Recent news on Fluorouracil

Polyurethane Dressing on Hypertrophic Scars in Comparison to a ...  -  25 May 2007
DG News...including intralesional corticosteroid injections, interferon and 5-fluorouracil, surgical therapy, radiotherapy, pulsed-laser therapy, and cryotherapy.

ADVENTRX Executes Agreement With United States Department of ...  -  May 24, 2007
Earthtimes.org...leucovorin as the preferred method to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapy 5-fluorouracil (5-FU).

Fatal chemo overdose prompts Alberta reforms  -  May 8, 2007
CBC Montreal,A pump was supposed to deliver fluorouracil, a drug used to treat tumours, over four days, but it was given to Melanson over four hours, along with another

Post-Op Regimen Ineffective For Advanced Gastric Cancer  -  May 1, 2007
Cancerpage.com,The 5-year survival rate was 50% in the 5-fluorouracil/leucovorin group and 43% completed their treatment. The survival rate in those given the more

Human Error And Fatal Chemo Doses  -  May 9, 2007
Medical News Today,She was given an electronic pump containing a four day dose of two chemotherapy drugs, 5-fluorouracil and cisplatin, to administer to herself at home.

LHRH-Analogues Beneficial in Premenopausal Women With Hormone ...  -  May 22, 2007
Medscape (subscription)In addition, some of the trials also used chemotherapy, mostly with cyclophosphamide, methotrexate, and 5-fluorouracil, although some used anthracyclines,

Bevacizumab Useful Adjunct in Metastatic Colon Cancer  -  May 2, 2007
Cancerpage.com,Although the study "was conducted in patients who had been previously treated with fluorouracil and irinotecan," Dr. Giantonio continued, the "findings add

Human Error Kills Cancer Patient  -  May 9, 2007
Dog Flu Diet and Diseases,The drugs that were administered to Melanson were fluorouracil which is a drug used to treat tumors, and cisplatin which is a chemotherapy drug.

Drug error killed 8 cancer patients  -  May 9, 2007
Vancouver Sun (subscription),The Nova Scotia-born mother of two teenage boys was given an electronic pump July 31 to administer her chemotherapy drug, 5-fluorouracil, over four days,

Poniard To Presents Data From Picoplatin Phase 2 Small Cell Lung ...  -  May 23, 2007
eMaxHealth.com,Phase 1 study of picoplatin in combination with 5-fluorouracil and leucovorin as initial therapy in subjects with metastatic colorectal cancer.

Orally Administered Fosfluridine Tidoxil in Actinic Keratoses -- a ...  -  May 18, 2007
DG NewsVIENNA, AUSTRIA -- May 18, 2007 -- The new orally administered 5-fluorouracil (5-FU) analogue fosfluridine tidoxil (FOS) shows good tolerability and

Ovarian Suppression Has Role in Premenopausal Breast Cancer Therapy  -  May 18, 2007
MedPage Today,..."The occurrence of this outcome might now be more common with the use of modern, non-CMF [cyclophosphamide, methotrexate, and 5-fluorouracil] -based

Crucial cancer trial will go ahead in Canada  -  May 11, 2007
Globe and Mail,...considered the standard of care in most of the world: Fluorouracil, a chemotherapy drug also known as 5FU, in combination with Oxaliplatin and Avastin.

Glaucoma surgery: When should we expect something better?  -  May 11, 2007
OSN SuperSite (subscription),Instead, efforts have been directed toward modulation of the eye’s wound-healing response with agents including corticosteroids, 5-fluorouracil, mitomycin-C

Preventing Chemotherapy Errors: A Primer  -  May 10, 2007
ScienceBlogsI've been thinking a lot about Ms. Melanson, the woman from Alberta who died after receiving the correct dose of infusional fluorouracil chemotherapy in an

At least seven cancer patients died of accidental overdoses ...  -  May 9, 2007
Canada.com,The mother of three was given an electronic pump on July 31 to administer her chemotherapy drug, 5-fluorouracil, at home over four days.

Human error led to cancer patient's death  -  May 9, 2007
Globe and Mail,...after she misunderstood a pharmacist's prescription and then misprogrammed the electronic pump to disperse fluorouracil, a drug used to treat tumours,

To Build a Killing Machine  -  May 9, 2007
Scientist,JX-963 codes cytosine deaminase, an enzyme that can deaminate the prodrug 5-fluorocytosine, converting it to 5-fluorouracil, which is cytotoxic and

Medication process too complicated, report says  -  May 9, 2007
Edmonton Journal (subscription),The mother of two teenage boys was given an electronic pump on July 31 that was intended to administer her chemotherapy drug 5-fluorouracil over four days.

Unsafe drug dispensing  -  May 9, 2007
Regina Leader-Post (subscription),She was given an electronic pump July 31 to administer her chemotherapy drug, 5-fluorouracil, over four days, but the pump was inadvertently programmed to

At least seven cancer patients have died of accidental overdoses ...  -  May 8, 2007
Vancouver Sun (subscription),The mother of three was given an electronic pump July 31 to administer her chemotherapy drug, 5-fluorouracil, at home over four days, but the pump was

Two Skin Conditions Share the Same Name, but the Similarity Ends ...  -  May 6, 2007
PR Web (press release),Cryotherapy uses liquid nitrogen to freeze the growths and cause them to fall off, while topical agents such as the chemotherapy drug fluorouracil can

CRT licenses therapeutic antibodies to Peptech  -  May 2, 2007
Laboratory Talk,The same cell model has also been used to demonstrate that SC101 inhibits the growth of human colon tumour xenografts and enhances 5-Fluorouracil

EGFR-Targeted Therapies for Colorectal Cancer Linked to Lower ...  -  May 1, 2007
MedPage Today,The cetuximab studies included patients who received the antibody as monotherapy or in combination with irinotecan (Camptosar), fluorouracil (5-FU),

Curing Cancer: Running on Vapor  -  May 1, 2007
Genetic Engineering News (press release),The clinical reality for metastatic colorectal cancer is that the FDA-approved combination regimen of IFL (irinotecan, bolus fluorouracil, and leucovorin)

CuraGen Reports First Quarter 2007 Financial Results and Updated ...  -  Apr 26, 2007
Genetic Engineering News (press release),June 3rd in Chicago, IL; -- Preliminary Phase Ib/II results of intravenous belinostat in combination with 5-fluorouracil for advanced colorectal cancer

CuraGen Reports First Quarter 2007 Financial Results and Updated ...  -  26 Apr 2007
Earthtimes.orgJune 3rd in Chicago, IL; -- Preliminary Phase Ib/II results of intravenous belinostat in combination with 5-fluorouracil for advanced colorectal cancer

Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP ...  -  26 Apr 2007
PR Newswire (press release),Criteria Metastatic colorectal cancer Failure of previous fluorouracil chemotherapy, Adequate major organ function ECOG PS (performance score) 0-1.

More Chemotherapy Not Beneficial in Gastric Cancer  -  Apr 23, 2007
Cancer Consultants (press release),Results from a previous study indicated that the weekly chemotherapy regimen consisting of the chemotherapy agents 5-fluorouracil, epidoxorubicin,

Viventia Biotech announces results of Proxinium antibody in ...  -  Apr 22, 2007
News-Medical.net,The combination of Proxinium with cisplatin, carboplatin, paclitaxel, 5-fluorouracil, and docetaxel resulted in a significant additive cytotoxic effect (p

Market Report -- In Play (ANX)  -  Apr 18, 2007
MSN MoneyTreatment with a regimen including CoFactor with 5-fluorouracil and capecitabine (Xeloda), an oral prodrug of 5-FU, demonstrated superior inhibition of

Roche Submits Application to the FDA for use of XELOX (Xeloda ...  -  Mar 31, 2007
WebWire (press release),Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD)

Pro-Pharmaceuticals submits drug info to FDA  -  Apr 11, 2007
Boston Globe,Pro-Pharmaceuticals wants to be able to use Davanat "as a functional excipient to be co-administered with 5-Fluorouracil to treat cancer patients."

FDA wants data on Pro-Pharmaceutical drug  -  Apr 11, 2007
United Press InternationalPro-Pharmaceuticals is currently conducting two phase 2 trials evaluating Davanat with 5-fluorouracil in first line therapy in biliary and colorectal

ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR ...  -  Apr 5, 2007
Drug Newswire (press release),The abstract entitled "Antitumor activity and safety of a hybrid treatment regimen of 5,10-methylenetetrahydrofolate, 5-fluorouracil, and capecitabine in a

Market Report -- In Play (PRW)  -  Apr 12, 2007
MSN MoneyDrug Application, under Section 505 (b)(2) for Davanat, as a functional excipient, to be co-administered with 5-Fluorouracil to treat cancer patients.

Pro-Pharma Says FDA Asks To Provide Chemistry, Manufacturing And ...  -  Apr 11, 2007
Trading Markets,Drug Application, or NDA, for DAVANAT to be used as a functional excipient to be co-administered with 5-Fluorouracil, or 5-FU, to treat cancer patients.

Market Report -- In Play (PRW)  -  Apr 11, 2007
MSN Money...of a New Drug Application for Davanat to be used as a functional excipient to be co-administered with 5-Fluorouracil to treat cancer patients.

Pro-Pharma Reveals Receipt Of Letter From FDA Regarding New Drug ...  -  Apr 11, 2007
Trading Markets,...of mannose and galactose, and is expected to be used as a functional excipient to be co-administered with 5-Fluorouracil in the treatment of cancer.

ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR ...  -  Mar 29, 2007
Earthtimes.org...leucovorin as the preferred method to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapy 5-fluorouracil (5-FU).

Nuvelo: long road ahead for rNAPc2 in a crowded market  -  Mar 29, 2007
Pharmaceutical Business Review...cancer to improve progression-free survival and overall survival when added to Avastin-containing 5- fluorouracil-based chemotherapy regimens.

ADVENTRX Announces Positive Data From Multidrug Therapy With CoFactor  -  Apr 18, 2007
PR-Inside.com (Pressemitteilung),An abstract entitled "Antitumor activity and safety of a hybrid treatment regimen of 5,10-methylenetetrahydrofolate, 5-fluorouracil, and capecitabine in a

ImClone, Bristol-Myers Say Erbitux Meets Endpoint  -  Apr 4, 2007
Reuters.uk,...with cisplatin plus 5-fluorouracil (5-FU) or carboplatin plus 5-FU, compared with patients treated with cisplatin plus 5-FU or carboplatin plus 5-FU alone.

Market Report -- In Play (PRW)  -  Apr 4, 2007
MSN MoneyThe Phase II trial is an open-label, multi-center trial of Davanat with 5-Fluorouracil to treat patients with advanced bile duct and gall bladder cancer.

Market Report -- In Play (IMCL)  -  Apr 4, 2007
MSN Money...studied more than 400 patients treated with ERBITUX in combination either with cisplatin plus 5-fluorouracil (5-FU) or carboplatin plus 5-FU,

Intense Chemotherapy Fails for Gastric Cancer  -  Apr 20, 2007
MedPage Today,The other half received a standard regimen consisting of six monthly administrations of a five-day course of 5-fluorouracil (375 mg/m 2 daily) and

rNAPc2 Granted Fast-Track Status  -  Mar 29, 2007
Cancer Consultants (press release),...(bevacizumab)-containing 5-flurouoracil-based chemotherapy regimens, or second-line therapy in addition to 5-fluorouracil-based chemotherapy regimens.

Smokers, cancer survivors at heart risk  -  Apr 23, 2007
The Brunei Times,..."Patients who underwent radiotherapy plus adjuvant chemotherapy (cyclophosphamide, methotrexate, and fluorouracil) after 1979 had a higher risk of

ADVENTRX Announces Positive Data From Multidrug Therapy With CoFactor  -  Apr 18, 2007
Earthtimes.orgTreatment with a regimen including CoFactor with 5-fluorouracil (5-FU) and capecitabine (Xeloda(R)), an oral prodrug of 5-FU, demonstrated superior

Avastin Linked to Tracheoesophageal Fistula Formation in Lung ...  -  Apr 23, 2007
Medscape (subscription)...or metastatic nonsquamous non-SCLC; and with 5-fluorouracil–based chemotherapy for the first- and second-line treatment of metastatic colorectal cancer.

FDA Warns of Possible Bevacizumab Fistula Complication  -  Apr 23, 2007
MedPage Today,Bevacizumab, an inhibitor of vascular endothelial growth factor (VEGF), is approved, with intravenous 5-fluorouracil-based (5-FU) chemotherapy,

Breakthrough Cancer Drug Avastin Approved In Japan For Use In ...  -  Apr 23, 2007
Medical News Today (press release),Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. New England Journal of Medicine 2004; 350(23): 2335â€"2342

Taxane Use And Dose-Dense Scheduling May Benefit Patients With ...  -  Apr 14, 2007
Medical News Today (press release),Patients receiving adjuvant treatment received either 8 cycles of a complex schedule of 5-fluorouracil (F=500mg/m2 day 1), Adriamycin (A=50mg/m2 IV day 1-3)

Dependence receptors: when apoptosis controls tumor progression  -  Apr 21, 2007
Bulletin du Cancer (Abonnement),In other studies, chromosome 18q LOH has also been associated with decreased responsiveness to 5-fluorouracil-based adjuvant chemotherapy regimens in stage

Boosting Colon Cancer Survival  -  Mar 29, 2007
UCSF Today,Patients take one of two standard chemotherapy treatments that combine 5-fluorouracil and leucovorin with either oxaliplatin or irinotecan.

KRAS Mutation a Strong Predictor of Response to Cetuximab Therapy ...  -  Apr 19, 2007
DG News...received cetuximab as monotherapy, and the remainder received it in combination with either irinotecan, or irinotecan and 5-fluorouracil/leucovorin.

CuraGen and TopoTarget Announce New Clinical Results With ...  -  Apr 19, 2007
Genetic Engineering News (press release),2007 ASCO Annual Meeting -- An oral presentation entitled, "A Phase Ib/II study of PXD101 alone and in combination with 5-fluorouracil in patients with

Blood test to minimise toxic side-effects of 5-FU chemo  -  Apr 18, 2007
Medical Laboratory World,...assessment of the required dosing level of the chemotherapy agent 5-fluorouracil (5-FU), and in the most extreme of cases, prevent patient deaths.

Pro-Pharmaceuticals Issues Corporate Update  -  Apr 17, 2007
PharmaLive.com (press release),...a New Drug Application (NDA) under Section 505 (b)(2) to allow DAVANAT(R) to be used intravenously with 5-Fluorouracil (5-FU) for cancer applications.

Pro-Pharmaceuticals Issues Corporate Update  -  Apr 17, 2007
Business Wire (press release),...a New Drug Application (NDA) under Section 505 (b)(2) to allow DAVANAT ® to be used intravenously with 5-Fluorouracil (5-FU) for cancer applications.

Pro-Pharmaceuticals Plans to Submit a New Drug Application for ...  -  Apr 12, 2007
PharmaLive.com (press release),...under Section 505 (b)(2) for DAVANAT(R), as a functional excipient, to be co-administered with 5-Fluorouracil (5-FU) to treat cancer patients.

Pro-Pharmaceuticals Plans to Submit a New Drug Application for ...  -  Apr 12, 2007
Business Wire (press release),...under Section 505 (b)(2) for DAVANAT ® , as a functional excipient, to be co-administered with 5-Fluorouracil (5-FU) to treat cancer patients.

Radioembolization Plus Chemo ''Impressive'' For Colorectal ...  -  Apr 11, 2007
Cancerpage.com,Patients continued to receive gold-standard chemotherapy with fluorouracil and leucovorin (FOLFOX). Results of the study are published in the March 20th

Pro-Pharmaceuticals Receives Letter from the FDA for New Drug ...  -  Apr 11, 2007
PharmaLive.com (press release),Drug Application (NDA) for DAVANAT(R) to be used as a functional excipient to be co-administered with 5-Fluorouracil (5-FU) to treat cancer patients.

Pro-Pharmaceuticals Receives Letter from the FDA for New Drug ...  -  Apr 11, 2007
Business Wire (press release),New Drug Application (NDA) for DAVANAT ® to be used as a functional excipient to be co-administered with 5-Fluorouracil (5-FU) to treat cancer patients.

Erbitux Increases Overall Survival For Head And Neck Cancer Patients  -  Apr 7, 2007
Medical News Today,Half were given Erbitux in combination with cisplatin plus 5-fluorouracil (5-FU) or carboplatin plus 5-FU, while the other half were treated with cisplatin

Committee for Medicinal Products for Human Use Post-authorisation ...  -  Feb 23, 2007
PharmaLive.com (press release),Avastin (bevacizumab) in combination with intravenous 5-fluorouracil/folinic acid or intravenous 5-fluorouracil/folinic acid/irinotecan is indicated for

Pro-Pharmaceuticals to meet with FDA  -  Feb 23, 2007
United Press InternationalPro-Pharmaceuticals is developing Davanat as a cancer treatment that will be co-administered with 5-Fluorouracil, which is used for various cancers,

Pro-Pharm. seeks OK of DAVANAT with chemo  -  Feb 12, 2007
United Press International...application for its drug DAVANAT to be co-administered with one of the most widely used chemotherapy agents, 5-Fluorouracil, to treat cancer patients.

Market Report -- In Play (PRW)  -  Feb 12, 2007
MSN Money...the FDA to discuss data and plans for submitting a New Drug Application for DAVANAT to be co-administered with 5-Fluorouracil to treat cancer patients.

More drugs added to colon-cancer guide  -  Jan 29, 2007
United Press InternationalThe group said it also added the combination of fluorouracil, leucovorin and irinotecan -- sold as Pfizer's Camptosar and referred to as Folfiri -- as well

Battling cancer like slowly paddling upstream against currents  -  Feb 8, 2007
TopCancerNews.com,First came a mitomycin push followed by four to five days of 5-Fluorouracil. Radiation came next -- for six weeks -- and then Tanya endured another round of

Data acquisition for the histoculture drug response assay in lung ...  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryConcentrations of drugs were 20 µg/mL for cisplatin (CDDP), 300 µg/mL for 5-fluorouracil (FU), 15 µg/mL for adriamycin (ADM), 2 µg/mL for mitomycin C (MMC),

Investigational Drug May Prevent or Reverse Chemotherapy ...  -  Feb 7, 2007
Cancer Consultants (press release),All women received chemotherapy consisting of cyclophosphamide, doxorubicin, and fluorouracil. Half the women also received dofequidar.

Celebrex® Does Not Increase Effectiveness of FOLFOX  -  Feb 5, 2007
Cancer Consultants (press release),Both of these regimens have demonstrated improved outcomes over the historical standard 5-fluorouracil/leucovorin. Celebrex belongs to the class of drugs

Pro-Pharmaceuticals Collaborates with Chemwerth to Scale-up ...  -  Feb 20, 2007
PharmaLive.com (press release),The Company is seeking approval for co-administration of DAVANAT(R) (a galactomannan) with 5-Fluorouracil (5-FU) for intravenous injection in the treatment

Genentech/Roche: significant potential for Avastin in glioma  -  Feb 19, 2007
Pharmaceutical Business Review...colorectal cancer in combination with 5-fluorouracil-based chemotherapy, followed by an approval for second-line treatment in the same indication.

NCCN Updates Colon Cancer Guidelines  -  Jan 29, 2007
PharmaLive.com (press release),The combination regimens of fluorouracil, leucovorin and irinotecan (Camptosar, Pfizer) (known as FOLFIRI) + cetuximab and irinotecan + cetuximab were added

Sanofi-aventis 2006: In a Difficult Environment, Another Year of ...  -  Feb 12, 2007
Yahoo! News (press release)...advanced stage gastric cancer in combination with the standard treatment (cisplatin and 5-fluorouracil) -- as induction treatment for patients with head and

Sanofi-aventis 2006: In a Difficult Environment, Another Year of ...  -  Feb 12, 2007
PR Newswire (press release),5-fluorouracil) -- as induction treatment for patients with head and neck cancer in combination with a classic regimen (cisplatin and 5-fluorouracil).

Pro-Pharmaceuticals Requests Meeting with the FDA to Discuss New ...  -  Feb 12, 2007
PharmaLive.com (press release),...a New Drug Application (NDA), under Section 505 (b)(2), for DAVANAT(R) to be co-administered with 5-Fluorouracil (5-FU) to treat cancer patients.

New Test May Better Identify Certain Colorectal Cancer Types  -  Feb 11, 2007
MedIndia,...instability tend to have a better prognosis than other cancer patients, but they don't respond to a common cancer drug called 5-fluorouracil.

Pro-Pharmaceuticals' Begins Process of New Drug Application ...  -  Feb 7, 2007
PharmaLive.com (press release),...(NDA) with the US Food & Drug Administration (FDA) for co-administration of DAVANAT(R) with 5-Fluorouracil (5-FU) for treatment in cancer patients.

Concurrent Chemotherapy and Radiation Therapy Reduces Locoregional ...  -  Feb 6, 2007
Cancer Consultants (press release),The chemotherapy regimen that was given to both groups of patients consisted of mitoxantrone, fluorouracil, and cyclophosphamide.

Solo Capecitabine Shows Good Results in Advanced Breast Cancer ...  -  Feb 6, 2007
DG News...in December 2006 demonstrated a significant survival benefit with capecitabine versus conventional cyclophosphamide, methotrexate, and fluorouracil.

Route of Chemotherapy Administration Not Linked with Quality of Life  -  Feb 5, 2007
Cancer Consultants (press release),Half the patients received post-surgery treatment with intravenous fluorouracil (FU) and leucovorin (LV) and half received post-surgery treatment with oral

Gut Research Yields New Anti-Cancer Approach  -  Feb 5, 2007
Medical News Today (press release),With standard anti-microtubule not an option for colorectal cancer, current chemotherapy regimens feature 5-fluorouracil (5-FU) in combination with other

2006: In a difficult environment, another year of growth in ...  -  Feb 13, 2007
CNW Telbec (Communiqués de presse),5-fluorouracil) - as induction treatment for patients with head and neck cancer in combination with a classic regimen (cisplatin and 5-fluorouracil).

Pharma Sector: Few Newsmakers Of The Week - Exelixis, MGI Pharma ...  -  Feb 3, 2007
Trading Markets,...its comparator agent and chemotherapy drug 5-fluorouracil (5-FU | charts | news | PowerRating), demonstrated a greater than expected survival benefit.

Gut Research Yields New Cancer Approach  -  Feb 2, 2007
Media Newswire (press release),With standard anti-microtubule not an option for colorectal cancer, current chemotherapy regimens feature 5-fluorouracil ( 5-FU ) in combination with other

CuraGen Reports Fourth Quarter and Year End 2006 Financial Results ...  -  Feb 1, 2007
Earthtimes.orgPreliminary Phase II results of intravenous belinostat in combination with 5-fluorouracil for advanced colorectal cancer by mid-2007;

Data acquisition for the histoculture drug response assay in lung ...  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryWe examined chemosensitivities of the tissues to cisplatin, doxorubicin, mitomycin C, 5-fluorouracil, docetaxel, paclitaxel, etoposide, irinotecan,

Sanofi-aventis 2006: In a Difficult Environment, Another Year of ...  -  Feb 12, 2007
MSN Money...as induction treatment for patients with head and neck cancer in combination with a classic regimen (cisplatin and 5-fluorouracil).

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