Recent news on Methotrexate

European Commission Grants Approval  -  May 23, 2007
Ad-Hoc-News (Pressemitteilung),ORENCIA(R), in combination with methotrexate - a standard therapy for RA patients - is indicated for the treatment of moderate to severe active rheumatoid

EU OK for B-MS' Orencia  -  May 24, 2007
Pharma Times (subscription),Specifically, the drug has been cleared for use in combination with the standard therapy methotrexate for moderate-to-severe active RA in adults intolerant

Voraxaze (TM) Update  -  May 23, 2007
PipelineReview.com (press release),Voraxaze™ is an adjunctive therapy for patients with impaired renal function who areexperiencing, or at risk of, toxicity from methotrexate (“MTX�),

Data Show ENBREL Significantly Improved Nail Psoriasis in Patients ...  -  May 18, 2007
campus med,ENBREL also is approved in combination with methotrexate for the treatment of moderate to severe active rheumatoid arthritis in adults when the response to

Cervical Pregnancies Can Be Managed Without Surgery  -  May 11, 2007
Medscape (subscription)Methotrexate injection was used in all cases and KCl was added if there was evidence of fetal cardiac activity. Fetal heart activity was noted in 22 cases

LHRH-Analogues Beneficial in Premenopausal Women With Hormone ...  -  May 22, 2007
Medscape (subscription)In addition, some of the trials also used chemotherapy, mostly with cyclophosphamide, methotrexate, and 5-fluorouracil, although some used anthracyclines,

Committee for Medicinal Products for Human Use Post-authorisation ...  -  Apr 27, 2007
PharmaLive.com (press release),...the treatment of severe, active and progressive rheumatoid arthritis in adults not previously treated with methotrexate. Humira can be given as monotherapy

Rheumatoid arthritis drug link to atherosclerosis  -  May 11, 2007
Healthcare Republic (press release),Under NICE guidance, RA patients are offered infliximab or the TNF-alpha blocker etanercept in combination with methotrexate if they have failed to respond

Ulcerative Colitis Study Shows Remicade Responders Maintained ...  -  May 24, 2007
eMaxHealth.com,In the US, REMICADE, in combination with methotrexate, is indicated for reducing signs and symptoms, inhibiting the progression of structural damage and

Providing assistance  -  May 8, 2007
Logan Herald Journal,Doctors have prescribed Arava and methotrexate for Davis, but affording the drugs is difficult. She is supposed to take one Arava pill per day,

Don't tell these 4 that arthritis is an 'old folks' disease  -  May 6, 2007
Annapolis Capital,The drug Methotrexate seems to work for them. Without realizing it, they also share the same pediatric rheumatologist, Dr. Edward Sills at Johns Hopkins.

Toddler to set the pace at Medina Arthritis Walk  -  May 3, 2007
Akron Beacon Journal,Taylor receives a weekly injection of methotrexate, an immune suppressant, and naproxen as needed for joint pain. She sees an eye specialist on a regular

FDA Approves Labeling Update For ORENCIA To Inhibit Structural ...  -  Apr 30, 2007
Compliance Home,...in adults with moderately to severely active RA who have had an inadequate response to one or more DMARDs, such as methotrexate or TNF antagonists.

Abbott seeks US and EU approvals for Humira as a treatment for ...  -  May 9, 2007
News-Medical.net,In the first part of the study, two groups of patients -- those taking methotrexate (MTX) and not taking MTX -- received HUMIRA subcutaneously every other

Oxford hospital’s software innovation set to revolutionise ...  -  May 22, 2007
Healthcare RepublicRituximab, in combination with methotrexate, is indicated for the treatment of adult patients with severe active RA who have had an inadequate response or

Aging Gracefully with the Chronic Disease – Rheumatoid Arthritis  -  May 15, 2007
SeniorJournal.com,Methotrexate and tumor necrosis factor (TNF) blockers are examples of DMARD that have been found to be helpful for many RA patients.

Protherics Plc announces Research Update(2)  -  May 21, 2007
Genetic Engineering News (press release),Protherics is preparing to resubmit a BLA for VoraxazeTM, an adjunct to high dose methotrexate therapy, under a rolling submission in the US starting in

Abbott Seeks US and EU Regulatory Approvals for HUMIRA(R ...  -  May 7, 2007
Earthtimes.orgHUMIRA can be used alone or in combination with methotrexate orother disease-modifying anti-rheumatic drugs (DMARDs). HUMIRA is alsoapproved for reducing

Rare disease hasn't defeated teen's champion spirit  -  May 17, 2007
Checkbiotech.org (press release),A: I have to take prednisone, Neoral and methotrexate. The prednisone causes calcium to leak out of my bones, forming these gross bumps in my skin,

Inherited variations in certain genes linked to toxicity of ...  -  May 16, 2007
News-Medical.net,And in all three phases, one polymorphism was linked to hyperbilirubinemia, or jaundice, partly caused by the drug methotrexate.

Exercise, drugs can keep arthritis in check  -  May 16, 2007
Asbury Park Press,So once again Blake was taking drugs like methotrexate, an anti-cancer drug that helps suppress the immune attack but doesn't stop the disease.

Inherited Genes Linked to Toxicity of Leukemia Therapy  -  May 14, 2007
Genetic Engineering News (press release),...it was during the continuation phase. Also, in all three phases, one polymorphism was linked to hyperbilirubinemia partly caused by the drug methotrexate.

Yellapragada: The forgotten Indian medical genius  -  May 14, 2007
Andhra Cafe,...young researchers isolated three medical molecules, one of which yielded the vitamin folic acid and the anti-folic gave Methotrexate, a cancer fighter.

Know your psoriasis to get the proper treatment  -  May 12, 2007
New Straits Times,...psoriasis but many of them are associated with organ toxicity, for example liver (methotrexate), kidney (cyclosporine), teratogenicity (retinoids).

Aggressive treatment helps arthritis  -  May 11, 2007
Deseret News,The first drug approved specifically for rheumatoid arthritis, back in 1985, was methotrexate, a drug developed as a cancer chemotherapy that in very low

Chelsea Therapeutics Reports First Quarter 2007 Results  -  May 9, 2007
Primenewswire (press release),Early clinical data suggests that Chelsea's lead antifolate compound, CH-1504, is a safe and effective treatment alternative to methotrexate for RA and may

Recommendations for Treatment of Pleurisy  -  May 8, 2007
Medscape (subscription)Toxic exposure: asbestosis and drugs including amiodarone, bleomycin, bromocriptine, cyclophosphamide, methotrexate, methysergide, minoxidil, mitomycin,

New EMIS Software Will Help GPs To Prevent Serious Drug Side Effects  -  May 8, 2007
Medical News Today (press release),Drugs such as Azathioprine, Ciclosporin, Methotrexate, Gold Therapy, Amiodarone, and ACE inhibitors have potentially severe complications that can be

Crippling at any age  -  26 Apr 2007
SalemNews.com,Methotrexate, an anti-inflammatory drug also used on cancer patients, does help with her joint aches and pains but has immediate and long-term side effects.

Bristol-Myers Squibb Company Reports First Quarter 2007 Financial ...  -  26 Apr 2007
PR Newswire (press release),RA who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs, such as methotrexate or tumor necrosis factor antagonists.

New Data on Genmab and GlaxoSmithKline's Ofatumumab: Phase II ...  -  26 Apr 2007
PharmaLive.com (press release),Patients were permitted to continue therapy with stable doses of methotrexate and low dose prednisolone. ACR and EULAR responses were assessed in the

Oral Lichen Planus Responds to Methotrexate, Pimecrolimus  -  Apr 18, 2007
Medscape (subscription)April 18, 2007 — Oral lichen planus (OLP) and oral erosive lichen planus (OELP) may respond to methotrexate or pimecrolimus, respectively, according to the

FDA Approves Labeling Update for Orencia (abatacept) to Inhibit ...  -  Apr 25, 2007
PharmaLive.com (press release),...in adults with moderately to severely active RA who have had an inadequate response to one or more DMARDs, such as methotrexate or TNF antagonists.

Introgen Initiates Efficacy Analyses of ADVEXIN Phase 3 Clinical ...  -  Apr 24, 2007
Business Wire (press release),The Phase 3 study compares ADVEXIN p53 therapy versus methotrexate in patients with recurrent head and neck cancer. The prospective efficacy assessment of

REMICADE(R) Receives Approval in European Union for Dosing ...  -  Mar 30, 2007
Drug Newswire (press release),For patients who had an incomplete response to initial combination treatment with methotrexate and REMICADE 3 mg/kg, the dose titration label extension will

French Guidelines for Pretreatment Screening Inadequate to ...  -  Apr 10, 2007
DG NewsAnalysis of their concomitant immunosuppressive therapies showed use of methotrexate in 19 patients, leflunomide in 2, azathiprine in 1 and salazopine in 5;

Budget threatens medical miracle  -  Apr 5, 2007
Carlisle Sentinel,...“It’s possible that he might do OK with just the methotrexate (a chemotherapy drug), just at a higher dosage,� Groh says. “But I am anxious that we’re going

Abbott Labs files Humira in the USA and Europe for psoriasis  -  Apr 3, 2007
Pharma Times (subscription),In CHAMPION, a 16-week study evaluating 271 patients, 80% of those treated with Humira achieved PASI 75 compared to those on methotrexate (36%),

Pet food recall cases in Oregon rise to 25  -  Mar 27, 2007
Hillsboro Argus,Aminopterin is closely related in chemical structure and mechanism to methotrexate, which is used to treat some cancers, both in humans and animals.

OK sought to use drug for psoriasis  -  Apr 2, 2007
Boston Globe,Clinical trial data showed that Humira significantly cleared up affected areas and and cut the severity of psoriasis, compared with placebo and methotrexate

Intraventricular Rituximab Safe in Recurrent CNS Lymphoma  -  Apr 24, 2007
Cancerpage.com,...pharmacokinetics, and efficacy of intra-CSF injection of rituximab plus methotrexate in the treatment of recurrent CNS and ocular lymphomas."

Array BioPharma Reports Financial Results for the Third Quarter of ...  -  Apr 24, 2007
PharmaLive.com (press release),Continued a Phase 1b combination trial with ARRY-162 and methotrexate in stable rheumatoid arthritis patients, which will evaluate safety, tolerability,

Abbott Seeks US and EU Regulatory Approval for HUMIRA(R ...  -  Apr 2, 2007
Earthtimes.orgNearly 17 percent of patients treated with HUMIRA achieved PASI 100 at week 16, compared to 7 percent of patients receiving methotrexate and 2 percent of

Smokers, cancer survivors at heart risk  -  Apr 23, 2007
The Brunei Times,..."Patients who underwent radiotherapy plus adjuvant chemotherapy (cyclophosphamide, methotrexate, and fluorouracil) after 1979 had a higher risk of

The NHS: What you need to know  -  Apr 23, 2007
Telegraph.co.uk,...that are repeated consistently - for example, over a 10-year period, 26 people died from being administered the wrong dose of the drug Methotrexate.

Abbott Opens New Biotechnology Manufacturing Facility In Puerto  -  Apr 16, 2007
Pharmaceutical Online (press release),HUMIRA can be used alone or in combination with methotrexate or other disease-modifying anti-rheumatic drugs (DMARDs). HUMIRA is also approved for reducing

European Union CHMP Recommends Approval of First and Only Biologic ...  -  Apr 2, 2007
Drug Newswire (press release),For RA patients in the EU, REMICADE, in combination with methotrexate, is indicated for the reduction of signs and symptoms as well as the improvement in

Living with cancer — and thriving  -  Apr 22, 2007
Los Angeles Daily News,...she underwent a mastectomy on her right breast and started a six-month chemotherapy cocktail of Cytoxan and Methotrexate in February 1995.

Viventia Biotech announces results of Proxinium antibody in ...  -  Apr 22, 2007
News-Medical.net,...and methotrexate) was assessed using an MTS assay. Growth inhibition, in combination with radiotherapy, was assessed using a clonogenic assay.

Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP ...  -  Apr 11, 2007
PipelineReview.com (press release),...double-blind, placebo-controlled, dose ranging clinical trial to evaluate up to three doses of R788 in RA patients, on methotrexate, for 90 days.

Genentech Q1 2007 Earnings Call Transcript  -  Apr 11, 2007
Seeking Alpha,This data demonstrated treatment with Rituxan in combination with a stable dose of methotrexate, inhibited joint erosion and joint space narrowing at 56

Body Parts: Connecting with the peculiar placenta  -  Apr 22, 2007
North County Times,In that year, Dr. Roy Hertz and Dr. Min C. Li discovered that the chemotherapy drug methotrexate could completely cure the disease.

A wonder drug beat my teenage arthritis  -  Apr 10, 2007
Daily Mail,After diagnosis, Kate was started on methotrexate and sulfasalazine. The treatment initially worked, but over the next three years it lost effectiveness,

Taxane Use And Dose-Dense Scheduling May Benefit Patients With ...  -  Apr 14, 2007
Medical News Today (press release),...taxol=250mg/m2; cytoxan=840mg/m2; methotrexate 47mg/m2; 5-flurouracil=840mg/m2) given every 2 weeks, or 4 cycles of epirubicin followed by 4 cycles of

CombinatoRx, Incorporated (CRXX) Says Arthritis Drug Misses ...  -  Mar 27, 2007
PipelineReview.com (press release),Patients had to be on a DMARD therapy (such as methotrexate or sulfasalazine) for at least 3 months and be on a stable dose of DMARD therapy for a minimum

Allos Therapeutics' PDX Granted Orphan Medicinal Product ...  -  Apr 19, 2007
PR Newswire (press release),...in a variety of tumors, suggest that PDX may have a favorable potency and toxicity profile relative to methotrexate and certain other DHFR inhibitors.

Merrimack Pharmaceuticals Initiates Enrollment in a Phase 2 Study ...  -  Apr 18, 2007
PipelineReview.com (press release),...to examine the safety and efficacy of MM-093 in approximately 90-100 patients with moderate to severe, active RA despite stable doses of methotrexate.

Researchers Propose Model for Treatment of Idiopathic ...  -  Apr 17, 2007
DG NewsMore difficult cases may require methotrexate or even surgery. Nonetheless, nonoperative therapy is desirable in most cases of idiopathic granulomatous

Studies Evaluate Combined Adjuvant Therapy for Early Breast Cancer  -  Apr 16, 2007
Cancer Consultants (press release),The first trial evaluated the effect of adding combination chemotherapy (most commonly consisting of cyclophosphamide, methotrexate, and 5-fluourouracil) to

Roche Posts Strong First Quarter Sales – Upgrade of Core Earnings ...  -  Apr 18, 2007
PharmaLive.com (press release),An international phase III study met its primary endpoint in RA patients who had an inadequate response to methotrexate. Three further Actemra studies are

Abortion pill close Freely available in months  -  Apr 14, 2007
The Canberra Times,...said Canberra women wanting to terminate pregnancies using a pill had to travel to Sydney to be prescribed a less-efficient drug, methotrexate.

Pharma Sector: Few Newsmakers Of The Week - Merck, Pfizer, Mylan ...  -  Apr 14, 2007
Trading Markets,In September 2006, Rigel commenced a Phase II trial to evaluate up to three doses of R788 in Rheumatoid Arthritis patients, on methotrexate, for 90 days.

Hana Biosciences Announces Data to be Presented On Talvesta ...  -  Apr 12, 2007
PharmaLive.com (press release),These studies suggest that Talvesta, as compared to methotrexate, enters into cells up to ten times more efficiently and demonstrates 10- to 100-fold more

Chelsea Therapeutics to Sponsor Orthostatic Hypotension Symposium ...  -  Apr 11, 2007
Primenewswire (press release),Early clinical data suggests that Chelsea's lead antifolate compound, CH-1504, is a safe and effective treatment alternative to methotrexate for RA and may

Then and Now: More abortion options available  -  Apr 11, 2007
The Daily Titan,A recent medical abortion has been made available in which a clinician gives the woman a dose of one of two drugs, mifeprestone and methotrexate,

Court: Supreme Court of Wisconsin on appeal from the Circuit Court ...  -  Apr 5, 2007
MoreLaw.com,Dr. Sheila Galbraith issued a prescription for the drug methotrexate in a dosage higher than Galbraith's supervising physician instructed.

Mixing Adjuvant Therapies Prolongs Early Breast Cancer Survival  -  Apr 4, 2007
Psychiatric Times,In most cases, chemotherapy consisted of cyclophosphamide (Cytoxan), methotrexate, and 5-fluorouracil (87%) or anthracycline-based regimens (11%),

Abbott Files for Humira Psoriasis Use  -  Apr 2, 2007
Forbes,...significantly cleared up affected areas and and cut the severity of psoriasis compared with placebo and methotrexate, a standard psoriasis treatment.

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