Recent news on Nelfinavir

HIV resistance mutations common but CXCR4 rare among untreated US ...  -  May 22, 2007
Aidsmap,Resistance to nevirapine (Viramune), delavirdine (Rescriptor), stavudine (Zerit), efavirenz (Sustiva), zidovudine (Retrovir), and nelfinavir (Viracept) were

No major metabolic differences between PI-based and NNRTI-based ...  -  Apr 29, 2007
Aidsmap,The treatments reflect what was in use during that period: nelfinavir (Viracept) was the most commonly used PI (61%), followed by ritonavir-boosted PIs

Zidovudine Syrup (Zidovudine capsule) Information  -  May 18, 2007
American Chronicle,Acetaminophen, nelfinavir, ribavirin, rifamycin, ritonavir, stavudine: May decrease zidovudine serum concentrations, reducing the therapeutic effect.

Breaking Merck patent may drive investment away from Brazil  -  May 9, 2007
Pharmaceutical Business ReviewThe same happened with Gilead's Viread (tenofovir), a high-selling NRTI and Roche/Pfizer's Viracept (nelfinavir), a PI that has been facing decreasing sales

Marijuana Use Does Not Accelerate HIV Infection  -  Mar 31, 2007
PakTribune.com,Previously it was shown that short-term marijuana use did not influence nelfinavir metabolism. Although marijuana use did produce a drop in indinavir levels

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal MedicineND = not detected; NFV = nelfinavir; NNRTI = nonnucleoside reverse transcriptase inhibitor; N(t)RTI = nucleotide reverse transcriptase inhibitor;

Abbott Agrees With World Health Organization (WHO) Director ...  -  Apr 11, 2007
Drug Newswire (press release),Co-administration of efavirenz, nevirapine, nelfinavir or amprenavir with Kaletra tablets 400/100 mg is not recommended. If co-administration of these

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Nelfinavir pharmacokinetics (625 mg tablets) during the third trimester of pregnancy and post partum. Program and abstracts of the 14th Conference on

Pediatric studies lead to more information on drug labels  -  Feb 1, 2007
AAP News (subscription)Viracept (nelfinavir) is a protease inhibitor that can be used in combination therapy for the treatment of HIV infection. Nelfinavir was the most frequently

Be careful if using fosamprenavir/ritonavir for PEP, and did HCV ...  -  Jan 31, 2007
Aidsmap,Until January 2006 doctors in Lille prescribed a PEP regimen consisting of AZT/3TC (Combivir) with the protease inhibitor, nelfinavir (Viracept).

Exploiting natural HIV defence  -  Feb 9, 2007
BiopharmaReporter.com,Roche's Invirase/Fortovase (saquinavir), Abbott Laboratories Norvir (ritonavir), Merck & Co's Crixivan (indinavir) and Pfizer's Viracept (nelfinavir).

Data Published In AIDS Show Viramune (nevirapine) Achieves Durable ...  -  Feb 5, 2007
Medical News Today (press release),...nelfinavir (n=135), ritonavir (n=15), saquinavir (n=13), or indinavir or saquinavir in combination with low-dose ritonavir (n=19) prior to study entry.

Company Announces Acquisition of Research and Development Programs ...  -  Dec 26, 2006
Drug Newswire (press release),Dr. Quart joined Agouron in 1993 and was instrumental in the development and registration of nelfinavir (Viracept(R)), which went from the lab bench to NDA

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...or fenofibrate) -- the antibiotics erythromycin, clarithromycin, and telithromycin -- HIV protease inhibitors (such as indinavir, nelfinavir, ritonavir,

Company Announces Acquisition of Research and Development Programs ...  -  26 Dec 2006
Drug Newswire (press release),Dr. Quart joined Agouron in 1993 and was instrumental in the development and registration of nelfinavir (Viracept(R)), which went from the lab bench to NDA

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine.

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients ...  -  Dec 14, 2006
DG News...ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and telithromycin).

Roche Diagnostics Will Mark World AIDS Day  -  Dec 1, 2006
Inside INdiana Business (press release),Roche makes its HIV protease inhibitors – Invirase (saquinavir) and Viracept (nelfinavir) available at no profit prices for direct supplies from Roche Basel

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...or fenofibrate) -- the antibiotics erythromycin, clarithromycin, and telithromycin -- HIV protease inhibitors (such as indinavir, nelfinavir, ritonavir,

Kaletra not associated with raised blood pressure, manufacturer ...  Oct 30, 2006
...inhibitor Kaletra (lopinavir/ritonavir) are no more likely to develop high blood pressure than those taking another protease inhibitor nelfinavir (Viracept) or ... -Aidsmap, Antiretroviral Treatment Strategies for Adults With HIV  Nov 2, 2006
SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS. ... -Medscape (subscription) Merck buys protease inhibitor from Ambrilia, may be potent booster ...  Oct 20, 2006
No cross-resistance to amprenavir, lopinavir, atazanavir, saquinavir, indinavir, and nelfinavir was observed for any viral mutants, but resistance mutations ... -Aidsmap, ARV drugs may also help fight malaria  Oct 10, 2006
Therapies which included nelfinavir (Viracept), amprenavir (Agenerase) and the NNRTI nevirapine (Viramune) did not inhibit the growth of the malaria parasite. ... -SABC News, Antiretroviral Drugs: A Shot in the Arm to Fight Malaria?  Oct 12, 2006
The presence of nelfinavir (Viracept), amprenavir (Agenerase) and the NNRTI nevirapine (Viramune) in thereapies did not hamper the proliferation of the ... -MedIndia, Findings from the United States, France and Canada in HIV/AIDS ...  Oct 12, 2006
Group (ACTG) study 384 randomized antiretroviral-naive individuals to receive didanosine/stavudine or zidovudine/lamivudine, plus efavirenz, nelfinavir, or both ... -Therapeutics Daily (subscription) (press release), Roche announces transfer of protease inhibitor know-how to 3 ...  Sep 22, 2006
Roche, the manufacturer of nelfinavir and saquinavir, announced today that it has agreed to pass on the know-how to make its protease inhibitor saquinavir to ... -Aidsmap

Antiretroviral Treatment Strategies for Adults  Sep 22, 2006
Because of the time of commencement several years ago of this planned long-term study, the predominant PI used was nelfinavir, and ritonavir boosting was rare. ... -Medscape (subscription)

Kaiser Daily HIV/AIDS Report Highlights Recently Released Journal ...  Sep 19, 2006
Among the participants, 56 were treated with protease inhibitors -- indinavir, nelfinavir, ritonavir or saquinavir -- and 54 were treated with non-nucleoside ... -Medical News Today

- Study of Chronic-Phase Patients with Chronic Myelogenous ...  -  Dec 11, 2006
PR Newswire (press release),...ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and telithromycin).

Roche Diagnostics Will Mark World AIDS Day  -  Dec 1, 2006
Inside INdiana Business (press release),Roche makes its HIV protease inhibitors – Invirase (saquinavir) and Viracept (nelfinavir) available at no profit prices for direct supplies from Roche Basel

Large analysis shows benefits of starting treatment with efavirenz  Aug 22, 2006
In contrast, patients starting with nelfinavir (Viracept), unboosted saquinavir, unboosted indinavir or abacavir (Ziagen) had a similar risk of AIDS or death ... -Aidsmap

IAC: Long-Term Therapy with Antiretrovirals Tolerated by Children  Aug 16, 2006
The protease inhibitors used at the hospital included Norvir (ritonavir), approved in 1996; Viracept (nelfinavir), approved in 1997; and Kaletra (lopinavir ... -MedPage Today

Marijuana Use Does Not Accelerate HIV Infection  Aug 19, 2006
...protease inhibitors. Previously it was shown that short-term marijuana use did not influence nelfinavir metabolism. Although marijuana ... -Online - International News Network

Two-class HAART just as good as three-class in the long-term, and ...  Aug 15, 2006
Four hundred and seventy patients were randomised to the protease inhibitor arm, of whom 61% started treatment with nelfinavir, 39% with a ritonavir-boosted ... -Aidsmap

Abacavir/3TC backbone proves most durable for children over five ...  Aug 16, 2006
...protease inhibitor (Viracept), but the minority of children participating in the study who were asymptomatic were randomised to receive either nelfinavir or a ... -Aidsmap

Abbott Statement Regarding New Initiatives To Expand Access And ...  Aug 20, 2006
Co-administration of efavirenz, nevirapine, nelfinavir or amprenavir with lopinavir/ritonavir tablets 400/100mg is not recommended. ... -Medical News Today

World looking to Brazil for answers  Aug 5, 2006
In 2001, threats to break patents prompted Roche to cut the cost of nelfinavir by 40 per cent, saving Brazil $40 million a year, and Merck & Co. ... -Toronto Star

WHO issues paediatric HIV treatment guidelines for low-income ...  Aug 8, 2006
...abacavir unless abacavir was used in first-line treatment, plus either lopinavir/ritonavir (Kaletra), saquinavir/ritonavir (Invirase) or nelfinavir (Viracept). ... -Aidsmap

BRAZIL PACT ON AIDS DRUGS LAUDED  Aug 7, 2006
In 2001, Swiss pharmaceutical giant Roche Holding AG bowed to similar pressure from the Brazilian government and cut the price of its AIDS drug, Nelfinavir. ... -Out In America

Drop d4T from first-line therapy, WHO advises low-income countries ...  Aug 8, 2006
Nelfinavir is an alternative protease inhibitor that does not need cold storage, but is less potent than a ritonavir-boosted protease inhibitor. ... -Aidsmap

Effects of highly activeantiretroviral therapy with Nelfinavir in ...  Jul 11, 2006
Nelfinavir (NFV) is an HIV-1 Protease Inhibitor (PI) which has become as one of the first choices of PI for ART in children. We ... -Daily News from The Scientist

New findings in HIV/AIDS described from Netherlands, United States ...  Jul 11, 2006
States and Mexico. Study 1: Nelfinavir-containing HAART is strongly associated with virologic failure in young children. "We sought ... -Therapeutics Daily (subscription)

Nevirapine-based triple-drug combinations safe for use in pregnant ...  Jul 10, 2006
Only ten of the 46 women with severe toxicity needed to change treatment, replacing nevirapine with either nelfinavir (Viracept) or indinavir (Crixivan). ... -Aidsmap

FDA Approves Sprycel (Dasatinib) With Two Indications  Jun 29, 2006
...are: CYP3A4 inhibitors (eg, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and ... -DG News

Clinical Pharmacology of Antiretroviral Therapy -- New Data for ...  Jun 22, 2006
The PIs saquinavir (Invirase, Roche), nelfinavir (Viracept, Agouron Pharmaceuticals), ritonavir (Norvir, Abbott), lopinavir, and atazanavir (Reyataz, Bristol ... -Medscape (subscription)



AnnKatrin Petersen, MD Joins MIGENIX as VP Clinical Development  May 1, 2006
Most recently at Pfizer she was responsible for the clinical development of Viracept (nelfinavir mesylate) for the treatment of HIV infection, including filing ... - Yahoo! News

Starting treatment with Kaletra involves greater risk of increased ...  Apr 24, 2006
...taking efavirenz having a 60% reduction in risk compared to Kaletra, with a 70% reduction in risk compared to Kaletra seen for both indinavir and nelfinavir. ... - Aidsmap





Wide variability in drug levels casts doubt on the practicality of ...  Mar 28, 2006
The two taking nelfinavir (Viracept) had ICVs of 30 and 39% for nelfinavir and of 44 and 54% for nelfinavir’s active metabolite M8. ... - Aidsmap

Marijuana Use Does Not Accelerate HIV Infection  Mar 31, 2006
...protease inhibitors. Previously it was shown that short-term marijuana use did not influence nelfinavir metabolism. Although marijuana ... - PakTribune.com

MSF calls for rapid registration of heat-stable Kaletra in low ...  Mar 16, 2006
...version of ritonavir, the protease inhibitor that can be used at a low dose in order to boost levels of all other protease inhibitors apart from nelfinavir. - Aidsmap

New hope for HIV mothers  Mar 8, 2006
Women with CD4 counts of more than 250 are given Combivir and Nelfinavir while those with less than 250 are put on Combivir and Nevirapine. ... - Daily Nation (subscription)



Restoration of CD4 T-cells limited in children starting HIV ...  Mar 2, 2006
...lamivudine, Epivir). The protease inhibitors taken by most children were nelfinavir (Viracept) and ritonavir (Norvir). Although ... - Aidsmap,

US, Brazil Dispute Patent Protection  Feb 24, 2006
...proceedings to issue a compulsory license for the production of three antiretroviral medications: Lopinavir/Ritonavir, Efavirenz, and Nelfinavir, patented by ... - The Heartland Institute,

Gilead Sciences Welcomes Guidance From Nice On Treatment Of ...  Feb 22, 2006
At doses of adefovir dipivoxil from 60 mg to 120 mg, no interactions with zidovudine, nelfinavir, nevirapine, indinavir, efavirenz, delaviridine, or lamivudine ... - Medical News Today,

Impaired Glucose Tolerance Frequent Among HIV-Infected Pregnant ...  Feb 10, 2006
The women in the study were most frequently using nelfinavir and lopinavir/ritonavir as their protease inhibitor; nevirapine was the most frequent non-protease ... - DG News

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Protease Inhibitors (PIs), which include amprenavir (Agenerase), nelfinavir (Viracept), saquinavir (Fortavase), indinavir (Crixivan), ritonavir (Norvir ... - Express Pharma Pulse,

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Protease Inhibitors (PIs), which include amprenavir (Agenerase), nelfinavir (Viracept), saquinavir (Fortavase), indinavir (Crixivan), ritonavir (Norvir ... - Express Pharma Pulse

Adolescents Adherence to HIV Regimens Falls Short of Optimal ...  Feb 7, 2006
...be possible to predict which of these patients was likely to remain faithful to the prescribed regimen -- either an efavirenz or a nelfinavir-based regimen ... - DG News

Roche to share know-how in making protease inhibitors with poorest ...  Jan 13, 2006
...for HIV medicines in least developed countries, which means that no action would be taken against any company that wanted to copy saquinavir or nelfinavir. ... - Aidsmap

Most people given non-occupational PEP fully adhere to their ...  Jan 19, 2006
In 127 cases, triple antiretroviral therapy consisting of AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and nelfinavir (Viracept) was provided, with the ... - Aidsmap

FDA Approves EMEND(R) (aprepitant), in Combination with Other ...  Jan 11, 2006
...of EMEND with strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir) should be approached ... - Business Wire

HIV Drug Resistance Linked to Viral Fitness  Jan 12, 2006
...of data on individual pharmacokinetic differences. Also, there was only one candidate protease inhibitor, Viracept (nelfinavir). - MedPage Today

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