Recent news on Prostacyclin

COX Inhibitors May Weaken Protective Qualities Of Estrogen Hormone ...  -  25 May 2007
Science Daily (press release)The Penn research group recently found in mice that estrogen acts via COX-2–dependent prostacyclin, a fat that has a role in limiting blood clotting.

Rosiglitazone and Cardiovascular Risk  -  May 21, 2007
New England Journal of Medicine (subscription),Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci USA 1999

Research Roundup  -  May 1, 2007
UPENN Almanac,Dr. Pratico’s team measured isoprostane, a biomarker for oxidative stress; thromboxane, an index of platelet activation; and prostacyclin, a measure of

New Strategies for Pulmonary Arterial Hypertension: Evaluation and ...  -  Apr 23, 2007
Medscape (subscription)Current wisdom concerning the endothelial dysfunction underlying PAH includes a decrease in nitric oxide and prostacyclin synthesis, and an increase in

Gilead's Atripla, Lower Costs Provide Lift To First Quarter  -  Apr 22, 2007
BioWorld Online,That deal gave Actelion a second marketed PAH product in Ventavis (iloprost), an inhaled, synthetic prostacyclin analogue that gained FDA approval in 2004.

Lack of Evidence for Recommended Low-Density Lipoprotein ...  -  Apr 16, 2007
Annals of Internal MedicineIn addition, HDL cholesterol decreases blood viscosity, improves endothelial dysfunction (promoting nitric oxide), stabilizes prostacyclin,

Exclusive License Agreement for Modified Release Beraprost Assumed ...  -  Mar 28, 2007
PharmaLive.com (press release),...variability in the patient population cries out for multiple unique molecules both beyond and within the prostacyclin class that includes beraprost."

Researchers Find Protective Effects of Natural Inhibitor  -  Mar 22, 2007
eMaxHealth.com,..."Our lab hypothesized that this potent vasodilator called prostacyclin may help shield patients with chronic obstructive pulmonary disease from pulmonary

Study Raises Questions For United Therapeutics  -  Feb 26, 2007
Washington Post,United Therapeutics sells the prostacyclin treprostinil under the trade name Remodulin. The warning came in reaction to a recent presentation by the Centers

United Therapeutics Volume Heavy on Data  -  Feb 26, 2007
Houston Chronicle,Silver Spring, Md.-based United Therapeutics sells the prostacyclin treprostinil under the trade name Remodulin. The guidance came in reaction to a recent

United Therapeutics Announces Pulmonary Hypertension Opinion ...  -  Feb 27, 2007
Medical News Today (press release),For a disease in which mean survival is counted in single digit years, everyone wants to go the extra mile to provide patients needing prostacyclin therapy

Biotechnology Study Center Honors Joan V. Ruderman, Salvador ...  -  Mar 20, 2007
Medical News Today (press release),He next elucidated the structure of prostacyclin, a compound formed by endothelial cells that relaxes blood vessels and prevents platelets from clumping;

Merck used U-Haul to deliver Vioxx research to FDA  -  Mar 15, 2007
St. Clair Record,Fitzgerald's theory stated that COX-2 inhibitors block the production of a substance called prostacyclin, which leads to blood vessel constriction and

Exercise Slows Lung Function Decline in Smokers  -  Mar 1, 2007
MedPage Today,...enhances other anti-inflammatory markers, and stimulates the synthesis of eNO, prostacyclin from the vascular endothelial cells, and tissue Mn-SOD.

Catheter-based infrared light scanner as a tool to assess conduit ...  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryBiopsy specimens were obtained for histologic confirmation and to analyze matrix metalloproteinase 2 levels (saphenous vein grafts) and prostacyclin/nitric

Engineering The 'Super Enzyme' -- A Potential New Weapon Against ...  -  Nov 28, 2006
Science Daily (press release)However, studies now suggest that those drugs also may increase the risk of heart attacks and strokes by decreasing the body's production of prostacyclin (a

Scientists May Have Found Key to Vioxx Heart Risk, Study Says  -  Nov 28, 2006
BloombergBy suppressing Cox-1, the drugs slow the production of the blood-thinning substance prostacyclin and thus heighten the heart risks, said scientists

Study may reveal cause of Vioxx side effects  -  Nov 29, 2006
Pharmaceutical Business ReviewBy suppressing Cox-1 the drugs also inhibit the body's production of prostacyclin, a blood vessel protector that prevents blood clots, therefore heightening

How Vioxx and Other Arthritis Drugs Pose Danger  -  Nov 29, 2006
Medgadget.com,COX-1 in these cells makes prostacyclin, which thins the blood. Where this is inhibited there is a greater chance of blood clotting, which, if the drugs are

Queen Mary researchers discover COX-2 heart attack link  -  Dec 6, 2006
Media Newswire (press release),COX-1 in these cells makes prostacyclin, which thins the blood. Where this is inhibited there is a greater risk of blood clotting, which can in a very small

Pulmonary Hypertension Patients Improve From Combination Therapy  -  Dec 6, 2006
Medical News Today (press release),The researchers gave 32 patients both bosentan and inhaled iloprost, a prostacyclin analog. The remaining patients received bosentan and a placebo.

Combination Therapy Eases Pulmonary Arterial Hypertension  -  Dec 1, 2006
Forbes,Of those patients, 32 were selected to receive inhaled iloprost (a prostacyclin analog) along with bosentan, while the remainder took a placebo and bosentan

This site is for informational purposes only--it does not offer medical advice or sell health products. If you need assistance, contact your physician or healthcare professional