Recent news on Lopinavir Ritonavir

Medicines for the world's poor  -  May 23, 2007
Chicago Tribune,The company has shown little concern about making heat-stable lopinavir/ritonavir available in developing countries. In fact, its every step has been taken

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  Apr 26, 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

Abbott drops price of its anti-AIDS medicines  -  Apr 30, 2007
ArabianBusiness.com,Kaletra/Aluvia (lopinavir/ritonavir) capsules and tablets are used in the treatment of HIV and AIDS. According to Abbott, the price reduction will apply to

World's premier law firm goes to bat for Abbott  -  Apr 26, 2007
Bangkok Post,Here, the use is clear _ Thailand will only use the licensed lopinavir/ritonavir within its national public health insurance schemes.

G8 summit – Drugs patent holders should relax their grip  -  May 7, 2007
Ethical Corporation Magazine,Since November 2006, Thailand has issued compulsory licences for three medicines, including Abbott’s HIV treatments efavirenz and lopinavir/ritonavir,

Africa: Q&A on Second-Line HIV/Aids Treatment  -  May 8, 2007
AllAfrica.com,The average price reduction for the seven formulations of the key second-line ARVs abacavir, didanosine, lopinavir/ritonavir, and tenofovir is 27% for low

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  26 Apr 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

WHO welcomes decision by Abbott Labs to reduce price of lopinavir ...  -  Apr 12, 2007
News-Medical.net,In this context, WHO welcomes the decision of Abbott Laboratories to significantly reduce the price of lopinavir/ritonavir (LPV/r,

Abbott agrees with WHO to expand access to lopinavir / ritonavir  -  Apr 11, 2007
News-Medical.net,Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above the age of 2 years, in combination with other

Price of AIDS drugs to go down  -  Apr 19, 2007
Joy Online,Organization has welcomed the decision of Abbott Laboratories to significantly reduce the price of an anti-retroviral drug, lopinavir/ritonavir (LPV/r).

Abbott Tries New Approach to Kaletra/Aluvia Pricing  -  Apr 12, 2007
Patent Baristas,Abbott and World Health Organization (WHO) Director-General, Margaret Chan, have agreed on a neew approach to provide Kaletra/Aluvia (lopinavir/ritonavir)

Abbott announces Kaletra price cut for lower middle-income ...  -  Apr 10, 2007
Aidsmap,Abbott announced today that it will cut the price of Kaletra (lopinavir/ritonavir) in 40 lower middle-income countries to $1000 a year following discussions

UN Health Agency Hails Move to Cut Price of Key HIV/aids Drug  -  Apr 11, 2007
NewsBlaze,The price of lopinavir/ritonavir (LPV/r, marketed as Kaletra/Aluvia) has been lowered by Abbott in some low and middle-income countries, where many HIV/AIDS

Tibotec licenses darunavir to Aspen in Africa  -  Apr 4, 2007
Aidsmap,Darunavir is not coformulated with ritonavir, unlike its competitor protease inhibitor Kaletra (lopinavir/ritonavir).

Guyana accessing key HIV drug cheaply from US-based company -Ramsammy  -  Apr 12, 2007
Stabroek News,According to information on the company's website Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Risk factors for loss of virologic suppression at 48 weeks in patients receiving Lopinavir/Ritonavir monotherapy in two clinical trials comparing LPV/r

Abbott sees dip in Q1 earnings  -  Apr 19, 2007
Pharma Times (subscription),...while the HIV protease inhibitor Kaletra (lopinavir/ritonavir) recorded revenues of $300 million, an increase of 7.2% over the same quarter last year.

Govt seeking new generic imports  -  Apr 18, 2007
Bangkok Post,A source said the Public Health Ministry was looking for generic drug producers of the new tablet form of the protease inhibitor lopinavir/ritonavir in

Abbott slashes the price of AIDS drug Kaletra and waits for ...  -  Apr 11, 2007
Pharma Times (subscription),...affordability and access while maintaining incentives to support developing new medicines" and has decided to offer Kaletra (lopinavir/ritonavir) to the

Abbott Ups the Ante in Thailand Patent-Breaking  -  Apr 6, 2007
Patent Baristas,...in retaliation for the Thai government’s decision to issue a compulsory license for the HIV protease inhibitor Kaletra (lopinavir/ritonavir).

Adverse effects of ARVs  -  Apr 1, 2007
ZimDaily,To reduce the dose given, some drugs are “boosted� by another PI, eg Lopinavir/ritonavir. In this part of the world we restrict them mainly to patients

How do ARVs work?  -  Mar 25, 2007
ZimDaily,Protease inhibitors (PIs) are the other class, and examples are: Saquinavir, Ritonavir, Indinavir, Nelfinavir, Lopinavir/ritonavir(boosted PI),

Lopinavir/Ritonavir Monotherapy Suppresses HIV Replication in ...  -  Mar 2, 2007
DG NewsTwelve of his patients agreed to undergo the lumbar tap procedure to investigate if lopinavir/ritonavir prevents HIV replication in central nervous system.

CROI: Therapeutic concentrations of efavirenz, Kaletra, could be ...  -  Mar 7, 2007
Aidsmap,They evaluated 58 children who were following a regimen of efavirenz (Sustiva) or Kaletra (lopinavir/ritonavir) with two nucleoside reverse transcriptase

Abbott's drug policy denounced by MSF  -  Mar 18, 2007
Nation Multimedia,Among the drugs the company is refusing to sell in Thailand is the new, heat-stable version lopinavir/ritonavir, marketed by Abbott as Kaletra.

MSF Denounces Abbott's Move to Withhold Medicines From People in ...  -  Mar 16, 2007
PharmaLive.com (press release),Among the drugs the company is refusing to sell in Thailand is the new, heat-stable version of the medicine lopinavir/ritonavir (LPV/r), marketed by Abbott

Pharma co’s move to withhold drugs to Thailand decried  -  Mar 15, 2007
The Statesman,Since November 2006, Thailand has issued compulsory licenses for three medicines, including AIDS drugs efavirenz and lopinavir/ritonavir.

CROI: Once daily Kaletra may be less effective when viral load ...  -  Mar 1, 2007
Aidsmap,Dosing Kaletra (lopinavir/ritonavir) once daily may be less effective than twice daily dosing in patients with high viral load (above 100000 copies/ml),

CROI: Experimental Hormone Reduces Visceral Fat in HIV Patients  -  Feb 27, 2007
MedPage Today,Specifically, Dr. Cameron reported, a treatment regimen that begins with lopinavir/ritonavir (Kaletra) combined with zidovudine and lamivudine (Combivir)

Pharmacokinetics of New Saquinavir Tablet Adequate in Pregnant ...  -  Mar 2, 2007
DG News..."In contrast to observations with other HIV-protease inhibitors, such as nelfinavir or lopinavir/ritonavir, saquinavir pharmacokinetics appear not to be

Opinion divided as Abbott stops selling new drugs in Thailand  -  Mar 16, 2007
Pharma Times (subscription),Kaletra (lopinavir/ritonavir), as well as Plavix (clopidogrel), the blockbuster anti-clotting agent sold by Sanofi-Aventis and Bristol-Myers Squibb.

CROI: Kaletra less likely to cause fat loss than efavirenz when ...  -  Feb 27, 2007
Aidsmap,Lopinavir/ritonavir (Kaletra) was less likely to cause fat loss (lipoatrophy) than efavirenz when paired with nucleoside analogues, analysis of the ACTG

In Clash With Activists, Critics Charge Thailand Violation Of ...  -  Mar 19, 2007
Intellectual Property Watch,...to register in Thailand seven new medicines, including a new heat-stable version of the AIDS drug lopinavir/ritonavir, marketed by Abbott as Kaletra.

Abbott to withold new drugs from Thailand in retaliation for ...  -  Mar 15, 2007
Aidsmap,...in retaliation for the Thai government’s decision to issue a compulsory license for the HIV protease inhibitor Kaletra (lopinavir/ritonavir).

Thailand Presents Report On Compulsory Licensing Experience  -  Mar 12, 2007
Intellectual Property Watch,...clopidogrel (Sanofi-Aventis’ Plavix) and the HIV/AIDS drug, lopinavir/ritonavir (Abbott’s Kaletra), and on 29 November 2006 for the HIV/AIDS medicine,

MSF study shows good outcomes for second-line AIDS treatment in ...  -  Mar 2, 2007
Reuters AlertNet,For example, the heat-stable form of the boosted protease-inhibitor lopinavir/ritonavir, marketed as Kaletra by Abbott Laboratories, is only sold in

Anti-HIV Medication PREZISTAâ„¢ (Darunavir) Receives Conditional ...  -  25 Feb 2007
Medical News Today (press release),Phase III comparative clinical trials in treatment-naïve (ARTEMIS) and less treatment-experienced patients (TITAN) versus Kaletra (lopinavir/ritonavir).

Merck & Co., Inc. To Distribute ATRIPLAâ„¢ in Developing Countries  -  Feb 16, 2007
WebWire (press release),Atazanavir and lopinavir/ritonavir have been shown to increase tenofovir concentrations. Patients on lopinavir/ritonavir plus ATRIPLA should be monitored

J&J unit's HIV drug Prezista gets conditional OK in Europe  -  Feb 19, 2007
Pharma Times (subscription),Phase III trials in treatment-naïve (ARTEMIS) and less treatment-experienced patients (TITAN) versus Abbott Laboratories' Kaletra (lopinavir/ritonavir).

Thai License Upsets Drug Company; Government Ready To Talk  -  Feb 16, 2007
Intellectual Property Watch,On 26 January, the Thai government also announced a compulsory license, or government use, for Abbott’s HIV/AIDS drug, Kaletra (lopinavir/ritonavir),

African-American Women Who Have Received HIV Treatment Are Sought ...  -  Feb 7, 2007
Medical News Today (press release),Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin,

(BPRW) AFRICAN-AMERICAN WOMEN WHO HAVE RECEIVED HIV TREATMENT ARE ...  -  Feb 6, 2007
Black PR Wire (press release),...rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, simvastatin, or products containing St. John’s wort (Hypericum perforatum).

Outcry as Thailand allows generic version of protected drugs  -  Jan 29, 2007
Pharma Times (subscription),Kaletra (lopinavir/ritonavir), and Plavix (clopidogrel), the blockbuster anti-clotting agent sold by Sanofi-Aventis and Bristol-Myers Squibb.

Minister's move ensures access to vital drugs  -  Feb 8, 2007
Nation Multimedia,...by Merck as Stocrin; lopinavir/ritonavir, produced by Abbott as Kaletra; and clopidogrel, produced by Sanofi-Aventis and Bristol Myers Squibb as Plavix.

Copycat heart drug in Thailand  -  Feb 2, 2007
LabTechnologist.com,Abbott's Kaletra (lopinavir/ritonavir), an HIV/AIDS drug, and Bristol-Myers Squibb and Sanofi-Aventis' Plavix (clopidogrel), an anti-clotting agent.

Asthma drug provides effective treatment for immune reconstitution ...  -  Jan 31, 2007
Aidsmap,Three weeks after initiating a nucleoside-sparing antiretroviral regimen consisting of saquinavir (Invirase) and Kaletra (lopinavir/ritonavir),

Pharma firms call on Thailand to talk, not issue licences  -  Jan 30, 2007
Pharma Times (subscription),...firms may freeze investment in Thailand in protest at his decision to import copycat versions of Kaletra (lopinavir/ritonavir) and Plavix (clopidogrel).

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  Dec 26, 2006
Medscape (subscription)The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection

More fixed dose ARVs for children needed urgently, says WHO  -  Jan 9, 2007
Aidsmap,...tablets for children, in addition to heat stable, scored tablets lopinavir/ritonavir tablets at a dose of 90mg of lopinavir and 22.5mg of ritonavir.

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Abbott Laboratories' Norvir Plan  -  Jan 2, 2007
Wall Street Journal (subscription),Announce a reformulation campaign for lopinavir/ritonavir combination. [This refers to a new formulation of Kaletra that Abbott later introduced.]

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  26 Dec 2006
Medscape (subscription)The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection

Severe interaction between low-dose ritonavir and a blood pressure ...  -  Dec 11, 2006
Aidsmap,A severe interaction between the ritonavir component of Kaletra (lopinavir/ritonavir) and the anti-hypertensive drug, nifedipine, has been reported.

96-Week Data From Gilead’s Study 934 Comparing Viread ® and ...  -  Dec 15, 2006
Business Wire (press release),Patients on lopinavir/ritonavir plus ATRIPLA should be monitored for tenofovir-associated adverse events. ATRIPLA should be discontinued in patients who

Prezista (darunavir) approved for treatment-experienced patients ...  -  Dec 15, 2006
Aidsmap,Darunavir, in combination with ritonavir, is currently in Phase III comparative clinical trials versus lopinavir/ritonavir in treatment-experienced (TITAN,

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Access denied to crucial new hiv/aids medicines: INP+  -  Nov 29, 2006
KanglaOnline,..."It`sa cruel irony that although Indian pharmaceutical companies are producing new AIDS drugs like Tenofovir and Lopinavir/Ritonavir recommended by the WHO,

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,Organisation said yesterday it plans to apply for a compulsory license to begin making its own versions of efavirenz and lopinavir/ritonavir next year.

Africa: Aids Drugs Unaffordable And Unavailable - Medical Body  -  Dec 19, 2006
AllAfrica.com,Abbott launched an improved version of one of its antiretrovirals - heat stable lopinavir/ritonavir - over a year ago in the US, but the drug is still not

Kaletra monotherapy: ultra-sensitive tests find viral loads ...  -  Dec 6, 2006
Aidsmap,However, recent studies have shown that standard-dose Kaletra (lopinavir/ritonavir) alone, without accompanying nucleosides, keeps viral loads undetectable

MSF Welcomes Move to Overcome Patent on AIDS Drug in Thailand  -  Nov 30, 2006
ag-IP-news Agency,...such as the AIDS drug lopinavir/ritonavir, which currently costs over 7000 baht a month ($194) and is far too expensive for Thailand," said Wilson.

Antiretroviral Drug Resistance in Patients With HIV  Nov 6, 2006
The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection ... -Medscape (subscription) Antiretroviral Treatment Strategies for Adults With HIV  Nov 2, 2006
ACTG 5142, was recently presented at the XVI International AIDS Conference in Toronto, Ontario, Canada, and showed that a regimen of lopinavir/ritonavir (LPV/r ... -Medscape (subscription) Bristol-Myers Squibb, Gilead Sciences And Merck & Co. Submit ...  Oct 10, 2006
Atazanavir and lopinavir/ritonavir have been shown to increase tenofovir concentrations. Patients on atazanavir or lopinavir/ritonavir ... -Medical News Today (press release), GlaxoSmithKline and Vertex Pharmaceuticals Announce Virologic and ...  Oct 12, 2006
The Lancet. The primary efficacy and safety analyses from this study, known as KLEAN (Kaletra(R) [lopinavir/ritonavir] vs. Lexiva ... -DG News Kaletra tablets better tolerated, patient survey finds  Oct 27, 2006
People taking Kaletra (lopinavir/ritonavir) prefer the new tablet version - taken once a day - over the soft gel capsules taken twice a day according to data ... -Aidsmap, Kaletra not associated with raised blood pressure, manufacturer ...  Oct 30, 2006
People taking a HAART combination including the protease inhibitor Kaletra (lopinavir/ritonavir) are no more likely to develop high blood pressure than those ... -Aidsmap, Bristol-Myers Squibb, Gilead Sciences and Merck & Co. Submit ...  Oct 8, 2006
Atazanavir andlopinavir/ritonavir have been shown to increase tenofovir concentrations.Patients on atazanavir or lopinavir/ritonavir plus ATRIPLA should ... -Earthtimes.org Abbott's New Tablet Formulation of Kaletra'R', Lopinavir/Ritonavir ...  Sep 12, 2006
Canada announced today that it has received marketing authorization from Health Canada for the tablet formulation of Kaletra ® (lopinavir/ritonavir), a new ... -CCNMatthews

Lopinavir/ritonavir Sharply Reduces Availability of Lamotrigine  Sep 1, 2006
NEW YORK (Reuters Health) Aug 31 - The HIV protease inhibitor combo lopinavir/ritonavir (Kaletra) reduces the area under the curve (AUC) of concentration-time ... -Medscape (subscription)

Antiretroviral Treatment Strategies for Adults  Sep 22, 2006
48-week analysis of 2 boosted protease inhibitor (PI) regimens: fosamprenavir/ritonavir (700/100 mg twice daily; fosAPV/r) vs lopinavir/ritonavir (400/100 mg ... -Medscape (subscription)

CHMP Posts Positive Opinion On Eli Lilly's Byetta  Sep 21, 2006
For use outside the European Union The Committee adopted a positive opinion for Aluvia (lopinavir/ritonavir), from Abbott Laboratories Limited (UK). ... -Easy Bourse (Communiqués de presse)

Pharma Majors Promise Cheap HIV/AIDS Drugs  Sep 6, 2006
...drugs at slashed prices. US multinational Abbott Laboratories, which manufactures Lopinavir/Ritonavir, is among them. ''We will have ... -Inter Press Service (subscription)

Research and Markets: View Detailed P&L and Investment Review of ...  Sep 1, 2006
Kaletra (lopinavir+ritonavir) is a combination of two antiretroviral protease inhibitors (ARV PIs) for the treatment of HIV infection in adults and children ... -Genetic Engineering News

Severe interaction between low-dose ritonavir and a blood pressure ...  -  Dec 11, 2006
Aidsmap,A severe interaction between the ritonavir component of Kaletra (lopinavir/ritonavir) and the anti-hypertensive drug, nifedipine, has been reported.

Tipranavir falls between two stools in naïve trial  -  Nov 20, 2006
Aidsmap,An analysis of a trial comparing the protease inhibitor tipranavir (Aptivus) with lopinavir/ritonavir (Kaletra) as a first-line therapy was stopped after 60

Drug-Drug Interactions Clinically Manageable With PREZISTA(TM)  -  Nov 14, 2006
Drug Newswire (press release),PREZISTA (darunavir) is an investigational protease inhibitor that is currently in Phase III comparative clinical trials versus lopinavir/ritonavir in

Drug-Drug Interactions Clinically Manageable With PREZISTA(TM)  -  Nov 14, 2006
campus med,...lopinavir/ritonavir, saquinavir/ritonavir, efavirenz, nevirapine, tenofovir disoproxil fumarate; antibiotics such as clarithromycin and ketoconazole;

Long-Term Data Show Aptivus(R) (tipranavir) Continues to ...  -  Nov 15, 2006
Juraforum.de,New data from the combined RESIST studies (RESIST-1 and RESIST-2) show that Aptivus(R) (tipranavir), used with ritonavir (tipranavir/r) as part of

Access denied to crucial new hiv/aids medicines: INP+  -  Nov 29, 2006
KanglaOnline,..."It`sa cruel irony that although Indian pharmaceutical companies are producing new AIDS drugs like Tenofovir and Lopinavir/Ritonavir recommended by the WHO,

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,Organisation said yesterday it plans to apply for a compulsory license to begin making its own versions of efavirenz and lopinavir/ritonavir next year.

TMC125 study highlights risk of staying on failing NNRTI regimen  -  Nov 16, 2006
Aidsmap,In this study the background regimen could include a protease inhibitor - usually Kaletra (lopinavir/ritonavir) - and could also include enfuvirtide (Fuzeon

Kaletra monotherapy: ultra-sensitive tests find viral loads ...  -  Dec 6, 2006
Aidsmap,However, recent studies have shown that standard-dose Kaletra (lopinavir/ritonavir) alone, without accompanying nucleosides, keeps viral loads undetectable

Africa: People Not Getting Treatment They Need to Stay Alive  -  Nov 29, 2006
AllAfrica.com,Abbott launched an improved version of one of its antiretrovirals—heat stable lopinavir/ritonavir—over a year ago in the US, but the drug is still not

MSF Welcomes Move to Overcome Patent on AIDS Drug in Thailand  -  Nov 30, 2006
ag-IP-news Agency,...such as the AIDS drug lopinavir/ritonavir, which currently costs over 7000 baht a month ($194) and is far too expensive for Thailand," said Wilson.

Finding the best combo of HIV drugs  -  Nov 16, 2006
News 8 Austin,Another regiment included two nucleoside reverse transcriptase inhibitors, but instead of Sustiva, a protease inhibitor called Kaletra (lopinavir/ritonavir)

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