Recent news on Nicotinic

NeuroSearch’s license partner Abbott initiates clinical Phase I ...  -  25 May 2007
PipelineReview.com (press release),ABT-107 is a neuronal nicotinic receptor (NNR) modulator, which has shown promise in preclinical models relevant for the treatment of cognitive deficits.

The Brain And Chronic Exposure To Nicotine  -  May 17, 2007
Science Daily (press release)It acts by binding to nicotinic acetylcholine receptors. These receptors result from the assembly of five subunits; as there are nine different subunits,

World No Tobacco Day is “Critically Importantâ€? for the Middle East  -  May 20, 2007
ArabianBusiness.com,When smokers inhale a lit cigarette, nicotine within seconds reaches the brain and binds to a nicotinic receptor which activates the reward pathway in the

Plant extract may block cannabis addiction  -  May 22, 2007
New Scientist (subscription),Scientists know that MLA binds to specific cell receptors in the brain called alpha-7 nicotinic receptors. They speculate that cannabis indirectly triggers

Guideline Watch (April 2007): Practice Guideline for the Treatment ...  -  May 18, 2007
Focus (subscription)Varenicline is a novel pharmacotherapy that has selective partial agonist activity at neuronal nicotinic acetylcholine receptors (nAChR), specifically the

New cognitive disorder treatment possible  -  May 3, 2007
PhysOrg.com,The three-year animal study showed activating a certain nicotinic receptor in the brain improved working memory and made it easier to filter sensory input.

New Class of Meds for Cognitive Disorders  -  May 3, 2007
PsychCentral.com,The three-year study conducted with rodents supported the anecdotal evidence, showing that activating a certain nicotinic receptor in the brain improved

News tips from the Journal of Neuroscience  -  May 22, 2007
EurekAlert (press release),This week, Solinas et al. focused on α 7 nicotinic receptors as a potential target for treatment of cannabis abuse. Homomeric α 7 receptors are coexpressed

Looking for God in All the Wrong Places  -  May 22, 2007
Reason Online,He gave either psilocybin or nicotinic acid (a placebo with noticeable physical effects) to 20 Protestant divinity students who were participating in a Good

Co-Occurring Mental and Substance Use Disorders: The ...  -  May 18, 2007
Focus (subscription)Opioid analgesic drugs act through a complex system of opioid receptors, and nicotine acts through specific nicotinic receptors distributed throughout the

Memory Pharmaceuticals Reports First Quarter 2007 Financial Results  -  May 10, 2007
Earthtimes.orgIn March 2007, Memory Pharmaceuticals announced that it had dosed the first subject in its Phase 2a trial of MEM 3454, its lead nicotinic alpha-7 receptor

Targacept Invited to Testify at Congressional Hearing on Current ...  -  May 15, 2007
Carolina Newswire (press release),Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic

Interaction of genes, environmental factors predisposes children ...  -  Apr 25, 2007
Washington University Record,..."These same cells also possess the nicotinic receptors that smoking activates, which also increases dopamine." There are 18 diagnostic symptoms that can go

Rodman & Renshaw Global Healthcare Conference 2007 Presenter Profiles  -  May 11, 2007
American Digital Networks (press release),In addition, Xytis has a rich portfolio of preclinical compounds that are highly selective positive allosteric modulators of nicotinic Acetylcholine and

Interaction of genes, environmental factors predisposes children ...  -  26 Apr 2007
Washington University Record,..."These same cells also possess the nicotinic receptors that smoking activates, which also increases dopamine." There are 18 diagnostic symptoms that can go

CoMentis initiates phase 2 trial of topical AMD drug  -  Apr 18, 2007
OSN SuperSite (subscription),The drug, called ATG3, is an antagonist of the nicotinic acetylcholine receptor pathway that mediates angiogenesis. The drug was developed to penetrate into

Memory Pharmaceuticals Commences Phase 2a Trial of MEM 3454 in ...  -  Apr 6, 2007
Drug Newswire (press release),Under the terms of the Company's nicotinic alpha-7 agonist collaboration with Roche, the Company leads the development of MEM 3454 through Phase 2a clinical

Targacept to Report First Quarter 2007 Financial Results on May 9 ...  -  Apr 25, 2007
Genetic Engineering News (press release),Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic

Targacept to Report First Quarter 2007 Financial Results on May 9 ...  -  Apr 25, 2007
Business Wire (press release),Targacept’s product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic

'The Biochemical Basis of Neuropharmacology' a Must for All Who ...  -  Apr 25, 2007
Fuerteventura Digital,...to the brain and the growing recognition of nicotinic receptors in the brain and their possible involvement in Alzheimers and Parkinsons disease.

Australia Comes Into Line With New Zealand On Supplement Ingredients  -  Apr 23, 2007
NPIcenter (press release),Australian permitted levels of Vitamin A will be raised to 10000 International Units and Niacin or Nicotinic Acid (Vit B3) will now be 100 mg to align with

COLLEGE DE FRANCE AND INSTITUT PASTEUR REVEAL KEY DETAILS OF HOW ...  -  Apr 15, 2007
Addiction,In an article published in Neuron (Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors), Jean-Pierre Changeux of CNRS,

CoMentis Initiates Phase II Clinical Trial for AMD Eye Drop Therapy  -  Apr 10, 2007
PipelineReview.com (press release),A proprietary ophthalmic formulation of mecamylamine, ATG3 is an antagonist of the nicotinic acetylcholine (nACh) receptor pathway that mediates

DSM unveils two new products at In Cosmetics  -  Apr 19, 2007
CosmeticsDesign.com,DSM is also launching Niacinamide PC, a niacinamide extract that is claimed to have absolute minimal traces of nicotinic acid - a compound that is widely

Some potential benefits of nicotine  -  Apr 18, 2007
ScienceBlogsThus when a post-synaptic neuron containing these particular receptors (called nicotinic ACh receptors, or nAChRs) is exposed to nicotine (as in when

How hard is it to quit smoking? Smokers agree that quitting would ...  -  Apr 17, 2007
CNW Telbec (Communiqués de presse),It is not a nicotine replacement, rather a specifically designed treatment that targets and partially activates the nicotinic receptors in the brain,

Maize, salt intake increases risk of cancer  -  Apr 17, 2007
Chandigarh Newsline,Also, a marked decrease in nutrients such as magnesium, zinc, nicotinic acid and riboflavin in artificial maize meals as compared to whole maize maybe a

Efforts underway to fight alcoholism among tribals  -  Apr 13, 2007
Indian Catholic,..."Neera contains a number of minerals and salts; acids like ascorbic acid, nicotinic acid and riboflavin; proteins and vitamin C. It has less calorific value

Xytis Enrolls First Patient in Phase II Clinical Study With ...  -  Apr 6, 2007
Drug Newswire (press release),Xytis has a rich portfolio of proprietary preclinical compounds that are novel, highly selective allosteric modulators of nicotinic Acetylcholine Receptors

Alzheimer's Cure  -  Apr 1, 2007
Barron's (subscription)Johnson & Johnson's Razadyne works similarly, but also makes the so-called nicotinic receptors produce more acetylcholine. Namenda, from Forest Labs (FRX),

Ten Keys to Smoking Yourself to Death  -  Apr 2, 2007
WhyQuit (press release),Plug your ears when scientists discuss tolerance and how nicotine has rewired and de-sensitized your brain by causing it to grow millions of extra nicotinic

The Effects of an Indigenous Muscarinic Drug, Betel Nut (Areca ...  -  Apr 2, 2007
Am J Psychiatry (subscription)Booth S, Mielke MM, Hoffman A, McCallum S: Nicotine self-administration in rats: estrus cycle effects, sex differences and nicotinic receptor binding.

Merck and Schering-Plough to Develop Another New Cholesterol ...  -  27 Mar 2007
Genetic Engineering News (press release),Others prefer use of drugs that primarily modify triglycerides and HDL, eg, nicotinic acid or fibrate. Clinical judgment also may call for deferring drug

Memory Pharmaceuticals Commences Phase 2a Trial of MEM 3454 in ...  -  Mar 14, 2007
PharmaLive.com (press release),Under the terms of the Company's nicotinic alpha-7 agonist collaboration with Roche, the Company leads the development of MEM 3454 through Phase 2a clinical

Studies identify DNA regions linked to nicotine dependence - 2007 ...  -  Mar 6, 2007
exduco.net,One gene in particular, the alpha-5 nicotinic cholinergic receptor (CHRNA5) gene, was a very strong indicator of risk for nicotine dependence.

Asset Chemist in Pfizer's New Blockbuster- Aid for giving up smoking  -  Mar 6, 2007
Business Portal 24 (press release),Varenicline is a type of medicine called a nicotinic acetylcholine receptor partial agonist. This means that it acts on the

Seeking next big thing in heart health care  -  Mar 24, 2007
Newark Star Ledger,Only one compound on the market, Niacin or nicotinic acid, one of the B vitamins, has proven effective in raising HDL. But sales so far have been hampered

Targacept to Present at Upcoming Investor Conferences  -  Mar 22, 2007
PharmaLive.com (press release),Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic

Smoking study finds attention deficits  -  Mar 22, 2007
Newsday,Nicotine targets nicotinic acetylcholine receptors in the brain, and during fetal development they are involved with all stages of brain development.

Pfizer's a Sell: Shrinking Top Line, No Blockbusters In the Pipeline  -  Mar 22, 2007
Seeking Alpha,The US launch of Chantix (varenicline), an oral nicotinic partial agonist for smoking cessation, came as expected on August 1, 2006.

Time to Quit Smoking?  -  Mar 18, 2007
WhyQuit (press release),As if that isn't enough, the brain’s physiology fights back by growing millions of extra nicotinic-type acetylcholine receptors in at least eleven different

Effect of Memantine on Cue-Induced Alcohol Craving in Recovering ...  -  Feb 28, 2007
Am J Psychiatry (subscription)Assessing the impact of smoking in this study might have been interesting because memantine blocks 7 subunit-containing nicotinic receptors in addition to

Biotech Day in Review: Critical Therapeutics Climbs on Co ...  -  Mar 15, 2007
Seeking Alpha,Memory Pharma (MEMY) began dosing patients in a Phase IIa trial of MEM 3454, its lead nicotinic alpha-7 receptor partial agonist as a therapy for

Xytis Enrolls First Patient in Phase II Clinical Study With ...  -  Mar 14, 2007
PipelineReview.com (press release),Xytis has a rich portfolio of proprietary preclinical compounds that are novel, highly selective allosteric modulators of nicotinic Acetylcholine Receptors

Pfizer's Chantix  -  Mar 12, 2007
Chicago Flame Online (subscription),In contrast to nicotine replacement therapies (NRTs) such as the trans-dermal patch, nicotine gum, sprays and inhalers, Chantix is a partial nicotinic

Gone Fishin’  -  Mar 9, 2007
Drug Discovery & Development,Some aquatic fungal cell extracts show nicotinic blocker and polysynaptic activities. Very few marine microorganisms are known to produce antiviral

NeuroSearch's license partner Abbott initiates clinical Phase II ...  -  Mar 8, 2007
PipelineReview.com (press release),ABT-894 is a subtype selective modulator of Neuronal Nicotinic Acetylcholine receptors (NNR), which had promising effects in pre-clinical models for pain

Schizophrenia Therapeutics Reviewed by NeuroInvestment  -  Mar 7, 2007
Genetic Engineering News (press release),This includes the most promising biochemical pathways for intervention: including glutamatergic, nicotinic, and 5HT-6 targets. Some of the programs worth

Full Text  -  Feb 22, 2007
Science Magazine (subscription)Nicotinic Acetylcholine Receptors concentrates on the French contribution to knowledge about these neurotransmitter receptors, and it's a good (if,

Understanding Genetic Factors Could Contribute To Better Smoking ...  -  Feb 20, 2007
Medical News Today (press release),One gene in particular, the alpha-5 nicotinic cholinergic receptor (CHRNA5) gene, was a very strong indicator of risk for nicotine dependence.

Memory Pharmaceuticals Reports Fourth Quarter and Full Year 2006 ...  -  Feb 22, 2007
Earthtimes.orgWe also made important progress on the business front by expanding our nicotinic alpha-7 collaboration with Roche, and by strengthening our balance sheet,"

Nicotine Won`t Slow Alzheimer`s  -  Feb 9, 2007
PakTribune.com,..."While it would be premature to leap to the conclusion from this mouse data that nicotinic drugs might make Alzheimer`s disease patients worse,

Targacept to Present at BIO CEO and Investor Conference  -  Feb 5, 2007
Earthtimes.orgTargacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system activity to promote

Targacept Reports Fourth Quarter and 2006 Financial Results  -  Feb 23, 2007
PharmaLive.com (press release),Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic

Successful Tobacco Dependence Treatment in Schizophrenia  -  Jan 31, 2007
Am J Psychiatry (subscription)High nicotine levels may be needed for activation of low-affinity alpha-7 nicotinic receptors, which are reduced in both number and function in

Athenagen Announces Name Change to CoMentis  -  Feb 20, 2007
Market Wire (press release)Athenagen was originally founded in 2004 to develop therapies targeting a novel angiogenic pathway mediated by the non-neuronal nicotinic acetylcholine

Nicotine: The link between cigarette smoking and kidney disease ...  -  Jan 31, 2007
PressZoom (press release),...demonstrates for the first time that human mesangial cells (MC) – cells in the blood vessels of the kidneys – are endowed with nicotinic receptors

Why cigarette warning labels don't always work  -  Feb 14, 2007
Ars Technica,But the strongest linkage was to a single base change in a nicotinic receptor. When people had two copies of this change, they were over two-fold more

Organization of ß-adrenoceptor signaling compartments by ...  -  Feb 12, 2007
Journal of Cell Biology (subscription)Abbreviations used in this paper: AR, adrenergic receptor; GPCR, G protein–coupled receptor; KO, knockout; nAChR, nicotinic acetylcholine receptor; SGN,

Lowering LDL Cholesterol -- Beyond Statins  -  Feb 5, 2007
Medscape (subscription)A number of other therapeutic options are available for combination therapy with a statin, such as ezetimibe, nicotinic acid, fibrates, and bile acid

2006 drug approvals: finding the niche  -  Feb 1, 2007
Nature.com (subscription),For Pfizer, highlights include the approval of Chantix (varenicline), a nicotinic acetylcholine receptor partial agonist approved for smoking cessation,

Targacept to Expand Facilities at Piedmont Triad Research Park  -  Jan 31, 2007
dBusinessNews Triad (press release),Targacept’s product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system activity to promote

Nicotine: The Link Between Cigarette Smoking And Kidney Disease ...  -  Jan 31, 2007
Medical News Today (press release),...demonstrates for the first time that human mesangial cells (MC) - cells in the blood vessels of the kidneys - are endowed with nicotinic receptors

Athenagen's Eye Drop Therapy for AMD Is Safe and Well Tolerated in ...  -  Jan 31, 2007
Genetic Engineering News (press release),ATG3, a proprietary ophthalmic formulation of mecamylamine, is an antagonist of the nicotinic acetylcholine (nACh) receptor pathway that mediates

Critical Therapeutics Licenses Rights for Vagus Nerve Stimulation ...  -  Jan 30, 2007
Genetic Engineering News (press release),...invest in the device opportunity may provide valuable insights into this pathway that can be leveraged in our alpha-7 nicotinic receptor program.

Researchers confirm link between smoking and kidney disease ...  -  Jan 30, 2007
DailyIndia.com,...vessels of the kidneys - are endowed with tobacco-related nicotinic receptors, which might play an active role in promoting certain kidney diseases.

Researchers confirm link between smoking and kidney disease ...  -  Jan 30, 2007
South Asian Women's Forum,...vessels of the kidneys – are endowed with tobacco-related nicotinic receptors, which might play an active role in promoting certain kidney diseases.

Targacept studies new anti-depression drug  -  Jan 9, 2007
Washington Business Journal,Like other drug compounds discovered by Targacept, TC-2216 works on a specific neuronal nicotinic receptor in the central nervous system.

Targacept Launches Trial of Depression, Anxiety Treatment  -  Jan 9, 2007
Local Tech Wire,Targacept is developing a series of drugs that target neuronal nicotinic receptors in the central nervous system. "Depression is a highly debilitating

Targacept Begins Phase II Clinical Trial in Acute Post-Operative Pain  -  Dec 20, 2006
PipelineReview.com (press release),TC-2696, a novel compound discovered using Targacept’s proprietary drug design platform known as Pentad™, modulates specific neuronal nicotinic receptors

Targacept Initiates Phase I Clinical Trial of TC-2216  -  Jan 9, 2007
Drug Newswire (press release),The compound targets specific neuronal nicotinic receptors (NNRs), a class of receptors found in the central nervous system that play a critical role in

Maize, salt increase risk of oesophageal cancer  -  Jan 11, 2007
Chandigarh Newsline,Secondly, a marked decrease in nutrients such as magnesium, zinc, nicotinic acid and riboflavin in commercial maize meals as compared to whole maize is also

Xytis Begins Phase II Clinical Study With Anatibant (XY2405) For ...  -  Jan 10, 2007
PipelineReview.com (press release),Xytis has a rich portfolio of proprietary preclinical compounds that are novel, highly selective allosteric modulators of nicotinic Acetylcholine Receptors

Xytis Pharmaceuticals Names Dr. Vincent F. Simmon President, Chief ...  -  Jan 7, 2007
Drug Newswire (press release),In addition, Xytis has a rich portfolio of proprietary preclinical compounds that are novel, highly selective allosteric modulators of nicotinic

TARGACEPT TO RECEIVE $20 MILLION MILESTONE PAYMENT AS ASTRAZENECA ...  -  Jan 1, 2007
dBusinessNews Triad (press release),Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system activity to promote

Pharma Sector: Few Newsmakers Of The Week - Eli Lilly, Bristol ...  -  Dec 29, 2006
Trading Markets,The four-year research collaboration signed in December 2005, also allows for the development of other compounds that act on neuronal nicotinic receptors.

Progress In Fight Against Alzheimer's Has Special Meaning For ...  -  Dec 29, 2006
Local Tech Wire,The company focuses on so-called neuronal nicotinic receptors (NNRs) that are part of the central nervous system. “It’s really given us an outstanding

Targacept Gets $20M as AstraZeneca Continues with Alzheimer’s ...  -  Dec 27, 2006
Genetic Engineering News (press release),AstraZeneca conducted additional safety and product characterization studies of AZD3480, a neuronal nicotinic receptor (NNR) agonist.

AstraZeneca Decides To Proceed With Targacept In Developing ...  -  Dec 27, 2006
Local Tech Wire,Targacept’s research is centered on use of neuronal nicotinic receptors, or NNR. The company is a spin-off of RJR. "AstraZeneca is committed to developing

New Discovery Opens Door For Drugs For Alcohol Addiction  -  Dec 23, 2006
Medical News Today (press release),...the sleep-inducing effects of alcohol. Title of dissertation: Conditional and non-conditional reward-related responses to alcohol-nicotinic mechanisms.

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),Others prefer use of drugs that primarily modify triglycerides and HDL, eg, nicotinic acid or fibrate. Clinical judgment also may call for deferring drug

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