Recent news on Interleukin

Anti-Interleukin-9 Data Presented At The American Thoracic Society ...  -  25 May 2007
Medical News Today (press release),Genaera Corporation (Nasdaq: GENR) today reported that MedImmune, Inc. (Nasdaq: MEDI) presented data related to the Interleukin-9 (IL-9) program at the

Harvard's Fishman Leads New Drug Strategy at Novartis (Update3)  -  25 May 2007
BloombergIn both diseases, the body is flooded with interleukin-1 beta, a substance the immune system normally releases to fight infection.

Inovio's electroporation tech delivers the goods in trial  -  25 May 2007
BiopharmaReporter.com,They involve interleukin-12 delivered directly to malignant melanomas, in collaboration with RMR and the H Lee Moffitt Cancer Center and Research Institute;

p150/95 (CD11c/CD18) Expression Is Required for the Development of ...  -  25 May 2007
Am J Pathology (subscription)T cells from MOG 35–55 peptide-primed CD11c –/– mice displayed an unusual cytokine phenotype with elevated levels of interleukin (IL)-2, IL-4, and IL-12 but

Leptin-Dependent Toll-Like Receptor Expression and Responsiveness ...  -  25 May 2007
Am J Pathology (subscription)...increased during maturation to adipocytes; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher interleukin-6 production.

Interleukin 1b modulates endogenous TRa gene transcription in ...  -  May 16, 2007
Journal of EndocrinologyThe proinflammatory cytokine interleukin (IL)-1b decreases TRb1 mRNA in an NFkB dependent way. The aim of this study was to unravel the effects of IL-1b on

Interleukin Genetics Reports First Quarter 2007 Financial Results  -  May 9, 2007
Earthtimes.orgInterleukin reported revenue of $2.4 million for the three months ended March 31, 2007, compared to revenue of $232000 for the comparable period last year.

Rheumatoid Arthritis Drug Drops A1c  -  May 15, 2007
Diabetes Health (press release),The message sent by interleukin-1 (IL-1) triggers action by disease-fighting cells that, in diabetes and rheumatoid arthritis, are misguided and cause

Scientists Tailor Immune Responses  -  May 8, 2007
Post ChronicleThe team discovered Candida albicans stimulates the development of T lymphocytes specialized in producing interleukin 17, an immuno-modulatory protein

Marathon Runners' Deaths Attributed to Antidiuretic Hormone  -  May 1, 2007
MedPage Today,They found that disturbance of arginine vasopressin (antidiuretic hormone) secretion, brought on by release of interleukin-6 associated with excess fluid

Abbott's novel psoriasis biologic shows promise  -  May 10, 2007
In-PharmaTechnologist.com,...has a novel mechanism whereby it targets and neutralizes interleukin-12 and interleukin-23, two proteins involved in the inflammatory response.

Biopharmaceuticals from plants simplified  -  May 24, 2007
Truth about Trade & Technology,Research has identified interleukin-6 (IL-6) as a crucial signaling molecule implied in the pathogenesis of Crohn's disease, rheumatoid arthritis and colon

HIV/AIDS project earns national award  -  May 11, 2007
Ottawa Citizen (subscription),He was the national champion in 2006, with a project on the relationship between HIV and a hormone called Interleukin-7, which helps T-cells survive and

AnaSpec Introduces Line Of Insulin Receptor Antibodies  -  May 23, 2007
Medical News Today (press release),Insulin receptor becomes phosphorylated as a response to stimulation of cells by insulin, insulin-like growth factor (IGF-I) and interleukin 4.

Treatment of Polymyalgia Rheumatica and Giant Cell Arteritis: Are ...  -  Apr 30, 2007
Annals of Internal MedicineExpression of the cytokines interleukin-1ß, TNF, and interleukin-6 and the local chemokine CCL2 in the temporal artery of patients with GCA may predict

Positive Clinical Data on CC-10004 Confirms Potential as Novel ...  -  May 23, 2007
PipelineReview.com (press release),...of multiple proinflammatory mediators including, PDE-4, TNF-alpha, interleukin-2 (IL-2), interferon-gamma, leukotrienes, and nitric oxide synthase.

Positive Clinical Data on CC-10004 Confirms Potential as Novel ...  -  May 22, 2007
PharmaLive.com (press release),...of multiple proinflammatory mediators including, PDE-4, TNF-alpha, interleukin-2 (IL-2), interferon-gamma, leukotrienes, and nitric oxide synthase.

Big Bucks  -  May 4, 2007
Forbes,University researchers had just pinpointed a source: a bad gene that causes the body to produce an oversupply of interleukin-1, an immune system protein.

New respiratory virus is discovered  -  May 21, 2007
Science Daily (press release)The culprit: interleukin-6 (IL-6), a chemical pathway used by the immune system. ... > full story. New Herpes Vaccine May Be Ready For Human Trials (January

Abbott’s Investigational Treatment ABT-874 Shows Positive Results ...  -  May 11, 2007
WebWire (press release),ABT-874 is a fully human monoclonal antibody designed to target and neutralize interleukin-12 and interleukin-23, two proteins associated with inflammation

New Diet & Special Stem Cell Program Proves Successful in Killing ...  -  May 10, 2007
Fuerteventura Digital,In experiments that led up to this new program, a 72 year old gentleman with prostate cancer that spread to his bones was given interleukin 2 & gamma

Chemistry: Ionic Etch-A-Sketch  -  May 9, 2007
Nature.com (subscription),Although interleukin-17 itself is well known, Sallusto and Napolitani's work represents the first characterization of the human cells that produce it.

Breastfeeding prevents type 2 diabetes mellitus: but, how and why?  -  May 8, 2007
Am J Clin Nutr (subscription),Human milk contains tumor necrosis factor (TNF-), interleukin (IL)-1, IL-6, transforming growth factor ß1 and ß2 (TGF-ß1 and TGF-ß2),

Narrative Review: The Pathophysiology of Fibromyalgia  -  May 14, 2007
Annals of Internal MedicineIn addition, microglia and astrocytes release proinflammatory cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor- (68).

Green tea may cut arthritis, study  -  May 2, 2007
Beverage Daily,The pro-inflammatory cytokine interleukin-1 beta (IL-1beta) was then added to the culture medium. IL-1beta is an immune system protein reported to play an

Zacks Analyst Interview Highlights: Xoma, Ltd., Merck & Co. and ...  -  May 17, 2007
Business Wire (press release),It is an antibody that targets interleukin-1, which is a well-known, clinically validated target for diabetes and inflammatory disease.

National Cancer Institute's Chief of Metabolism to Deliver ...  -  May 15, 2007
UCSF Today,A major area of his efforts is the critical role of the receptor for interleukin-2 (IL-2) on the growth, differentiation and regulation of normal and

Cancer stem cells therapies in clinical trials  -  May 15, 2007
LabTechnologist.com,SL-401 is designed to inhibit the Interleukin-3 receptor, which is overproduced on the surface of multiple cancers, including both leukaemia blast cells and

Cancer stem cell therapies neglected by big pharma  -  May 14, 2007
OutSourcing-Pharma.com,SL-401 is an antibody designed to inhibit Interleukin-3, which is overproduced on the surface of leukaemia stem cells. Geron, a US biopharma company,

2007 Gladstone Distinguished Lecturer: Thomas A. Waldmann, MD  -  26 Apr 2007
Synapse,A major area of his efforts is the critical role of the receptor for interleukin-2 (IL-2) on the growth, differentiation and regulation of normal and

Interleukin & Chemokine Antibodies – Two Types of Cytokine Antibodies  -  Apr 18, 2007
PR.com (press release),San Jose, CA, April 18, 2007 --(PR.com)-- Interleukin-32 (IL-32), whose expression is increased following activation by IL-2, was initially identified as a

Interleukin & Chemokine Antibodies – Two Types of Cytokine Antibodies  -  Apr 17, 2007
PharmaLive.com (press release),SAN JOSE, CA, April 16, 2007 –Interleukin Antibodies Interleukin-32 (IL-32), whose expression is increased following activation by IL-2, was initially

Interleukin & Chemokine Antibodies – Two Types of Cytokine Antibodies  -  Apr 16, 2007
Newswire Today (press release),Interleukin-32 (IL-32), whose expression is increased following activation by IL-2, was initially identified as a transcript (NK4) selectively expressed in

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus  -  Apr 11, 2007
New England Journal of Medicine (subscription),Background The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose

Interleukin Antagonist Anakinra good for Type 2 Diabetes  -  Apr 11, 2007
Insider Medicine,There is some evidence to suggest that in type 2 diabetes, high blood sugar concentrations can lead to the production of interleukin-1, a protein that

Interleukin Genetics to Hold Investor Meeting on June 12 Following ...  -  Apr 9, 2007
PR Newswire (press release),Interleukin will provide an overview of the operations of its businesses and discuss its go-forward strategy and key goals at the meeting.

Interleukin Genetics Reports 2006 Year-End and Fourth Quarter ...  -  Apr 3, 2007
PharmaLive.com (press release),Interleukin Genetics' reported revenues resulted from the processing of genetic assessment tests launched in the first quarter of 2006 for cardiovascular

Enzyme Halts Allergic Reaction To Chitin  -  Apr 23, 2007
Post Chronicle...mice treated with the biopolymer chitin develop an allergic response, characterized by a build-up of interleukin-4-expressing innate immune cells.

Interleukin Genetics Expands Research Collaboration with Alticor  -  Mar 30, 2007
Genetic Engineering News (press release),Interleukin Genetics, Inc. (AMEX: ILI) reported today that it has entered into a new research agreement with Access Business Group International LLC (ABG),

Interleukin Genetics Expands Research Collaboration with Alticor  -  Mar 30, 2007
Business Wire (press release),Under the terms of the agreement, Interleukin is eligible to receive up to $2.3 million in additional research funding during 2007.

Interleukin Genetics Extends Slump  -  Apr 4, 2007
Trading Markets,...(RTTNews) - Interleukin Genetics (ILI | charts | news | PowerRating) extended its new low with another sharp drop on Wednesday. The stock fell sharply in

ACC Presentation Indicates Interleukin-1 Gene Variants Determine ...  -  Mar 28, 2007
PharmaLive.com (press release),Interleukin Genetics, Inc. is focused on developing, acquiring, and commercializing personalized health products that can help individuals improve and

ACC Presentation Indicates Interleukin-1 Gene Variants Determine ...  -  Mar 27, 2007
Genetic Engineering News (press release),Interleukin Genetics, Inc. (AMEX:ILI) and collaborators at the University of California San Diego today reported at the American College of Cardiology

Inhibition of the MEK/ERK pathway reduces microglial activation ...  -  Mar 29, 2007
The Journal of Thoracic and Cardiovascular SurgeryParameters, including neurologic performance, neuronal survival, inflammatory cell infiltration, and interleukin-1ß production in the spinal cords,

Interleukin Genetics Says ACC Presentation Shows Interleukin-1 ...  -  Mar 27, 2007
Trading Markets,...(RTTNews) - Interleukin Genetics Inc. (ILI | charts | news | PowerRating) and collaborators at the University of California San Diego reported at the

Enzyme halts allergic reaction to chitin  -  Apr 23, 2007
United Press International...mice treated with the biopolymer chitin develop an allergic response, characterized by a build-up of interleukin-4-expressing innate immune cells.

An Update on Transcription Factors in Asthma  -  Apr 23, 2007
Medscape (subscription)Schwandner R, Yamaguchi K, Cao Z. Requirement of tumour necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med.

Arthritis Drug Helps With Type 2 Diabetes  -  Apr 16, 2007
Medical News Today,Anakinra is a manufactured version of a natural interleukin-1 antagonist that blocks the action of interleukin-1 and is normally used to treat arthritis.

Arthritis Medication Proves Effective for Diabetes  -  Apr 18, 2007
About - News & Issues,It is a recombinant human interleukin-1-receptor antagonist. What does this mean? The immune system produces cytokines in response to inflammation in the

Effects of Antioxidant Vitamins  -  Apr 24, 2007
Am J Pathology (subscription)Downstream consequences included increased tissue concentrations and secretion of tumor necrosis factor- and interleukin-1ß, increased expression of

Imbalance of fatty acids linked to depression  -  Apr 18, 2007
Food Consumer,The inflammation-promoting compounds including tumor necrosis factor alpha and interleukin-6 have been associated with heart disease, type 2 diabetes,

New Treatment Improves Type 2 Diabetes  -  Apr 11, 2007
Ivanhoe,The study was spurred by the knowledge that type 2 diabetes patients often have a reduced expression of interleukin-1 receptor antagonist in their

Fatty acid tied to depression  -  Apr 17, 2007
ReutersThese compounds, which include tumor necrosis factor alpha and interleukin-6, are "all-purpose 'nasties' for aging," and have been tied to heart disease,

Rheumatoid Arthritis Drug May Help Treat Type 2 Diabetes  -  Apr 11, 2007
Washington Post,Through previous research, Donath and his colleagues learned that a substance called interleukin-1 beta was a factor in the demise of these cells in people

Cytokine Blocker Eases Beta Cell Stress in Type 2 Diabetes  -  Apr 11, 2007
MedPage Today,In a placebo controlled trial of 70 patients, those given anakinra (Kineret), a recombinant human interleukin-1-receptor antagonist, had a mean hemoglobin

Swiss researchers make diabetes treatment breakthrough  -  Apr 13, 2007
People's Daily Online,Donath and his team already knew that a substance called interleukin-1 beta was responsible for this in type 2. Anakinra is an interleukin-1-receptor

Zurich researchers make diabetes breakthrough  -  Apr 12, 2007
NZZ Online,Donath and his team already knew that a substance called interleukin:1 beta was responsible for this in type 2. Anakinra is an interleukin:1:receptor

Diabetes News: Arthritis Drug May Benefit Patients with Type 2 ...  -  Apr 11, 2007
Associated Content,In earlier studies, Donath's team found that interleukin-1 beta played a part in the destruction in pancreatic beta cells, which produce insulin.

XOMA Announces Clinical Trial Plans for XOMA 052 in Type 2 Diabetes  -  Apr 12, 2007
PharmaLive.com (press release),...clinical testing of XOMA 052, a potent anti-inflammatory monoclonal antibody targeting Interleukin 1-beta (IL-1beta), in Type 2 diabetes patients.

Abbott Laboratories opens new $450 million Puerto Rico plant  -  Apr 11, 2007
Worcester Telegram,In Worcester, Mr. Aruffo said, Abbott Bioresearch Center will remain busy producing experimental drugs such as ABT-874, an anti-interleukin-12 compound that

Protein Kinase C (PKC) Regulates Ocular Inflammation and Apoptosis ...  -  Mar 27, 2007
Am J Pathology (subscription)We show that inhibitory effect of interleukin-13 on endotoxin-induced uveitis in the Lewis rat is dependent on signaling activity of protein kinase C (PKC)

Xoma announces trials for type 2 diabetes treatment  -  Apr 13, 2007
Bizjournals.com,Berkeley-based Xoma (NASDAQ: XOMA) plans to initiate clinical testing of Xoma 052, an antibody that targets a compound in the body called interleukin 1.

XOMA (XOMA) Announces Clinical Trial Plans for XOMA 052 in Type 2 ...  -  Apr 12, 2007
StreetInsider.com (subscription),XOMA Ltd. (Nasdaq: XOMA) announced plans to initiate clinical testing of XOMA 052, a potent anti-inflammatory monoclonal antibody targeting Interleukin

Arthritis Drug Works For Diabetics  -  Apr 12, 2007
Dog Flu Diet and Diseases,Anakinra works by blocking an inflamatory compound in the body known as interleukin 1, and is usually used to treat patients who have arthritis.

Cytheris Names CFO and CMO as Company Boosts Clinical Development ...  -  Apr 2, 2007
PharmaLive.com (press release),In late 2006 - early 2007, Cytheris announced promising preliminary results in Phase I/II clinical trials for its lead product, Interleukin-7.

Use of genetic profile to individualize diet and vitamins lacks ...  -  Apr 2, 2007
Chicago Flame Online (subscription),Companies such as Interleukin Genetics are selling kits for individuals to take a cheek sample, have their genes sequenced, and have customized vitamins or

Data Presented at AACR Meeting Shows Peregrine's Immunocytokine ...  -  Apr 18, 2007
PharmaLive.com (press release),In these proof of principle studies, VTA immunocytokines were created by combining type I interferon and interleukin 2 with 2aG4, an anti-phospholipid

Callisto's Guanilib moves into clincial testing  -  Apr 5, 2007
Therapeutics Daily (subscription) (press release),...and confirm earlier evidence of down-regulation of interleukin-17, IL-23 and tumor necrosis factor, key cytokines that are known to be involved in

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