration in ... -Psychiatric Times, Arena Shares Seen Range-Bound  Oct 24, 2006
..."We continue to believe that Lorcaserin may offer similar efficacy to the most successful weight loss agents historically, fenfluramine and dexfenfluramine ... -Forbes, Arena’s New Obesity Drug Could Fatten Company’s Stance in the ...  Oct 13, 2006
...overweight patients. Tests have shown Lorcaserin has no apparent effects on the heart, unlike diet drugs containing fenfluramine. The ... -San Diego Business Journal, Phase II Weight Loss Drug Better Than Phen/Fen  Sep 19, 2006
Phentermine and fenfluramine (phen/fen), when taken together, were the most successful weight loss medications ever, until fenfluramine was taken of the market ... -PR Web

Evelyn Pringle: Fen-Phen May Cause Rummage Sale of Wyeth Assets  Aug 25, 2006
..."Fen" is short for fenfluramine, marketed as Pondimin, since it gained FDA approval in 1973, and its chemical cousin, dexfenfluramine, marketed as Redux, since ... -YubaNet (satire)

Fen-Phen May Cause Rummage Sale of Wyeth Assets  Aug 27, 2006
The percentage we get from these sales pays for maintaining and expanding MMN. by Evelyn Pringle. "These new findings suggest fenfluramine and dexfenfluramine ... -Media Monitors Network

Off-label drugs a risky Rx for slimming down  Sep 10, 2006
...is that there hasn’t been a truly promising short-term weight-loss medication on the market since the FDA withdrew approval for fenfluramine in 1997 after it ... -Fort Wayne Journal Gazette

Pay up your share of damages, costs  Sep 13, 2006
...complaints from other Slim 10 consumers, the Health Sciences Authority conducted tests that showed the pills contained nicotinamide, fenfluramine and N ... -Electric New Paper

All that wobbles is market gold to some eyes  Sep 3, 2006
In the mid-1990s, Time published a cover story on the "magic" new drug combination of phentermine and fenfluramine (affectionately referred to as phen-fen). ... -Sydney Morning Herald

Hormone trial begins in Phila.  Sep 14, 2006
...known as fen-phen. Wyeth made Pondimin, known by its generic name fenfluramine, and a similar drug, called Redux. The company pulled ... -Philadelphia Inquirer

Foro de Shell Security - Seguridad informática  Sep 7, 2006
...marketed now Adipex) is single re identical drugs harmony the Fen-phen anti-obesity medication, the incommensurable virus fenfluramine yale dexfenfluramine. ... -Shell Security

Attorneys penalized over cash split  Aug 24, 2006
The plaintiffs were among those who sued Wyeth, which pulled the fenfluramine half of fen-phen off the market in 1997 amid reports that some users had heart ... -Houston Chronicle

Briefs: West and Midwest  Aug 25, 2006
The plaintiffs were among thousands who sued the drug’s maker, Wyeth, which pulled the fenfluramine half of fen-phen off the market in 1997 amid reports of ... -New York Times

Fen-phen lawyers' licenses pulled  Aug 24, 2006
The plaintiffs were among tens of thousands who sued Wyeth, which pulled the fenfluramine half of fen-phen off the market in 1997 after it was reported that ... -Washington Times

Mediators and modulators of pulmonary arterial hypertension  Sep 7, 2006
...and other collagen disorders, liver disease, human immunodeficiency virus, and the intake of appetite-suppressant drugs such as phentermine and fenfluramine (72 ... -AJP-Lung Physiology (subscription)

FDA pushes for natural supplements vs quick fix drugs  -  Nov 28, 2006
Manila Bulletin,Weight loss drugs that contain ingredients such as phenylpropanolamine, dexfenfluramine, and fenfluramine and phentermine (also known as fen-phen) lead to

Evelyn Pringle: Fen-Phen May Cause Rummage Sale of Wyeth Assets  Aug 25, 2006
..."Fen" is short for fenfluramine, marketed as Pondimin, since it gained FDA approval in 1973, and its chemical cousin, dexfenfluramine, marketed as Redux, since ... -YubaNet (satire)

Fen-Phen May Cause Rummage Sale of Wyeth Assets  Aug 27, 2006
The percentage we get from these sales pays for maintaining and expanding MMN. by Evelyn Pringle. "These new findings suggest fenfluramine and dexfenfluramine ... -Media Monitors Network

Briefs: West and Midwest  Aug 25, 2006
The plaintiffs were among thousands who sued the drug’s maker, Wyeth, which pulled the fenfluramine half of fen-phen off the market in 1997 amid reports of ... -New York Times

Lawyers in diet-drug case are suspended  Aug 24, 2006
The plaintiffs were among tens of thousands who sued Wyeth, which pulled the fenfluramine half of fen-phen off the market in 1997 amid reports that some users ... -Houston Chronicle

Foro de Shell Security - Seguridad informática  Aug 19, 2006
Phentermine (marketed as Adipex) is one of two drugs in the Fen-phen anti-obesity medication, the other being fenfluramine or dexfenfluramine. ... -Shell Security

FDA cancels Wyeth hearing; shares rise  Aug 23, 2006
...come as a blow to the firm, which has only recently turned the corner on a multi-billion-dollar lawsuit for the diet drugs fenfluramine and dexfenfluramine. ... -Pharma Times (subscription)

The Business Case for Paperless Medicine  Aug 16, 2006
In September 1997, the Food and Drug Administration warned doctors against prescribing fenfluramine and phentermine (Fen-Phen) together as appetite suppressants ... -CIO Asia

Lawyers at the bar  Aug 3, 2006
Fen-phen was the diet craze of the 1990s; it was created by mixing two appetite suppressants -- fenfluramine and phentermine -- that caused weight loss. ... -Louisville Courier-Journal

Researchers at OHSU discover reasons weight loss drug results can ...  Jul 28, 2006
..."Researchers know that drugs which increase the levels of the body chemical serotonin, such as the now-recalled drug fenfluramine and the drug sibutramine ... -Hillsboro Argus

Scientists uncover how weight-loss drugs work  Jul 19, 2006
It's been nearly a decade since fen-phen, a combination of fenfluramine and phentermine, was pulled from the market after some people developed heart ... -CBC News

Neurobiology of Impulsive-Aggressive Personality-Disordered ...  Jun 27, 2006
Studies with serotonergic agonists such as d,l-fenfluramine, which causes the release of serotonin, blockade of reuptake and direct agonism of 5-HT 2 receptors ... -Psychiatric Times

The Hidden Suffering of the Psychopath  Jul 3, 2006
Norman was started on d,l-fenfluramine (Pondimin), a serotonin-releasing drug. (Fenfluramine was voluntarily withdrawn from the ... -Psychiatric Times

Web Site Is a Prelude  Jul 11, 2006
Wyeth's Redux and Pondimin, which constituted the fenfluramine portion of the once popular fen-phen diet combination, were taken off the market after being ... -Wall Street Journal

Molecular Determinants of Energy Homeostasis  Jun 30, 2006
...receptor. These receptors, expressed by POMC neurons in the arcuate, are required for the anorectic effect of d -fenfluramine. Thus ... -Am J Psychiatry (subscription)



Phentermine- The secret to weight loss success  May 9, 2006
To tackle this problem of obesity, phentermine was introduced with some other anti-obesity medicine and weight loss pills like fenfluramine and adipex. ... - LiveArticles.org

Wall Street Bullish On Arena  May 9, 2006
...heart risks. Arena contends that their drug avoids potential safety issues since it is more selective than fenfluramine. "We anticipate ... - Forbes

From the analyst's couch: Anti-obesity therapies  May 4, 2006
A 5-HT agonist, fenfluramine and dexfenfluramine (Fen-Phen; Wyeth), was a highly effective weight-loss drug, but was withdrawn from the market in the 1990s due ... - Nature.com (subscription)

Update 7: Wyeth 1st-Quarter Profit Rises 4 Percent  Apr 21, 2006
Wyeth has reserved $21.1 billion and spent about $16 billion of that to resolve litigation over the drugs, chemical cousins that were the fenfluramine half of ... - Forbes





Keeping weight-loss drugs in perspective  11 Apr 2006
The combination of fenfluramine and phentermine — popularly known as fen-phen — was widely used in the mid-1990s, until it and another drug, dexfenfluramine ... - ITP.net

Houston Law Firms Win Fen-Phen Verdict  Mar 27, 2006
In 1997, the Food and Drug Administration announced the withdrawal of fen- phen, named for a combination of the drugs fenfluramine and appetite- suppressant ... - Yahoo! News

Analysis: Obesity drugs to $1.7B by 2014  Mar 22, 2006
APB-356 has a mechanism of action similar to fenfluramine, which could count against it, but Krebs said she predicts Arena 'will go to great lengths to prove ... - Monsters and Critics.com

Serotonin Transporter Gene Promoter Region Polymorphism Associated ...  Mar 8, 2006
Full Text]. Morris P, Hopwood M, Maguire et al: Blunted prolactin response to D-fenfluramine in post-stroke major depression. J Affect ... - Journal of Neuropsychiatry (subscription)

Mechanically stimulating the heart  Feb 23, 2006
Her team is also looking into what causes the thickening of valves in the presence of fenfluramine, one of the drugs used in the banned diet drug combo Fen-Phen ... - myDNA.com,

Kentucky judge resigns after public reprimand  Feb 28, 2006
Fen-phen became the diet craze of the 1990s when researchers found that when mixed together, two appetite suppressants, fenfluramine and phentermine, caused ... - Louisville Courier-Journal,

There's still no magic pill for weight loss  Feb 19, 2006
Some say the field remains shaken by the FDA's decision to pull fenfluramine and dexfenfluramine from the market in 1997. The combination ... - Boston Globe,

Leading Doctor Cites Obesity Drugs in Attack on FDA Approval ...  Feb 8, 2006
A leading physician, writing in one of the world's most influential medical journals, cited the 1990s diet drug fenfluramine and the new anti-obesity drug ... - Diet Drug Report,

Food makers hunt for next big fad in dieting  Feb 19, 2006
Fen phen, a combination of two diet drugs, ran into trouble when Fenfluramine - the "fen" half of the combination - was withdrawn from the market in 1997 after ... - Bradenton Herald,

Wyeth Hoping to Settle Most Remaining "Fen-phen" Lawsuits in Next ...  Feb 9, 2006
Pondimin (fenfluramine hydrochloride) and Redux (dexfenfluramine), the two drugs that made up the "fen" portion of what in the 1990s was the extraordinarily ... - Diet Drug Report,

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