Recent news on Lamotrigine

Effectiveness and Weight Effects of Open-Label Lamotrigine  -  May 23, 2007
Medscape (subscription)A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry. 2004;65:432-441.

Mum's epilepsy med linked to low IQ in kids  -  May 11, 2007
National Review of Medicine,In an ongoing study, now in its seventh year, of the effects of four common antiepileptic drugs (AEDs) — carbamazepine, lamotrigine, phenytoin and valproate

General Practitioners and Women Still Not Getting Valproate Message  -  May 11, 2007
Medscape (subscription)Carbamazepine, lamotrigine, and phenytoin did not affect this relationship. But valproate did interfere with this normal relationship," said Dr. Meador.

Epilepsy Drug Valproate Used During Pregnancy Linked To Lower IQ ...  -  May 8, 2007
Science Daily (press release)The study looked at IQ test results for 187 two-year-old children of mothers who took the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate

Popular epilepsy drug damages the unborn  -  May 7, 2007
News-Medical.net,Children whose mothers took carbamazepine scored an average of 93 points on the IQ tests, those on phenytoin 93, lamotrigine 96, and 84 for valproate.

Study finds more risks to unborn in epilepsy drug Depakote  -  May 4, 2007
Los Angeles Times,Twenty-four percent of children whose mothers took valproate had IQs below 70, compared to 13% for carbamazepine, 11% for lamotrigine and 12% for phenytoin.

Women Taking Antiepileptics Give Birth to Babies at Risk ...  -  May 4, 2007
DG NewsThis finding held across all drug groups except lamotrigine and gabapentin. Over 15% of infants exposed to valproate, lamotrigine, carbamazepine and

Lamictal effective in treating patients with partial seizures  -  May 8, 2007
SpiritIndia,...formulation of Lamictal® (lamotrigine) is effective as add-on treatment in patients with partial epilepsy with and without secondary generalization.

Lower IQ for Children of Women who Took Epilepsy Drug  -  May 6, 2007
drkoop.comFor those who took carbamazepine or phenytoin, it was 12 percent, and 9 percent for children whose moms took lamotrigine. Results also show lower IQ scores

Anti-Epileptic Drug Intake May Result In Children With Mental ...  -  May 5, 2007
MedIndia,...at IQ results of 187 children born to mothers who had taken the epilepsy drugs carbamazepine, lamotrigine, phenytoin, or valproate during pregnancy.

Epilepsy Drug Damages Unborn Babies  -  May 7, 2007
E Canada Now,This was compared to far lower levels in other epilepsy drugs such as carbamazepine which was at 12%, lamotrigine at 9%, and phenytoin at 12%.

Study: Valproate linked to kids' low IQ  -  May 3, 2007
United Press InternationalWhen compared to treatment with other drugs like carbamazepine, lamotrigine and phenytoin, the intelligence quotient of 2-year-old children was 9 to 12

GSK hit by strong sterling but underlying growth is good  -  Apr 26, 2007
Pharma Times (subscription),Sales of Lamictal (lamotrigine) for epilepsy were up 17% to £250 million, while heart disease drug Coreg (carvedilol) increased 8% to £217 million.

Ask the Expert: Treatment Strategy for Co-occurring Bipolar ...  -  May 18, 2007
Focus (subscription)Second-line agents include lamotrigine and carbamazepine. Lamotrigine has been reported to be particularly effective for rapid cycling (4),

New Data Shows Once a Day Lamictal XR is Effective in Treating ...  -  May 2, 2007
PharmaLive.com (press release),The study outcomes included lamotrigine pharmacokinetics upon conversion and seizure frequency during each treatment phase. Results showed the steady state

New Medication Strategies for Comorbid Substance Use and Bipolar ...  -  May 18, 2007
Focus (subscription)The excitatory amino acid antagonists, such as lamotrigine, might be helpful for BPD or psychotic depression with stimulant dependence (Brown et al 2003).

AAN: In Utero Exposure to Valproate Lowers IQ  -  May 3, 2007
MedPage Today,In contrast, the IQ of the children was significantly associated with the mother's IQ for women who took either carbemazepine (Tegretol), lamotrigine

GSK hit by strong sterling but underlying growth is good  -  26 Apr 2007
Pharma Times (subscription),Sales of Lamictal (lamotrigine) for epilepsy were up 17% to £250 million, while heart disease drug Coreg (carvedilol) increased 8% to £217 million.

View larger version (91K):  -  Apr 18, 2007
New England Journal of Medicine (subscription),The patient was treated with lamotrigine, and within 6 months her symptoms had resolved. She resides with her daughter but continues to live independently.

Research Finds Newer Drug For Partial Epilepsy Is Superior,But Old ...  -  Mar 29, 2007
Medical News Today (press release),Researchers found that a newer drug, lamotrigine, is clinically superior and is a cost-effective alternative to carbamazepine for the majority of patients

Treatment of Bipolar Depression  -  Mar 28, 2007
New England Journal of Medicine (subscription),Lamotrigine is an anticonvulsant agent that large trials have shown to be efficacious as prophylaxis for bipolar depression, although the size of the

Stimulating Research: A Prospective, Randomized, Double-Blind ...  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)Patients were maintained on their medications: lithium (N=2), risperidone (N=1), quetiapine (N=1), divalproex (N=1), and lamotrigine (N=1).

Trends in the Use of Psychotropic Drugs in Taiwan: A Population ...  -  Apr 5, 2007
Psychiatric Services (subscription)...valproate, gabapentin, topiramate, and lamotrigine), and anxiolytic-hypnotic drugs (including benzodiazepines and nonbenzodiazepine compounds).

Bipolar disorder can cause mood swings, out-of-control behavior  -  Apr 4, 2007
Casa Grande Valley Newspapers,A newer anti-seizure medication, lamotrigine, was approved by the FDA in 2003. Recently, second generation antipsychotics (olanzapine, risperidone,

Feeling Unreal: Depersonalization Disorder and the Loss of the Self  -  Mar 30, 2007
British Journal of Psychiatry (subscription),Depersonalisation disorder is notoriously resistant to treatment but promising results are claimed for treatment with either lamotrigine, the combination of

SC News Lab: Better Than Nothing?  -  Mar 28, 2007
ScienCentral News,My wife, who is prescribed a combination of lamictal (lamotrigine) and Zoloft (sertraline)-- by our primary care physician, not the numerous psychiatrists

Depression: What you need to know  -  Apr 7, 2007
Food Consumer,Other anticonvulsants that are being used now include lamotrigine (Lamictal ® ) and gabapentin (Neurontin ® ): their role in the treatment hierarchy of

Advances in the Treatment of Epilepsy and Other Important Research ...  -  Feb 2, 2007
Medscape (subscription)Experience with lamotrigine. A generic form of lamotrigine (Lamictal, GlaxoSmithKline) has been available in Canada since 2002. Two studies with different

Bentley Announces Latest Marketing Approvals and Product Launch in EU  -  Feb 2, 2007
Business Wire (press release),The Company also noted that its subsidiary, Laboratorios Davur, SL, has obtained approval to market lamotrigine from the Ministry of Health in Spain.

Marijuana lessens HIV nerve pain  -  Feb 12, 2007
The Advocate,Some HIV patients with chronic nerve pain are able to take anticonvulsant drugs, such as lamotrigine and gabapentin, to ease pain.

Defining the Boundaries of Childhood Bipolar Disorder  -  Jan 31, 2007
Am J Psychiatry (subscription)Guberman AH, Besag FM, Brodie MJ, Dooley JM, Duchowny MS, Pellock JM, Richens A, Stern RS, Trevathan E: Lamotrigine-associated rash: risk/benefit

Cannabis may be safe and effective for HIV-related neuropathic pain  -  Feb 15, 2007
Aidsmap,Neuropathy is often treated with the anticonvulsant drugs lamotrigine and gabapentin, which not all patients find effective or tolerable.

“Smoke Two Joints and Call Me in the Morningâ€?: Health Benefits of ...  -  Feb 14, 2007
American Chronicle,...usage would expand the array of pain relief options for persons who cannot take anticonvulsant drugs such as lamotrigine and gabapentin to ease pain.

Marijuana a natural pain killer -study  -  Feb 13, 2007
Food Consumer,...a wider host of patients than did the anticonvulsant drugs such as lamotrigine and gabapentin, which are prescribed to HIV patients to help ease pain.

Marijuana May Help With Pain  -  Feb 13, 2007
International News Service,Abrams says while some HIV patients with chronic nerve pain are able to take anti-convulsant drugs, such as lamotrigine and gabapentin, some patients don't

Pipeline paying dividends as GSK posts strong earnings rise  -  Feb 9, 2007
Pharma Times (subscription),Sales of Lamictal (lamotrigine) for epilepsy were up 23% to £257 million in the quarter, helped by a new indication, to treat primary generalised

False Positive Phencyclidine Results Caused by Venlafaxine  -  Jan 31, 2007
Am J Psychiatry (subscription)She was receiving treatment with venlafaxine 225 mg/day, lamotrigine 100 mg/day, and lormetazepam 2 mg/day. During the prior month she experienced worsening

A Case of Mania Following the Use of Pramipexole  -  Jan 31, 2007
Am J Psychiatry (subscription)...including lamotrigine, oxcarbazepine, and modafinil, we decided to add pramipexole to valproic acid 750 mg bid (serum level 110 µg /ml).

More Treatment Options For People With Bipolar  -  Jan 8, 2007
Scoop.co.nz (press release),The Government drug funding agency PHARMAC has announced it will widen access to two brands of lamotrigine (Mogine and Arrow-Lamotrigine) from February 2007

Funding for new bipolar drug  -  Jan 9, 2007
New Zealand Herald,Two brands of lamotrigine (Mogine and Arrow-Lamotrigine) would be available from February for people whose medication was ineffective or caused adverse

Pregnant Women on Lamotrigine Have Greater Risk of Seizures When ...  -  Dec 7, 2006
DG NewsSAN DIEGO, CA -- December 7, 2006 -- Women with epilepsy who are treated with lamotrigine (Lamictal) during pregnancy and have low therapeutic levels of the

Quick Reference FOR PSYCHOPHARMACOLOGY  -  Dec 6, 2006
Focus (subscription)Olanzepine-fluoxetine combination and quetiapine approved for bipolar depression. Lamotrigine approved for the prevention of depression.

Ask the Expert PSYCHOPHARMACOLOGY: MAJOR DEPRESSIVE DISORDER  -  Dec 6, 2006
Focus (subscription)In such situations, mood stabilizers, perhaps particularly lamotrigine and/or atypical anti-psychotics may be indicated. It is also worth considering

Clinical Trial Design  -  Nov 27, 2006
Medscape (subscription)In experimental allergic encephalomyelitis, sodium channel blockers, such as flecainide and lamotrigine, can block this influx and reduce disease severity.

No Weight Gain Seen in Patients on Investigative Antiepileptic ...  -  Dec 6, 2006
DG NewsPhenytoin, lamotrigine and leviteracetam are weight neutral. While the cohort of patients overall did not show any weight gain, 3 patients did gain weight,

PAINFUL FACIAL TIC MAKES LIFE UNBEARABLE  -  Dec 2, 2006
Charlotte Sun-Herald,Carbamazepine, phenytoin and lamotrigine are the names of some of the medicines that are often prescribed and often bring relief. However, if medicines fail

Bibliography PSYCHOPHARMACOLOGY  -  Dec 6, 2006
Focus (subscription)Marangell LB, Martinez JM, Ketter TA, Bowden CL, Goldberg JF, Calabrese JR, Miyahara S, Miklowitz DJ, Sachs GS, Thase ME, STEP-BD Investigators: Lamotrigine

STAR D: The Results Begin to Roll in  -  Dec 6, 2006
Focus (subscription)Green B: Lamotrigine in mood disorders. Curr Med Res Opin 2003; 19:272–277[Medline]. Menza M, Marin H, Opper RS: Residual symptoms in depression: can

Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients  -  Dec 6, 2006
Focus (subscription)...relative to other compounds with demonstrated antidepressant effects—such as standard antidepressants or lamotrigine—deserves investigation (10).

Predictors of Recurrence in Bipolar Disorder: Primary Outcomes ...  -  Dec 6, 2006
Focus (subscription)White R, Greene P, Leadbetter R: A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder.

Effectiveness Of Potential Huntington's Disease Drugs Revealed By ...  Nov 2, 2006
...glutamate. Gabapentin and lamotrigine, both glutamate inhibitors, are used in epilepsy treatment and as a mood stabilizer, respectively. ... -Medical News Today (press release), Actavis: Epitrigine Meets all Safety and Efficiency Requirements  Oct 30, 2006
Epitrigine (Lamotrigine) has been very successfully used for two years now in 13 European states, including Great Britain, Austria, Denmark, Spain and the ... -Focus News, Comparative effectiveness of second-generation antipsychotics and ...  Oct 31, 2006
...did not differ significantly in the addition of a mood stabiliser (divalproex 12 patients, gabapentin 5 patients, lithium 2 patients, lamotrigine 2 patients ... -British Journal of Psychiatry (subscription), An Interaction Between Aspirin and Valproate: The Relevance of ...  Oct 30, 2006
J Pharmacol Exp Ther 1997; 283:698–703 [Abstract/Free Full Text]. Bottiger Y, Svensson JO, Stahle L: Lamotrigine drug interactions in a TDM material. ... -Am J Psychiatry (subscription) Successful Use of VNS for Depression  Oct 11, 2006
She has been seen in our community mental health center since February 2001. Current medications are lamotrigine, bupropion, lithium, and paroxetine. ... -Psychiatric Services (subscription) Lopinavir/ritonavir Sharply Reduces Availability of Lamotrigine  Sep 1, 2006
The HIV protease inhibitor combo lopinavir/ritonavir (Kaletra) reduces the area under the curve (AUC) of concentration-time curves of lamotrigine, such that ... -Medscape (subscription)

Progress in the Treatment of Bipolar Depression  Aug 26, 2006
...depression emerged in 1999, when Calabrese and associates 7 published the first randomized, parallel group, placebo-controlled trial of lamotrigine in the ... -Psychiatric Times

In two minds  Sep 12, 2006
...antipsychotic drug. For bipolar depression, either lithium or the anticonvulsant lamotrigine (Lamictal) are commonly prescribed. There ... -ITP.net

Examine Detailed Profiles of Key Compounds in Development for Use ...  Sep 20, 2006
Despite the commercial success of Lamictal (lamotrigine) and Depakote (valproate), the late-stage bipolar disorder pipeline only includes one anticonvulsant ... -Business Wire

First-Time Generic Approvals: Cipro IV, Surmontil, Lamictal  Sep 6, 2006
...including exposure to inhalational anthrax; trimipramine maleate 25-mg, 50-mg, and 100-mg capsules for the treatment of depression; and lamotrigine 25-mg, 100 ... -Medscape (subscription)

Torrent eyes Australian pharma mart  Sep 11, 2006
To begin with,TPL plans to register anti-epileptic drug Lamotrigine in Australia and follow it up with other four to five drugs. -Times of India

Diagnostic Challenges and Treatment Strategies  Aug 26, 2006
...of depression is described. Data regarding the efficacy and safety of lamotrigine are reviewed and critiqued. The emerging data ... -Psychiatric Times

GSK: given green light to restrict Greek drug supply  Sep 6, 2006
...now GlaxoSmithKline [GSK]), imposed restrictions on wholesalers' supply of three of its drugs, Imigran (sumatriptan), Lamictal (lamotrigine) and Serevent ... -Pharmaceutical Business Review

GSK claims victory in parallel trade dispute  Sep 6, 2006
...in Greece ruled that GSK had not acted unlawfully in restricting supplies of the three products - epilepsy drug Lamictal (lamotrigine), Imigran (sumatriptan ... -Pharma Times (subscription)

Pregnant Women on Lamotrigine Have Greater Risk of Seizures When ...  -  Dec 7, 2006
DG NewsSAN DIEGO, CA -- December 7, 2006 -- Women with epilepsy who are treated with lamotrigine (Lamictal) during pregnancy and have low therapeutic levels of the

Quick Reference FOR PSYCHOPHARMACOLOGY  -  Dec 6, 2006
Focus (subscription)Olanzepine-fluoxetine combination and quetiapine approved for bipolar depression. Lamotrigine approved for the prevention of depression.

Ask the Expert PSYCHOPHARMACOLOGY: MAJOR DEPRESSIVE DISORDER  -  Dec 6, 2006
Focus (subscription)In such situations, mood stabilizers, perhaps particularly lamotrigine and/or atypical anti-psychotics may be indicated. It is also worth considering

No Weight Gain Seen in Patients on Investigative Antiepileptic ...  -  Dec 6, 2006
DG NewsPhenytoin, lamotrigine and leviteracetam are weight neutral. While the cohort of patients overall did not show any weight gain, 3 patients did gain weight,

Clinical Trial Design  -  Nov 27, 2006
Medscape (subscription)In experimental allergic encephalomyelitis, sodium channel blockers, such as flecainide and lamotrigine, can block this influx and reduce disease severity.

Bibliography PSYCHOPHARMACOLOGY  -  Dec 6, 2006
Focus (subscription)Marangell LB, Martinez JM, Ketter TA, Bowden CL, Goldberg JF, Calabrese JR, Miyahara S, Miklowitz DJ, Sachs GS, Thase ME, STEP-BD Investigators: Lamotrigine

STAR D: The Results Begin to Roll in  -  Dec 6, 2006
Focus (subscription)Green B: Lamotrigine in mood disorders. Curr Med Res Opin 2003; 19:272–277[Medline]. Menza M, Marin H, Opper RS: Residual symptoms in depression: can

PAINFUL FACIAL TIC MAKES LIFE UNBEARABLE  -  Dec 2, 2006
Charlotte Sun-Herald,Carbamazepine, phenytoin and lamotrigine are the names of some of the medicines that are often prescribed and often bring relief. However, if medicines fail

Suicidal Ideation and Pharmacotherapy Among STEP-BD Patients  -  Dec 6, 2006
Focus (subscription)...relative to other compounds with demonstrated antidepressant effects—such as standard antidepressants or lamotrigine—deserves investigation (10).

Predictors of Recurrence in Bipolar Disorder: Primary Outcomes ...  -  Dec 6, 2006
Focus (subscription)White R, Greene P, Leadbetter R: A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder.

Fluoxetine - All Information & Buy Fluoxetine Now  -  Nov 21, 2006
Lokalavisen PÃ¥Gaden,Visit my site. fluoxetine metoprolol beclomethasone lamotrigine indapamide carbamazepine buspirone isosorbide gemfibrozil fluticasone

Impact of Lamotrigine and Lithium on Weight in Obese and Nonobese ...  Jun 30, 2006
METHOD: A post hoc analysis was conducted to assess the effects of lamotrigine, lithium, and placebo administration on body weight in obese and nonobese ... -Am J Psychiatry (subscription)

First-Time Generic Approvals: Zocor, Propecia, Lamictal Chewables  Jun 30, 2006
...heart disease and cardiovascular events; finasteride 1-mg tablets for the treatment of androgenetic alopecia in men aged 18 to 41 years; and lamotrigine 5- and ... -Medscape (subscription)

What Happened to Lithium? Antidepressant Augmentation in Clinical ...  Jun 30, 2006
We discovered one small controlled trial reporting positive results when lamotrigine, an anticonvulsant, was added to fluoxetine, an antidepressant (12), and ... -Am J Psychiatry (subscription)

FDA Approves First Generic Version Of Merck's Zocor, Move To ...  Jun 23, 2006
...the pill. In addition, FDA approved the first generic products of two versions each of Finasteride and Lamotrigine. Finasteride ... -Trading Markets

FDA Approves First Generic Simvastatin  Jun 23, 2006
...prostate. Lamotrigine Tablets (Chewable), 5 mg and 25 mg (Lamictal) - therapy for treating patients with seizures due to epilepsy. ... -FDA.gov

Your Health  Jul 1, 2006
They need a mood stabilizer like Lithium or Lamotrigine before they take any antidepressants. Svend: Hmm, I like the grandiosity bit. ... -Richmond News

Shingles and Chickenpox (Varicella-Zoster Virus)  Jun 23, 2006
Newer anti-seizure agents, including lamotrigine, oxcarbazepine, topiramate, and zonisamide, are being investigated but no data supports their use for PHN as ... -About - News & Issues

Persistent Auditory Hallucinations That Are Unresponsive to ...  Jun 30, 2006
There was some improvement in the volume of the hallucinations; they were described at this point as "softer." Lamotrigine was added, titrated to a full dose ... -Am J Psychiatry (subscription)

Category: Fairway Woods  Jun 28, 2006
...fastpages.com/bestvalium/viagra-online.html]Digoxin[/url] http://fastpages.com/bestvalium/digoxin.html http://fastpages.com/bestvalium/lamotrigine.html. ... -Golf-Gear-Review.com



Lamotrigine Improves Depressed Mood in Women With Epilepsy ...  May 11, 2006
WASHINGTON, DC -- May 11, 2006 -- Depressed mood in patients with epilepsy can be improved with addition of lamotrigine to background anticonvulsant medication ... - DG News

Joseph Calabrese, MD Receives Prestigious Ellis Island Medal of ...  May 15, 2006
In 1998, Dr. Calabrese's research resulted in the FDA approval of the use of Lamotrigine, a drug originally developed for treatment of epilepsy, for the ... - Yahoo! News

Neuropathic Pain: An Update on Effective Management Strategies  May 5, 2006
...agents include the first-generation agents (eg, phenytoin and carbamazepine) and second-generation agents (eg, lamotrigine, levetiracetam, oxcarbazepine ... - Medscape (subscription)

Anticonvulsant Treatment for Psychiatric and Seizure Indications ...  May 4, 2006
...valproic acid (the term is used collectively to refer to all valproic acid-related products), gabapentin, oxcarbazepine, lamotrigine, topiramate, phenytoin ... - Psychiatric Services (subscription)

Chronic nerve pain strikes in jaw and cheek  Apr 17, 2006
...drug therapy. Common drugs prescribed are oxcarbazepine, carbamazepine, gabapentin, lamotrigine, topiramate and baclofen. With the ... - Newark Star Ledger

COMBINATION OF METHYLPHENIDATE, VENLAFAXINE, AND ESCITALOPRAM ...  Apr 21, 2006
Despite these treatment interventions, depressive symptoms persisted during combination therapy with venlafaxine, lamotrigine, and gabapentin. ... - The Journal of Pharmacy Technology

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