Recent news on Phenylalanine

BioMarin Submits New Drug Application for US Marketing ...  -  25 May 2007
PR Newswire (press release),PKU, a genetic disorder affecting approximately 50000 diagnosed patients in the developed world, is caused by a deficiency of the enzyme phenylalanine

Full Text  -  25 May 2007
Science Magazine (subscription)The presence of a phenylalanine in place of the tyrosine residue in R2 that normally harbors the essential initiating Y was revealed first by sequence

Medarex Announces the Appointment of Mr. Howard H. Pien as ...  -  May 18, 2007
Financial News USA (press release),Kuvan is a candidate to treat phenylketonuria, or PKU, an inherited disease that leaves patients unable to process a protein called phenylalanine.

Mette M Berger , Christophe Binnert , René L Chiolero , William ...  -  May 8, 2007
Am J Clin Nutr (subscription),On day 10, [ 13 C]phenylalanine (600-µg/kg bolus followed by 12 µg · kg –1 · min –1 ) plus 6-[ 2 H 2 ]glucose and [ 2 H 5 ]glycerol were infused for 6 h to

PKU affects one in 10000 -- two are in this area  -  May 16, 2007
Gateway Newspapers,They also order a special infant formula that will be used throughout life as a protein source that is low in phenylalanine.

Sweet addictions in the new millennium  -  May 21, 2007
Rio Rancho Observer,...triple molecule combination of aspartic acid (a major neurotoxin - MSG is 99% aspartic acid), phenylalanine (an amino acid necessary for brain function,

Allergy, intolerance: which is it?  -  May 21, 2007
Health24.com,This is a reaction to all foods containing phenylalanine, which can lead to mental retardation if not identified at an early stage.

Protein Sequences Converted Into Classical Music By UCLA Molecular ...  -  May 21, 2007
Medical News Today (press release),For example, the amino acids tyrosine and phenylalanine are both assigned aG major chord, but they can be distinguished because the notes in the chord are

BioMarin Seeks  -  May 15, 2007
Wall Street JournalPKU is a genetic disorder in which the body can't process part of a protein called phenylalanine, also known as Phe, according to the National Institutes of

Music of the genes  -  May 4, 2007
MSNBCTakahashi added some extra twists: For example, similar amino acids are represented by the same chord - say, G-major for tyrosine and phenylalanine - but

FDA allows inspectors to detain any vegetable-protein imports from ...  -  May 1, 2007
Associated Content,Those 10 amino acids that the body cannot produce are: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, and Valine.

Overwhelming Scientific Evidence Confirms Aspartame Safety  -  Apr 23, 2007
Newswise (press release)Aspartame is composed of two amino acids, aspartic acid and phenylalanine, as the methyl ester. Amino acids are the building blocks of protein.

Everything starts with recognition  -  Apr 23, 2007
PhysOrg.com,An STM image of individual L and D Di-phenylalanine molecules adsorbed onto Cu (110). A human body has more than one thousand trillion trillion molecules

Rare metabolic disease requires costly diet  -  Apr 10, 2007
The News Journal,People with PKU are missing a key enzyme called phenylalanine hydroxylase that is needed to break down the essential amino acid phenylalanine,

Artificial sweetener accused of causing many illnesses  -  Apr 9, 2007
DetNews.com,They must avoid the amino acid phenylalanine in all foods. Aspartame metabolism does produce phenylalanine, so it is off-limits to these individuals.

Genetic Mutations Work Differently in Research Monkeys  -  Apr 13, 2007
Wired NewsAbout one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can't process a protein found in most foods called phenylalanine.

Care for Some Chemicals with Your Cafe Latte?  -  Apr 10, 2007
American Digital Networks (press release),...sweet has been either sugar - high in calories and glycemic index - or artificial sweeteners that include chlorine, phenylalanine or aspartic acid.

Meet the Monkey Cousins  -  Apr 12, 2007
ScienceBlogsHealthy people, for example, convert a chemical called phenylalanine into another one called tyrosine in the process of building proteins.

Everything starts with Recognition  -  Apr 24, 2007
Nanowerk LLC,An STM image of individual L and D Di-phenylalanine molecules adsorbed onto Cu (110). A human body has more than one thousand trillion trillion molecules

Closer to Physiology  -  Apr 9, 2007
Genomics & Proteomics,PKU is caused by the deletion of the gene for phenylalanine hydrolase, an enzyme necessary for the normal conversion of phenylalanine to tyrosine,

Macaque genome is decoded  -  Apr 13, 2007
Los Angeles Times,...for example, is born with a mutated gene that causes phenylketonuria, the inability to metabolize an amino acid called phenylalanine common in food.

Macaque DNA unraveled will aid in human studies  -  Apr 13, 2007
Worcester Telegram,...•About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can’t process a protein found in most foods called phenylalanine.

Scientists map DNA of research monkeys  -  Apr 12, 2007
Seattle Post Intelligencer,...-About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can't process a protein found in most foods called phenylalanine.

monkey’s genetic code deciphered  -  Apr 12, 2007
MSNBCAbout one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can’t process a protein found in most foods called phenylalanine.

Scientists Map DNA of Research Monkeys  -  Apr 13, 2007
Wyoming News,..._About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can't process a protein found in most foods called phenylalanine.

Scientists decode rhesus macaque DNA  -  Apr 12, 2007
Long Beach Press-Telegram,One in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can't process a protein found in most foods called phenylalanine.

Monkey gene map may improve drug testing, shed light on human biology  -  Apr 12, 2007
North County Times,...--About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can't process a protein found in most foods called phenylalanine.

Scientists Map DNA of Research Monkeys  -  Apr 12, 2007
KSTP.com,..._About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can’t process a protein found in most foods called phenylalanine.

Scientists map DNA of research monkeys  -  Apr 12, 2007
Chandler News-Dispatch,..._About one in 14000 babies is born with PKU, or phenylketonuria, meaning their bodies can‘t process a protein found in most foods called phenylalanine.

LOCAL LINKS  -  Apr 12, 2007
Bradenton Herald,STAPAD benefits individuals with metabolic disorders that prevent them from processing phenylalanine, an amino acid present in most foods.

Full Text  -  Apr 12, 2007
Science Magazine (subscription)For example, about 1 in 15000 people have phenylketonuria because their gene for an enzyme needed to process the amino acid phenylalanine is defective.

Super fat burner! Instant results! Lose 10 pounds fast  -  Apr 4, 2007
Danbury News Times,Phenylalanine is a common additive to on-the-market, just-add-milk or water shakes, which are often used as a meal-replacement for fitness followers.

Tiger should impress once again at Augusta National  -  Mar 29, 2007
Bradenton Herald,STAPAD is a non-profit organization that helps enrich the lives of individuals with metabolic disorders that prevent them from processing phenylalanine,

Hormones key to dropping excess weight  -  Mar 28, 2007
Rocklin and Roseville Today,...to poor disassembly of proteins, and a deficiency of available amino acids such as phenylalanine or tyrosine, necessary for production of epinephrine.

HYPP: getting to grips with Hyperkalemic Periodic Paralysis  -  Mar 28, 2007
Horsetalk,HYPP results from a point mutation that causes a phenylalanine/leucine substitution in a key part of the voltage-dependent skeletal muscle sodium channel

Essential role of protein kinase C in transducing a motility ...  -  27 Mar 2007
Journal of Cell Biology (subscription)We also disclose that motility of hPMs and J774.1 induced by a chemotactic peptide (N-formyl-methionyl-leucyl-phenylalanine [fMLP]) was inhibited by

Full Text  -  Mar 22, 2007
Science Magazine (subscription)...domains: coiled-coils, - helical solenoids, ß propellers, and natively unfolded segments containing phenylalanine-glycine repeats (FG repeats) (6).

The Perils of Too Much Sugar  -  Mar 6, 2007
Mother Earth News,High levels of the amino acid phenylalanine found in aspartame can cause brain damage in people with a genetic disease called phenylketonuria (PKU) and

Paddle your own canoe  -  Mar 19, 2007
separationsNOW.com (subscription),Then they demonstrated the real benefit of GEMBE by using it to separate five amino acids: tryptophan; phenylalanine; serine; glycine; and aspartic acid.

Dr. Collins: Good sleep critical to safety when undertaking ...  -  Mar 14, 2007
Fort Wayne News Sentinel,Eating foods with the amino acids tyrosine and phenylalanine can help with the body's production of adrenaline and dopamine. These control many functions,

Oral strip for generic Zofran  -  Mar 5, 2007
In-PharmaTechnologist.com,...the product suitable for patients suffering from phenylketonuria and unable to metabolise phenylalanine, one of the amino acids present in aspartame.

Care for Some Chemicals with Your Cafe Latte?  -  Feb 26, 2007
Business Wire (press release),...sweet has been either sugar – high in calories and glycemic index – or artificial sweeteners that include chlorine, phenylalanine or aspartic acid.

Cell-cell adhesion in lung endothelium  -  Mar 6, 2007
AJP-Lung Physiology (subscription)Mutation of Tyr685 to phenylalanine blocked Csk binding and prevented contact inhibition of cell proliferation. Overexpression of Csk limited cell

Buckyballs Ferry Drugs into Cancer Cells Safely  -  Feb 8, 2007
Nanotechwire.com,The new buckyballs, known as bucky amino acids, are made of a buckyball linked to the amino acid phenylalanine and were designed to mimic viruses capable of

Bill banning use of Aspartame submitted to Legislature  -  Jan 26, 2007
Bizjournals.com,Elements of the sweetening agent that have been cited in the bill as a concern include phenylalanine, aspartic acid, methanol, formaldehyde, and formic acid

Zacks Analyst Blog Highlights: Home Depot, Lowe’s, Gilead Sciences ...  -  Feb 22, 2007
Business Wire (press release),Ambrisentan should become the best-in-class ETRA [endothelin receptor antagonist] for PAH [phenylalanine hydroxylase], and given the lack of drug-drug

Two New Studies on Aspartame and Diet Drinks Confirm Source of ...  -  Feb 16, 2007
Asianjournal.com,...that the amount of toxic phenylalanine reaching the baby is twice as high as that in the mother's blood because the placenta concentrates the toxin.

Chocolate, A Delicious Way To Celebrate Valentine  -  Feb 13, 2007
Daily Graphic,Rather, eating chocolate has been found to induce feelings of happiness as it contains the substance phenylalanine, which is virtually identical to the

Freedom of expression. Focus on "Endoplasmic reticulum stress and ...  -  Feb 12, 2007
AJP - Cell Physiology (subscription)Deletion of the codon for phenylalanine-508 ( F508) accounts for 70% of all disease-causing alleles (12) and yields a protein that is unable to exit from

Enzymes and allergies  -  Feb 12, 2007
Health24.com,...who are unable to metabolise the branched chain amino acids or phenylketonuria patients who cannot metabolise an amino acid called phenylalanine).

Mariëlle PKJ Engelen , Erica PA Rutten , Carmen LN De Castro ...  -  Feb 6, 2007
Am J Clin Nutr (subscription),Simultaneous continuous intravenous infusion of L-[ring- 2 H 5 ]phenylalanine (Phe) and L-[ring- 2 H 2 ]tyrosine tracers was done postabsorptively and at 2

Response of albumin synthesis to oral nutrients in young and ...  -  Feb 6, 2007
Am J Clin Nutr (subscription),Design: Albumin synthesis was determined from the incorporation of 43 mg L-[ 2 H 5 ]phenylalanine/kg body wt. Eight elderly subjects (aged >60 y) and 8

Family tradition  -  Feb 2, 2007
Mail Tribune,PKU individuals do not have an enzyme in their liver that breaks down phenylalanine, an amino acid that is prevalent in red meat, poultry, fish, wheat,

JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic ...  -  Jan 31, 2007
New England Journal of Medicine (subscription),Background The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK) 2 gene (JAK2),

Lighten Up: Chef Emily's Basic Vinaigrette  -  Jan 27, 2007
Appleton Post Crescent,Do you know how to make sorbitol? Texturized vegetable protein? Xanthum gum? High-fructose corn syrup? Phenylalanine? No? Then make your own salad dressing.

Nanoparticles Sneak Drugs into Cancer Cells  -  18 Jan 2007
Photonics.com,Bucky amino acid, or Baa, is a marriage of Buckyballs and phenylalanine, one of the 20 essential amino acids that are the building blocks of all proteins.

Editorial: Dietary advice best taken with a pinch of salt  -  Jan 17, 2007
New Scientist (subscription),People with the single-gene disorder phenylketonuria, for example, must avoid foods containing phenylalanine or risk brain damage.

Letters: Artificial sweeteners don't cause overeating  -  Jan 7, 2007
Sheboygan Press,As Ms. Adams mentioned, aspartame is broken down in the body into two amino acids, aspartic acid and phenylalanine, plus methanol.

BioMarin Announces Positive Results from Phase 3 Diet Study of ...  -  Jan 17, 2007
Financial News USA (press release),...developed in partnership with Merck Serono, for the treatment of patients with phenylketonuria (PKU), who have elevated phenylalanine (Phe) levels.

Dizziness of labyrinthitis can persist  -  Jan 12, 2007
The Australian,Aspartame does contain a number of chemicals, some of which, such as phenylalanine and methanol, can be poisonous in certain circumstances.

Repetitive Motion Speeds Nanoparticle Uptake: 'Bucky Amino Acid ...  -  Jan 9, 2007
Science Daily (press release)Baa is a marriage of buckyballs and phenylalanine, one of the 20 essential amino acids that are the building blocks of all proteins.

Cathryn Scott, Western Mail  -  Jan 8, 2007
ic Wales,Some chemicals such as phenylalanine, often found in ready foods, burgers, and so on, actually encourage appetite. n Discard the junk.

Ask doctor about artificial sweeteners  -  Dec 26, 2006
Hattiesburg American,...called phenylkenoturia, a disorder of amino acid metabolism, are advised not to use aspartame because it contains an amino acid called phenylalanine.

Anne Adams: Sit-ups can be beneficial for relief of back pain  -  Dec 20, 2006
Sheboygan Press,It is made of three chemicals: aspartic acid, phenylalanine and methanol. A food's natural sweetness provides valuable clues about its caloric content and

Ask doctor about artificial sweeteners  -  26 Dec 2006
Hattiesburg American,...called phenylkenoturia, a disorder of amino acid metabolism, are advised not to use aspartame because it contains an amino acid called phenylalanine.

BioMarin Announces Positive Results From Phase 3 Extension Study ...  -  Dec 19, 2006
PharmaLive.com (press release),PKU, a genetic disorder affecting approximately 50000 diagnosed patients in the developed world, is caused by a deficiency of the enzyme phenylalanine

BioMarin Announces Positive Results From Phase 3 Extension Study ...  -  Dec 18, 2006
PR Newswire (press release),PAH is required for the metabolism of phenylalanine (Phe), an essential amino acid found in most protein-containing foods. If the active enzyme is not

Tuesday's Early Winners & Losers  -  Dec 19, 2006
TheStreet.comIt also found that a once-daily dose of the drug maintained a reduction of blood phenylalanine levels for 24 hours. The rates of reduction were roughly

Aftermarket Movers: Applied Signal Down  -  Dec 18, 2006
Houston Chronicle,The drug is used to treat phenylketonuria, a genetic disorder, where the deficiency of a certain enzyme used to metabolize the phenylalanine allows that

BioMarin Reports Good Phenoptin Results  -  Dec 18, 2006
Forbes,The 80-patient extension study followed a Phase III clinical trial showing that Phenoptin significantly reduced the levels of phenylalanine in treated

BioMarin drug does well in Phase III study  -  Dec 18, 2006
San Francisco Business Times,PKU is a genetic disorder that keeps its sufferers from being able to break down the enzyme phenylalanine. The trial demonstrated the drug's safety and

What's in my? Aspartame  -  Dec 8, 2006
The Columbian,Made of: Aspartame is composed of two naturally occurring amino acids: phenylalanine and aspartic acid. Amino acids are the building blocks of proteins and

BioMarin Announces Positive Results From Phase 3 Extension Study ...  -  Dec 18, 2006
Earthtimes.org...an investigational oral small molecule for the treatment of patients with phenylketonuria (PKU), who have elevated phenylalanine (Phe) levels.

Anne Adams: Sit-ups can be beneficial for relief of back pain  -  Dec 20, 2006
Sheboygan Press,It is made of three chemicals: aspartic acid, phenylalanine and methanol. A food's natural sweetness provides valuable clues about its caloric content and

An Examination of the Carbon Isotope Effects Associated with Amino ...  -  Dec 12, 2006
Astrobiology News (press release),Stable carbon isotope ratios (_13C) were determined for alanine, proline, phenylalanine, valine, leucine, isoleucine, aspartate (aspartic acid and

Full sugar fizzy drinks out of schools by 2009  -  Dec 10, 2006
Scoop.co.nz (press release),Aspartame is digested to aspartic acid, phenylalanine and methanol. These compounds occur naturally in foods and are absorbed, metabolised and excreted by

Anyone for chemical soup?  -  Dec 6, 2006
Boston Herald,Diet Coke: Caramel color, phosphoric acid, potassium benzoate, citric acid, caffeine and phenylalanine, an essential amino acid found in aspartame,

Atrophy and Impaired Muscle Protein Synthesis during Prolonged ...  -  Dec 5, 2006
Journal of Clinical Endocrinology and Metabolism,Design: Muscle protein kinetics were calculated during a primed, continuous infusion (0.08 µmol/kg·min) of 13 C 6 -phenylalanine on d 1 and 28 of bed rest.

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