Recent news on Perphenazine

BioLineRx unveils 'innovative' antipsychotic drug  -  May 21, 2007
DrugResearcher.com,The drug is a conjugate of perphenazine, and older drug for schizophrenia, and GABA itself. To date, the development of GABA as a standalone therapy has

Antidepressants linked to suicide risk in young adults  -  May 5, 2007
Food Consumer,Effexor (venlafaxine HCl), Emsam (selegiline), Etrafon (perphenazine/amitriptyline), fluvoxamine maleate, Lexapro (escitalopram hydrobromide),

Chinese herbal medicine for schizophrenia Cochrane systematic ...  -  Apr 30, 2007
British Journal of Psychiatry (subscription),2(c)) also favoured the herbal medicine plus antipsychotic combination: Luo et al (1997), antipsychotics clozapine, chlorpromazine, sulpiride, perphenazine

No good drug for treating schizophrenia  -  Apr 23, 2007
The Brunei Times,They looked at 114 patients who had quit taking the older drug perphenazine and who had been randomly assigned to take one of the newer drugs.

Dr. Rosenheck and Colleagues Reply  -  Apr 2, 2007
Am J Psychiatry (subscription)While almost everyone in CATIE who switched from perphenazine took second-generation antipsychotics, this was determined by the protocol.

Cost-Effectiveness of Schizophrenia Pharmacotherapy  -  Apr 2, 2007
Am J Psychiatry (subscription)However, their abstract—which is all many busy policymakers will ever read—states that perphenazine treatment "was less costly than treatment with

Patients Diagnosed Schizophrenic and Bipolar To Boost Seroquel Sales  -  Apr 11, 2007
Lawyers and Settlements,By comparison, the cost of perphenazine was $50 a month, and Zyprexa was $545. But the results of this $40-odd million dollar tax payer funded study is not

Neurological Soft Signs in Schizophrenia Patients With Obsessive ...  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)...quetiapine (three and two patients), clozapine (14 and eight patients), haloperidol (nine and 11 patients), and perphenazine (six and six patients).

Agitation in the Elderly  -  Feb 16, 2007
Psychiatric Times,...a traditional major tranquilizer such as haloperidol (Haldol), thioridazine (Mellaril), thiothixene (Navane) or perphenazine (Etrafon, Trilafon).

Regulatory policies on medicines for psychiatric disorders: is ...  -  Jan 31, 2007
British Journal of Psychiatry (subscription),This study, which randomly assigned a total of 1493 patients with schizophrenia to receive olanzapine, perphenazine, quetiapine or risperidone for up to 18

The New Year in Psychiatry  -  18 Jan 2007
Psychiatric Times,CATIE was a prospective randomized trial that compared Trilafon (perphenazine), an older antipsychotic drug, with four second-generation antipsychotics in

Courthouse records  -  18 Jan 2007
Worcester Telegram,...fined $50, $50 victim witness fee; malicious destruction of property over $250, disturbing the peace, and possession of perphenazine, dismissed.

January 2007 Clinical Briefs  -  Dec 29, 2006
U.S. Medicine,In addition, the researchers found no statistically significant difference in overall effectiveness between perphenazine and the second generation

Public Has Right To Know Zyprexa Secrets  -  Jan 14, 2007
Scoop.co.nz (press release),..."The 40-year-old drug perphenazine costs less than $1.50 a day," Bloomberg wrote, "while the newer medicines can cost 10 times as much."

Battle over drugs hits crescendo  -  Dec 22, 2006
Austin American-Statesman (subscription),It concluded that an older, less expensive drug called perphenazine performed as well in treating schizophrenia as Risperdal and three other newer drugs.

Cost-Effectiveness of Second-Generation Antipsychotics and ...  -  Dec 6, 2006
Am J Psychiatry (subscription)Patients with tardive dyskinesia were prohibited from assignment to perphenazine. Patients could be reassigned at any time to another second-generation drug

The Costs of Drugs for Schizophrenia  -  Dec 6, 2006
Am J Psychiatry (subscription)...("Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine in a Randomized Trial of Treatment for Chronic Schizophrenia") summarizes the

Older Medication May Be More Cost-effective For Some Patients With ...  -  Dec 6, 2006
Medical News Today (press release),In addition, the researchers found no statistically significant difference in overall effectiveness between perphenazine and the second generation

Latest Round of CATIE Data Sparks Many Questions  -  Dec 1, 2006
Psychiatric News,Patients who had tardive dyskinesia (TD) at baseline were prevented from assignment to perphenazine, which was thought at the time the study was designed to

Older Drug May be More Cost-effective for Some Patients with ...  -  Dec 4, 2006
Kansas City infoZine,..."The results from CATIE should encourage doctors to reconsider the use of perphenazine as another choice for patients with schizophrenia," said NIMH

Lilly Responds to the Cost-Effectiveness Analysis of the CATIE ...  -  Dec 3, 2006
Drug Newswire (press release),According to the CATIE CEA, perphenazine, a first-generation typical, was found to be the most cost-effective treatment when used in modest doses in the

Older Schizophrenia Drug Called More Cost-Effective Than Newer Ones  -  Dec 1, 2006
Psychiatric Times,Explain to patients who ask that this study suggests that one of the so-called typical anti-psychotics, Trilafon (perphenazine), is more cost-effective than

Schizophrenia Treatment With Older, Generic Antipsychotics Cheaper ...  -  Dec 5, 2006
Medical News Today (press release),The study found that the average monthly cost of treatment with perphenazine was $960, including the $50 cost of the medication. In comparison, the average

Cost Benefits of New Schizophrenia Drugs Doubted  -  Nov 30, 2006
Washington Post,..."You are saying perphenazine is $500 cheaper," said the doctor, who spoke on condition of anonymity because of the sensitivity of the issue , to explain why

Interpreting the Results of the CATIE Study  -  Dec 6, 2006
Focus (subscription)The lack of difference between the new second-generation antipsychotics and perphenazine surprised Dr. Ragins. It also surprised us.

Older schizophrenia drugs cheaper and work just as well  -  Dec 4, 2006
News-Medical.net,In a study funded by the National Institutes of Health in the USA the first generation antipsychotic drug perphenazine proved to be less expensive and just

Drugmakers highlight limits of CATIE study  -  Dec 4, 2006
Pharma Times (subscription),...hospitalisation and social services, were about 40%-50% higher for patients who received second-generation antipsychotics compared to those on perphenazine.

Older schizophrenia drug works, costs less - study  -  Dec 1, 2006
Malaysia Star,The American Journal of Psychiatry study concluded that the older, first-generation antipsychotic drug perphenazine was less expensive and as effective as

New Study Supports Older Schizophrenia Drugs, Mirrors...  -  Dec 1, 2006
U.S. Newswire (press release),The study finds that people taking an older generic drug - perphenazine - fared just as well at a cost of $300 to $600 a month less than those taking newer

Effectiveness of Switching Antipsychotic Medications  -  Dec 6, 2006
Am J Psychiatry (subscription)Comparisons of ziprasidone with perphenazine excluded tardive dyskinesia patients. We used Kaplan-Meier survival curves to estimate the time to

600 a Month More—But Not Better  -  Dec 1, 2006
U.S. News & World Report,...including olanzapine, quietapine, risperidone, and ziprasidone, work better and cause fewer side effects than older drugs such as perphenazine–and more

Older schizophrenia drug as effective as new ones  -  Dec 1, 2006
San Diego Union Tribune,The American Journal of Psychiatry study concluded that the older, first-generation antipsychotic drug perphenazine was less expensive and no less effective

Zyprexa oversold by Eli Lilly  -  Dec 1, 2006
ProgressiveU.org,The older anti-psychotic drug, Trilafon (perphenazine), is significantly cheaper and no less effective than four newer medications for the treatment of

Drug Continuity May Aid In Better Treatment Outcomes  -  Dec 15, 2006
Psychiatric News,Less than 5 percent of patients randomly assigned by the study to take perphenazine or ziprasidone were taking those drugs prior to entering the study.

Battle over drugs hits crescendo  -  Dec 22, 2006
Austin American-Statesman (subscription),It concluded that an older, less expensive drug called perphenazine performed as well in treating schizophrenia as Risperdal and three other newer drugs.

Antipsychotic Use and Expenditure in the United States  -  Dec 7, 2006
Psychiatric Services (subscription)...risperidone, quetiapine, and ziprasidone) and a first-generation agent (perphenazine) were comparably effective for patients with schizophrenia (2).

New Anti-Psychotic Drugs Not Worth the Cost?  -  Dec 6, 2006
PsychCentral.com,...perphenazine, was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment.

Pfizer`s loss AstraZeneca`s gain  -  Dec 4, 2006
Monsters and Critics.com,The CATIE study released last week found the older anti-psychotic perphenazine was less expensive but just as effective as newer medications,

Old Schizophrenia Drugs Again Perform Well  -  Dec 1, 2006
TheStreet.comHowever, this study, like other chapters in the series, points to limitations in comparing newer drugs with the older, generic perphenazine.

Switching Drugs No Panacea in Schizophrenia  -  Dec 1, 2006
Psychiatric Times,The finding came from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial, which compared Trilafon (perphenazine) with four

Essential Blepharospasm Responding to Haloperidol  -  Nov 29, 2006
Journal of Neuropsychiatry (subscription)There are many reports that show that blepharoclonus/Meige syndrome responds to clonazepam, 11 clozapine, 12 trihexyphenidyl, perphenazine, fluphenazine 10

California investigates anti-psychotics  Nov 3, 2006
In another government-funded study, an older anti-psychotic called perphenazine was found to have similar effectiveness to three newer ones: Risperdal ... -Life Style Extra, Limbaugh "Just Acting" Instead of Taking Medication, Say Experts  Oct 25, 2006
..."People on drugs like perphenazine are calmer and, according to all known clinical trials, experience fewer symptoms of paranoia and grandiosity.". ... -Brainsnap (satire), Little Benefit Seen in Antipsychotics Used in Alzheimer's  Oct 11, 2006
Another government-funded study recently showed that the drugs were no better than an older and much cheaper drug called perphenazine in the treatment of ... -Washington Post, Anti-psychotic-drug study jolts conventional wisdom  Oct 14, 2006
...effects. Last year, the US government trial found that an older drug called perphenazine did about as well as the newer medications. ... -AZ Central.com, Anti-dementia treatments fall short in study  Oct 12, 2006
Another government-funded study recently showed that the drugs were no better than the older and much cheaper drug perphenazine for treating schizophrenia. ... -Carlsbad Current Argus, Antipsychotics Effective and Safe in Patients With Chronic ...  Sep 20, 2006
The intermediate potency first-generation antipsychotics, like perphenazine (and potentially loxapine, molindone and thiothizene) appear comparably effective ... -DG News

Mirtazapine for Severe Gastroparesis Unresponsive to Conventional ...  Sep 7, 2006
...patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and ... -Psychosomatics (subscription)

Big Pharma Bankrupting US Health Care System  Aug 31, 2006
...study conducted by the National Institute of Mental Health compared four new generation antipsychotics against an older medication, perphenazine and only one ... -OpEdNews

Cost-Effectiveness of Second-Generation Antipsychotics and ...  -  12 Dec 2006
Am J Psychiatry (subscription)Patients with tardive dyskinesia were prohibited from assignment to perphenazine. Patients could be reassigned at any time to another second-generation drug

The Costs of Drugs for Schizophrenia  -  Dec 6, 2006
Am J Psychiatry (subscription)...("Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine in a Randomized Trial of Treatment for Chronic Schizophrenia") summarizes the

Older Medication May Be More Cost-effective For Some Patients With ...  -  Dec 6, 2006
Medical News Today (press release),In addition, the researchers found no statistically significant difference in overall effectiveness between perphenazine and the second generation

Older Drug May be More Cost-effective for Some Patients with ...  -  Dec 4, 2006
Kansas City infoZine,..."The results from CATIE should encourage doctors to reconsider the use of perphenazine as another choice for patients with schizophrenia," said NIMH

Lilly Responds to the Cost-Effectiveness Analysis of the CATIE ...  -  Dec 3, 2006
Drug Newswire (press release),According to the CATIE CEA, perphenazine, a first-generation typical, was found to be the most cost-effective treatment when used in modest doses in the

Latest Round of CATIE Data Sparks Many Questions  -  Dec 1, 2006
Psychiatric News,Patients who had tardive dyskinesia (TD) at baseline were prevented from assignment to perphenazine, which was thought at the time the study was designed to

Interpreting the Results of the CATIE Study  -  Dec 6, 2006
Focus (subscription)The lack of difference between the new second-generation antipsychotics and perphenazine surprised Dr. Ragins. It also surprised us.

Schizophrenia Treatment With Older, Generic Antipsychotics Cheaper ...  -  Dec 5, 2006
Medical News Today (press release),The study found that the average monthly cost of treatment with perphenazine was $960, including the $50 cost of the medication. In comparison, the average

Older schizophrenia drugs cheaper and work just as well  -  Dec 4, 2006
News-Medical.net,In a study funded by the National Institutes of Health in the USA the first generation antipsychotic drug perphenazine proved to be less expensive and just

Older Schizophrenia Drug Called More Cost-Effective Than Newer Ones  -  Dec 1, 2006
Psychiatric Times,Explain to patients who ask that this study suggests that one of the so-called typical anti-psychotics, Trilafon (perphenazine), is more cost-effective than

Drugmakers highlight limits of CATIE study  -  Dec 4, 2006
Pharma Times (subscription),...hospitalisation and social services, were about 40%-50% higher for patients who received second-generation antipsychotics compared to those on perphenazine.

Older Antipsychotic Drugs As Effective As Newer Ones  -  Nov 19, 2006
HealthNewsDigest.com,In particular, the report chooses generic perphenazine as a Best Buy and recommends that doctors consider prescribing it for newly diagnosed patients and

Effectiveness of Switching Antipsychotic Medications  -  Dec 6, 2006
Am J Psychiatry (subscription)Comparisons of ziprasidone with perphenazine excluded tardive dyskinesia patients. We used Kaplan-Meier survival curves to estimate the time to

New Study Supports Older Schizophrenia Drugs, Mirrors...  -  Dec 1, 2006
U.S. Newswire (press release),The study finds that people taking an older generic drug - perphenazine - fared just as well at a cost of $300 to $600 a month less than those taking newer

600 a Month More—But Not Better  -  Dec 1, 2006
U.S. News & World Report,...including olanzapine, quietapine, risperidone, and ziprasidone, work better and cause fewer side effects than older drugs such as perphenazine–and more

Older schizophrenia drug as effective as new ones  -  Dec 1, 2006
San Diego Union Tribune,The American Journal of Psychiatry study concluded that the older, first-generation antipsychotic drug perphenazine was less expensive and no less effective

Zyprexa oversold by Eli Lilly  -  Dec 1, 2006
ProgressiveU.org,The older anti-psychotic drug, Trilafon (perphenazine), is significantly cheaper and no less effective than four newer medications for the treatment of

Antipsychotic Use and Expenditure in the United States  -  Dec 7, 2006
Psychiatric Services (subscription)...risperidone, quetiapine, and ziprasidone) and a first-generation agent (perphenazine) were comparably effective for patients with schizophrenia (2).

New Anti-Psychotic Drugs Not Worth the Cost?  -  Dec 6, 2006
PsychCentral.com,...perphenazine, was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment.

Pfizer`s loss AstraZeneca`s gain  -  Dec 4, 2006
Monsters and Critics.com,The CATIE study released last week found the older anti-psychotic perphenazine was less expensive but just as effective as newer medications,

Old Schizophrenia Drugs Again Perform Well  -  Dec 1, 2006
TheStreet.comHowever, this study, like other chapters in the series, points to limitations in comparing newer drugs with the older, generic perphenazine.

Switching Drugs No Panacea in Schizophrenia  -  Dec 1, 2006
Psychiatric Times,The finding came from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial, which compared Trilafon (perphenazine) with four

Essential Blepharospasm Responding to Haloperidol  -  Nov 29, 2006
Journal of Neuropsychiatry (subscription)There are many reports that show that blepharoclonus/Meige syndrome responds to clonazepam, 11 clozapine, 12 trihexyphenidyl, perphenazine, fluphenazine 10

USPSYCH: Newer Antipsychotics Not Always Better  -  Nov 22, 2006
Psychiatric Times,Triavil (perphenazine) at 8 to 32 mg per day, Seroquel (quetiapine) at 200 to 800 mg per day, Risperdal (risperidone) at 1.5 to 6 mg per day,

New Biologic Tools in Psychiatry  Aug 23, 2006
...and contributes to the metabolism of many psychotropic drugs, including antipsychotics (haloperidol, thioridazine, perphenazine, chlorpromazine, risperidone, 7 ... -Psychiatric Times

Tardive Dyskinesia Circa 2006  Jul 28, 2006
...dyskinesia at baseline (231 subjects) were not eligible to be randomly assigned to the conventional, or "typical," medication (perphenazine) included in the ... -Am J Psychiatry (subscription)

The Biology of Schizophrenia  Jul 10, 2006
...patients with schizophrenia (not first episode or treatment resistant) to olanzapine, quetiapine, risperidone, ziprasidone, or the typical agent perphenazine. ... -Medscape (subscription)

Health Tip: Understanding Schizophrenia: Usually can be controlled  Jul 12, 2006
Besides therapy and rehabilitation, antipsychotic drugs such as chlorpromazine, fluphenazine, haloperidol, thiothixene, perphenazine, risperidone, or clozapine ... -CBC News



The CATIE Study  Mar 10, 2006
Perphenazine use reached its manufacturer’s suggested maximum for hospitalized patients, 32 mg/day, but not the absolute safe limit of 64 mg/day ... - Am J Psychiatry (subscription)

Practical Treatment Information for Schizophrenia  Apr 3, 2006
Some have pointed out that older drugs like perphenazine, with their lower costs, may now once again become rational first-line therapies. ... - Am J Psychiatry (subscription)

Older Drug Is Best for Schizophrenia  Apr 1, 2006
...olanzapine (trade-named Zyprexa), quetiapine (Seroquel), risperidone (Risperdal) or ziprasidone (Geodon) — or to receive an older drug, perphenazine. ... - Los Angeles Times

BIJU BASIL, MD , MAJU MATHEWS, MD, MRCPsych. , BABATUNDE ADETUNJI ...  Mar 10, 2006
...there. The cost of "typical" antipsychotics (haloperidol and perphenazine) is just a fraction of that of atypical antipsychotics. ... - Am J Psychiatry (subscription)



Dr. Lieberman and Colleagues Reply  Mar 2, 2006
Although the patients with tardive dyskinesia could not be randomly assigned to perphenazine, in all analyses of outcomes, the patients with tardive dyskinesia ... - Am J Psychiatry (subscription)

CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment  Jan 12, 2006
...olanzapine [Zyprexa], quetiapine [Seroquel], risperidone [Risperdal] and ziprasidone [Geodon]) and one first-generation antipsychotic, perphenazine (Trilafon). ... - Psychiatric Times

We need more studies like CATIE - says Principal Investigator  Jan 11, 2006
...olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), and ziprasidone (Geodon); or to the older, 'typical' medication, perphenazine (Trilafon). ... - Pharma Times (subscription)

Brief Reports: Patterns of Psychotropic Medication Use by Race ...  Jan 25, 2006
First-generation antipsychotics included chlorpromazine, fluphenazine, mesoridazine, thiothixene, perphenazine, thioridazine, trifluoperazine, haloperidol ... - Psychiatric Services (subscription)

Interpreting the Results of the CATIE Study  Jan 7, 2006
The lack of difference between the new second-generation antipsychot-ics and perphenazine surprised Dr. Ragins. It also surprised us. ... - Psychiatric Services (subscription)

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