Recent news on Irinotecan

Coca-Cola To Buy Glaceau, Maker Of Vitaminwater, For $4.1 Bln ...  -  25 May 2007
RTT News,...survival for mCRC patients who have progressed on, or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens.

Advance in colorectal cancer  -  May 7, 2007
Citrus County Chronicle,The latest results show that Erbitux improves survival when used as a second-line agent in combination with irinotecan in colorectal cancer resistant to

Nektar Announces New Organizational Structure and Spending ...  -  May 24, 2007
PharmaLive.com (press release),PEGylated small molecule programs, NKTR-102 (PEGylated-irinotecan) for solid tumors and NKTR-118 (PEGylated-naloxol) for opioid-induced constipation.

Bevacizumab Useful Adjunct in Metastatic Colon Cancer  -  May 2, 2007
Cancerpage.com,Although the study "was conducted in patients who had been previously treated with fluorouracil and irinotecan," Dr. Giantonio continued, the "findings add

Amgen: Vectibix trial shows prolonged survival in patients  -  Apr 30, 2007
MarketWatch...the trial studied 463 patients who had failed or showed resistance to chemotherapy therapies containing fluoropyrimidine, irinotecan and oxaliplatin.

Navarra spin-out signs drug deal to develop Hepatitis C treatment  -  May 4, 2007
Science Business (subscription),The Company is testing a library of products— carbohydrate derivatives of marketed chemotherapeutics and biologics, including doxorubicin, irinotecan,

Looking Into ImClone's Crystal Ball  -  May 17, 2007
CNBC,CRYSTAL is an acronym, but you won't believe how they stretched to create it: Cetuximab combined with iRinotecan in first line therapY for metaSTatic

Pro-Pharmaceuticals And Digna Biotech Sign Agreement To Apply  -  May 1, 2007
Chemical Online.com (press release),The Company is testing a library of products—carbohydrate derivatives of marketed chemotherapeutics and biologics, including doxorubicin, irinotecan,

Alchemia Reports Preliminary Positive Efficacy Data From HyCAMP ...  -  26 Apr 2007
PR Newswire (press release),Primary safety endpoint - Comparison of the incidence of late grade 3 or 4 diarrhoea in patients receiving HyCAMP(TM) versus irinotecan alone: -- not met

Cetuximab and Irinotecan Combination Increases Survival in Metastatic  -  Apr 20, 2007
WebWire (press release),LOS ANGELES - A phase III trial of 1298 colorectal cancer patients has found that a combination of the drugs cetuximab (Erbitux) and irinotecan showed a

Cetuximab-Irinotecan Improves Progression-Free Survival and ...  -  Apr 17, 2007
DG NewsLOS ANGELES, CA -- April 17, 2007 -- Combining cetuximab with irinotecan as a chemotherapeutic regimen for patients with advanced colorectal cancer who have

Cetuximab and irinotecan combination increases survival in ...  -  Apr 17, 2007
Cancer Focus,The Erbitux Plus Irinotecan in Colorectal Cancer (EPIC) study looked at survival in metastaticterm colorectal cancer patients who had already shown

Combination boosts progression free survival  -  Apr 19, 2007
Cancerfacts.com,The patients were randomly placed in groups to receive irinotecan every three weeks or irinotecan plus cetuximab every three weeks, and were treated until

AACR: Cetuximab Shows Survival Edge as Third-Line Colorectal ...  -  Apr 17, 2007
MedPage Today,But as a second-line therapy in combination with irinotecan (Camptosar), the addition of centuximab but did not extend survival over irinotecan monotherapy.

Randomized Phase III Trial Showed ERBITUX Significantly Improved ...  -  Apr 17, 2007
PipelineReview.com (press release),Results showed that the secondary endpoints of progression-free survival and response rate were significantly higher in the ERBITUX-irinotecan arm.

Cetuximab Improves Overall Survival In Advanced Colorectal Cancer  -  Apr 17, 2007
Medical News Today,A second phase III trial reported at the meeting, the Erbitux Plus Irinotecan in Colorectal Cancer (EPIC) study, showed that a combination of cetuximab and

ImClone Systems Showcases Extensive Research and Development ...  -  Apr 19, 2007
PharmaLive.com (press release),In a large randomized phase III trial ERBITUX added to irinotecan significantly improved the secondary end points of progression free survival and tumor

Randomized Phase III Trial Showed ERBITUX Significantly Improved ...  -  Apr 16, 2007
Earthtimes.orgAnalysis of the data show that a considerable number of patients randomized to the irinotecan arm went on to receive ERBITUX with or without irinotecan

ImClone Systems Cancer Drug ERBITUX Shows Higher Secondary ...  -  Apr 16, 2007
Trading Markets,...(BMY | charts | news | PowerRating) on Monday said results from the EPIC study, which compares ERBITUX or Cetuximab plus chemotherapy drug irinotecan to

Merck's Erbitux increases survival in metastatic colorectal cancer ...  -  Apr 18, 2007
SpiritIndia,The international EPIC trial (European Prospective Investigation of Cancer) compared Erbitux plus irinotecan-based chemotherapy (n=648) with

Merck KGaA's Erbitux ups survival 50% in colorectal cancer  -  Apr 17, 2007
Pharma Times (subscription),The International EPIC (European prospective Investigation of Cancer) compared Erbitux plus irinotecan-based chemotherapy with irinotecan-based chemotherapy

ImClone drug shows promise in clinical trials  -  Apr 16, 2007
Crain's New York Business,The phase III study compared a combination of Erbitux and a chemotherapy drug called irinotecan, versus irinotecan alone, in colon cancer patients who

Mixed Results in Erbitux Colon Cancer Trial  -  Apr 17, 2007
Cancerpage.com,Researchers said a 1300-patient trial found that a combination of Erbitux, also known as cetuximab, and chemotherapy drug irinotecan significantly improved

ImClone cancer drug trials mixed but encouraging  -  Apr 16, 2007
Scientific AmericanAn international trial involving 1300 patients found that a combination of Erbitux, also known as cetuximab, and chemotherapy drug irinotecan significantly

Innovative Pulmonary & PEGylation-based Therapeutic Product ...  -  Apr 14, 2007
Medical News Today (press release),It is a PEGylated form of irinotecan, a chemotherapeutic agent used for the treatment of solid tumors. In preclinical studies in tumor-bearing mice,

Survival Data Available From ERBITUX(R) Study in First-Line ...  -  Apr 3, 2007
Earthtimes.orgERBITUX is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) in combination with irinotecan for patients who are

ImClone Systems: Erbitux takes a knock  -  Apr 11, 2007
Pharmaceutical Business ReviewErbitux is also indicated for the treatment of metastatic colorectal carcinoma (mCRC) in combination with irinotecan for patients who are refractory to

Amgen Discontinues Vectibix(TM) Treatment In PACCE Trial ...  -  Apr 2, 2007
Medical News Today (press release),The PACCE trial investigated a treatment regimen that used dual biologics combined with oxaliplatin- or irinotecan-based chemotherapy.

Personalized Medicine: Dream or Reality?  -  Apr 6, 2007
Drug Discovery & Development,Another example of personalized medicine in oncology is irinotecan. This drug is inactivated by the enzyme UGT1A1. The gene promoter for this enzyme is

Avastin Linked to Potentially Fatal Fistulas  -  Apr 24, 2007
Cancerpage.com,In the company's press release, they report that Avastin was used along with irinotecan, carboplatin, and radiation therapy, followed by maintenance Avastin

KRAS Mutation a Strong Predictor of Response to Cetuximab Therapy ...  -  Apr 19, 2007
DG NewsTwo patients received cetuximab as monotherapy, and the remainder received it in combination with either irinotecan, or irinotecan and

Genes And Biomarkers That Allow Doctors To Choose The Right ...  -  Apr 23, 2007
Medical News Today (press release),Dr. Laurent-Puig and his colleagues studied 114 patients who had been given cetuximab in combination with another drug, irinotecan.

Enzon's PEG-SN38 Shows Anti-Tumor Activity in Resistant ...  -  Apr 18, 2007
PipelineReview.com (press release),SN38 is the active metabolite of the widely used cancer drug irinotecan, marketed as Camptosar(R) in the US Although unmodified SN38 is 1000 times more

News For Your Web Site  -  Apr 18, 2007
dBusinessNews Newark (press release),SN38 is the active metabolite of the widely used cancer drug irinotecan, marketed as Camptosar® in the US Although unmodified SN38 is 1000 times more potent

Avastin Linked to Tracheoesophageal Fistula Formation in Lung ...  -  Apr 23, 2007
Medscape (subscription)...multicenter, single-group phase 2 trial of patients with limited-stage small-cell lung cancer (SCLC) who received 4 cycles of irinotecan, carboplatin,

FDA Warns of Possible Bevacizumab Fistula Complication  -  Apr 23, 2007
MedPage Today,The multicenter, non-randomized phase II trial, which was closed to new accruals on March 12, combined four cycles of concurrent irinotecan (Campto),

Breakthrough Cancer Drug Avastin Approved In Japan For Use In ...  -  Apr 23, 2007
Medical News Today (press release),Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer. New England Journal of Medicine 2004; 350(23): 2335â€"2342

Boosting Colon Cancer Survival  -  Mar 29, 2007
UCSF Today,Patients take one of two standard chemotherapy treatments that combine 5-fluorouracil and leucovorin with either oxaliplatin or irinotecan.

Pro-Pharmaceuticals Receives Letter from the FDA for New Drug ...  -  Apr 11, 2007
PharmaLive.com (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT(R), in combination with 5-FU, leucovorin, irinotecan,

Pro-Pharmaceuticals Receives Letter from the FDA for New Drug ...  -  Apr 11, 2007
Business Wire (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT ® , in combination with 5-FU, leucovorin, irinotecan,

Pro-Pharmaceuticals Reports Fourth Quarter and Full Year 2006 ...  -  Apr 3, 2007
PharmaLive.com (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT(r), in combination with 5-FU, leucovorin, irinotecan,

Cetuximab improves Survival In Advanced Colorectal Cancer Patients ...  -  Apr 20, 2007
Medical News Today (press release),...colorectal cancer whose disease was no longer responding to all available chemotherapy, including irinotecan, oxaliplatin and fluoropyrimidines.

Researchers link gene mutation to Erbitux response  -  Apr 17, 2007
Reuters.uk,The French study, involving 114 patients who had been given Erbitux in combination with chemotherapy drug irinotecan, found that almost none of the patients

Market Report -- In Play (ENZN)  -  Apr 17, 2007
MSN Money...resulted in significant tumor growth inhibition in mice resistant to Camptosar (irinotecan HCl injection) and outperformed Camptosar in mice when given

Study the First to Show Survival Benefits of Cetuximab in Patients ...  -  Apr 17, 2007
DG NewsThese patients had failed all other available forms of therapy, including irinotecan (96%) and oxaliplatin (97%). More than two thirds of patients had

Pro-Pharmaceuticals Issues Corporate Update  -  Apr 17, 2007
PharmaLive.com (press release),5-FU is a case study as DAVANAT(R) has broad application and has been tested in clinical and pre-clinical studies in combination with leucovorin, irinotecan

Pro-Pharmaceuticals Issues Corporate Update  -  Apr 17, 2007
Business Wire (press release),5-FU is a case study as DAVANAT ® has broad application and has been tested in clinical and pre-clinical studies in combination with leucovorin, irinotecan,

Combination of Irinotecan and Vincristine Active Against ...  -  Feb 12, 2007
Cancer Consultants (press release),According to the results of a study published in the Journal of Clinical Oncology, treatment with the chemotherapy drugs irinotecan and vincristine reduced

Camptosar® Evaluated in Children with Relapsed or Refractory ...  -  Feb 14, 2007
Cancer Consultants (press release),In a Phase II clinical trial published in the Journal of Clinical Oncology, Camptosar® (irinotecan) reduced or eliminated detectable cancer in 11% of

Reducing Risks of Infusion Related Reactions in Targeted Cancer ...  -  Jan 30, 2007
PharmiWeb.com (press release),The 1147 patients participating in MABEL were treated with the EGFR inhibitor cetuximab plus irinotecan having previously failed irinotecan therapy alone.

Merck KGaA Seeks Approval for Erbitux for Colorectal Cancer in Japan  -  Feb 6, 2007
PipelineReview.com (press release),The BOND study demonstrated that Erbitux when used in combination with irinotecan-based chemotherapy in the treatment of patients with metastatic colorectal

Pro-Pharmaceuticals Meeting Scheduled with the FDA  -  Feb 23, 2007
American Digital Networks (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT(R), in combination with 5-FU, leucovorin, irinotecan,

ImClone Systems Incorporated and Bristol-Myers Squibb Announce ...  -  Feb 4, 2007
Earthtimes.orgERBITUX is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) in combination with irinotecan for patients who are

ImClone Opts Out Of UCB Deal To Develop CDP-791  -  Feb 6, 2007
BioWorld Online,The compound won approval three years ago for use with irinotecan in epidermal growth factor receptor-expressing, metastatic colorectal cancer patients who

Pro-Pharmaceuticals Collaborates with Chemwerth to Scale-up ...  -  Feb 20, 2007
PharmaLive.com (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT(R), in combination with 5-FU, leucovorin, irinotecan,

NCCN Updates Colon Cancer Guidelines  -  Jan 29, 2007
PharmaLive.com (press release),The combination regimens of fluorouracil, leucovorin and irinotecan (Camptosar, Pfizer) (known as FOLFIRI) + cetuximab and irinotecan + cetuximab were added

Drug may fight brain cancer  -  Feb 21, 2007
San Francisco Chronicle,That trial, which compares Avastin alone to Avastin plus irinotecan, is ongoing. If successful, Avastin would provide an option for treatment of one of the

More drugs added to colon-cancer guide  -  Jan 29, 2007
United Press InternationalThe group said it also added the combination of fluorouracil, leucovorin and irinotecan -- sold as Pfizer's Camptosar and referred to as Folfiri -- as well

Avastin halts brain cancer  -  Feb 20, 2007
Monsters and Critics.com,The patients in the pilot trial were also given another chemotherapy drug known as irinotecan along with Avastin. Vredenburgh, who has no connection to

Committee for Medicinal Products for Human Use Post-authorisation ...  -  Feb 23, 2007
PharmaLive.com (press release),Avastin (bevacizumab) in combination with intravenous 5-fluorouracil/folinic acid or intravenous 5-fluorouracil/folinic acid/irinotecan is indicated for

New Type of Cancer Drug Can Slow Deadliest Form of Brain Cancer ...  -  Feb 22, 2007
Local Tech Wire,In the pilot study, the researchers found that dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumors or restricted their

Data acquisition for the histoculture drug response assay in lung ...  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryWe examined chemosensitivities of the tissues to cisplatin, doxorubicin, mitomycin C, 5-fluorouracil, docetaxel, paclitaxel, etoposide, irinotecan,

Cancer drug can extend survival in patients with deadly brain tumors  -  Feb 22, 2007
innovations report,In the pilot study, the researchers found that dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumors or restricted their

Study Finds Drug Avastin Slows Brain Tumor Growth  -  Feb 20, 2007
Cancerpage.com,When they added Avastin to the more standard chemotherapy drug irinotecan, the combination either shrank the tumors or restricted their growth in nearly all

Cancer drug Avastin can slow growth of deadly brain tumours, find ...  -  Feb 20, 2007
DailyIndia.com,The researchers noted that a dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumours or restricted their growth in nearly

Cancer drug Avastin can slow growth of deadly brain tumors  -  Feb 20, 2007
South Asian Women's Forum,The researchers noted that a dual therapy with Avastin and the chemotherapy drug irinotecan either shrank the tumors or restricted their growth in nearly

Genentech/Roche: significant potential for Avastin in glioma  -  Feb 19, 2007
Pharmaceutical Business Review...(bevacizumab) is added to Pfizer's Camptosar (irinotecan) for the treatment of stage III and IV glioma, significant antitumor effects are conferred.

Pediatric studies lead to more information on drug labels  -  Feb 1, 2007
AAP News (subscription)For example, while clofarabine is effective in the treatment of pediatric cancer, irinotecan has not proven to be effective. Ondansetron is useful for

Pro-Pharmaceuticals to Account for Warrants as Liabilities from ...  -  Feb 16, 2007
Business Wire (press release),The Company has been conducting clinical and pre-clinical studies with its lead compound, DAVANAT ® , in combination with 5-FU, leucovorin, irinotecan,

Camptosar® Confirmed Active in Recurrent or Refractory ...  -  Feb 13, 2007
Cancer Consultants (press release),Two clinical trials published in the January 2007 issue of the Journal of Clinical Oncology suggest that Camptosar (irinotecan) has significant activity and

Threshold Pharmaceuticals Initiates Phase 2 Clinical Trial ...  -  Feb 6, 2007
PharmaLive.com (press release),...variety of single agent and combination regimens including topotecan, cyclophosphamide, doxorubicin, vincristine, irinotecan, ifosfamide and cisplatin.

Gut Research Yields New Anti-Cancer Approach  -  Feb 5, 2007
Medical News Today (press release),...regimens feature 5-fluorouracil (5-FU) in combination with other chemotherapy drugs (oxaliplatin, irinotecan) and antibodies (bevacizumab, cetuximab).

Celebrex® Does Not Increase Effectiveness of FOLFOX  -  Feb 5, 2007
Cancer Consultants (press release),FOLFOX includes the chemotherapy agents Eloxatin® (oxaliplatin), 5-flourouracil, and leucovorin, while FOLFIRI includes Camptosar® (irinotecan),

Gut Research Yields New Cancer Approach  -  Feb 2, 2007
Media Newswire (press release),...irinotecan ) and antibodies ( bevacizumab, cetuximab ). Once again, response rates of current drugs are low ( less than 30 percent as single agents ).

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