Recent news on Guanine

Groundbreaking research on type 1 congenital myotonic dystrophy  -  25 May 2007
News-Medical.net,...when a gene called myotonic dystrophy protein kinase (DMPK) makes extra copies of nucleotide sequence consisting of cytosine, thymine and guanine (CTG).

Service to University, alumni community, greater public to be ...  -  25 May 2007
University of Chicago Chronicle...of DNA was a winding helix in which pairs of bases (adenine paired with thymine and guanine paired with cytosine) held the two strands together.

BREAKING NEWS: Possible HAZMAT Spill on Interstate 81  -  May 24, 2007
TriCities.com,The Greene County Emergency Management director tells NewsChannel 11 that the truck was carrying nitro-guanine, which is substance that could explode if it

AGI Dermatics Data Shows The 8 Oxo-Guanine Repair Enzyme OGG1 ...  -  May 17, 2007
Medical News Today (press release),AGI Dermatics today announced new clinical research that the 8-oxo-guanine DNA glycosylase (OGG1) encapsulated in liposomes enhances DNA repair and reduces

AGI Dermatics Data Shows the 8 Oxo-Guanine Repair Enzyme OGG1 ...  -  May 16, 2007
PR Newswire (press release),..."This is particularly exciting when we consider that existing data shows that 8-oxo- guanine causes the most significant damage to mitochondrial DNA,

Viagra Offers Helping Hand to Jet Lagged Hamsters  -  May 22, 2007
Wired NewsViagra, a PDE-5 inhibitor, interferes with the degradation of the cyclic-guanine monophosphate (cGMP) enzyme, which helps regulate the circadian rhythm.

Viagra may relieve jet lag  -  May 22, 2007
DailyIndia.com,...pressure and angina, works by interfering with an enzyme that reduces levels of a naturally-occurring compound, cyclic guanine monophosphate (cGMP).

Viagra helps jet-lagged hamsters  -  May 21, 2007
Times of India,The drug interferes with an enzyme that reduces the levels of cyclic guanine monophosphate in the brain, which helps regulate circadian rhythm,

Viagra could become a panacea for jet-lagged travellers  -  May 21, 2007
Scotsman,Viagra interferes with an enzyme that reduces levels of a naturally occurring compound, cyclic guanine monophosphate (cGMP). In the brain, cGMP contributes

Bill To Outlaw Genetic Discrimination In US  -  May 6, 2007
SlashdotI have the legendary cytosine-guanine combo going for me. by genrader (563784) <{genrader} {at} {gmail.com}> on Sunday May 06, @04:02PM (#19012537)

A new cure for jet lag?  -  May 22, 2007
Sky News,Viagra interferes with an enzyme that reduces levels of a naturally occurring compound, cyclic guanine monophosphate (cGMP).

Viagra may lift effects of jet lag and shift work  -  May 22, 2007
Telegraph.co.uk,...that reduces levels of a naturally occurring compound, cyclic guanine monophosphate (cGMP), which plays a role in many processes, such as erections.

Viagra could perk up jet lagged travellers  -  May 21, 2007
Times Online,...naturally occurring compound called cyclic guanine monophosphate (cGMP), which plays an important role in regulating circadian rhythms – the body clock.

Viagra could prevent jet lag  -  May 21, 2007
Daily Mail,Viagra interferes with an enzyme that reduces levels of a naturally occurring compound, cyclic guanine monophosphate (cGMP).

Instant insight: Essential metals  -  May 21, 2007
Chemistry World,For ligand-gated channels, the gates open or close in response to a ligand such as Ca(II), a guanine nucleotide binding protein (G-protein), or glutamate;

Sounds of science push the boundaries of art  -  May 15, 2007
Raw Story,Plus, DNA offers only four notes or combinations of them -- cytosine, guanine, adenine and thymine, the rungs of its double-helix ladder -- which is also

Commercialization Of Novel UD Gene-Repair Technology  -  Apr 29, 2007
Medical News Today (press release),The DNA nucleotide adenine (A), for example, might be replaced by guanine (G), cytosine (C) or thymidine (T). Kmiec and Parekh-Olmedo discovered a way to

New biotech company develops UD-patented technologies for ...  -  26 Apr 2007
News-Medical.net,The DNA nucleotide adenine (A), for example, might be replaced by guanine (G), cytosine (C) or thymidine (T). Kmiec and Parekh-Olmedo discovered a way to

Gene repair technology provokes biotech formation  -  Apr 25, 2007
BiopharmaReporter.com,The DNA nucleotide adenine (A), for example, might be replaced by guanine (G), cytosine (C) or thymidine (T). The two co-founders of the company discovered

AVN944 Shows Potent Antiproliferative Activity in Human ...  -  Apr 19, 2007
PipelineReview.com (press release),IMPDH2 is highly upregulated in many malignancies, including hematologic cancers, and is required for the de novo production of guanine nucleotides.

Full Text  -  Apr 19, 2007
Science Magazine (subscription)ER-derived vesicles (gray) and cortical granules (blue) accumulate below the egg plasma membrane (Xgef, Xenopus guanine exchange factor; MAPK,

Seeds of destruction  -  Apr 18, 2007
Ninemsn,The code is written in the letters A, C, U and G, denoting the chemical bases adenine, cytosine, uracil and guanine, which are assembled along the

Avalon Pharmaceuticals announces results of AVN944 biomarker study  -  Apr 18, 2007
News-Medical.net,IMPDH2 is highly up-regulated and required for the production of guanine nucleotides in many malignancies, including hematologic cancers.

How Equine Genetic Diseases are Inherited  -  Apr 12, 2007
EquiSearch.com,The familiar double-helix-shaped molecule is made of two chains of nucleotides--adenine (A), cytosine (C), guanine (G) and thymine (T).

University Events  -  Apr 12, 2007
Washington University Record,..."From the Pi-way to the Bedside: Use of Accelerator Mass Spectrometry to Study Mutagenic Guanine Oxidation and the Mechanisms of DNA Adduction by Platinum

Spare Times: For Children  -  Apr 6, 2007
New York Times,In biology A, T, C and G stand for adenine, thymine, cytosine and guanine, the four bases that are the chemical building blocks of DNA and the foundation of

Diagnosing Your Demise  -  Mar 30, 2007
Reason Online,Everyone carries the gene, but only those who have a segment that repeats three bases of genetic code cytosine, adenine and guanine (CAG) many times will

Comments, corrections, clarifications, and c*ckups  -  Mar 27, 2007
Crikey,...causes colorectal cancer (Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: Implications for colorectal cancer risk.

Polymorphisms in One Gene May Play Role in Aggressive Nature of ...  -  Mar 4, 2007
Cancer Focus,Since there are two copies of the gene, a patient can have the genotype AA (both copies are alanine), AG (one copy alanine, one copy guanine), and GG.

2007 Update of What is in the Oncology Pipeline at Glaxosmithkline  -  Mar 6, 2007
Cancer Focus,Arranon/Atriance is a guanine arabinoside prodrug indicated for use in acute lymphoblastic leukaemia & lymphomas and has been approved May06.

Deadly DNA sought  -  Mar 2, 2007
Capital Press (subscription),Hampikian randomly chooses combinations of the four letters of DNA's alphabet - A, G, C and T, which stand for adenine, cytosine, guanine and thymine - that

Soil Microbial Community Analysis Using Denaturing Gradient Gel ...  -  Mar 12, 2007
Soil Science Society of America Journal (subscription)Differential migration occurs because more denaturant is needed to separate sequences with higher guanine (G) + cytosine (C) content due to differences in

PF-3512676 (CPG 7909) Non-Small-Cell-Lung Immuno-modulatory ...  -  Mar 16, 2007
Cancer Focus,Coley Phamaceutical Group has developed oligonucleotides which contain CpG motifs (the nucleotides cytosine and guanine in repetition) that help immune

Plasmid’s Brush With Greatness  -  Mar 16, 2007
Palm Beach Post,Beating out another rock star of science, Linus Pauling, Watson and Crick in 1953 discerned how the nucleic acids adenine, thymine, guanine and cytosine

Data from Preclinical Studies of Gilead Nucleotide Compound GS ...  -  Mar 16, 2007
PharmaLive.com (press release),GS 9219 is a prodrug of the nucleotide analog PMEG (9-(2-phosphonylmethoxyethyl)guanine). It is selectively enriched in lymphocytes, and therefore may have

Gegevens van preklinisch onderzoek Gilead Nucleotide Compound GS ...  -  Mar 15, 2007
Netherlands Corporate News (persbericht),About GS 9219 GS 9219 is a prodrug of the nucleotide analog PMEG (9-(2-phosphonylmethoxyethyl)guanine). It is selectively enriched in lymphocytes,

Genes May Contribute to Hip Graft Failure  -  Mar 15, 2007
MedPage Today,In addition, a mutation in the vitamin D receptor gene in which guanine is replaced by thymine (the T allele) and the T/T genotype were both significantly

Full Text  -  Mar 15, 2007
Science Magazine (subscription)...by tertiary contacts involving a guanine-adenineuracil base triple and by ionic interactions between a single Mg 2+ ion and three phosphate groups.

Allergy Sufferers Helped by Innovative New Business  -  Mar 14, 2007
Mass Media Distribution LLC (press release),Their findings, along with extensive medical evidence, indicates that dust mites excrete a compound called guanine which has been found to be the dominant

The Par polarity complex regulates Rap1- and chemokine-induced T ...  -  Mar 12, 2007
Journal of Cell Biology (subscription)Abbreviations used in this paper: GAP, GTPase-activating protein; GEF, guanine nucleotide exchange factor; SDF1, stromal cell–derived factor-1 ; Tiam,

Small computer tackles big workload  -  Mar 8, 2007
New River Valley Current,...into pieces and determining its structure based on the order of the molecules -- adenine, cytosine, guanine and thymine -- that make up a DNA strand.

Lost tomb of Jesus: Indiana Jones meets Dan Brown meets CSI  -  Mar 7, 2007
Florida Baptist Witness,The word "Gattaca" derives from the abbreviations for the DNA nuclei acid bases guanine, adenine, thymine, and cytosine. Not enough nuclear DNA exists to

Celebrating Black Scientific  -  Mar 6, 2007
Black Star News,DNA cyclase that recluses imidazole rings of guanine and adenine damaged by x-irradiation (1983). Another well known Zimbabwean industrial chemist Dr.

California Scientists Map God Genome  -  Mar 1, 2007
Avant News (satire),...ever analyzed – a very long double helix formation of nucleotides comprising sequences of four paired bases: adenine, cytosine, guanine and thymine.

What Is in the Pipeline at GlaxoSmithKline?  -  Feb 25, 2007
Cancer Focus,Arranon, a guanine arabinoside prodrug, is an indicated therapy for acute lymphoblastic leukaemiaterm & lymphomas approved 2006.

DNA Sequencing: Strategies for Soil Microbiology  -  Mar 12, 2007
Soil Science Society of America Journal (subscription)The sequences were assembled into genome scaffolds for different organisms based on the guanine + cytosine content of the sequence fragments.

Full Text  -  Feb 22, 2007
Science Magazine (subscription)...also, studies of mammalian hypoxanthine-guanine phosphoribosyltransferase (HPRT) genes have shown that at least one site within the transcribed region

Maternal Blood Test Diagnoses Down's Syndrome  -  Feb 2, 2007
MedPage Today,...the two dozen or so that had unique fetal allele signal (ie mother homozygous for guanine, G/G, versus fetus heterozygous for guanine and thymine, G/T).

Full Text  -  Feb 1, 2007
Science Magazine (subscription)Stimulation of 7TMRs activates heterotrimeric guanine nucleotide–binding proteins (G proteins), initiating the production of second messenger molecules.

Alternative Ways of Reading DNA Have Spurred Evolution  -  Feb 16, 2007
HealthNewsDigest.com,...islands — stretches of DNA containing multiple copies of the dinucleotide CpG, which consists of the nucleotide cytosine (C) followed by guanine (G).

Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors ...  -  Feb 1, 2007
Science Magazine (subscription)...to the heterotrimeric guanine nucleotide–binding protein G q and is terminated by receptor desensitization and degradation of the second messengers.

Multimodality Imaging of Tumor Xenografts and Metastases in Mice ...  -  Jan 31, 2007
Journal of Nuclear Medicine (subscription)Melanoma metastases were detected by 18 F-FDG PET, 9-[4- 18 F-fluoro-3-(hydroxymethyl)butyl]guanine ( 18 F-FHBG) PET, CT, and BLI and confirmed by ex vivo

Looking for unnatural DNA  -  Jan 30, 2007
Jackson Hole Star-Tribune,Hampikian randomly chooses combinations of the four letters of DNA's alphabet -- A, G, C and T, which stand for adenine, cytosine, guanine and thymine

Bending and breaking the code: dynamic changes in promoter ...  -  Jan 10, 2007
AJP-Lung Physiology (subscription)In our studies, incorporation of a model abasic site at the hypoxia-modified guanine in an oligonucleotide sequence of the VEGF hypoxic response element was

Erythrocyte G Protein As A Novel Target For Malarial Chemotherapy  -  Jan 2, 2007
Medical News Today (press release),Kasturi Haldar and colleagues from Northwestern University Medical School, Chicago, investigated a protein in red blood cells (erythrocyte guanine

Illumina Introduces High-Throughput DNA Methylation Profiling on ...  -  Jan 10, 2007
PharmaLive.com (press release),CpG sites are regions of DNA where a cytosine nucleotide is located adjacent to a guanine nucleotide, the nucleotides linked together by a phosphate.

Was DNA greatest medical discovery?  -  Jan 6, 2007
Cambridge Evening News,He first joined the chemical bases adenine with thymine, and then guanine with cytosine. He discovered the two structures were identical in shape.

UK Firm Spirogen Focuses On DNA-Targeted Therapies  -  Jan 2, 2007
BioWorld Online,It selectively crosslinks guanine residues located on opposite strands of DNA, exhibits potent in vitro cytotoxicity, and is unlike other covalent binding

Two possible new malaria therapies  -  Dec 27, 2006
United Press InternationalAt Northwestern University Medical School in Chicago, Kasturi Haldar led a research group that investigated whether the erythrocyte guanine nucleotide

Full Text  -  Nov 30, 2006
Science Magazine (subscription)Signaling by cell surface receptors and heterotrimeric guanine nucleotide–binding proteins (G proteins) is one of the most exhaustively studied processes in ...

New chips on the block  -  Dec 4, 2006
Financial Express,Each individual chain is composed of four bases, called A (adenine), C (cytosine), G (guanine) and T (thymine), that may occur in any order. ...

A Shadow Biosphere  -  Nov 30, 2006
Astrobiology MagazineFour bases -- adenine, thymine, guanine, and cytosine -- are arranged in two mutually exclusive pairs to encode the information. ...

Nobel Laureate finds 'elegant' explanation for DNA transcribing ...  -  Dec 1, 2006
innovations report,The chemical attraction alone between RNA bases—adenine, cytosine, guanine, and uracil—and their complementary bases on the DNA template strand is far from ...

Genetic link found with tenofovir-associated kidney problems  -  Dec 8, 2006
Aidsmap,A single nucleotide change in the ABCC2 gene sequence (guanine to adenine at position 1249) was found to increase the likelihood of rPT more than six fold ...

Avalon Pharmaceuticals To Present At The American Society Of ...  -  Dec 5, 2006
Medical News Today (press release),...to AVN944 exposure in a multitude of laboratory settings, correlate with biochemical effects of the drug on protein function and guanine nucleotide levels, and ...

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