Recent news on Linezolid

Researchers discover how antibiotic linezolid inhibits bacterial ...  -  May 13, 2007
News-Medical.net,Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes,

Resisting the call for new antibacterials?  -  Apr 30, 2007
In-PharmaTechnologist.com,...but drugs such as Pfizer's Zyvox (linezolid), which had 2006 sales of $782m, seem to buck the trend and have almost hit blockbuster status.

Targanta Seeks $86M In IPO For Antibiotic Development  -  May 14, 2007
BioWorld Online,Vancomycin accounts for about 85 percent of those courses of therapy, with Zyvox (linezolid, Pfizer Inc.) and Cubicin (daptomycin for injection,

Severe Methicillin-Resistant Staphylococcus aureus Community ...  -  May 15, 2007
Journal of American Medical Association (subscription),If MRSA CAP is suspected, clinicians should add vancomycin or linezolid to the empiric regimen. 9. These cases serve to remind health-care providers that

Arming the Fight Against Resistant Bacteria  -  May 8, 2007
TheHorse.com,For example, bacteria resistant to one of the newest antibiotics, linezolid, appeared within one year of the drug's approval for use.

MRSA Increasing in Children  -  May 7, 2007
Medscape (subscription)The MRSA isolates demonstrated 100% sensitivity to vancomycin, trimethoprim/sulfamethoxazole, and linezolid. The isolates had decreased sensitivities to

Astellas Pharma: telavancin enters EU battle for MRSA market share  -  May 2, 2007
Pharmaceutical Business ReviewIf approved, telavancin will enter the market behind a number of key competitors: Pfizer’s Zyvox, (linezolid) first launched in the EU in 2001 (and is

Linezolid-Rifampicin Combination Shows Benefit as Oral Therapy for ...  -  Apr 9, 2007
DG NewsHigh clinical success rates and satisfactory tolerance have been reported for linezolid in the treatment of patients with chronic osteomyelitis and

Linezolid Shows Potency Against Rarely-Isolated, Non-Indicated ...  -  Apr 2, 2007
DG NewsLinezolid is the first of the new class of the oxazolidinones. It was introduced in 1997 and was initially released in the United States in spring of the

Aggressive Screening For 'Superbugs' In Children  -  Apr 20, 2007
Medical News Today (press release),Vancomycin (Vancocin) is currently the only FDA-approved drug for MRSA in children, and only one drug, linezolid (Zyvox), is approved in pediatrics for VRE.

GSK meet no resistance for new antibacterial  -  Apr 16, 2007
DrugResearcher.com,In recent months, new antibiotics from the likes of Wyeth (Tygacil; tigecycline) Pfizer (Zyvox; linezolid) and Novartis/Cubist (Cubicin; daptomycin) have

In 2005 The Global Antibacterial Market Was Valued At ...  -  Apr 5, 2007
PharmaLive.com (press release),The fastest growing classes were the carbapenems, glycopeptides and "others" (eg Pfizers Zyvox (linezolid)). The best selling drug was J&Js/Sanofi-Aventis

Researchers Identify Risk Factors for Nocardia infection After ...  -  Apr 3, 2007
DG News...(n = 15) or in combination with minocycline (n = 4), amoxicillin/clavulanate (n = 2) or linezolid (n = 1), with a median treatment duration of 6 months.

Severe Methicillin-resistant Staphylococcus aureus community ...  -  Apr 12, 2007
Food Consumer,If MRSA CAP is suspected, clinicians should add vancomycin or linezolid to the empiric regimen (9). These cases serve to remind health-care providers that

FDA Warns About Risk of Linezolid (Zyvox) for Septicemia  -  Mar 20, 2007
MedPage Today,ROCKVILLE, Md., March 20 -- The FDA has issued a safety alert for linezolid (Zyvox) after clinical trial data the suggested excess mortality when the drug

Off-Label Use of Linezolid Linked to Increased Death Risk  -  Mar 19, 2007
Medscape (subscription)March 19, 2007 — Use of linezolid (Zyvox; Pfizer, Inc) to treat patients with catheter-related bloodstream infection may be linked to an increased risk for

New Zyvox Safety Concerns  -  Mar 20, 2007
Facts and Comparisons,Health care professionals are being notified by the FDA of emerging safety concerns about Zyvox (linezolid). A recent, open-label, randomized trial compared

Health ministry says 'risky antibiotic' is a restricted drug  -  Mar 20, 2007
Gulf News,The US Food and Drug Administration (FDA) issued a safety alert to infectious disease specialists on antibiotic linezolid, sold under brand name Zyvox by

FDA issues safety alert on Pfizer's Zyvox  -  Mar 19, 2007
Pharma Times (subscription),The US Food and Drug Administration published the alert after "new emerging safety concerns" about Zyvox (linezolid) emerged from a recent clinical study.

Study shows more risk with Pfizer antibiotic: FDA  -  Mar 16, 2007
ReutersZyvox, also known as linezolid, is approved in the United States to treat a variety of bacterial infections, including pneumonia and skin infections as well

UK orders Pfizer to withdraw antibiotic advert  -  Mar 7, 2007
Reuters.uk,Zyvox, or linezolid, is an antibiotic used to treat certain types of serious infection. The MHRA said the move followed discussions with the company about

Rise of the superbug set to drive antibacterials growth  -  Mar 9, 2007
Pharmaceutical Business Review...indicated for the treatment of resistant infections, and former niche antibiotics such as Pfizer's Zyvox (linezolid) on the verge of blockbuster status.

Risk for Invasive MRSA Multiplied 100-Fold in Dialysis Patients  -  Mar 9, 2007
Medscape (subscription)Antibiotic susceptibility tests performed on 113 isolates showed that none were resistant to vancomycin, daptomycin, or linezolid. According to the authors,

Drug Resistant bacteria in dialysis patients in 2005  -  Mar 8, 2007
Food Consumer,None of the isolates were resistant to vancomycin, daptomycin, or linezolid. Reported by: A Collins, MD, B Forrest, United States Renal Data System

FDA grants approval to Lipitor in five new indications  -  Mar 8, 2007
Pharma Times (subscription),Regulatory Agency (MHRA) asked the firm to withdraw an advertisement making "potentially misleading claims" about the antibiotic Zyvox (linezolid).

Pharmaceutical Company Ordered to Withdraw Advertising  -  Mar 7, 2007
PharmaLive.com (press release),...withdraw an advertisement making potentially misleading claims about Zyvox (linezolid), an antibiotic used to treat certain types of serious infection.

Serotonin Syndrome Precipitated by the Monoamine Oxidase Inhibitor ...  -  Jan 31, 2007
Am J Psychiatry (subscription)To the Editor: The following case report suggests that serotonin syndrome precipitated by linezolid-antidepressant interactions may go undiagnosed and

Protein may help fight resistant bacteria  -  Feb 14, 2007
Science Daily (press release)Linezolid Is Highly Effective Against Antibiotic-Resistant Infections (August 17, 1999) -- A study by researchers at Northwestern University Medical School

Pediatric studies lead to more information on drug labels  -  Feb 1, 2007
AAP News (subscription)Antiviral therapies such as oseltamivir and antibacterials such as ciprofloxacin, ertapenem and linezolid are important additions to the pediatric

Can An Ugly Toenail Predict Amputation?  -  Feb 8, 2007
Science Daily (press release)...in eight countries shows that linezolid, a new antibiotic, is at least as effective as two older therapies for treating diabetic foot infections.

Can anything stop the superbug?  -  Jan 17, 2007
Guardian Unlimited,In the last two years, only one new agent has come along, called linezolid. The reasons are fairly straightforward. If you were the chief finance officer of

Pfizer licences MRSA antibodies from Elusys  -  Jan 5, 2007
DrugResearcher.com,Pfizer currently has Zyvox (linezolid) indicated as a treatment for MRSA, and other bacterial infections, which had worldwide sales of $618m in 2005.

Commercial Insight: Antibacterials - Growth in resistance rates ...  -  Dec 19, 2006
Pharmaceutical Business ReviewThe fastest growing classes were the carbapenems, glycopeptides and "others" (eg Pfizer's Zyvox (linezolid)). The best selling drug was

Arpida Announces Positive Results in First Phase III Trial of ...  -  Nov 30, 2006
PharmaLive.com (press release),In this Phase III trial, iclaprim was compared to linezolid, marketed by Pfizer as Zyvox®. The primary efficacy endpoint of statistical non-inferiority in

Arpida's Iclaprim Jumps Over Hurdle, Hits In Phase III Study  -  Dec 5, 2006
BioWorld Online,Among clinically evaluable patients, the cure rates were 93.8 percent and 99.1 percent for iclaprim and linezolid, respectively,

Arpida shares surge on positive superbug drug trial  -  Nov 30, 2006
Reuters..."Iclaprim demonstrated a clinical cure rate which was statistically non-inferior to that of (Pfizer's) linezolid ... thereby achieving the primary endpoint

UPDATE 1-Arpida shares rise on positive trial results  -  Nov 30, 2006
ReutersThe Phase III trials were designed to compare the efficacy and safety of iclaprim with that of market leader linezolid, marketed by Pfizer Inc. as Zyvox.

Old antibiotic is finally synthesized  -  Nov 27, 2006
Science Daily (press release)Linezolid Is Highly Effective Against Antibiotic-Resistant Infections (August 17, 1999) -- A study by researchers at Northwestern University Medical School

Commercial Insight: Antibacterials - Growth in resistance rates ...  -  Dec 19, 2006
Pharmaceutical Business ReviewThe fastest growing classes were the carbapenems, glycopeptides and "others" (eg Pfizer's Zyvox (linezolid)). The best selling drug was

Many Diagnostics (eg, Phenotypic Tests, Molecular Tests) Are Now ...  Nov 7, 2006
...use of current drugs? Will it increase or decrease use of drugs such as daptomycin, linezolid, and tigecycline? -- Impact of drug ... -Genetic Engineering News (press release), Killing Resistant Germs: Total Synthesis Of New Antibiotic ...  Oct 14, 2006
Linezolid Is Highly Effective Against Antibiotic-Resistant Infections (August 17, 1999) -- A study by researchers at Northwestern University Medical School and ... -Science Daily (press release) News Category : PressRelease  Oct 11, 2006
Ampicillin for E. faecalis (Positive - Green Fluorescing Cells) * Linezolid for other enterococci (Positive - Red Fluorescing Cells) * Ampicillin/Ceftriaxone ... -Earthtimes.org Mortality Rate Is Twice As High In Patients With Pneumonia Caused ...  Aug 29, 2006
Linezolid Is Highly Effective Against Antibiotic-Resistant Infections (August 17, 1999) -- A study by researchers at Northwestern University Medical School and ... -Science Daily

Arpida Announces Positive Results in First Phase III Trial of ...  -  Nov 30, 2006
PharmaLive.com (press release),Studies) clinical trial. In this Phase III trial, iclaprim was compared to linezolid, marketed by Pfizer as Zyvox®. The primary ...

Arpida's Iclaprim Jumps Over Hurdle, Hits In Phase III Study  -  Dec 5, 2006
BioWorld Online,...which attained the primary endpoint in the first of two Phase III clinical trials by demonstrating statistical non-inferiority to linezolid (Zyvox) in the ...

UPDATE 2-Arpida shares surge on positive superbug drug trial  -  Nov 30, 2006
ReutersArpida's value has almost doubled in 2006. "Iclaprim demonstrated a clinical cure rate which was statistically non-inferior to that of (Pfizer's) linezolid ... ...

Old antibiotic is finally synthesized  -  Nov 27, 2006
Science Daily (press release)Linezolid Is Highly Effective Against Antibiotic-Resistant Infections (August 17, 1999) -- A study by researchers at Northwestern University Medical School and ...

Arpida says skin drug shows benefits in trial  -  Nov 29, 2006
ReutersThe Phase III trials were designed to compare the efficacy and safety of iclaprim with that of market leader linezolid, marketed by Pfizer Inc. as Zyvox. ...

Daptomycin Knocks Out Most Infections in Dialysis Patients ...  -  Nov 20, 2006
DG NewsBefore getting daptomycin, the patients had been treated with a wide variety of antibiotics, including vancomycin, linezolid and cephalosporins. ...

CA-MRSA infections an increasing concern in early infancy  Aug 1, 2006
Virtually all strains also are susceptible to a recently Food and Drug Administration (FDA)-approved antibacterial, linezolid (Zyvox), available in both oral ... -AAP News (subscription)

State watching for supergerms  Jul 18, 2006
13. After four months, Levine and her husband took expensive courses of the antibiotic Linezolid, which killed the bacteria. The ... -Arizona Republic



Mitochondrial Toxicity Associated with Linezolid  Apr 29, 2006
Synopsis: Six patients developed lactic acidosis during prolonged linezolid therapy, possibly as the result of mitochondrial protein synthesis. ... - Therapeutics Daily (subscription)

International Approvals: Tygacil, DepoDur, and Zyvox  May 8, 2006
...morphine sulfate for the treatment of postsurgical pain; and Japan's Ministry of Health, Labor, and Welfare has approved a new indication for linezolid 600-mg ... - Medscape (subscription)

Pfizer Japan Obtains Approval for ZYVOX, Detrusitol, J Zoloft in ...  Apr 24, 2006
ZYVOX (linezolid), which has been marketed in Japan since 2001, is currently used in the treatment of infections associated with vancomycin-resistant ... - Japan Corporate News





Long-Term Linezolid Associated With Rare Instances of Optic ...  Mar 10, 2006
NEW YORK (Reuters Health) Mar 10 - The oxazolidinone antimicrobial agent linezolid may cause reversible optic neuropathy -- as well as irreversible peripheral ... - Medscape (subscription)

The Hospital Antibacterial Market Presents New Opportunities for ...  Mar 15, 2006
With the availability of several products active against MRSA and VRE (eg, linezolid (Pfizer's Zyvox), daptomycin (Cubist's Cubicin)), the most significant ... - Genetic Engineering News

Arpida announces positive review by Data and Safety Monitoring ...  Mar 21, 2006
The global Phase III ASSIST trials are designed to compare the efficacy and safety of iclaprim with that of market leader linezolid (marketed by Pfizer as Zyvox ... - PharmaLive.com



Scientists re-engineer antibiotic to counter drug resistance  Feb 9, 2006
The product, tigecycline (Tygacil) joins the oxazolidinones, (Pfizer's linezolid) and lipopeptides (Cubist's daptomycin) in a small but growing arsenal against ... - DrugResearcher.com,

Scientists re-engineer antibiotic to counter drug resistance  09 Feb 2006
The product, tigecycline (Tygacil) joins the oxazolidinones, (Pfizer's linezolid) and lipopeptides (Cubist's daptomycin) in a small but growing arsenal against ... - DrugResearcher.com

Genomics in Antibacterial Drug Discovery  Feb 7, 2006
Development of resistance to every class of antibiotic, including the recently marketed Zyvox (linezolid) from Pfizer, is seriously limiting antibiotic options ... - Drug Discovery & Development (subscription)

With Many Big Pharma Companies Recently Choosing to Withdraw From ...  Jan 26, 2006
With the availability of several products active against MRSA and VRE (eg, linezolid (Pfizer's Zyvox), daptomycin (Cubist's Cubicin)), the most significant ... - Genetic Engineering News

Malaria, AIDS, Avian Flu, and MRSA-will we survive?  Jan 19, 2006
...develop a new antibiotic. In the year 2000, $800 million was spent developing the last new antibiotic, Linezolid. Within only twelve ... - IPP Media - Guardian

Chiron wins EU approval for IV antibiotic  Jan 24, 2006
The others are Pfizer's Zyvox (linezolid) and Sanofi-Aventis' Ketek (telithromycin; which hit the headlines itself yesterday after being linked to liver ... - Pharma Times (subscription)

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