Recent news on Pioglitazone

The rosiglitazone aftermath: Legitimate concerns or hype?  -  25 May 2007
TheHeart.Org,Nathan believes pioglitazone is a better bet than rosiglitazone, as it does not have the same adverse lipid profile. "I don't use a lot of these drugs,

Combined Low-Dose Pioglitazone, Flutamide, and Metformin for Women ...  -  May 4, 2007
Journal of Clinical Endocrinology and Metabolism,We tested whether adding low-dose pioglitazone (Pio; 7.5 mg/d) confers more benefit. Setting: The study was conducted at a university hospital.

Diabetes drug may soon be pulled  -  May 22, 2007
What Doctors Don't Tell You,The only other thiazolidinedione that's still on the market is Pioglitazone, and the researchers who have uncovered safety issues about Avandia claim that

Array BioPharma Appoints John Yates, MB ChB, MD, to Chief Medical ...  -  May 15, 2007
PharmaLive.com (press release),From 2004 to 2007, Dr. Yates was involved in simultaneous development of over 25 compounds including two Phase 4 products: Actos(R) (pioglitazone) for

Rosiglitazone May Lower Risk of Lung Cancer and Boost ...  -  May 15, 2007
About - News & Issues,The diabetes drugs, rosiglitazone (Avandia) and pioglitazone (Actos) have been shown to reduce the incidence of lung cancer in a study that appeared in the

Actos drives growth at Takeda but Januvia threat is hovering  -  May 11, 2007
Pharma Times (subscription),Group turnover fell just shy of 1.31 trillion yen while Actos (pioglitazone) brought in 336.3 billion yen, a rise of 37.9%, with US sales of the drug

Diabetes drugs may lower risk of lung cancer  -  May 3, 2007
ReutersNEW YORK (Reuters Health) - The use of diabetes drugs called thiazolidinediones, such as rosiglitazone (Avandia) and pioglitazone (Actos), may reduce the

Group says FDA knew of Avandia risk years ago  -  May 22, 2007
Scientific AmericanActos, also known as pioglitazone, and Avandia, are part of a class of drugs known as thiazolidinediones (TZDs) that target the PPAR-gamma gene to help the

Rosiglitazone analysis sparks safety controversy  -  May 22, 2007
Aidsmap,But they note that pioglitazone, the other anti-diabetes drug in the same class, showed a significant reduction in myocardial infarction and stroke and

Avandia: Getting the Facts  -  May 22, 2007
FOX NewsIt's a tablet with the active ingredient pioglitazone, which is also in the thiazolidinedione class of drugs. There have been reports of hepatitis and

FDA Issues Safety Alert on Avandia  -  May 22, 2007
Southwest Nebraska News,Pending questions include whether the other approved treatment from the same class of drugs, pioglitazone, has less, the same or greater risks.

Diabetes pill raises risk of heart attacks, study suggests  -  May 22, 2007
HULIQ,Only one other drug like it - pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals - is sold in the United States.

Drug for diabetes is linked to heart risks  -  May 22, 2007
Baltimore Sun,The other insulin sensitizer available is pioglitazone, which is manufactured by Takeda Pharmaceutical Co. and sold under the name Actos.

Discovery of heart risks with popular diabetes pill renews ...  -  May 22, 2007
Canton Repository (subscription),Only one other drug like it — pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals — is sold in the United States.

Diabetes pill raises risk of heart attacks, study suggests, and ...  -  May 21, 2007
San Diego Union Tribune,Only one other drug like it – pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals – is sold in the United States.

Diabetes Pill Tied to Heart Risks  -  May 21, 2007
Chicago Tribune,Only one other drug like it -- pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals -- is sold in the United States.

Diabetes Pill Tied to Heart Risks  -  May 21, 2007
Helena Independent Record,Only one other drug like it _ pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals _ is sold in the United States.

FDA Issues Safety Alert for Diabetes Drug Avandia  -  May 21, 2007
MyFox WGHP,Only one other drug like it -- pioglitazone, sold as Actos and Actoplus Met by Takeda pharmaceuticals -- is sold in the United States.

Diabetes Pill Tied to Heart Risks  -  May 21, 2007
phillyBurbs.com,Only one other drug like it , pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals , is sold in the United States.

Analysis Associates Avandia With Greater Risk of Heart Attack  -  May 21, 2007
Diabetes Health (press release),Earlier this year, the Cochrane Library published a meta-analysis of Actos (pioglitazone), a thiazolidinedione similar to Avandia, which implicated it in

Diabetes drug linked to higher risk of heart-attacks  -  May 21, 2007
WXYZ,...possible NEJM data is ongoing and that it is also comparing the new information to the safety profile of another drug in the same class, pioglitazone.

ALERT: Diabetes Pill Tied to Heart Risks  -  May 21, 2007
WXYZ,Only one other drug like it—pioglitazone, sold as Actos and Actoplus Met by Takeda Pharmaceuticals—is sold in the United States.

Glaxo Diabetes Drug Tied to Heart Attacks  -  May 21, 2007
Smartmoney.comThe agency also said it was looking at whether pioglitazone, a drug sold under the brand name Actos by Takeda Pharmaceuticals and Eli Lilly and Co.

Potency Of Platinum Chemotherapy Dramatically Boosted By Diabetes Drug  -  May 11, 2007
Medical News Today (press release),In addition to rosizitaglone, the scientists tested pioglitazone and an experimental compound made by Glaxo Smith Kline, combining each of them with

Reuters Health News Summary  -  May 4, 2007
San Diego Union Tribune,NEW YORK (Reuters Health) – The use of diabetes drugs called thiazolidinediones, such as rosiglitazone (Avandia) and pioglitazone (Actos), may reduce the

Diabetes drugs mayy lower risk of lung cancer  -  May 3, 2007
Antara,New York (ANTARA News) - The use of diabetes drugs called thiazolidinediones, such as rosiglitazone (Avandia) and pioglitazone (Actos), may reduce the risk

Pioglitazone beneficial in diabetes patients with previous MI?  -  Apr 20, 2007
TheHeart.Org,Koln, Germany - A new subgroup analysis of the PROactive trial of pioglitazone in diabetes patients has shown that in patients with previous MI,

Pioglitazone vs Glimepiride and Carotid Intima-Media Thickness—Reply  -  Mar 27, 2007
Journal of American Medical Association (subscription),Because randomization was to glimepiride or pioglitazone, it was necessary for these patients to discontinue baseline sulfonylurea therapy before

Pioglitazone vs Glimepiride and Carotid Intima-Media Thickness  -  Mar 27, 2007
Journal of American Medical Association (subscription),To the Editor: The CHICAGO (Carotid Intima-Media Thickness in Atherosclerosis Using Pioglitazone) trial by Dr Mazzone and colleagues 1 found a reduced

Pioglitazone vs Glimepiride and Carotid Intima-Media Thickness  -  Mar 27, 2007
Journal of American Medical Association (subscription),To the Editor: Dr Mazzone and colleagues 1 showed that pioglitazone slowed progression of CIMT compared with glimepiride in patients with type 2 diabetes.

Diabetes Drugs Tied to Fractures in Women  -  Apr 17, 2007
Journal of American Medical Association (subscription),A warning from the US Food and Drug Administration (FDA) has linked pioglitazone (Actos), a thiazolidinedione prescribed for the treatment of type 2

Effects of PPAR activation on gonadotropin transcription and cell ...  -  Apr 19, 2007
Journal of EndocrinologyIn accordance with the effects on cell mitosis, pioglitazone but not fenofibric acid significantly decreased BMP-induced Id-1-Luc activation.

Diabetes drug 'protects arteries'  -  Mar 30, 2007
BBC News,Tests on patients given pioglitazone showed their arteries were less thick than those given another diabetes drug. The University of Chicago study was

Relationship between Vascular Reactivity and Lipids in Mexican ...  -  Apr 4, 2007
Journal of Clinical Endocrinology and Metabolism,Design and Setting: We conducted a randomized, double-blind, controlled trial of pioglitazone vs. placebo and other therapies aimed at equal glycemic

People with type 2 diabetes to have improved access to Actos  -  Mar 29, 2007
Antara (press release),Pioglitazone is effective as a single agent and may also be used in combination with sulfonylureas, metformin or insulin when diet plus the single agent

Improved Access To Diabetes Medicine  -  Mar 29, 2007
Scoop.co.nz,Pioglitazone received its first regulatory approval in July 1999 in the United States. Pioglitazone was approved by Medsafe in June 2002.

Further step in battle with Type 2 diabetes  -  Mar 29, 2007
Scoop.co.nz,PHARMAC’s Medical Director Dr Peter Moodie says pioglitazone and related medicines make people more sensitive to the insulin their body produces.

Cost vs. compliance: Physicians encouraged to discuss prescriptions  -  Apr 15, 2007
American Medical News (subscription)He decided to add pioglitazone, a thiazolidinedione marketed as Actos, to the patient's armamentarium. The woman's blood sugar levels did not drop after

Application for an Additional Indication of Combination Therapy of ...  -  Apr 23, 2007
PipelineReview.com (press release),Insulin-resistance is a condition where the body does not effectively use the insulin it produces, and pioglitazone HCl, which is insulin sensitizer

Oral medications to treat Type 2 diabetes  -  Apr 19, 2007
Chennai Online,Rosiglitazone (sold as Avandia by Glaxo Smith Kline), and Pioglitazone (sold in the name of Actos by Lilly/Takeda) are the two drugs available in this class

FDA Approvals: Janumet  -  Apr 12, 2007
Medscape (subscription)Pioglitazone rescue was used for those who did not meet specific glycemic goals during the study. Results showed that the addition of sitagliptin to

Insulin Analogs or Premixed Insulin Analogs in Combination With ...  -  Apr 17, 2007
Medscape (subscription)Over 75% of patients with type 2 diabetes reached target A1C by adding biphasic insulin aspart 70/30 to optimized metformin and pioglitazone treatment.

Adding new diabetes drug may aid glycemic control  -  Apr 4, 2007
Scientific AmericanThe addition of exenatide to thiazolidinediones (TZDs), drugs such as rosiglitazone or pioglitazone, that increase cell response to insulin,

Exenatide in Combination Therapy: Small Study, Big Market, and ...  -  Apr 2, 2007
Annals of Internal Medicine...added to rosiglitazone (4 mg/d) or pioglitazone (30 mg/d) alone or in combination with metformin (79%) for 16 weeks to assess both efficacy and safety.

Exenatide Therapy for Type 2 Diabetes  -  Apr 2, 2007
Annals of Internal Medicine...biguanides (metformin), sulfonyureas (glipizide or glyburide), and thiazolidinediones (TZDs, such as rosiglitazone and pioglitazone).

Merck & Co's Janumet approved by the FDA  -  Apr 2, 2007
Pharma Times (subscription),...of oral diabetes medications, metformin or thiazolidinediones such as GlaxoSmithKline's Avandia (rosiglitazone) and Takeda/Lilly's Actos (pioglitazone).

Eli Lilly Advances Study of PPAR-alpha Agonist  -  Mar 28, 2007
Seeking Alpha,...marketed in the US are the relatively PPAR-gamma-selective agonists, rosiglitazone and pioglitazone for treatment of hyperglycemia in type 2 diabetes,

Lilly Reports Strong First-Quarter Results; Raises Full-Year Sales ...  -  Apr 16, 2007
Earthtimes.orgActos(R) (pioglitazone hydrochloride, Takeda) Alimta(R) (pemetrexed, Lilly) Arxxant(TM) (ruboxistaurin mesylate, Lilly) Byetta(R) (exenatide injection,

Human Visfatin Expression: Relationship to Insulin Sensitivity ...  -  Feb 6, 2007
Journal of Clinical Endocrinology and Metabolism,In impaired glucose tolerance subjects, these procedures were performed before and after treatment with pioglitazone or metformin.

Sales strong for Takeda but pressure to expand is on  -  Feb 1, 2007
Pharma Times (subscription),Sales of Actos (pioglitazone) brought in 253.6 billion yen, a rise of 43.2% over the like, year-earlier period, with US sales of the drug making up almost

Thiazolidinediones reduce need of post-PCI revascularization  -  Feb 7, 2007
Therapeutics Daily (subscription) (press release),...patients suggest that the thiazolidinediones (TZDs) rosiglitazone and pioglitazone reduce restenosis following percutaneous coronary intervention (PCI),

All Sources Medscape MEDLINE Drug Reference  -  Feb 2, 2007
Medscape (subscription)The CHICAGO (Carotid Intima-media Thickness in Atherosclerosis Using Pioglitazone) study compared the impact of glycemic control with pioglitazone or

Health Watch: Unwanted hair in women  -  Feb 8, 2007
Ithaca Journal,Medications reducing insulin resistance, such as metformin, pioglitazone and rosiglitazone also have a role. There are many other less common causes of

Takeda Announces Submission Of Application For Additional ...  -  Jan 28, 2007
Medical News Today (press release),Takeda Pharmaceutical Company Limited announced that today it submitted an application for an additional indication of ACTOS(R) (pioglitazone HCl) with

Lilly Announces 2006 Adjusted EPS of $3.18 Excluding Charges and ...  -  Jan 31, 2007
Earthtimes.orgActos(R) (pioglitazone hydrochloride, Takeda), Takeda Alimta(R) (pemetrexed, Lilly) Byetta(R) (exenatide injection, Amylin Pharmaceuticals) Cialis(R)

Lilly Announces 2006 Adjusted EPS of $3.18 Excluding Charges and ...  -  Jan 31, 2007
Yahoo! News (press release)Actos® (pioglitazone hydrochloride, Takeda), Takeda Alimta® (pemetrexed, Lilly) Byetta® (exenatide injection, Amylin Pharmaceuticals) Cialis® (tadalafil,

Marketing Authorisation Granted for Tandemact (TM) (pioglitazone ...  -  18 Jan 2007
PipelineReview.com (press release),The two approved strengths for Tandemact™ are pioglitazone HCl/glimepiride 30mg/4mg and 45mg/4mg. "We are very pleased with this approval of Tandemact™,

Metabolex Shows MBX-102/JNJ-39659100 Reduces Inflammation in ...  -  18 Jan 2007
PipelineReview.com (press release),MBX-102/JNJ-39659100 has the potential to offer efficacy similar to drugs such as rosiglitazone and pioglitazone from the thiazolidinedione (TZD) class.

Chronic Treatment with Pioglitazone Does Not Protect Obese ...  -  Jan 5, 2007
Journal of Clinical Endocrinology and Metabolism,Objective: We studied the protective effect of pioglitazone on FFA-induced insulin resistance and the effects on intramyocellular glycosphingolipids.

Medicines for diabetes and cholesterol cut risk factors for heart ...  -  Jan 15, 2007
CBC News,...(HealthDay News) - Nondiabetics with heart disease who take the diabetes drug pioglitazone (Actos) along with the cholesterol-lowering drug simvastatin

Positive Opinion From European Regulatory Authorities for ...  -  Dec 21, 2006
PipelineReview.com (press release),Committee for Medicinal Products for Human Use of the European Medicines Agency, recommending to grant the new indication for ACTOS® (pioglitazone HCl).

Endocrinology & Metabolism News, January 2007  -  Jan 5, 2007
Journal of Clinical Endocrinology and Metabolism,Pioglitazone slowed progression of carotid artery intima-media thickness compared with glimepiride in a randomized, double-blind, comparator-controlled,

The right balance drives the field of PPAR agonist R&D  -  Jan 15, 2007
PR Leap (press release),COM) BARCELONA, Spain | Jan 15, 2007 | The commercial success of the two peroxisome proliferator-activated receptor (PPAR) gamma agonists pioglitazone and

The Right Balance Drives The Field Of PPAR Agonist R&D  -  Jan 14, 2007
Medical News Today (press release),The commercial success of the two peroxisome proliferator-activated receptor (PPAR) gamma agonists pioglitazone and rosiglitazone from Takeda & Lilly and

Diabetes Drug Shows Promise For Preventing Brain Injury From ...  -  Jan 12, 2007
Medical News Today (press release),The study by Robbins and colleagues was based on evidence that the diabetes drug pioglitazone prevents inflammation. The drug activates a specific type of

Takeda Announces Positive Opinion From European Regulatory ...  -  Jan 4, 2007
Medical News Today (press release),Products for Human Use ("CHMP") of the European Medicines Agency ("EMEA"), recommending to grant the new indication for ACTOS(R) (pioglitazone HCl).

The Year in Diabetes  -  Dec 22, 2006
MedPage Today,...with Glucophage (metformin) or a peroxisome proliferator-activated receptor (PPAR) agonist, such as Actos (pioglitazone).or Avandia (rosiglitazone).

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...double-blind, 24-week trial, 214 patients with type 2 diabetes mellitus treated with thiazolidinediones (rosiglitazone or pioglitazone) for a minimum of

Positive Opinion From European Regulatory Authorities for ...  -  Dec 21, 2006
PipelineReview.com (press release),Committee for Medicinal Products for Human Use of the European Medicines Agency, recommending to grant the new indication for ACTOS® (pioglitazone HCl).

Effect of Pioglitazone Compared With Glimepiride on Carotid Intima ...  -  Dec 5, 2006
Journal of American Medical Association (subscription),While studies of relatively short duration have suggested that thiazolidinediones such as pioglitazone might reduce progression of CIMT in persons with

A Placebo-Controlled Trial of Pioglitazone in Subjects with ...  -  Nov 29, 2006
New England Journal of Medicine (subscription),Pioglitazone is a thiazolidinedione that ameliorates insulin resistance and improves glucose and lipid metabolism in type 2 diabetes mellitus.

NovoMix® 30 Helps People With Type 2 Diabetes Achieve Recommended ...  -  Dec 11, 2006
Medical News Today (press release),..."In fact, our study showed that no patient with an HbA1c level above 9% could achieve the recommended goal of 7% by taking metformin and pioglitazone alone

Committee for Medicinal Products for Human Use Post-authorisation ...  -  Dec 15, 2006
PharmaLive.com (press release),The new indication adopted by CHMP is: "Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus patients with insufficient

Diabetes Drug Helps Prevent Fatty Liver Complications  -  Nov 29, 2006
Washington Post,30 issue of theNew England Journal of Medicine, University of Texas researchers report that pioglitazone -- brand name Actos -- reduced liver fat by 54

Drug appears to fight liver problems  -  Nov 29, 2006
San Antonio Express,Although the current standard of treatment for the condition is diet and exercise, a drug called pioglitazone has shown promise in reducing complications

The Relationship between Plasma Adiponectin Concentration and ...  -  Dec 5, 2006
Journal of Clinical Endocrinology and Metabolism,Intervention: Intervention included pioglitazone administration for 3 months to 12 IR smokers and eight IS smokers. Main Outcome Measures: Measures included

Drug Treatment for Liver Disease  -  Nov 29, 2006
Ivanhoe,One group of patients followed a low calorie diet and pioglitazone treatment. The other group followed a low calorie diet and took placebo.

AUDIO SUMMARY  -  Nov 29, 2006
New England Journal of Medicine (subscription),Featured are articles on CD4+ count–guided interruption of antiretroviral treatment, pioglitazone for nonalcoholic steatohepatitis, strategies for reducing

Diabetes drug may help heart disease  -  Nov 28, 2006
Jackson Clarion Ledger,The drug, pioglitazone, sold under the brand name Actos, already is approved for treating insulin resistance, in which the body does not properly use the

The Year in Diabetes  -  Dec 22, 2006
MedPage Today,...with Glucophage (metformin) or a peroxisome proliferator-activated receptor (PPAR) agonist, such as Actos (pioglitazone).or Avandia (rosiglitazone).

Takeda Announces Positive Opinion from European Regulatory ...  -  Dec 20, 2006
PharmaLive.com (press release),Products for Human Use ("CHMP") of the European Medicines Agency ("EMEA"), recommending to grant the new indication for ACTOS(R) (pioglitazone HCl).

Thiazolidinedione Promising for Nonalcoholic Fatty Liver Disease  -  Nov 29, 2006
MedPage Today,29 -- The thiazolidinedione Actos (pioglitazone) produced metabolic and histologic improvements in patients with nonalcoholic steatohepatitis,

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...double-blind, 24-week trial, 214 patients with type 2 diabetes mellitus treated with thiazolidinediones (rosiglitazone or pioglitazone) for a minimum of

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