Recent news on Lopinavir

Medicines for the world's poor  -  May 23, 2007
Chicago Tribune,The company has shown little concern about making heat-stable lopinavir/ritonavir available in developing countries. In fact, its every step has been taken

Clarification of compulsory licensing makes little progress  -  May 22, 2007
Thai News Agency MCOT,The USTR did not have any doubt nor deny Thailand's legal argument since it issued the CL for key drugs Efavirenz, Lopinavir and Ritronavir for HIV/AIDS

Full Text  -  May 10, 2007
Science Magazine (subscription)AIDS advocates in particular have protested its plans to withdraw the registration of its new drugs, including a heat-stable form of lopinavir/ritonavir

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  Apr 26, 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

Drop drug policy, US tells Thais  -  May 22, 2007
Nation Multimedia,Mongkol invoked the move to allow cheap generic versions of two HIV/Aids treatments Lopinavir/Ritronavir and Efavirenz, plus a heart disease drug

World's premier law firm goes to bat for Abbott  -  Apr 26, 2007
Bangkok Post,Here, the use is clear _ Thailand will only use the licensed lopinavir/ritonavir within its national public health insurance schemes.

G8 summit – Drugs patent holders should relax their grip  -  May 7, 2007
Ethical Corporation Magazine,Since November 2006, Thailand has issued compulsory licences for three medicines, including Abbott’s HIV treatments efavirenz and lopinavir/ritonavir,

Africa: Q&A on Second-Line HIV/Aids Treatment  -  May 8, 2007
AllAfrica.com,The average price reduction for the seven formulations of the key second-line ARVs abacavir, didanosine, lopinavir/ritonavir, and tenofovir is 27% for low

Pharmaceutical firm draws flak  -  Apr 26, 2007
Hindu,The Thai Government issued compulsory licence on lopinavir+ritonavir (generic name Kaletra) for the procurement of affordable generic drugs to protect the

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  26 Apr 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

WHO welcomes decision by Abbott Labs to reduce price of lopinavir ...  -  Apr 12, 2007
News-Medical.net,In this context, WHO welcomes the decision of Abbott Laboratories to significantly reduce the price of lopinavir/ritonavir (LPV/r,

Abbott agrees with WHO to expand access to lopinavir / ritonavir  -  Apr 11, 2007
News-Medical.net,Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above the age of 2 years, in combination with other

Price of AIDS drugs to go down  -  Apr 19, 2007
Joy Online,Organization has welcomed the decision of Abbott Laboratories to significantly reduce the price of an anti-retroviral drug, lopinavir/ritonavir (LPV/r).

Abbott Tries New Approach to Kaletra/Aluvia Pricing  -  Apr 12, 2007
Patent Baristas,Abbott and World Health Organization (WHO) Director-General, Margaret Chan, have agreed on a neew approach to provide Kaletra/Aluvia (lopinavir/ritonavir)

Abbott announces Kaletra price cut for lower middle-income ...  -  Apr 10, 2007
Aidsmap,Abbott announced today that it will cut the price of Kaletra (lopinavir/ritonavir) in 40 lower middle-income countries to $1000 a year following discussions

UN Health Agency Hails Move to Cut Price of Key HIV/aids Drug  -  Apr 11, 2007
NewsBlaze,The price of lopinavir/ritonavir (LPV/r, marketed as Kaletra/Aluvia) has been lowered by Abbott in some low and middle-income countries, where many HIV/AIDS

More HIV drugs needed for children, doctors say  -  Apr 2, 2007
Chicago Sun-Times,FDA approval for a new pill version of its Kaletra liquid medicine for children, which combines the virus-fighting drugs lopinavir and ritonavir. AP.

Guyana accessing key HIV drug cheaply from US-based company -Ramsammy  -  Apr 12, 2007
Stabroek News,According to information on the company's website Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Risk factors for loss of virologic suppression at 48 weeks in patients receiving Lopinavir/Ritonavir monotherapy in two clinical trials comparing LPV/r

Abbott sees dip in Q1 earnings  -  Apr 19, 2007
Pharma Times (subscription),...while the HIV protease inhibitor Kaletra (lopinavir/ritonavir) recorded revenues of $300 million, an increase of 7.2% over the same quarter last year.

Govt seeking new generic imports  -  Apr 18, 2007
Bangkok Post,A source said the Public Health Ministry was looking for generic drug producers of the new tablet form of the protease inhibitor lopinavir/ritonavir in

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal MedicineDLV = delavirdine; EFV = efavirenz; ENF = enfuvirtide; FI = fusion inhibitor; FTC = emtricitabine; IDV = indinavir; LPV = lopinavir; ND = not detected;

Thailand Mulls Offer for Low-Cost AIDS Drugs  -  Apr 12, 2007
Sci-Tech Today...in ending a dispute between Thailand and Abbott over the high price of Kaletra, which comprises the pharmaceutical ingredients lopinavir and ritonavir.

Thailand to consider AIDS drug offer  -  Apr 10, 2007
BusinessWeek...it had decided to offer its drug Kaletra, also known as lopinavir, and Aluvia, also known as ritonavir, at a reduced price in the developing world.

Abbott slashes the price of AIDS drug Kaletra and waits for ...  -  Apr 11, 2007
Pharma Times (subscription),...affordability and access while maintaining incentives to support developing new medicines" and has decided to offer Kaletra (lopinavir/ritonavir) to the

Abbott to Subsidize Price of HIV Drug  -  Apr 10, 2007
MedIndia,Kaletra is actually two drugs combined into a single capsule: lopinavir and low doses of ritonavir, another protease inhibitor manufactured by Abbott

Abbott Ups the Ante in Thailand Patent-Breaking  -  Apr 6, 2007
Patent Baristas,...in retaliation for the Thai government’s decision to issue a compulsory license for the HIV protease inhibitor Kaletra (lopinavir/ritonavir).

Pediatrics Academy urges smaller pills, more accessible HIV ...  -  Apr 3, 2007
Canada.com,FDA approval for a new pill version of its Kaletra liquid medicine for children, which combines the virus-fighting drugs lopinavir and ritonavir.

Tibotec licenses darunavir to Aspen in Africa  -  Apr 4, 2007
Aidsmap,Darunavir is not coformulated with ritonavir, unlike its competitor protease inhibitor Kaletra (lopinavir/ritonavir).

Adverse effects of ARVs  -  Apr 1, 2007
ZimDaily,To reduce the dose given, some drugs are “boosted� by another PI, eg Lopinavir/ritonavir. In this part of the world we restrict them mainly to patients

Christian Brothers Investment Services, ICCR Shareholders Urge ...  -  Mar 29, 2007
Drug Newswire (press release),A combination of drugs lopinavir and ritonovir, Kaletra is crucial for patients who have developed drug resistance or have adverse side effects from other

Lopinavir/Ritonavir Monotherapy Suppresses HIV Replication in ...  -  Mar 2, 2007
DG NewsTwelve of his patients agreed to undergo the lumbar tap procedure to investigate if lopinavir/ritonavir prevents HIV replication in central nervous system.

How do ARVs work?  -  Mar 25, 2007
ZimDaily,Protease inhibitors (PIs) are the other class, and examples are: Saquinavir, Ritonavir, Indinavir, Nelfinavir, Lopinavir/ritonavir(boosted PI),

CROI: Therapeutic concentrations of efavirenz, Kaletra, could be ...  -  Mar 7, 2007
Aidsmap,They evaluated 58 children who were following a regimen of efavirenz (Sustiva) or Kaletra (lopinavir/ritonavir) with two nucleoside reverse transcriptase

Abbott's drug policy denounced by MSF  -  Mar 18, 2007
Nation Multimedia,Among the drugs the company is refusing to sell in Thailand is the new, heat-stable version lopinavir/ritonavir, marketed by Abbott as Kaletra.

NRTIs Have Varying Effects on Serum Lipids and Body Fat: Presented ...  -  Feb 27, 2007
DG NewsHowever, NRTIs also are associated with lower serum lipid levels than the NRTI-sparing combination of lopinavir and efavirenz, said Richard Haubrich, MD,

MSF Denounces Abbott's Move to Withhold Medicines From People in ...  -  Mar 16, 2007
PharmaLive.com (press release),Among the drugs the company is refusing to sell in Thailand is the new, heat-stable version of the medicine lopinavir/ritonavir (LPV/r), marketed by Abbott

Pharma co’s move to withhold drugs to Thailand decried  -  Mar 15, 2007
The Statesman,Since November 2006, Thailand has issued compulsory licenses for three medicines, including AIDS drugs efavirenz and lopinavir/ritonavir.

CROI: Once daily Kaletra may be less effective when viral load ...  -  Mar 1, 2007
Aidsmap,Dosing Kaletra (lopinavir/ritonavir) once daily may be less effective than twice daily dosing in patients with high viral load (above 100000 copies/ml),

CROI: Experimental Hormone Reduces Visceral Fat in HIV Patients  -  Feb 27, 2007
MedPage Today,Specifically, Dr. Cameron reported, a treatment regimen that begins with lopinavir/ritonavir (Kaletra) combined with zidovudine and lamivudine (Combivir)

Opinion divided as Abbott stops selling new drugs in Thailand  -  Mar 16, 2007
Pharma Times (subscription),Kaletra (lopinavir/ritonavir), as well as Plavix (clopidogrel), the blockbuster anti-clotting agent sold by Sanofi-Aventis and Bristol-Myers Squibb.

CROI: Kaletra less likely to cause fat loss than efavirenz when ...  -  Feb 27, 2007
Aidsmap,Lopinavir/ritonavir (Kaletra) was less likely to cause fat loss (lipoatrophy) than efavirenz when paired with nucleoside analogues, analysis of the ACTG

Christian Brothers Investment Services, ICCR Shareholders Urge ...  -  Mar 22, 2007
PharmaLive.com (press release),A combination of drugs lopinavir and ritonovir, Kaletra is crucial for patients who have developed drug resistance or have adverse side effects from other

In Clash With Activists, Critics Charge Thailand Violation Of ...  -  Mar 19, 2007
Intellectual Property Watch,...to register in Thailand seven new medicines, including a new heat-stable version of the AIDS drug lopinavir/ritonavir, marketed by Abbott as Kaletra.

Abbott to withold new drugs from Thailand in retaliation for ...  -  Mar 15, 2007
Aidsmap,...in retaliation for the Thai government’s decision to issue a compulsory license for the HIV protease inhibitor Kaletra (lopinavir/ritonavir).

Thailand Presents Report On Compulsory Licensing Experience  -  Mar 12, 2007
Intellectual Property Watch,...clopidogrel (Sanofi-Aventis’ Plavix) and the HIV/AIDS drug, lopinavir/ritonavir (Abbott’s Kaletra), and on 29 November 2006 for the HIV/AIDS medicine,

MSF study shows good outcomes for second-line AIDS treatment in ...  -  Mar 2, 2007
Reuters AlertNet,For example, the heat-stable form of the boosted protease-inhibitor lopinavir/ritonavir, marketed as Kaletra by Abbott Laboratories, is only sold in

Pharmacokinetics of New Saquinavir Tablet Adequate in Pregnant ...  -  Mar 2, 2007
DG News..."In contrast to observations with other HIV-protease inhibitors, such as nelfinavir or lopinavir/ritonavir, saquinavir pharmacokinetics appear not to be

Anti-HIV Medication PREZISTAâ„¢ (Darunavir) Receives Conditional ...  -  25 Feb 2007
Medical News Today (press release),Phase III comparative clinical trials in treatment-naïve (ARTEMIS) and less treatment-experienced patients (TITAN) versus Kaletra (lopinavir/ritonavir).

Abbott's AIDS drug in a patent spot in India  -  Feb 20, 2007
Moneycontrol.com,Kaletra is a combination of lopinavir and ritonavir and is used in the second line treatment of AIDS. In addition to the soft-gel version, Kaletra is also

Thai License Upsets Drug Company; Government Ready To Talk  -  Feb 16, 2007
Intellectual Property Watch,...“For the lopinavir/ritronavr we have tried several times to negotiate with Abbott in the last two years. They have reduced the price down but [it is] still

Thailand Invokes WTO Rule To Sell Generics For HIV And Heart ...  -  Jan 30, 2007
Medical News Today,Kaletra (lopinavir) is a protease inhibitor antiretroviral drug and is given in combination with ritonavir as a multi-drug capsule to treat HIV/AIDS.

Thailand windfall awaits AIDS drug manufacturers  -  Jan 30, 2007
Daily News & Analysis,An estimated 20000 HIV-positive people have developed a resistance to the drug, and need the Lopinavir plus Ritonavir combination. YK Hamied, CEO, Cipla,

Outcry as Thailand allows generic version of protected drugs  -  Jan 29, 2007
Pharma Times (subscription),Kaletra (lopinavir/ritonavir), and Plavix (clopidogrel), the blockbuster anti-clotting agent sold by Sanofi-Aventis and Bristol-Myers Squibb.

Merck & Co., Inc. To Distribute ATRIPLAâ„¢ in Developing Countries  -  Feb 16, 2007
WebWire (press release),Atazanavir and lopinavir/ritonavir have been shown to increase tenofovir concentrations. Patients on lopinavir/ritonavir plus ATRIPLA should be monitored

J&J unit's HIV drug Prezista gets conditional OK in Europe  -  Feb 19, 2007
Pharma Times (subscription),Phase III trials in treatment-naïve (ARTEMIS) and less treatment-experienced patients (TITAN) versus Abbott Laboratories' Kaletra (lopinavir/ritonavir).

It’s patent vs patient in AIDS fight  -  Feb 14, 2007
Economic Times,More recently, the Karnataka Network of Positive (KNP) and INP have opposed the grant of a patent for three of Abbott’s products — Ritonavir, Lopinavir and

Abbott offers price cut to thwart Thai compulsory license on Kaletra  -  Feb 12, 2007
Aidsmap,Kaletra is a fixed dose protease inhibitor combination containing lopinavir and ritonavir, and is recommended by the World Health Organization as a

Minister's move ensures access to vital drugs  -  Feb 8, 2007
Nation Multimedia,...by Merck as Stocrin; lopinavir/ritonavir, produced by Abbott as Kaletra; and clopidogrel, produced by Sanofi-Aventis and Bristol Myers Squibb as Plavix.

African-American Women Who Have Received HIV Treatment Are Sought ...  -  Feb 7, 2007
Medical News Today (press release),Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin,

(BPRW) AFRICAN-AMERICAN WOMEN WHO HAVE RECEIVED HIV TREATMENT ARE ...  -  Feb 6, 2007
Black PR Wire (press release),...rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, simvastatin, or products containing St. John’s wort (Hypericum perforatum).

WHO raps compulsory licensing plan  -  Feb 1, 2007
Bangkok Post,An estimated 20000 HIV-positive people have developed resistance to the drug, and need a combination of lopinavir and ritonavir, which is marketed as

Copycat heart drug in Thailand  -  Feb 2, 2007
LabTechnologist.com,Abbott's Kaletra (lopinavir/ritonavir), an HIV/AIDS drug, and Bristol-Myers Squibb and Sanofi-Aventis' Plavix (clopidogrel), an anti-clotting agent.

Asthma drug provides effective treatment for immune reconstitution ...  -  Jan 31, 2007
Aidsmap,Three weeks after initiating a nucleoside-sparing antiretroviral regimen consisting of saquinavir (Invirase) and Kaletra (lopinavir/ritonavir),

Thailand approves generic versions of two drugs  -  Jan 29, 2007
Bangkok Post,An estimated 20000 HIV-positive people have developed a resistance to the drug, and need the combination drugs of lopinavir and ritonavir, which is marketed

Pharma firms call on Thailand to talk, not issue licences  -  Jan 30, 2007
Pharma Times (subscription),...firms may freeze investment in Thailand in protest at his decision to import copycat versions of Kaletra (lopinavir/ritonavir) and Plavix (clopidogrel).

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  Dec 26, 2006
Medscape (subscription)...[4] The authors concluded that compensated liver cirrhosis does not significantly influence plasma levels of lopinavir/r or atazanavir/r, but that plasma

More fixed dose ARVs for children needed urgently, says WHO  -  Jan 9, 2007
Aidsmap,...tablets for children, in addition to heat stable, scored tablets lopinavir/ritonavir tablets at a dose of 90mg of lopinavir and 22.5mg of ritonavir.

Abbott Laboratories' Norvir Plan  -  Jan 2, 2007
Wall Street Journal (subscription),Announce a reformulation campaign for lopinavir/ritonavir combination. [This refers to a new formulation of Kaletra that Abbott later introduced.]

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  26 Dec 2006
Medscape (subscription)...[4] The authors concluded that compensated liver cirrhosis does not significantly influence plasma levels of lopinavir/r or atazanavir/r, but that plasma

Severe interaction between low-dose ritonavir and a blood pressure ...  -  Dec 11, 2006
Aidsmap,Lopinavir is metabolised by the body using the P450 (CYP)34A cytochrome in the liver. Ritonavir is also metabolised using this pathway,

Local version of new Aids drug planned  -  Nov 28, 2006
Bangkok Post,Other anti-Aids drugs the GPO expects to produce in the next two years include Indinavir, Saquinavir, ddI and Lopinavir, the GPO chief added.

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,GPO Director Mongkol Jivasantikarn told the Bangkok Post that the organisation plans to manufacture indinavir, saquinavir, lopinavir and ddI in the next two

96-Week Data From Gilead’s Study 934 Comparing Viread ® and ...  -  Dec 15, 2006
Business Wire (press release),Patients on lopinavir/ritonavir plus ATRIPLA should be monitored for tenofovir-associated adverse events. ATRIPLA should be discontinued in patients who

Access denied to crucial new hiv/aids medicines: INP+  -  Nov 29, 2006
KanglaOnline,..."It`sa cruel irony that although Indian pharmaceutical companies are producing new AIDS drugs like Tenofovir and Lopinavir/Ritonavir recommended by the WHO,

Africa: Aids Drugs Unaffordable And Unavailable - Medical Body  -  Dec 19, 2006
AllAfrica.com,Abbott launched an improved version of one of its antiretrovirals - heat stable lopinavir/ritonavir - over a year ago in the US, but the drug is still not

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Prezista (darunavir) approved for treatment-experienced patients ...  -  Dec 15, 2006
Aidsmap,Darunavir, in combination with ritonavir, is currently in Phase III comparative clinical trials versus lopinavir/ritonavir in treatment-experienced (TITAN,

South Africa: Scientists Warn State-Supplied Aids Drug Poses ...  -  Dec 6, 2006
AllAfrica.com,...they switch to "second-line therapy", based on zidovudine (AZT), didanosine (ddI), and ritonavir-boosted lopinavir (Kaletra).

Kaletra monotherapy: ultra-sensitive tests find viral loads ...  -  Dec 6, 2006
Aidsmap,However, recent studies have shown that standard-dose Kaletra (lopinavir/ritonavir) alone, without accompanying nucleosides, keeps viral loads undetectable

Thai drug move sends 'negative' signal to investors  -  Dec 1, 2006
San Diego Union Tribune,Doctors Without Borders has urged Thailand to break the patent on Abbott Laboratories' anti-HIV drug Lopinavir, also known as Kaletra, which it says costs

MSF Welcomes Move to Overcome Patent on AIDS Drug in Thailand  -  Nov 30, 2006
ag-IP-news Agency,...such as the AIDS drug lopinavir/ritonavir, which currently costs over 7000 baht a month ($194) and is far too expensive for Thailand," said Wilson.

Antiretroviral Drug Resistance in Patients With HIV  Nov 6, 2006
The KLEAN study, which was published in an August 2006 issue of the Lancet, [7] randomized 878 persons to receive either ritonavir-boosted lopinavir (LPV/r) or ... -Medscape (subscription) Antiretroviral Treatment Strategies for Adults With HIV  Nov 2, 2006
ACTG 5142, was recently presented at the XVI International AIDS Conference in Toronto, Ontario, Canada, and showed that a regimen of lopinavir/ritonavir (LPV/r ... -Medscape (subscription) GlaxoSmithKline and Vertex Pharmaceuticals Announce Virologic and ...  Oct 12, 2006
The virologic analysis from a 48-week study in treatment-naive patients, compared Lexiva/r to lopinavir/r, both administered twice daily, and showed that ... -DG News Kaletra tablets better tolerated, patient survey finds  Oct 27, 2006
People taking Kaletra (lopinavir/ritonavir) prefer the new tablet version - taken once a day - over the soft gel capsules taken twice a day according to data ... -Aidsmap, Kaletra not associated with raised blood pressure, manufacturer ...  Oct 30, 2006
People taking a HAART combination including the protease inhibitor Kaletra (lopinavir/ritonavir) are no more likely to develop high blood pressure than those ... -Aidsmap, Bristol-Myers Squibb, Gilead Sciences And Merck & Co. Submit ...  Oct 10, 2006
Atazanavir and lopinavir/ritonavir have been shown to increase tenofovir concentrations. Patients on atazanavir or lopinavir/ritonavir ... -Medical News Today (press release), Merck buys protease inhibitor from Ambrilia, may be potent booster ...  Oct 20, 2006
No cross-resistance to amprenavir, lopinavir, atazanavir, saquinavir, indinavir, and nelfinavir was observed for any viral mutants, but resistance mutations ... -Aidsmap, Bristol-Myers Squibb, Gilead Sciences and Merck & Co. Submit ...  Oct 8, 2006
Atazanavir andlopinavir/ritonavir have been shown to increase tenofovir concentrations.Patients on atazanavir or lopinavir/ritonavir plus ATRIPLA should ... -Earthtimes.org ARV drugs may also help fight malaria  Oct 10, 2006
...that serum taken from people who were taking antiretroviral therapy - which included ritonavir-boosted saquinavir (Invirase) or lopinavir (Kaletra) - showed ... -SABC News, Antiretroviral Drugs: A Shot in the Arm to Fight Malaria?  Oct 12, 2006
...that serum taken from people who were undergoing antiretroviral therapy, consisting of ritonavir-boosted saquinavir (Invirase) or lopinavir (Kaletra), showed ... -MedIndia, Aptivus®(tipranavir) Demonstrates Durable Response Through Nearly ...  Oct 15, 2006
At 96 weeks, Aptivus® continues to outperform a group of ritonavir-boosted comparator protease inhibitors (PIs) that included lopinavir/r (Kaletra ... -Medical News Today (press release), Darunavir response did not differ by prior PI in POWER studies  Oct 8, 2006
Specific comparisons were made between those whose previous (failing) regimen had contained tipranavir (TPV), lopinavir (LPV), and fosamprenavir (fAPV). ... -Aidsmap,

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