Recent news on Murine

CCR5 Deficiency Drives Enhanced Natural Killer Cell Trafficking to ...  -  25 May 2007
Am J Pathology (subscription)Concanavalin A (Con A) hepatitis is a murine model mimicking many aspects of human T cell-mediated liver diseases. Here we demonstrate that severe hepatitis

MedImmune Highlights Advances in Inflammatory Disease Pipeline ...  -  25 May 2007
PipelineReview.com (press release),..."Fc dependent mechanisms are necessary for ADCC and effective depletion of murine B cells by humanized anti-CD19 MAb," J. Immunol., Apr 2007; 178: 131.27.

Whatever we did as kids, it seemed to result in yelling  -  25 May 2007
The Times,I’d come into the house (not once, but twice) with eyes so full of ground-in dirt my dad used up a whole bottle of Murine getting them cleaned out.

Interleukin-6 Receptor-Mediated Activation of Signal Transducer ...  -  25 May 2007
Am J Pathology (subscription)The present study reveals the critical contribution of IL-6 signaling and its downstream STAT3 pathway to the murine model of laser-induced CNV.

Control of Pseudomonas aeruginosa Skin Infections in Mice Is Mast ...  -  25 May 2007
Am J Pathology (subscription)Mast cells (MCs) have recently been shown to be essential for the elicitation of efficient immune responses in murine sepsis. To explore whether MCs also

Evidence for a Role of Tumor-Derived Laminin-511 in the Metastatic ...  -  25 May 2007
Am J Pathology (subscription)LM-511 was a potent adhesive substrate for both murine and human breast carcinoma cells and promoted strong haptotactic responses in metastatic lines.

Targanta Study Shows Oritavancin Treatment Effective in a Mouse ...  -  25 May 2007
PR Newswire (press release),Study Methods and Results: Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax Using an aerosol-anthrax mouse model,

Nanoparticulate Delivery of Suicide DNA to Murine Prostate and ...  -  May 22, 2007
AZoNano.com,This work is detailed in a paper titled, "Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors." An investigator from the Harvard

Flash! Murine Mop Misfortune Mitigated!  -  May 16, 2007
ScienceBlogs..."Researchers at the University of Pennsylvania report in the journal Nature that mice with deep skin wounds can send reprogrammed stem cells to the naked

Adenoviral-mediated correction of methylmalonyl-CoA mutase ...  -  Apr 30, 2007
BMC Pediatrics,Primary hepatocytes, isolated from the native liver after removal subsequent to a combined liver-kidney transplantation procedure, or Mut murine fibroblasts

In Murine Model, Migraine Causes TIA-Like Brain Damage  -  May 2, 2007
MedPage Today,ROCHESTER, NY, May 2 -- An induced mouse migraine, or migraine-like event, may cause brain damage as well as a bad murine headache, suggest researchers here

Irvington-based Prestige Brands earns $8.4 million  -  May 9, 2007
Business in the Burbs,Irvington-based Prestige Brands Holdings Inc., which markets Comet, Murine eye and ear drops and other consumer products, earned $8.4 million during the

The Contribution of Microglia to Neurologic Disorders  -  May 22, 2007
The New York Academy of Sciences,Conversely, intracerebral injections of LPS/IFNg into the adult murine CNS, lead to a reproducible, robust activation of CNS-resident microglia coupled with

Accelreon Pharma's ACE-031Shown to Increase Muscle Mass in ...  -  May 15, 2007
PharmaLive.com (press release),In the mdx murine model of muscular dystrophy, treated animals showed increases in muscle mass which translated into significantly increased muscle strength

HIV dementia: why might some viruses cause more problems than others?  -  May 18, 2007
Aidsmap,...loss of neuronal integrity, gliosis (neuroglial cell proliferation), and infiltration of murine monocytes to the site of HIV infection.

RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds ...  -  May 15, 2007
Genetic Engineering News (press release),The article, "The Novel Triterpenoid C-28 Methyl Ester of 2-Cyano-3, 12-Dioxooleen-1, 9-Dien-28-Oic Acid Inhibits Metastatic Murine Breast Tumor Growth

ACE-301 shows potential against muscle disorders  -  May 15, 2007
Therapeutics Daily (subscription) (press release),...its product candidate ACE-301 demonstrated the ability to increase muscle mass and strength in normal mice and murine models of muscular dystrophy.

Mighty Mouse  -  May 12, 2007
Dallas Morning News (subscription),Like its murine eponym, the Mouse is surprisingly muscular and even sinewy, able to flex thick ropes of musical strength. Mr. Marr references his past

Next Generation Performance Enhancing Drugs Are Already Being Used ...  -  May 5, 2007
Blogcritics.org,Despite the fact that much of the IGF-1 research dealt with lab rats, the results of these murine (lab rat) studies did lead to successful human trials that

Supplemental Data Supplemental Data  -  May 4, 2007
Journal of Clinical Endocrinology and Metabolism,Murine NIH 3T3 fibroblasts treated with lipopolysaccharide (LPS) were used as a positive control of NF-kB nuclear translocation. Original magnification 40X.

Artemis and Taconic Acquire Chemical Genetics Technology from CGI ...  -  May 4, 2007
CombiChem.net (subscription),...market, and distribute ASKA transgenic mouse models in which a fully functional ASKA replaces the normal kinase gene in the murine genome.

Study findings from University of Central Florida, US, are ...  -  May 3, 2007
Therapeutics Daily (subscription) (press release),Study 1: Scientists discuss in "Cardioprotective effects of cerium oxide nanoparticles in a transgenic murine model of cardiomyopathy" new findings in

Alacrity Biosciences Announces Presentation of Clinical Data From ...  -  May 3, 2007
Primenewswire (press release),Poster Title: Correlation of the Controlled Adverse Environment (CAE) Model With a Murine Model of Experimental Dry Eye in Assessing the Ability of Topical

Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor ...  -  May 1, 2007
Journal of Bone and Joint Surgery (subscription)Methods: Cultured RAW264.7 murine macrophages were incubated with titanium particles with adherent endotoxin or with endotoxin-free titanium particles in

Prestige Brands Holdings, Inc. to Release Fiscal '07 Fourth ...  -  26 Apr 2007
Business Wire (press release),Key brands include Compound W(R) wart remover, Chloraseptic(R) sore throat relief products, New Skin(R) liquid bandage, Clear eyes(R) and Murine(R) eye care

Murine Cerebral Malaria Development Is Independent of Toll-Like ...  -  Apr 24, 2007
Am J Pathology (subscription)Dieudonnée Togbe * , Louis Schofield , Georges E. Grau , Bruno Schnyder * , Victorine Boissay * , Sabine Charron * , Stéphanie Rose * , Bruce Beutler

The Host Inflammatory Response Promotes Liver Metastasis by ...  -  Apr 24, 2007
Am J Pathology (subscription)Here, we analyzed spatio-temporal aspects of the ensuing tumor-endothelial cell interaction using human colorectal carcinoma CX-1 and murine carcinoma H-59

Human Antibody Against C Domain of Tenascin-C Visualizes Murine ...  -  Mar 30, 2007
Journal of Nuclear Medicine (subscription)We tested the ability of the human antibody G11, specific to this antigen, to reveal murine atherosclerotic plaques ex vivo. The antibody directed against

Prestige Taps Kelly  -  Apr 18, 2007
Promo Magazine,Fink is one of the founding executives of the five-year-old company, whose brands range from Chloraseptic, Compound W and Murine to Spic and Span,

WARF Stem Cell Patents Knocked Down in Round One  -  Apr 3, 2007
Patent Baristas,5690926 (Hogan), directed towards non-murine pluripotential cells that have the ability to be passaged in vitro for at least 20 passages and which

'Guerilla scientist' kicks ALS research in the pants  -  Apr 7, 2007
National Review of Medicine,...budget of $12 million US and a staff of 35 including some very eminent medical minds and has earned praise worldwide for its innovative murine studies.

Open Biosystems' Open Access RNAi Program Adopted by John's ...  -  Apr 23, 2007
PharmaLive.com (press release),..."Open Biosystems' Open Access Programs for RNAi and genomic resources provides a unique consolidated toolkit for murine and human gene analysis to our

Tapestry Pharmaceuticals Presents Data on TPI at the AACR Annual ...  -  Apr 16, 2007
PipelineReview.com (press release),Studies Show that TPI 287 Crosses the Blood-Brain Barrier and is Orally Active In Murine Models. BOULDER, CO, USA | Apr 15, 2007 | Tapestry Pharmaceuticals,

Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR ...  -  Apr 15, 2007
PR Newswire (press release),Studies Show that TPI 287 Crosses the Blood-Brain Barrier and is Orally Active In Murine Models BOULDER, Colo., April 15 /PRNewswire-FirstCall/ -- Tapestry

Where is the Pied Piper?  -  Apr 23, 2007
Afternoon Dispatch & Courier,Rats can cause diseases like Leptospirosis, Plague, Salmonellosis, Rat bite fever, Murine Typhus and various intestinal worms.

An Update on Transcription Factors in Asthma  -  Apr 23, 2007
Medscape (subscription)Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity. 1999;11:473-482. Abstract

Autoantibodies to Vimentin Cause Accelerated Rejection of Cardiac ...  -  Mar 27, 2007
Am J Pathology (subscription)The aim of these studies was to investigate the effects of vimentin preimmunization on allogeneic and isografted hearts in a murine transplant model.

Idera Pharmaceuticals Announces Presentations of Preclinical Data ...  -  Apr 19, 2007
PipelineReview.com (press release),In this study, the antitumor activity of a murine analog of IMO-2055 was examined following intranasal delivery in mouse models of colon carcinoma and

The Transitioning Germ Line  -  Apr 19, 2007
Science Magazine (subscription)394) tell of the murine system, invoking an inductive signal. Although model systems use different strategies, common themes exist.

Full Text  -  Apr 19, 2007
Science Magazine (subscription)...cues direct germ cells to transition from mitosis to meiosis; meiotic initiation is among the first signs of sexual dimorphism in the murine ovary (1).

'Retiring' Prestige executive to make $211000, plus bonus, at home  -  Apr 18, 2007
White Plains Journal News,...well-known consumer products such as Chloraseptic throat treatment, Compound W wart remover, Comet and Spic and Span cleansers, and Murine eye products.

Dietary Factors in the Modulation of Inflammatory Bowel Disease  -  Mar 28, 2007
Medscape (subscription)1, 25 dihydrocholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr. 2000;130:2648-2652. Abstract

Peregrine's selective anti-VEGF antibodies shown to be as ...  -  Apr 18, 2007
News-Medical.net,Now that we have also demonstrated that a fully human anti-VEGF antibody (R3) is comparable to our earlier murine versions, we intend to accelerate our

Effects of tribuli saponins on ventricular remodeling after ...  -  Apr 17, 2007
HeartZine,...determine whether Tribuli saponins (TS) relieve left ventricular remodeling (VR) after myocardial infarction (MI) in a murine hyperlipemia (HL) model.

Calando Pharmaceuticals Announces Preclinical Efficacy and Safety ...  -  Apr 16, 2007
PR Newswire (press release),..."This formulation was well-tolerated in mice and monkeys at concentrations that elicited a significant anti-tumor effect in a murine cancer model.

Prestige Brands Holdings, Inc. Announces Retirement of Michael ...  -  Apr 16, 2007
Business Wire (press release),Key brands include Chloraseptic® sore throat treatment, Compound W® wart remover, New Skin® liquid bandage, Clear eyes® and Murine® eye care products,

Calando Pharmaceuticals Announces Preclinical Efficacy and Safety ...  -  Apr 16, 2007
Nanotechnology News (press release)...elicited a significant anti-tumor effect in a murine cancer model. These. results suggest that this formulation has promise for human use."

Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR ...  -  Apr 15, 2007
American Digital Networks (press release),...barrier and to be orally bioavailable in murine models, which suggests the potential to treat tumors not responsive to the currently marketed taxanes."

Gentium's Defibrotide Highlighted in Two Poster Presentations at ...  -  Apr 13, 2007
PharmaLive.com (press release),In vivo, tumor angiogenesis was assessed in the murine dorsal skin-fold chamber model using the inoculation of human gastric adenocarcinoma (TMK-1) cells.

Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP ...  -  Apr 11, 2007
PipelineReview.com (press release),In addition, in a murine model of ITP, R788 was shown to increase platelet counts significantly. Lymphoma is a large class of blood cancers that affect the

PrimeCell Therapeutics' Lead Researcher Available to Discuss ...  -  Apr 11, 2007
PharmaLive.com (press release),They've been successfully transformed into beating murine heart cells, through therapeutic reprogramming. -- Reprogramming an adult cell to dedifferentiate

PrimeCell™ Therapeutics’ Lead Researcher Available to Discuss ...  -  Apr 11, 2007
Business Wire (press release),They’ve been successfully transformed into beating murine heart cells, through therapeutic reprogramming. Reprogramming an adult cell to dedifferentiate it

Rigel Provides Clinical Update of R788 Phase 2 Trials in ITP ...  -  Apr 11, 2007
PR Newswire (press release),In addition, in a murine model of ITP, R788 was shown to increase platelet counts significantly. About B-Cell Lymphoma Lymphoma is a large class of blood

Prestige Brands Holdings, Inc. Anticipates Fourth Quarter Revenues ...  -  Apr 9, 2007
Business Wire (press release),Key brands include Compound W® wart remover, Chloraseptic® sore throat treatment, New-Skin® liquid bandage, Clear eyes® and Murine® eye care products,

Model Behavior  -  Apr 6, 2007
Drug Discovery & Development,...in conjunction with Canadian and European counterparts, is to build, and make publicly available, knockout models for every gene in the murine genome.

Use of TGF- ß Inhibitor Could Reduce Metastases  -  Apr 6, 2007
Medscape (subscription)The study was conducted in a murine model of metastatic breast cancer, in which ionizing radiation or treatment with doxorubicin caused an increase in

New Biomarker, Therapeutic Target for Melanoma ''Truly Exciting''  -  Apr 5, 2007
Cancerpage.com,Dr. Spanjaard and associates at Boston University School of Medicine, Massachusetts used murine S91 melanoma cells to search for novel melanoma-specific

Prestige Brands Executives to Present at the SunTrust Robinson ...  -  Apr 4, 2007
Business Wire (press release),Key brands include Chloraseptic® sore throat relief products; Compound W® wart removers; New Skin® liquid bandage; Clear eyes® and Murine® eye care products

RbAp48 is a Target of Nuclear Factor-B Activity in Thyroid Cancer  -  Apr 4, 2007
Journal of Clinical Endocrinology and Metabolism,...and embryonic fibroblasts isolated from the p65 knockout mouse (murine embryonic fibroblasts p65 –/– ) showed decreased expression of RbAp48.

Pharma consolidates its grip on post-antibody landscape  -  Apr 3, 2007
Nature.com (subscription),Meanwhile, R&D in the field has shifted from murine to chimeric entities, to humanized, and to fully human antibodies. Antibody fragments, which are smaller

CD25 expression on donor CD4+ or CD8+ T cells is associated with ...  -  Apr 2, 2007
Cancer Focus,...frequencies of CD4( )CD25( ) regulatory T cells in donor grafts has been shown to ameliorate GVHD after allogeneic transplantation in murine models.

Reproducibility of 18 F-FDG microPET Studies in Mouse Tumor Xenografts  -  Mar 30, 2007
Journal of Nuclear Medicine (subscription)Methods: Mouse tumor xenografts were formed with B16F10 murine melanoma cells. A 7-min small-animal PET scan was performed 1 h after a 3.7- to 7.4-MBq 18

Michael Longaker  -  Mar 30, 2007
Stanford University School of Medicine,Wan DC, Siedhoff MT, Kwan MD, Nacamuli RP, Wu BM, Longaker MT "Refining Retinoic Acid Stimulation for Osteogenic Differentiation of Murine Adipose-Derived

Decay-Accelerating Factor Ameliorates Systemic Autoimmune Disease ...  -  Mar 27, 2007
Am J Pathology (subscription)Previous studies have established a significant protective activity of DAF in the MRL/lpr murine model of human systemic lupus erythematosus.

Vasoactive intestinal peptide, periodontal disease, and the innate ...  -  27 Mar 2007
Journal of Leukocyte Biology (subscription)...the regulation of TLR expression in mice and humans and most of the research on VIP (including the Gomariz study) has been conducted in murine systems.

Essential role of protein kinase C in transducing a motility ...  -  27 Mar 2007
Journal of Cell Biology (subscription)...of human squamous carcinoma SASH1 cells, human peripheral monocytes (hPMs), and murine macrophage-like cell line J774.1 by superoxide stimulation.

Submillimeter Total-Body Murine Imaging with U-SPECT-I  -  Mar 1, 2007
Journal of Nuclear Medicine (subscription)Correspondence: For correspondence or reprints contact: Brendan Vastenhouw, University Medical Centre, Utrecht, Room STR 5.203, Universiteitsweg 100,

University of Saarland, Germany, describe new medical findings  -  Mar 22, 2007
Therapeutics Daily (subscription) (press release),According to recent research from Germany, "We herein report on a novel locking intramedullary nail system in a murine closed femur fracture model.

About the Cover  -  Mar 15, 2007
AJRCMB (subscription)About the cover: Cover is based on an image showing Fog 2 expression present in the early developing murine lung. By embryonic day 11.5, Fog 2 expression

Staying Current with Virus Testing Requirements for Biological ...  -  Mar 13, 2007
Pharmaceutical Processing,Some viruses are endogenous to cells, such as that found in murine cells. (Murine cells can contain endogenous retrovirus sequences and infectious

Mystery Of Embryonic Stem Cell Signaling Pathway Unlocked By ...  -  Mar 22, 2007
Medical News Today (press release),Tomoyuki Miyabayashi, Jia-Ling Teo, Masashi Yamamoto, Michael McMillan, Cu Nguyen, Michael Kahn, "Wnt/ß-catenin/CBP signaling maintains long-term murine

Calcium regulation of troponin and its role in the dynamics of ...  -  Mar 6, 2007
AJP-Regul Integr Comp Physiology (subscription)Incorporation of human cTn complex into murine cardiac myofibrils does not slow down myofibrillar activation-relaxation kinetics (11), despite the fact that

New Study Suggests Antiviral Protein May Inhibit Ebola And Marburg ...  -  Mar 21, 2007
Medical News Today (press release),In a previous study researchers found the zinc finger antiviral protein (ZAP) capable of inhibiting Moloney murine leukemia virus and Sindbis virus

Eric Vivier’s Team at the Marseille-luminy Immunology Centre and ...  -  Feb 28, 2007
PharmaLive.com (press release),The only murine model available thus far involved monoclonal antibodies targeting antigens mainly expressed by NK cells (GM1, NK1.1) but also found on the

Nature in our outback  -  Mar 20, 2007
Long Beach Press-Telegram,On the debit side, the squirrels have lost their once-fetching shyness and have turned more sinisterly murine, gnawing through electric insulation and cable

SUFU 2007 - The Effect of Sildenafil Citrate on Bladder Outlet ...  -  Mar 20, 2007
UroToday,We investigated if sildenafil citrate can inhibit the fibrosis and detrusor overactivity that accompany bladder outlet obstruction (BOO) in a murine model.

Stem Cell Signaling Mystery Solved  -  Mar 20, 2007
Science Daily (press release)Masashi Yamamoto, Michael McMillan, Cu Nguyen, Michael Kahn, "Wnt/ß-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.

Drug, Vaccine Research Target Avian Flu  -  Mar 20, 2007
Journal of American Medical Association (subscription),..."You can start as late as 96 hours after inoculation of virus and still see therapeutic activity, and single doses appear to be active, at least in murine

Calando Pharmaceuticals Publishes the First Non-Human Primate ...  -  Mar 20, 2007
Business Wire (press release),...well-tolerated at doses significantly above those that had been previously shown to be efficacious with a similar formulation in murine cancer models.

Tree Bark Extract Shows Promise Against Retinoblastoma  -  Mar 19, 2007
Cancerpage.com,The team is currently conducting in vivo studies in a transgenic murine model of retinoblastoma to better evaluate efficacy and toxicity of beta-lapachone.

Hot Paper in Aging  -  Mar 13, 2007
Scientist,SE Schriner et al., "Extension of murine lifespan by overexpression of catalase targeted to mitochondria." Science, 308:1909-11, 2005.

New drug target for herpes viruses  -  Mar 11, 2007
News-Medical.net,...to delineate the intricate structure of M48, a close relative of UL36 that is found in murine cytomegalovirus, also a member of the herpesvirus family.

Lactococcus Strain may Offer End to Food Allergies  -  Mar 10, 2007
MedIndia,The researchers used a mouse model of food allergy to test their hypothesis that oral administration of Lactococcus lactis bioengineered to secrete murine

Micro level therapy  -  Mar 8, 2007
Express Pharma,...humanise monoclonal antibodies, removing the reactions that many monoclonal antibodies caused in some patients due to murine origin," informs Maithal.

Full Text  -  Mar 8, 2007
Science Magazine (subscription)The authors noted that for some viruses, such as vesicular stomatitis virus or Sendai virus, infection of murine plasmacytoid dendritic cells,

Heterozygous Missense Mutations in Steroidogenic Factor 1 (SF1 ...  -  Mar 6, 2007
Journal of Clinical Endocrinology and Metabolism,Consistent with the murine phenotype, human mutations in SF1 were described initially in two 46,XY individuals with female external genitalia,

CRWAD honors Carmichael  -  Mar 5, 2007
American Veterinary Medical Association,N. Fittipaldi, Université de Montréal, "Deletion of the pgdA gene severely diminishes the virulence of Streptococcus suis in a murine model of infection.

Hypertrophy into heart failure: Is preserving angiogenesis key to ...  -  Mar 5, 2007
TheHeart.Org,Increased levels of tumor-suppressor protein p53 in a murine model of hypertrophic cardiomyopathy led to ventricular dysfunction and heart failure by

Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, C-868 ...  -  Mar 7, 2007
European Journal of Cardio-Thoracic Surgery (subscription)Immuno-gene therapy with inteferon-ß before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.

Melanoma Imaging with Pretargeted Bivalent Bacteriophage  -  Mar 1, 2007
Journal of Nuclear Medicine (subscription)...the use of phage displaying multiple melanocortin-1 receptor–homing peptides for the pretargeting and subsequent imaging of murine melanomas in vivo.

Cell-cell adhesion in lung endothelium  -  Mar 6, 2007
AJP-Lung Physiology (subscription)Nectin 1 was found in murine corneal microvessels (128). Otherwise, I could find no other primary data for nectin and endothelium.

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis  -  Mar 8, 2007
AJP - Cell Physiology (subscription)Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 201: 1307–1318, 2005.

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