Recent news on Pyrimethamine

Evaluation of leading combination regimens for treating malaria  -  25 May 2007
News-Medical.net,The children were randomized to receive 1 of 3 combination therapies (amodiaquine plus sulfadoxine-pyrimethamine, amodiaquine plus artesunate,

Novartis Malaria Drug Works Best, Study Finds  -  May 22, 2007
Javno.hr,Amodiaquine plus sulfadoxine-pyrimethamine, a low-cost combination of two older drugs, fared worst, with a risk for failure rate of 26.1 percent.

New Drugs, Better Care Can Beat Malaria  -  May 22, 2007
HealthCentral.com,They were randomized to receive one of three drug combination treatments: amodiaquine plus sulfadoxine-pyrimethamine; amodiaquine plus artesunate;

Malaria in Multiple Family Members—Chicago, Illinois, 2006  -  May 22, 2007
Journal of American Medical Association (subscription),For example, chloroquine-resistant malaria is widespread in sub-Saharan Africa, including Nigeria, and resistance to sulfadoxine-pyrimethamine also occurs

Combination Therapy for Uncomplicated Falciparum Malaria in ...  -  May 22, 2007
Journal of American Medical Association (subscription),Interventions Study participants were randomized to receive 1 of 3 combination therapies (amodiaquine plus sulfadoxine-pyrimethamine, amodiaquine plus

Uganda: Four New Malaria Drugs in the Offing  -  May 16, 2007
AllAfrica.com,The malaria parasite has become resistant to widely-used drugs, including two inexpensive medications, chloroquine and sulfadoxine/pyrimethamine."

Antifolate Drugs may Be Effective in Treating P Vivax Malaria  -  May 24, 2007
MedIndia,Toby Leslie, M.Sc., and colleagues tested the relative efficacy and safety of two antifolate drugs (sulfadoxine-pyrimethamine and chlorproguanil-dapsone)

Malaria, Still a Deadly Threat in Nigeria – FG  -  Apr 25, 2007
This Day (subscription),...while 17 per cent pregnant women had access to recommended drug (sulphadoxine pyrimethamine) for intermittent preventive treatment.

Artemether-lumefantrine most effective combination therapy for ...  -  May 22, 2007
Aidsmap,In the wake of escalating treatment failures associated with chloroquine and sulfadoxine pyrimethamine (SP), the World Health Organization (WHO) has

Don’t Sleep With Your Chickens  -  May 22, 2007
Journal of American Medical Association (subscription),Half-empty bottles of sulfadoxine-pyrimethamine for intermittent preventive treatment (IPTp), along with tattered pink registry forms and a hand-ruled

Campaign Against Malaria Making Gains in Africa  -  Apr 30, 2007
HULIQ,That treatment campaign relied on older malaria drugs -- amodiaquine and fansidar [sulfadozine-pyrimethamine]. She expects an even greater number of

East Africa: Region Unveils Tougher Measures to Fight Malaria  -  Apr 25, 2007
AllAfrica.com,..."Drugs which were formerly used for treatment of malaria, including chloroquine and SP [Sulfadoxine/pyrimethamine] have proved ineffective and the

Malaria, Still a Deadly Threat in Nigeria – FG  -  26 Apr 2007
This Day (subscription),...while 17 per cent pregnant women had access to recommended drug (sulphadoxine pyrimethamine) for intermittent preventive treatment.

East Africa unveils tougher malaria fight  -  26 Apr 2007
afrol News,..."Drugs which were formerly used for treatment of malaria, including chloroquine and SP [Sulfadoxine/pyrimethamine] have proved ineffective and the

South Africa: Drug Subsidy May Be Malaria's Death Knell  -  Apr 16, 2007
AllAfrica.com,Faced with widespread resistance to older malaria treatments such as chloroquine and sulphadoxine-pyrimethamine, African nations are increasingly turning to

Tanzania: We Can Beat Malaria Now  -  Apr 25, 2007
AllAfrica.com,Third, if you are pregnant, in addition to sleeping under an insecticide treated bed net every night, get two does of Sulfadoxine-Pyrimethamine (SP) as part

Judd: How a $10 net can stop a killer  -  Apr 24, 2007
CNN InternationalSimilarly, pregnant women who take a drug called sulfadoxine-pyrimethamine can protect their unborn children from anemia, low birth weight, and death.

Eguarding Against Malaria - Using Insecticide Treated Nets  -  Mar 30, 2007
AllAfrica.com,Prevention Therapy(IPT) and Sulphadoxine-Pyrimethamine(SP), both of which are drugs specifically designed to fight malaria in pregnant women.

Vitamins and Perinatal Outcomes among HIV-Negative Women in Tanzania  -  Apr 4, 2007
New England Journal of Medicine (subscription),They were also given malaria prophylaxis in the form of sulfadoxine–pyrimethamine tablets (Fansidar, Roche) at 20 weeks and 30 weeks of gestation.

Beat the shivers the right way  -  Jan 30, 2007
Newindpress (subscription),...are recommended by WHO: artemether - lumefantrine, artesunate - amodiaquine, artesunate - mefloquine, artesunate - sulphadoxine and pyrimethamine (SP).

Current Treatments for Equine Protozoal Myeloencephalitis  -  Jan 16, 2007
TheHorse.com,Traditionally, EPM was treated with combinations of pyrimethamine and a sulfonamide, one of the so-called "potentiated sulfonamides" used in classic

Opposition mounts as Malawi plans to re-introduce DDT in malaria fight  -  Jan 13, 2007
AngolaPress,...last year that Malawi `s malaria problem was worsening due to increasing resistance of malaria parasite to the line drug, Sulfaxodine Pyrimethamine (SP).

A returning scourge reminds us to be disciplined, vigilant  -  Dec 29, 2006
Jamaica Observer,Some strains of plasmodium, the organism which causes the disease, have developed resistance to chloroquine and sulfadoxine-pyrimethamine, and as many as

Nigeria: Issues Expert Provides Antidote to Malaria-Induced ...  -  Dec 28, 2006
AllAfrica.com,Anorlu said previous study has shown that, Intermittent preventive treatment of malaria in Pregnancy with the combination of Sulphadoxine Pyrimethamine has

Genetic Map Offers New Tool For Malaria Research  -  Dec 26, 2006
Medical News Today (press release),...the scientists identified a novel region that is strongly implicated in resistance to the drug pyrimethamine, and also confirmed a region of the genome

"Tuesday Talk" Highlights Neurologic Issues  -  Dec 24, 2006
TheHorse.com,There are several medical treatments available for EPM including ponazuril (Marquis), nitazoxanide (NTZ or Navigator) and sulfadiazine/pyrimethamine

Genetic Map Offers New Tool For Malaria Research  -  26 Dec 2006
Medical News Today (press release),...the scientists identified a novel region that is strongly implicated in resistance to the drug pyrimethamine, and also confirmed a region of the genome

Malaria treatment compromised by suppressed immunity in HIV ...  -  Dec 13, 2006
Aidsmap,Specifically, it highlights low CD4 cell counts of less than 200 cells/mm 3 as a significant risk factor for sulfadoxine-pyrimethamine treatment failure.

Group advises on malaria prevention and control  -  Dec 5, 2006
The Statesman Online,On Intermittent Preventive Treatment of infants, the expert committee said that given the high levels of sulfadoxine-pyrimethamine resistance emerging in

WHO launches new drive for malaria vaccine by 2015  -  Dec 4, 2006
Scientific AmericanThere is no vaccine against the parasite, which has grown resistant to a number of well-known anti-malarial drugs, including chloroquine and pyrimethamine.

"Tuesday Talk" Highlights Neurologic Issues  -  Dec 24, 2006
TheHorse.com,There are several medical treatments available for EPM including ponazuril (Marquis), nitazoxanide (NTZ or Navigator) and sulfadiazine/pyrimethamine

Continuing Medical Education-V Fight Malaria - Anti-malarial drugs  -  Dec 5, 2006
Newindpress (subscription),These drugs include quinine, chloroquine, sulphadoxine-pyrimethamine combination, mefloquine, atemisinin derivatives etc. Other anti-malarial drugs act on

Bottlenecks, fakes hobble herb's war on malaria  -  Dec 14, 2006
Jamaica Gleaner,There is no vaccine against the parasite, which has grown resistant to well-known antimalarial drugs, like chloroquine and pyrimethamine.

Africa: Taking the Fight Against Malaria to Americans  -  Dec 14, 2006
AllAfrica.com,And then there are sulfadoxine-pyrimethamine, or SPs, which the project will buy and distribute, as pre-emptive treatment, to pregnant women.

Scientists Create Genome-Scale Map Of Genetic Variation For ...  -  Dec 14, 2006
Medical News Today (press release),...the scientists identified a novel region that is strongly implicated in resistance to the drug pyrimethamine, and also confirmed a region of the genome

Tanzania to launch new malaria treatment strategy  -  Dec 12, 2006
SciDev.net,ALU is meant to combat malaria parasites that have developed resistance to the drugs chloroquine and sulphurdoxine pyrimethamine, according to Alex Mwita,

Genetic variation across entire malaria parasite genome mapped  -  Dec 11, 2006
DailyIndia.com,...implicated in resistance to the drug pyrimethamine, and also confirmed a region of the genome known to be involved in chloroquine drug resistance.

A military outbreak spurs research  -  Dec 4, 2006
Scientist,The move followed decades of malaria breakthroughs from the Walter Reed Army Institute of Research (WRAIR): chloroquine in 1949, sulfadoxine-pyrimethamine

Health professionals want inclusion of ACTs on NHIS drug list  -  Nov 27, 2006
Vanguard,...alternative to Sulphadoxine-Pyrimethamine(SP) in Intermittent Preventive Therapy (IPT) for women who are hypersensitive to sulpha drugs.

Return of Chloroquine Antimalarial Efficacy in Malawi  Nov 8, 2006
Background In 1993, Malawi became the first country in Africa to replace chloroquine with the combination of sulfadoxine and pyrimethamine for the treatment of ... -New England Journal of Medicine (subscription), Travel to Malaria-Endemic Areas Requires a Mosquito Map  Nov 8, 2006
...cautioned. Halfan (halofantrine) and Fansidar (sulfadoxine-pyrimethamine) are not recommended because of fatal adverse events. "Because ... -MedPage Today, Folate Supplement Interacts With Malaria Treatment In Pregnant ...  Oct 22, 2006
Research Institute, therefore carried out a randomized trial, comparing failure of antimalarial treatment with a drug called sulfadoxine-pyrimethamine, in 415 ... -Medical News Today (press release), Rwanda: Outdated Malaria Drugs Deadline for January  Nov 2, 2006
..."Beyond the set period, the drugs like Amodiaquine, Alaxin, Sulfadoxine and Pyrimethamine will no longer be allowed on the market," Nkulikiyimana told The New ... -AllAfrica.com, Safe And Effective Treatment Of Malaria In Pregnant Women In West ...  Oct 15, 2006
Treating women with the drug amodiaquine, either alone or in combination with sulphadoxine-pyrimethamine (SP), was found to almost completely eliminate the ... -Medical News Today (press release), Malaria drug helps at-risk group  Oct 15, 2006
The parasite that causes malaria has begun to develop resistance to established treatments such as choloroquine and sulphadoxine-pyrimethamine. ... -Monsters and Critics.com, Folate, pregnant malaria drug interact  Oct 20, 2006
Medical Research Institute carried out a randomized trial comparing failure of anti-malarial treatment with a drug called sulfadoxine-pyrimethamine in 415 ... -United Press International HIV immigrant died alone  Oct 17, 2006
A post-mortem examination revealed he had high levels of pyrimethamine in his system, a drug sometimes used by HIV sufferers, which can cause fits when taken ... -Wimbledon Guardian, New method to treat malaria in pregnant women  Oct 13, 2006
...in the women being treated was observed when they were treated either only with the drug amodiaquine or in combination with sulphadoxine-pyrimethamine (SP). ... -MedIndia, Malaria drug effective, safe in pregnancy  Oct 13, 2006
..."Previous studies had already found amodiaquine alone or in combination with sulphadoxine-pyrimethamine (SP) to be an effective treatment of malaria in ... -Independent Online, Africa: Folic Acid for Pregnancy Affects Malaria Treatment  Oct 20, 2006
The findings, published in PLoS Clinical Trials yesterday (19 October), could mean that countries using Sulfadoxine pyrimethamine (SP) to treat malaria in ... -AllAfrica.com, Folic acid 'hinders malaria drug'  Oct 20, 2006
Expectant mums on high dose folic acid, as recommended in Kenya, were twice as likely as others to fail treatment with sulfacoxine-pyrimethamine (SP). ... -BBC News, Africa: Study Offers Hope to Pregnant Women With Malaria  Oct 18, 2006
The study concluded that amodiaquine used alone or in combination with sulphadoxine-pyrimethamine (SP), was a safe and effective treatment for pregnant women. ... -AllAfrica.com, Folic acid in pregnancy hampers malaria drug  Oct 22, 2006
...findings, published in the journal, Public Library of Science - Clinical Trials this month, could mean that countries using Sulfadoxine pyrimethamine (SP) to ... -Cosmos, 'Safe alternative' treatment for malaria in pregnancy  Oct 16, 2006
...carried out in Ghana showed that treating pregnant women with the drug amodiaquine, either alone or in combination with sulphadoxine-pyrimethamine (SP), can ... -SciDev.net, ARTECOM clinical malaria trials require urgent funding  Oct 16, 2006
...parasite plasmodium developed resistance to overcome chloroquine efficacy and the Ministry of Health in Tanzania selected Sulphadoxine Pyrimethamine (SP) to ... -IPP Media - Guardian, Ugandans die as ARVs expire in govt stores  Sep 10, 2006
Finance. Previous cases of drugs expiring in the stores involved the malaria drugs chloroquine and sulfadoxine-pyrimethamine. Mr ... -East African

CD4 count below 300 predicts poorer malaria treatment outcome  Sep 12, 2006
...other studies in Kenya and Malawi reported that HIV-1 infection decreased the efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP ... -Aidsmap

Theme Issue on Malaria A Call for Papers  Sep 12, 2006
...toxic insecticides 1 ; and the discovery and use of other antimalarial drugs and drug combinations, including sulfadoxine-pyrimethamine, mefloquine, atovaquone ... -Journal of American Medical Association (subscription)

The dangers of counterfeit anti-infectives  Sep 5, 2006
...in 1998, where artesunate preparations contained 6% chloroquine but no artesunate, while mefloquine-labeled pills contained sulphadoxine-pyrimethamine but no ... -Computer Business Review

New drugs for malaria  Sep 5, 2006
She disclosed that the countries agreed to phase out of SP (sulfadoxine-pyrimethamine) in favour of ACT (artemisinin – based combination therapies). ... -African News Dimension (subscription)

Tanzania to launch new malaria treatment strategy  -  12 Dec 2006
SciDev.net,ALU is meant to combat malaria parasites that have developed resistance to the drugs chloroquine and sulphurdoxine pyrimethamine, according to Alex Mwita,

Fakes, regulations crippling herbal fight against malaria  -  12 Dec 2006
The Brunei Times,There is no vaccine against the parasite, which has grown resistant to well-known anti-malarial drugs, like chloroquine and pyrimethamine.

Group advises on malaria prevention and control  -  Dec 5, 2006
The Statesman Online,On Intermittent Preventive Treatment of infants, the expert committee said that given the high levels of sulfadoxine-pyrimethamine resistance emerging in

WHO launches new drive for malaria vaccine by 2015  -  Dec 4, 2006
Scientific AmericanThere is no vaccine against the parasite, which has grown resistant to a number of well-known anti-malarial drugs, including chloroquine and pyrimethamine.

Old Malaria Drug Makes New Comeback in Malawi  -  Nov 15, 2006
Voice of AmericaIn 1993, Malawi become the first African country to shift from chloroquine therapy to a combination of sulfadoxine and pyrimethamine.

Continuing Medical Education-V Fight Malaria - Anti-malarial drugs  -  Dec 5, 2006
Newindpress (subscription),These drugs include quinine, chloroquine, sulphadoxine-pyrimethamine combination, mefloquine, atemisinin derivatives etc. Other anti-malarial drugs act on

A military outbreak spurs research  -  Dec 4, 2006
Scientist,The move followed decades of malaria breakthroughs from the Walter Reed Army Institute of Research (WRAIR): chloroquine in 1949, sulfadoxine-pyrimethamine

Health professionals want inclusion of ACTs on NHIS drug list  -  Nov 27, 2006
Vanguard,...alternative to Sulphadoxine-Pyrimethamine(SP) in Intermittent Preventive Therapy (IPT) for women who are hypersensitive to sulpha drugs.

Malaria: older drugs may be good treatment in some parts of Africa  Aug 6, 2006
After 28 days of treatment, there were fewer cases of malaria among children taking a combination of the older Sulfadoxine-Pyrimethamine ( sold under the brand ... -Xagena.it

WHO issues guidelines on use of cotrimoxazole prophylaxis  Aug 10, 2006
Also, there were concerns about fostering resistance to the drug (a widely used antibiotic) and cross-resistance to sulfadoxine/pyrimethamine (used to treat ... -Aidsmap

Malawi gains aid from ADB, World Bank  Jul 29, 2006
...several challenges such as the grave shortage of human resources and the increasing resistance of malaria parasites to Sulfaxodine Pyrimethamine, the first ... -People's Daily Online

Uganda: Mulago Hospital to Train Malaria Health Workers  Aug 8, 2006
...from chloroquine to ACT as the first-line of treatment after the malaria parasite became resistant to chloroquine and sulfadoxine-pyrimethamine, the former ... -AllAfrica.com

Tanzania to introduce new malaria drugs  Aug 3, 2006
...one. "In fact, chloroquine failed in 2001, that is when the government adopted Sulfadoxine/Pyrimethamine (SP)," said the minister. ... -African News Dimension

Kenya: All Out War As Malaria Death Toll Rises to 72  Jul 28, 2006
Dr Misore delivered 10 metric tons of drugs that included antibiotics, pain killers, sulfadoxine, pyrimethamine (SP), intravenous fluid and quinine to the ... -AllAfrica.com

Malawi: World Bank boosts malaria support by US$5 million  Jul 27, 2006
...the severe human resource constraints that plague the entire health sector; increasing resistance of malaria parasites to Sulfaxodine Pyrimethamine (SP), the ... -ReliefWeb

Monthly sulfadoxine-pyrimethamine might protect HIV-positive ...  Jul 10, 2006
Monthly treatment with sulfadoxine-pyrimethamine (SP) is significantly more effective in preventing malaria in pregnant women than the current practice of ... -Aidsmap

Intermittent Treatment Efficiency Against Malaria Reassessed By ...  Jul 18, 2006
As published in Journal of Infectious Diseases, the intermittent treatment with sulfadoxine-pyrimethamine (SP) reduces by 22.2 percent the cases of clinical ... -Medical News Today

Fundación BBVA And IDIBAPS Reassess Intermittent Treatment ...  Jul 14, 2006
BARCELONA, SPAIN -- July 14, 2006 -- Research has demonstrated that intermittent treatment with sulfadoxine-pyrimethamine (SP) is safe, well tolerated and ... -DG News

Intermittent Treatment Found Effective In Malaria  Jul 16, 2006
An intermittent treatment with sulfadoxine-pyrimethamine, a common and cheap anti-malarial was found effective in treating malaria in Mozambican children by ... -MedIndia

KENYA: Battling malaria in western region  Jul 13, 2006
Unfortunately, ACTs cost 10 to 15 times more than chloroquine and sulfadoxine pyrimethamine (SP), formerly the most effective anti-malarials. ... -Reuters AlertNet

Artesunate-Amodiaquine Works  Jul 11, 2006
It is for this reason that the intermittent preventive treatment (IPT) of malaria with Sulphadoxine-Pyrimethamine (SP) tablet in pregnant women is considered a ... -Daily Graphic

Preventive Treatment Reduces Risk Of Malaria In Infants  Jun 29, 2006
Clara Menendez, MD, and her colleagues in Mozambique and Spain explored the intermittent administration of the antimalarial sulfadoxine-pyrimethamine (SP) to ... -Medical News Today

Ask Science  Jun 30, 2006
...cases, resistance to chloroquine is widespread, while resistance to Fansidar, the brand name for a combination of sulfadoxine and pyrimethamine, is common but ... -New York Times



Adherence of community caretakers of children to pre-packaged ...  16 May 2006
Implementation is through community drug distributors (CDDs) who distribute pre-packaged chloroquine plus sulfadoxine-pyrimethamine free of charge to ... - ReliefWeb

Zimbabwe: Malaria claims 125 lives  May 2, 2006
Chemically treated mosquito nets, chloroquine and sulphadoxine pyrimethamine (SP) for a pregnant woman have been supplied to the areas. - African News Dimension

Malaria Claims 125 in Four Months  May 2, 2006
Chemically treated mosquito nets, chloroquine and sulphadoxine pyrimethamine (SP) for preg nant women have been supplied to the areas. ... - AllAfrica.com

Workshop on poverty alleviation held at Saltpond  May 3, 2006
...awareness in the use of insecticide treated nets and compliance with the Intermittent Preventive Treatments (IPT) using Sulphadoxine-Pyrimethamine by pregnant ... - Crusading Guide

AFRICA : Fewer people access effective malaria treatment  Apr 22, 2006
...in Sudan, Kenya, Malawi, Côte d'Ivoire and Sierra Leone, the ministries of health are still using chloroquine or sulfadoxine-pyrimethamine, even though these ... - African News Dimension

Nigeria: Lagos gives out treated nets to curb malaria  Apr 25, 2006
Two doses of Sulphadoxine Pyrimethamine, the drug of choice for IPT, are given to pregnant women after the first trimester, at one-month interval. ... - African News Dimension

Zambia: Effective Malaria Treatment is a Human Right, Says Masebo  Apr 25, 2006
...several African countries there were similar experiences where the ministries of health were still using chloroquine or sulfadoxine-pyrimethamine, even though ... - AllAfrica.com

Botswana: Malaria Commemoration in Maun  Apr 25, 2006
...this year. Botswana does not use ACT but instead uses Sulphadoxine Pyrimethamine and Quinine because they are still effective. The ... - AllAfrica.com

Kenya to train shopkeepers in dispensing anit-malarial drugs  Apr 21, 2006
...drugs as a first-line drug to treat uncomplicated Plasmodium falciparum malaria, instead propagated the use of the Sulfadoxine-pyrimethamine (SP) which though ... - African News Dimension

Kenya: Timely Campaign On Drugs  Apr 28, 2006
By the late 1990s resistance to the drug had risen so high that the ministry adopted sulphadoxine/pyrimethamine combinations as first-line treatments. ... - AllAfrica.com

Sierra Leone join to celebrate Africa Malaria Day Today Malaria ...  Apr 25, 2006
...of Artesunate and Amodiaquine (AS+ AQ), Artemether Lumefantrine (CO-ARTEM) , Artesunate and Amodiaquine, Quinine and Sulphodoxine-Pyrimethamine (SP) or ... - Awareness Times

Combo treatment offers cheap prevention for malaria  Apr 25, 2006
The researchers found mixing an old drug called sulfadoxine-pyrimethamine with artemisinin, a naturally derived chemical, reduced the risks of catching full ... - CBC.ca

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