Recent news on Mitoxantrone

AUA 2007 - Plenary Session: Point-Counterpoint; "Managing High ...  -  25 May 2007
UroToday,He cited SWOG trial 9921 that randomized patients to ADT alone or with mitoxantrone chemotherapy. It was closed early, due to an increased of leukemia in

Mitoxantrone Can Extend Time to Disease Progression in Worsening ...  -  May 7, 2007
DG NewsPrevious research has shown that early and aggressive treatment with mitoxantrone may delay or limit long-term disability. Of the 509 patients enrolled into

COPAXONE(R) Treatment over Two Years after Short Term Induction ...  -  May 4, 2007
Genetic Engineering News (press release),Treatment with COPAXONE(R) after induction with mitoxantrone remained safe and effective throughout the treatment period. These new findings were presented

New drug improves long term survival for mantle cell lymphoma  -  May 22, 2007
TopCancerNews.com,The usual treatment is MCP(mitoxantrone, chlorambucil, and prednisolone), a type of chemotherapy. The Journal of Clinical Oncology found that by adding

AUA 2007 - The Cytoprotective Chaperone, Clusterin, is Associated ...  -  May 22, 2007
UroToday,OGX-011 chemosensitized PC-3R cells to docetaxel and mitoxantrone in vitro with a reduction in IC50 from >1000 nM to 125 nM and 1500 to 200 nM respectively.

Friday's Health Winners & Losers  -  May 4, 2007
TheStreet.comThe company announced that new data showed patients with multiple sclerosis who were treated with Copaxone following chemotherapy-drug Mitoxantrone showed

Innovative Cancer Drug MabThera Again Shown To Improve Survival ...  -  May 21, 2007
PharmaLive.com (press release),Hematological Malignancies _ Rituximab Added to First-Line Mitoxantrone, Chlorambucil and Prednisolone Chemotherapy Followed by Interferon Maintenance

Addition of Rituxan® to MCP Improves Survival in Follicular and ...  -  May 2, 2007
Cancer Consultants (press release),Rituximab added to first-line mitoxantrone, chlorambucil, and prednisolone chemotherapy followed by interferon maintenance prolongs survival in patients

News For Your Web Site  -  May 6, 2007
dBusinessNews St. Louis (press release),COPAXONE® has shown efficacy and safety both in combination with intravenous steroids and after induction with the immunosuppressant mitoxantrone;

Treatment with Copaxone Plus Minocycline Showed Substantial ...  -  May 4, 2007
PharmaLive.com (press release),...with the immunosuppressant mitoxantrone; its compatibility with other compounds may make it unique among the disease modifying class of drugs and a

OSI Pharmaceuticals Announces First Quarter 2007 Financial Results  -  Apr 27, 2007
PharmaLive.com (press release),Offsetting these increases was a decline in commissions related to sales of Novantrone(R) (mitoxantrone for injection concentrate) which lost patent

Novacea Presents New Evidence That Its AQ4N Prodrug Candidate ...  -  Apr 17, 2007
Genetic Engineering News (press release),Additionally, the study showed that when used in combination with mitoxantrone, a chemotherapeutic agent, tumor growth delay in rodent breast cancer models

BTG signs agreement with Novacea and KuDOS for AQ4N  -  Apr 19, 2007
PharmaLive.com (press release),...investigators presented new and important pre-clinical evidence that AQ4N in combination with mitoxantrone is able to permeate deeply within all tumour

J&J shares set positive pharma tone  -  Apr 17, 2007
MarketWatchThe study also showed the agent appeared to retard tumor growth when used in combination with the chemotherapy drug mitoxantrone, according to Novacea.

MS Patients Not Receiving Medications To Slow Disease Progression ...  -  Apr 20, 2007
Medical News Today (press release),...interferon-1a (Avonex®), glatiramer acetate (GA or Copaxone®), interferon-1a (Rebif®), mitoxantrone (Novantrone®) and natalizumab (Tysabri®).

MS patients not receiving medications to slow disease progression  -  Apr 18, 2007
News-Medical.net,They are: interferon-1b (sold under the name Betaseron), interferon-1a (Avonex), glatiramer acetate (GA or Copaxone), interferon-1a (Rebif), mitoxantrone

Clarifying the Issues Surrounding Dendreon's Provenge  -  Apr 16, 2007
Seeking Alpha,...a 997 patient three arm randomized trial that evaluated two different dose schedules of docetaxel in comparison to mitoxantrone,(NEJM 351:1052,

Poniard Pharmaceuticals Announces Picoplatin Abstract Accepted for ...  -  Feb 22, 2007
PharmaLive.com (press release),Other options include mitoxantrone, estramustine or prednisone monotherapy as second-line treatment. Poniard Pharmaceuticals, Inc. is a biopharmaceutical

Poniard Pharmaceuticals Announces Picoplatin Abstract Accepted for ...  -  Feb 22, 2007
Earthtimes.orgOther options include mitoxantrone, estramustine or prednisone monotherapy as second-line treatment. This release contains forward-looking statements,

Pro-Pharmaceuticals Collaborates with Chemwerth to Scale-up ...  -  Feb 20, 2007
PharmaLive.com (press release),Etoposide USP, Fludarabine Phosphate, Gemcitabine HCl USP, Ifosfamide USP, Irinotecan HCl 3H2O, Mitoxantrone HCl USP/PhEur and Thiotepa USP.

Improving Outcomes in Lymphoma  -  Feb 5, 2007
Medscape (subscription)Addition of rituximab to first-line MCP (mitoxantrone, chlorambucil, prednisolone) chemotherapy prolongs survival in advanced follicular lymphoma - 4 year

Specialty Infusion Brings New Challenges, Solutions to Payers  -  Feb 12, 2007
Atlantic Information Services, Inc.,...under which drugs such as Remicade (infliximab), Novantrone (mitoxantrone), Flolan (epoprostenol sodium) and Remodulin (treprostinil sodium) fall.

Concurrent Chemotherapy and Radiation Therapy Reduces Locoregional ...  -  Feb 6, 2007
Cancer Consultants (press release),The chemotherapy regimen that was given to both groups of patients consisted of mitoxantrone, fluorouracil, and cyclophosphamide.

MCP Chemotherapy Regimen May Reduce Amount of Stem Cells Collected ...  -  Feb 1, 2007
Cancer Consultants (press release),Initial chemotherapy with mitoxantrone, chlorambucil, prednisone impairs the collection of stem cells in patients with indolent lymphomas-results of a

YM BioSciences announces termination of the tesmilifene Phase III ...  -  Feb 1, 2007
Drug Newswire (press release),In hormone-refractory prostate cancer (HRPC), two single-arm Phase II trials of tesmilifene in combination with chemotherapy (one with mitoxantrone plus

5AM Solutions Adds Dr. Dan Von Hoff to Advisory Board  -  Jan 31, 2007
Emediawire (press release),He and his colleagues were involved in the early development of drugs that are now routinely used to treat cancer, including: mitoxantrone, fludarabine,

Mitoxantrone-based Therapy Increases Risk for Subsequent Leukemia ...  -  Jan 12, 2007
Cancer Consultants (press release),According to an early online publication from the Journal of Clinical Oncology, the use of the chemotherapy agent Novantrone® (mitoxantrone) to treat breast

'Impressive' Complete Remission And 'Survival Data In Relapsed ...  -  Dec 25, 2006
Medical News Today (press release),This trial examined the safety and potential efficacy for pixantrone when substituted for mitoxantrone in the FND-R regimen (fludarabine, mitoxantrone,

Merck Serono Completes Patient Enrollment in CLARITY Phase III ...  -  Jan 16, 2007
Drug Newswire (press release),In addition to Rebif(R), the Company also offers a second therapy within its US portfolio of MS therapies: Novantrone(R) (mitoxantrone for injection

YM BioSciences Provides Update On Tesmilifene Pivotal Trial  -  Jan 16, 2007
Medical News Today (press release),In hormone-refractory prostate cancer (HRPC), two single-arm Phase II trials of tesmilifene in combination with chemotherapy (one with mitoxantrone plus

YM BioSciences provides update on tesmilifene pivotal trial  -  Jan 15, 2007
Drug Newswire (press release),In hormone-refractory prostate cancer (HRPC), two single-arm Phase II trials of tesmilifene in combination with chemotherapy (one with mitoxantrone plus

High-Dose Sequential Chemotherapy with Rituxan® is Superior to ...  -  Jan 11, 2007
Cancer Consultants (press release),...(2) etoposide cyclophosphamide and Rituxan followed by stem cell harvest and (3) high-dose chemotherapy with mitoxantrone and Alkeran® (melphalan) with

MabThera(REG) Helps Patients With Lymphoma Stay Symptom Free And ...  -  Dec 27, 2006
Medical News Today (press release),The study design comprised of 4 courses of chemotherapy (Fluarabine, Cyclophosphamide, and Mitoxantrone (FCM) +/- Rituximab). Responding patients underwent

'Impressive' Complete Remission And 'Survival Data In Relapsed ...  -  26 Dec 2006
Medical News Today (press release),This trial examined the safety and potential efficacy for pixantrone when substituted for mitoxantrone in the FND-R regimen (fludarabine, mitoxantrone,

Clinical Trial Design  -  26 Dec 2006
Medscape (subscription)Induction with mitoxantrone prior to glatiramer therapy was investigated in a randomized trial of 40 relapsing-remitting patients with at least 1

'Impressive' Complete Remission and 'Durable' Survival Data in ...  -  Dec 10, 2006
PR Newswire (press release),About the FPD-R Study This trial examined the safety and potential efficacy for pixantrone when substituted for mitoxantrone in the FND-R regimen

Diagnosis and Monitoring of Multiple Sclerosis: Focus on ...  -  Nov 27, 2006
Medscape (subscription)Mitoxantrone is approved for the treatment of worsening relapsing-remitting and secondary progressive MS. Walczak and colleagues [8] investigated the

Fludara®-Novantrone® Induction and Zevalin® Consolidation Results ...  -  Dec 19, 2006
Cancer Consultants (press release),Researchers from Italy have reported a 100% complete response (CR) rate to induction therapy with oral Fludara (fludarabine) and Novantrone (mitoxantrone)

FDA Approvals: Velcade and Herceptin  -  Dec 14, 2006
Medscape (subscription)A total of 91% of patients had received anthracycline or mitoxantrone, cyclophosphamide, and rituximab, and 37% overall were refractory to their last prior

Serono Announces Initiation of the Reflex Trial to Evaluate New ...  -  Dec 12, 2006
Drug Newswire (press release),In addition to Rebif(R), Serono also offers a second therapy within its US portfolio of multiple sclerosis (MS) therapies: Novantrone(R) (mitoxantrone for

Serono Announces Initiation of the Reflex Trial to Evaluate New ...  -  Dec 11, 2006
PR Newswire (press release),...therapy within its US portfolio of multiple sclerosis (MS) therapies: Novantrone(R) (mitoxantrone for injection concentrate) for worsening forms of MS.

Aggressive Treatment of PSA Recurrences After Primary Treatment Is ...  -  Dec 6, 2006
Cancer Consultants (press release),Currently, only three drugs, Taxotere, Emcyt and Novantrone® (mitoxantrone), are FDA-approved for the treatment of prostate cancer.

Patients 'denied prostate drug'  Nov 3, 2006
...for about another year. Another drug, mitoxantrone, can help - but has been out-performed by Taxotere in trials. The drug, known ... -BBC News, Serono Delivers Strong Adjusted* Net Income of $183.5m in Third ...  Oct 18, 2006
Novantrone(R) sales in the third quarter of 2006 were $2.8m, down 84.6%, consequent to the introduction of generics of mitoxantrone in the US in April 2006 (Q3 ... -MSN Money Serono Q3 Adj. Profit Rises 15.5% On Strong Sales Of Rebif And ...  Oct 19, 2006
...disability, generated third quarter sales of $2.8 million, down 84.6% from $18.2 million a year ago, due to the introduction of generics of mitoxantrone in the ... -Trading Markets, Serono Delivers Strong Adjusted* Net Income of $183.5m in Third ...  Oct 18, 2006
Q3 2005: $102.5m). Novantrone(R) sales in the third quarter of 2006 were $2.8m, down 84.6%, consequent to the introduction of generics of mitoxantrone in the ... -PR Newswire (press release), Mesothelioma Reseaerch Shows Promise  Aug 26, 2006
Italy are reporting that sequential chemotherapy with Platinol® (cisplatin) and Gemzar (gemcitabine) followed by Novantrone® (mitoxantrone), methotrexate and ... -World Fitness

'Impressive' Complete Remission and 'Durable' Survival Data in ...  -  Dec 11, 2006
Drug Newswire (press release),This trial examined the safety and potential efficacy for pixantrone when substituted for mitoxantrone in the FND-R regimen (fludarabine, mitoxantrone,

Clinical Trial Design  -  Nov 27, 2006
Medscape (subscription)Induction with mitoxantrone prior to glatiramer therapy was investigated in a randomized trial of 40 relapsing-remitting patients with at least 1

Aggressive Treatment of PSA Recurrences After Primary Treatment Is ...  -  Dec 6, 2006
Cancer Consultants (press release),Currently, only three drugs, Taxotere, Emcyt and Novantrone® (mitoxantrone), are FDA-approved for the treatment of prostate cancer.

Natural Sciences professors and students conduct summer research  Aug 3, 2006
Last year, Hensley’s research focused on mitoxantrone, a chemotherapy drug that works to counteract the effects of MS. Hensley ... -Ouachita Baptist University News

Why are doctors so reluctant to prescribe treatment for MS?  Aug 3, 2006
Research has shown that a combination of Novan-trone and Onkotrone, the trade names of mitoxantrone, a drug more often used in the treatment of malignancies ... -Times Online

New kick in teeth for MS man  Aug 6, 2006
The revolutionary new treatment, using a cocktail comprised of chemotherapy drug mitoxantrone and MS anti-relapse drug copaxone, has been a remarkable success. ... -Sunday Life

Researchers' work from the United Kingdom, United States and Japan ...  Aug 10, 2006
Japan. Study 1: Heat shock protein 90 inhibitors enhance the activity of topoisomerase II poisons etoposide and mitoxantrone. According ... -Therapeutics Daily (subscription)

Abraxis BioScience Reports Second Quarter 2006 Adjusted Earnings ...  Aug 3, 2006
In the second quarter, the Abraxis Pharmaceutical Products division launched three new products, carboplatin 600 mg, mitoxantrone and octreotide. ... -PharmaLive.com

Mayne lifts profit guidance  Jul 27, 2006
...and resilient margins on paclitaxel in Europe, the strong performance of irinotecan and oxaplatin in Canada and successful launch of mitoxantrone and relaunch ... -The Age

Mayne reports earnings jump  Jul 27, 2006
...performance of irinotecan (for colon cancer) and oxaplatin (for cancer of the large bowel) in Canada, and a successful launch of mitoxantrone (for leukemia and ... -NEWS.com.au

Israeli IT company Mercury bought by HP for $4.5 billion  Jul 26, 2006
...due to be published in next month's Journal of Neurology August 2006 The treatment regime, consisting of a limited course of mitoxantrone (an immunosuppressant ... -Israel 21C

Serono Delivers Second Quarter EPS of $12.92, Up 25.2% on Adjusted ...  Jul 26, 2006
Novantrone® sales in the second quarter of 2006 were $5.4m, down 70.4%, consequent to the introduction of generics of mitoxantrone in the US in April 2006 (Q2 ... -Yahoo! News

New Hope for Patients With Aggressive MS  Jul 17, 2006
The treatment regime, consisting of a limited course of mitoxantrone (an immunosuppressant normally used to treat cancer) followed by long-term glatiramer ... -Drug Newswire

Prostate cancer drug cleared for free use  Jun 27, 2006
Another anti-cancer drug, mitoxantrone, is sometimes given to this group of patients despite not being licensed for prostate cancer in the UK. ... -Daily Mail - UK

Recent studies from Canada, Italy and Germany add new data to ...  Jun 21, 2006
Study 1: Hormone-refractory prostate cancer (HRPC) should be treated by docetaxel or mitoxantrone as first- rather than second-line chemotherapy. ... -Therapeutics Daily (subscription)

European Commission Approves Revision of Therapeutic Indication ...  Jul 9, 2006
...addition to Rebif®, Serono also offers a second therapy within its US portfolio of multiple sclerosis (MS) therapies: Novantrone® (mitoxantrone for injection ... -Yahoo! News

European Commission Approves Revision of Therapeutic Indication ...  Jul 10, 2006
...to Rebif(R), Serono also offers a second therapy within its US portfolio of multiple sclerosis (MS) therapies: Novantrone(R) (mitoxantrone for injection ... -PharmaLive.com

NHS green light for prostate drug  Jun 28, 2006
...for about another year. Another drug, mitoxantrone can help - but has been out-performed by Taxotere in trials. The drug, known ... -BBC News

Lenograstim Effective After Consolidation Chemotherapy for Elderly ...  Jun 21, 2006
Following consolidation chemotherapy with BH-AC 200 mg/m 2 (3 hour IV, days 1-5) and mitoxantrone (MIT) 7 mg/m 2 (greater than or equal to 70 years, 5 mg/m 2 ... -DG News

Spotlight on Multiple Sclerosis  Jun 23, 2006
...immune diseases. A fifth FDA-approved drug for MS is mitoxantrone that is given intravenously every 3 months for two years. It serves ... -FOX News

Breast Cancer Drug To Extend Lives Of Men With Late Stage Prostate ...  Jun 29, 2006
Median patient survival with the Taxotere based regimen was 18.9 months compared to 16.5 months for the standard treatment (mitoxantrone). ... -Medical News Today

Short Course of Rituxan®/Chemotherapy Plus Maintenance Rituxan® ...  Jun 20, 2006
Patients were treated with R-CNOP (Rituxan, cyclophosphamide, mitoxantrone, vincristine, and prednisone), or R-CVP (Rituxan, cyclophosphamide, vincristine and ... -Cancer Consultants

Short Course of Rituxan®/Chemotherapy Plus Maintenance Rituxan® ...  Jun 21, 2006
34% of patients. Those treated with CVP received the same regimen with the exception of mitoxantrone. Maintenance therapy includes ... -Cancer Consultants



Pixantrone Produces High Rate of Complete Tumor Disappearance in ...  16 May 2006
This trial examines the safety and potential efficacy for pixantrone when substituted for mitoxantrone in the FND-R regimen (fludarabine, mitoxantrone ... - DG News

Multiple Sclerosis: New Insights and Trends  May 10, 2006
...phase. For SPMS, the most convincing data favors mitoxantrone (Novantrone) as most likely to retard progression and delay disability. ... - AJNR (subscription)

Rituxan® Improves Outcomes of Young Patients with Good-Prognosis ...  May 1, 2006
...added etoposide), MACOP-B (cyclophosphamide, doxorubicin, methotrexate, oncovin, bleomycin, and prednisone), PMitCEB (mitoxantrone, cyclophosphamide, bleomycin ... - Cancer Consultants

Phase III Trial Of Oral Cladribine, A Novel Investigational ...  May 5, 2006
...two therapies available for the treatment of MS: Rebif (interferon beta-1a), indicated for relapsing forms of MS, and Novantrone (mitoxantrone for injection ... - Medical News Today

Lung cancer CPT-11/SN-38 resistance marked by ABCG2 expression  Apr 20, 2006
..."Because H23/SN-38 cells show cross resistance to certain anticancer drugs, such as topotecan, etoposide, doxorubicin and mitoxantrone, ... - Therapeutics Daily (subscription)

Scholars Day features presentations from across the University  Apr 19, 2006
Trail�); Jeff Neal, a senior biology major from Laveen, Arizona and Cameron Tull, a senior biology major from Little Rock (“Mitoxantrone Represses Markers ... - Ouachita Baptist University News

Survival Improving for Patients with Stage IV Follicular Lymphoma  Apr 17, 2006
The third protocol evaluated alternating non-cross resistant regimes with the addition of etoposide, cytarabine, cisplatin and mitoxantrone, the fourth added ... - Cancer Consultants





Long-Term Follow-up Data of Mitoxantrone in Multiple Sclerosis ...  Apr 7, 2006
CA -- April 7, 2006 -- Five-year cardiac and haematological data from a large cohort of multiple sclerosis (MS) patients show that mitoxantrone is generally ... - DG News

Scholars Day will highlight research projects throughout the ...  Apr 6, 2006
Cameron Tull, a senior biology major, will present “Mitoxantrone Represses Markers of Microglial Activation and Inflammation,� which investigates multiple ... - Ouachita Baptist University News

European Urology - Pre-Treatment Nomogram for Disease-Specific ...  Apr 3, 2006
...[7] Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. ... - UroToday

Preclinical Progress Reported at American Association of Cancer ...  Apr 4, 2006
Using a cell culture model of acute myeloid leukemia (AML), it was shown that Quinamed combined with mitoxantrone resulted in more than additive anticancer ... - Yahoo! News

Tysabri poised for return to market  Mar 31, 2006
AG's Betaferon/Betaseron (interferon beta- 1b), Teva Neuroscience's Copaxone (glatiramer acetate), Serono SA's Novantrone (mitoxantrone hydrochloride) and ... - Pharmaceutical Business Review

Arsenic Trioxide Effective as Single Agent in Newly Diagnosed APL  Mar 31, 2006
Standard initial treatment for APL consists of chemotherapy, including an anthracycline (doxorubicin, epirubicin, mitoxantrone, idarubicin) and the agent all ... - Cancer Consultants

Wonder drugs don’t exist for MS; stick with proven options  Mar 26, 2006
Interferon beta-1b (Betaseron), interferon beta-1a (Avonex, Rebif), glatiramer (Copaxone), and mitoxantrone (Novantrone) are only partially effective in the ... - Fort Wayne Journal Gazette

Taxol® and Paraplatin® Superior to Novantrone® for Hormone ...  Mar 10, 2006
Researchers from France have reported that the combination of Taxol (paclitaxel) and Paraplatin (carboplatin) is superior to Novantrone (mitoxantrone) for the ... - Cancer Consultants

Taxol® and Paraplatin® Superior to Novantrone® for Hormone ...  Mar 10, 2006
Randomized phase II study comparing paclitaxel and carboplatin versus mitoxantrone in patients with hormone-refractory prostate cancer. Urology. ... - Cancer Consultants



New studies highlight the benefit of anti-MS drug  Mar 2, 2006
Interferon-beta, a cytokine, has been used for some years as a therapy, along with other drugs such as glatiramer acetate and mitoxantrone. ... - Ars Technica,

YM BioSciences reports second quarter 2006 operational and ...  Feb 10, 2006
...is now expected to be advanced with the first randomized trial in this indication and is expected to compare a standard of care mitoxantrone/prednisone used in ... - MSN Money

Xanthus' Symadex(TM) shows Remyelination in Multiple Sclerosis ...  Feb 13, 2006
Symadex was developed to deliver efficacy comparable to the anthracenediones (eg, Novantrone(R) (mitoxantrone)), but with a molecular scaffold intended to ... - Canada NewsWire,

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