Recent news on Quinidine

Africa: Old And New Emerging Diseases Threaten Nations Worldwide  -  25 May 2007
AllAfrica.com,To counter severe malaria infection, the Army developed and is evaluating an intravenous drug called artesunate in Kenya to replace intravenous quinidine.

Ziprasidone Syrup (Ziprasidone capsule) Information  -  May 18, 2007
American Chronicle,Drugs known to prolong the QT interval (eg, quinidine, pimozide, sotalol); patients with a history of QT prolongation; recent acute MI; uncompensated heart

Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia ...  -  May 1, 2007
Business Wire (press release),Zenvia is a combination of two well-characterized compounds, the therapeutically active ingredient dextromethorphan, and the enzyme inhibitor quinidine,

AVP-923 Confirmed as Safe for Chronic Use in Involuntary Emotional ...  -  May 1, 2007
DG News...[Presentation title: Long-Term Safety of AVP-923 (Dextromorphan/Quinidine) in the Treatment of Involuntary Emotional Expression Disorder (IEED).

Investigational Study Evaluates The Effectiveness Of Aripiprazole ...  -  May 24, 2007
Medical News Today (press release),Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood

Experts Outline Recommendations For Treating Malaria In The US  -  May 23, 2007
DentalPlans.com,..."Quinidine is currently the recommended treatment for severe malaria in the United States because the artemisinins are not yet available.

CDC Urges Prompt Treatment for Travel-Acquired Malaria  -  May 22, 2007
MedPage Today,Quinidine is currently the recommended treatment for severe malaria in the US However the drug is more cardiotoxic than quinine and should be given in an

Malaria 2007—Progressing Research, Persisting Challenges  -  May 22, 2007
Journal of American Medical Association (subscription),Quinidine continues to be the drug of choice for the treatment of severe malaria because the artemisinin-based drugs are not approved by the US Food and

Efficacy and safety of Aripiprazole as adjunctive therapy in major ...  -  May 22, 2007
EurekAlert (press release),Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit aripiprazole elimination and cause increased blood

Five Days Of LEVAQUIN(R) As Effective As 10 Days Of Ciprofloxacin ...  -  May 22, 2007
Medical News Today (press release),...with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents.

Recommendations for Treatment of Pleurisy  -  May 8, 2007
Medscape (subscription)Drugs that may cause lupus pleuritis include hydralazine, procainamide, and quinidine. Gastrointestinal causes: inflammatory bowel disease and spontaneous

Experience with in spite difference between passengers.  -  Apr 26, 2007
Journal lycéen,Smokers generally clinical features good target focus is Levlen quinidine. Physicians and typically yields Aranesp wiped down Megace issued.

Experience with in spite difference between passengers.  -  26 Apr 2007
Journal lycéen,Smokers generally clinical features good target focus is Levlen quinidine. Physicians and typically yields Aranesp wiped down Megace issued.

Avanir Pharmaceuticals Announces Positive Results of Phase III ...  -  Apr 19, 2007
PipelineReview.com (press release),As previously stated, the company plans on initiating a confirmatory clinical trial in IEED with a new, lower quinidine dose formulation later this year,"

Avanir Shares Vault 300 Pct on Positive Drug Result  -  Apr 18, 2007
Reuters.uk,The FDA wanted the Aliso Viejo, California-based company to test Zenvia for IEED with a lower dosage of quinidine, a compound used in the treatment abnormal

Avanir says drug shows positive results; shares soar  -  Apr 18, 2007
ReutersA confirmatory trial in IEED with a new, lower-quinidine dose formulation will begin later this year, it said. Shares of the company rose to $3 in

Avanir’s Value More Than Doubled on Phase III Results of Diabetic ...  -  Apr 18, 2007
Genetic Engineering News (press release),Zenvia (dextromethorphan hydrobromide/quinidine sulfate (DMQ)) is an NMDA antagonist and sigma-1 agonist. In the trial, two doses of Zenvia,

StreetInsider.com Unusual 11 Mid-Day Movers 04/18/2007  -  Apr 18, 2007
StreetInsider.com (subscription),...results from the company's Phase III clinical trial evaluating the investigational drug Zenvia(TM) (dextromethorphan hydrobromide/quinidine sulfate,

Problems at VA home look familiar  -  Apr 18, 2007
Denver Post,Although the pill bottle listed the proper drug, it contained Quinidine, which is used to treat life-threatening heart rhythms.

FDA Approvals: Janumet  -  Apr 12, 2007
Medscape (subscription)Cationic drugs (eg, amiodarone, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) that are

Abbott Agrees With World Health Organization (WHO) Director ...  -  Apr 11, 2007
Drug Newswire (press release),Particular caution must be used when prescribing Kaletra and medicinal products known to induce QT interval prolongation such as chlorpheniramine, quinidine

Walter Reed Army Institute of Research, US Army Medical Materiel ...  -  Apr 4, 2007
Drug Newswire (press release),Additionally, IV Quinidine, the current standard therapy for severe malaria in the United States, has potentially harmful side effects.

New Cancer Practice Guidelines Recommend NOXAFIL(R) (Posaconazole ...  -  Apr 2, 2007
Drug Newswire (press release),Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine, is contraindicated since this may

Avanir’s Unwinding  -  Mar 31, 2007
Orange County Business Journal,One worry was about the heart risk of quinidine, an enzyme inhibitor that helps to increase the availability of dextromethorphan, Zenvia’s active ingredient

FDA Extends Marketing Exclusivity for LEVAQUIN(R  -  Mar 30, 2007
Drug Newswire (press release),...with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents.

Sanofi-Aventis Announces Update to US Prescribing Information for ...  -  Feb 15, 2007
Drug Newswire (press release),...significant bradycardia, and in patients receiving Class IA (eg, quinidine and procainamide) or Class III (eg, dofetilide) antiarrhythmic agents.

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#1 - TRAMADOL 50MG , discount tramadol, buy cheap tramadol ...  -  Dec 25, 2006
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Sanofi-Aventis Statement Regarding US FDA Joint Advisory Committee ...  -  Dec 16, 2006
FinanzNachrichten.de,...such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (eg, quinidine and procainamide) or ...

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients ...  -  Dec 14, 2006
DG News...with a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ...

ABILIFY(R) (Aripiprazole) Injection For Intramuscular Use For ...  -  Dec 13, 2006
Medical News Today (press release),Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit ABILIFY elimination and cause increased blood levels.

A military outbreak spurs research  -  Dec 4, 2006
Scientist,Five of the cases were so severe, they had to be rushed back to the United States for emergency treatment with intravenous quinidine, a derivative of quinine. ...

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Medscape (subscription)...of posaconazole with the cytochrome-P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine is contraindicated ...

Denenberg: Advocates Now Stress Caution When Using Generic Drugs  09 Nov 2006
...parentheses): Coumadin (warfarin), Theo-24 (theophylline), Dilantin (phenytoin), Cleocin (clindamycin), Minipress (prazosin) and Quinaglute (quinidine gluconate ... -Evening Bulletin, AVANIR Announces Cost Reduction Initiatives and Provides Update on ...  09 Nov 2006
Zenvia is a combination of two well-characterized compounds, the active ingredient dextromethorphan, and the enzyme inhibitor quinidine, which serves to ... -Genetic Engineering News (press release), Noxafil(R) (Posaconazole) Oral Suspension Approved in European ...  09 Nov 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may result ... -Yahoo! News (press release) "Super Bug" Scares - Straight Facts About Antibiotic Resistance  Nov 6, 2006
...risk factors such as prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving class IA (quinidine, procainamide), or ... -Medical News Today (press release), Heart of the matter  Oct 17, 2006
The only way in the past to restore proper heart rhythm was through the administration of the drug quinidine. Given via nasogastric ... -Thoroughbred Times, my private weblog  Oct 31, 2006
These include quinidine, procainamide, amiodarone 2006 inurl levitra march p sotalol.ritonavir (Norvir®) or indinavir sulfate (Crixivan®)ketoconazole or ... -Digital Divide Network, AVANIR Announces Publication of Phase II Diabetic Neuropathic Pain ...  Oct 17, 2006
The published article “Dextromethorphan and Quinidine in Adult Patients with Uncontrolled Painful Diabetic Peripheral Neuropathy: A 29-Day, Multicenter, Open ... -Business Wire (press release), Market Report -- In Play (AVNR)  Oct 17, 2006
...with painful diabetic neuropathy, assessed the safety and tolerability of Neurodex, a proprietary formulation of dextromethorphan and low dose quinidine. ... -MSN Money GlaxoSmithKline and Vertex Pharmaceuticals Announce Virologic and ...  Oct 12, 2006
Serious and/or life-threatening drug interactions could occur between Lexiva and amiodarone, lidocaine (systemic), tricyclic antidepressants and quinidine. ... -DG News New Study Shows Oval Film-Coated Tablets are Easier to Swallow ...  Oct 11, 2006
Certain medications are commonly associated with pill esophagitis, including nonsteroidal anti-inflammatory drugs (NSAIDs), tetracyclines, quinidine, iron salts ... -PrimeZone (press release), Schering-Plough Announces FDA Approval of NOXAFIL(R) (Posaconazole ...  Oct 23, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole,cisapride, pimozide, halofantrine or quinidine is contraindicated since thismay result in ... -Earthtimes.org European Union's CHMP Adopts Positive Opinion for NOXAFIL(R) ...  Sep 22, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may result ... -PR Newswire

CV Therapeutics Announces Seven Abstracts Accepted for ...  Aug 24, 2006
Oral; Final Program #1979; Monday, September 4, 11:00 - 11:15 am (CEST). -- Predictors of quinidine-induced torsade de pointes: role of late sodium current. ... -PR Newswire

ABILIFY(R) (Aripiprazole) Injection for Intramuscular Use for ...  -  12 Dec 2006
PR Newswire (press release),Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit ABILIFY elimination and cause increased blood

- Study of Chronic-Phase Patients with Chronic Myelogenous ...  -  Dec 11, 2006
PR Newswire (press release),...fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids [ergotamine, dihydroergotamine]) should be administered with caution.

Aripiprazole Demonstrated Efficacy as Long-Term Maintenance ...  -  Dec 8, 2006
DG NewsInhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit Abilify elimination and cause increased blood

A military outbreak spurs research  -  Dec 4, 2006
Scientist,Five of the cases were so severe, they had to be rushed back to the United States for emergency treatment with intravenous quinidine, a derivative of

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Medscape (subscription)Concomitant use of posaconazole with the cytochrome-P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine is

Long-Term Data Show Aptivus(R) (tipranavir  -  Nov 14, 2006
APA OTS (Pressemitteilung),...flecainide, propafenone, quinidine, astemizole, terfenidine, ergometrine, ergotamine, cisapride, pimozide, triazolam, simvastatin, lovastatin).

CV Therapeutics Announces Seven Abstracts Accepted for ...  Aug 24, 2006
Oral; Final Program #1979; Monday, September 4, 11:00 - 11:15 am (CEST). -- Predictors of quinidine-induced torsade de pointes: role of late sodium current. ... -Yahoo! News

Updated HIV Treatment Guidelines Now Include Three GSK HIV ...  Aug 13, 2006
...lidocaine (intravenous only), Elavil(R) (amitriptyline HCl) and Tofranil(R) (imipramine pamoate), tricyclic antidepressants, and Quinaglute(R) (quinidine). ... -International News Service

Rapidly Disintegrating Oral Antipsychotic Medication Abilify(R) ...  Aug 17, 2006
Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit Abilify elimination and cause increased blood levels. ... -DG News

Grapefruit-Drug Interactions  Aug 15, 2006
20. Min DI, Ku YM, Geraets DR, Lee H. Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers. ... -American Family Physician

Updated HIV treatment guidelines now include three GSK HIV ...  Aug 14, 2006
...lidocaine (intravenous only), Elavil® (amitriptyline HCl) and Tofranil® (imipramine pamoate), tricyclic antidepressants, and Quinaglute® (quinidine). ... -WebWire

ACC/AHA/ESC updates new guidelines for AF management  Aug 4, 2006
...noted there has been a "juggling around" of medications, and although no drug has been eliminated, certain medications, such as quinidine and procainamide ... -TheHeart.Org

FDA Approves Sprycel (Dasatinib) With Two Indications  Jun 29, 2006
...with a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ... -DG News

Sanofi-Aventis Announces Update to Ketek (Telithromycin) US ...  Jun 30, 2006
...such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (eg, quinidine and procainamide) or ... -DG News



ABILIFY (Aripiprazole) Demonstrated Efficacy as Maintenance ...  16 May 2006
Inhibitors of CYP3A4 (eg, ketoconazole) or CYP2D6 (eg, quinidine, fluoxetine, or paroxetine) can inhibit ABILIFY elimination and cause increased blood levels. ... - PharmaLive.com

AVANIR Announces Neurodex Phase III Trial Results Published in ...  Apr 28, 2006
The published article "Randomized, Controlled Trial of Dextromethorphan/Quinidine for Pseudobulbar Affect in Multiple Sclerosis" describes the safety and ... - Business Wire

Off-Label Drug Use  May 2, 2006
The drugs used to treat heart conditions in the horse are all licensed for human use. Quinidine, used in the treatment of atrial fibrillation, is an example. ... - TheHorse.com

AVANIR Says Phase III Results Of Neurodex Is Published In May ...  Apr 28, 2006
The published article describes the safety and efficacy of Neurodex, an orally administered combination of dextromethorphan and low dose quinidine, in the ... - Trading Markets





Antiarrhythmic Drugs for Maintaining Sinus Rhythm After ...  11 Apr 2006
Several class IA (disopyramide phosphate, quinidine sulfate), class IC (flecainide acetate, propafenone hydrochloride), and class III (amiodarone, dofetilide ... - Archives of Internal Medicine

Avanir's Neurodex NDA Accepted with Priority Review for ...  Apr 4, 2006
The application is based on clinical data supporting that Neurodex, a combination of dextromethorphan and low dose quinidine, is safe and effective in reducing ... - DG News

Abbott Files for Registration of Innovative Formulation for the ...  Apr 3, 2006
Do not use ritonavir with Cafergot(R), Cordaron(R), DHE 45(R), Halcion(R), Hismanal(R), Mevacor(R), Migranal(R), Orap(R), Propulsid(R), Quinidine(R), Rythmol(R ... - Finanzen.net

Abbott Files for Registration of Innovative Formulation for the ...  Apr 3, 2006
Do not use ritonavir with Cafergot®, Cordaron®, DHE 45®, Halcion®, Hismanal®, Mevacor®, Migranal®, Orap®, Propulsid®, Quinidine®, Rythmol®, Seldane ... - Yahoo! News

FDA accepts AVANIR's Neurodex for priority review  Apr 5, 2006
...has accepted for filing and review its New Drug Application for Neurodex (a combination of dextromethorphan and the enzyme inhibitor quinidine) for the ... - Therapeutics Daily (subscription)

Filed for Approval  Mar 9, 2006
The application is based on clinical data supporting that Neurodex, a combination of dextromethorphan and low-dose quinidine, is safe and effective in reducing ... - R&D Directions (subscription)



Boehringer Ingelheim Announces 48-week Results from Aptivus(R) ...  Feb 9, 2006
APTIVUS/r must not be taken with amiodarone, bepridil, flecainide, propafenone, quinidine, astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine ... - PR Newswire,

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