Recent news on Retinoic

Efficacy and Safety Profile of Basilea’s Alitretinoin for Severe ...  -  May 22, 2007
PipelineReview.com (press release),P280 / Re-treatment study of alitretinoin (9-cis retinoic acid) in severe chronic hand eczema refractory to topical treatment. Ruzicka T, Lahfa M, Lynde Ch,

Topical Retinol Bolsters Elderly Skin and Reduces Wrinkles  -  May 21, 2007
MedPage Today,Typically, at least two to three months of topical retinoic acid therapy is needed before noting any significant improvement in wrinkles caused by

Basilea Shares Rise On NDA, Alitretinoin Phase III Data  -  May 22, 2007
Therapeutics Daily (subscription) (press release),Basilea also remains on track to file in the second half of 2007 for European Union and Canadian approval for alitretinoin (9-cis retinoic acid) in chronic,

Developmental biology: A chordate with a difference  -  May 11, 2007
Nature.com (subscription),1) has retained the fundamental chordate body plan, it has lost the mechanism of retinoic-acid signalling that otherwise operates during chordate

INNOVIVE Pharmaceuticals: Wall Street Analyst Forum Presentation ...  -  May 22, 2007
Seeking Alpha,The current therapy for APL is ATRA (All-Trans Retinoic Acid) currently a generic drug, it's used in induction and in maintenance in combination with

Researchers Have Identified Cancer Promoter Genes  -  May 17, 2007
MedIndia,Cancer epidemiologists examined methylation significance in three genes, known as E-cadherin, p16 and retinoic acid B2 receptor (RAR-B2), using tissue

Effects on Breast Tumors of DNA Alternations in 3 Genes Described  -  May 17, 2007
MedIndia,The researchers analyzed methylation status in three genes, known as E-cadherin, p16 and retinoic acid B2 receptor (RAR-B2), using tissue samples from 887

Protein Cuts Early Infection Down to Size - 2007-05-24  -  May 24, 2007
exduco.net,The pathway’s key sensor, retinoic acid–inducible gene I (RIG-I), stands guard inside cells and activates the same intracellular virus-clearing chemicals as

Alitretinoin Effective in Severe Chronic Hand Eczema Refractory to ...  -  May 21, 2007
DG NewsVIENNA, AUSTRIA -- May 22, 2007 -- Once daily oral administration of the retinoid alitretinoin (9-cis retinoic acid) shows good tolerability and efficacy

Pirate adventure fulfills a dream  -  Apr 29, 2007
Tampa Bay's 10,Cole underwent 6 months of retinoic acid therapy which is the standard protocol for this type of cancer. On April 17, his family learned that the bone

Quest Group International, Inc. Raises $20 Million, Acquires ...  -  May 18, 2007
PharmaLive.com (press release),The extensive portfolio of compounds acquired from Vitae includes selective retinoic acid receptor agonists and antagonists and rexinoids, the latter being

Quest Group International, Inc. Raises $20 Million, Acquires ...  -  May 18, 2007
PR-Inside.com (Pressemitteilung),Vitae includes selective retinoic acid receptor agonists and antagonists and rexinoids, the latter being small molecule synthetic compounds.

THE VITAMIN CREAM THAT REALLY DOES WIPE OUT WRINKLES  -  May 21, 2007
UK Express,The body converts retinol to tretinoin, or retinoic acid, an active form of vitamin A. Tretinoin benefits the skin but it has side effects even more severe

Leading dermatologist in walk to save our skins  -  May 10, 2007
University of Manchester,More recently, his surprising test results that showed an over-the-counter anti-ageing cream could match the effectiveness of retinoic acid, a prescription

Scientist who helped create furore sees too little evidence to ...  -  May 5, 2007
Financial Times,The Manchester experiment compared the impact on the volunteers' skin of tretinoin (retinoic acid), the Boots serum and a simple moisturising cream.

Wonder cream set for sales stampede  -  May 4, 2007
ic Coventry,On the Horizon programme in March, a study compared the effect of Protect and Perfect on collagen production with the performance of retinoic acid - a

CuraGen And TopoTarget Initiate Phase I/II Clinical Trial Of ...  -  May 3, 2007
Medical News Today (press release),...with other active anti-cancer agents, including 5-FU, carboplatin, paclitaxel, cis-retinoic acid, azacitidine and Velcade(R) (bortezomib) for Injection.

We road test that Boots miracle cream  -  May 4, 2007
Daily Mail,...at Manchester University confirmed that our cream had equivalent benefits to those of retinoic acid, which is used by doctors to help repair skin cells.

Alternative Inhibition Strategy For Treating Acute Promyleocytic ...  -  Apr 12, 2007
Science Daily (press release)Science Daily — The acid form of vitamin A (retinoic acid; RA) is used to treat a type of leukemia known as acute promyleocytic leukemia (APL).

Sold out: The £17 cream even scientists say can banish wrinkles  -  Mar 29, 2007
Daily Mail,The study compared the effect of No7 Protect & Perfect on collagen production with the performance of retinoic-acid or Tretinoin - a prescription drug used

Retinal (Vitamin A and Vision)  -  Apr 3, 2007
ScienceBlogsThis is why vitamin A is so essential for vision - retinal is just one oxidation state up from retinol or one down from retinoic acid.

Full Text  -  Apr 19, 2007
Science Magazine (subscription)A novel cytoplasmic protein, called STRA8 (stimulated by retinoic acid-8), governs initiation of meiosis in embryonic mouse ovaries (11).

Adult Leukemia: A Comprehensive Guide for Patients and Families  -  Apr 18, 2007
Science Daily (press release)Alternative Inhibition Strategy For Treating Acute Promyleocytic Leukemia (April 13, 2007) -- The acid form of vitamin A (retinoic acid; RA) is used to

Eat yourself beautiful  -  Apr 23, 2007
Independent Online,It's no coincidence that the best skin-repairing ingredients in face creams, retinoic acid and retinol, are vitamin A derivatives. Plus, beta-carotene acts

An Update on Transcription Factors in Asthma  -  Apr 23, 2007
Medscape (subscription)...[26-28] There are recent data that the retinoic acid-related orphan receptor (ROR)-gamma is necessary and sufficient for Th17 commitment and differentiation

Acne Treatment - Isotretinoin The Best Medicine  -  Apr 22, 2007
Best Syndication,Retinoids are derived from Vitamin A. Isotretinoin is chemically known as 13-cis retinoic acid. Isotretinoin is a drug of choice for acne patients who may

Full Text  -  Apr 12, 2007
Science Magazine (subscription)In test-tube experiments, they found that dendritic cells from the intestinal lymph nodes convert retinol to retinoic acid, which induces T cells to make

CuraGen and TopoTarget Announce New Clinical Results With ...  -  Apr 19, 2007
PharmaLive.com (press release),...with other active anti-cancer agents, including 5-FU, carboplatin, paclitaxel, cis-retinoic acid, azacitidine and Velcade(R) (bortezomib) for Injection.

Research Supported by Samuel Waxman Cancer Research Foundation ...  -  Apr 16, 2007
Genetic Engineering News (press release),Recent information indicates that the combination of the vitamin A derivative retinoic acid, arsenic and chemotherapy may cure over 90% of APL patients,

Here's what to do when it's time to get rid of those blotches  -  Apr 16, 2007
New Albany Tribune,...last as long as possible by using creams that stimulate the turnover of new collagen in the skin. These creams can include fruit acids or retinoic acids.

Here's what to do when it's time to get rid of those blotches  -  Apr 16, 2007
Mineral Wells Index,These creams can include fruit acids or retinoic acids. McKenzie said that when physician’s assistant Bonnie Buchanan did the treatment she felt little in

Cream turns back time  -  Apr 14, 2007
Melbourne Herald Sun,Lead researcher Professor Chris Griffiths was surprised to find the cream acted in the same way as retinoic acid or Tretinoin, a prescription drug used to

Family's joy as daughter beats rare form of cancer  -  Apr 12, 2007
Kent News,However, consultant John Anderson, asked the family about starting Molly on a drug trial which saw her being given retinoic acid.

How Does Vitamin A Prevent Acne Outbreaks?  -  Apr 11, 2007
American Chronicle,The body can then transform this retinol into other active forms of vitamin A like retinal and retinoic acid. Food sources of vitamin A include beef liver,

News tips from the Journal of Neuroscience  -  Apr 10, 2007
EurekAlert (press release),Retinoic acid, critical for photoreceptor genesis, enhanced the latter effect. Michael L. Spezio, Po-Yin Samuel Huang, Fulvia Castelli, and Ralph Adolphs

Anti-wrinkle cream flies off shelves at Boots  -  Apr 6, 2007
Worcester News,The Horizon programme highlighted a study comparing the effect of No7 Protect & Perfect on collagen production with the performance of retinoic-acid - a

Winners of the 2007 La Roche-Posay North American Foundation Award ...  -  Apr 4, 2007
PR Newswire (press release),First prize was awarded to Amanda Nelson, PhD from Penn State University for her abstract "Determining the mechanisms by which 13-cis retinoic acid

Senior CIIT Researcher Honored By The Society Of Toxicology  -  Apr 2, 2007
dBusinessNews Triangle (press release),...and has developed models for such chemicals as acetone, arsenic, coumarin, isopropanol, manganese, methylene chloride, methylmercury, retinoic acid,

Riots in aisles for anti-wrinkle lotion that actually works  -  Mar 31, 2007
Times Online,Professor Chris Griffiths, an eminent dermatologist, did not believe that any over-the-coun-ter cream could match the effectiveness of retinoic acid or

Michael Longaker  -  Mar 30, 2007
Stanford University School of Medicine,Wan DC, Siedhoff MT, Kwan MD, Nacamuli RP, Wu BM, Longaker MT "Refining Retinoic Acid Stimulation for Osteogenic Differentiation of Murine Adipose-Derived

'Real' anti-ageing cream sold out  -  Mar 30, 2007
This is Money,Their study compared the effect of No7 Protect & Perfect on collagen production with the performance of retinoic-acid or Tretinoin, a vitamin A derivative

Mass market serum innovates anti-aging market  -  Mar 30, 2007
CosmeticsDesign-Europe.com,In order to do this Regan compared the effects of the No7 serum on collagen production against the effects of retinoic-acid or tretinoin, both prescription

Midway through a conversation with a friend discussing her spec ...  -  Mar 30, 2007
Chiang Mai City Life,These included hydroquinone, retinoic acid and ammoniated mercury. Using these products could lead to severe skin irritation, white spots, incurable melasma

Enhanced Expression of Adenovirus-Mediated Sodium Iodide Symporter ...  -  Mar 1, 2007
Journal of Nuclear Medicine (subscription)We investigated the effect of retinoic acid on adenovirus-mediated expression of the human NIS gene in the MCF-7 breast cancer cell line.

Excentral cleavage of ß-carotene in vivo in a healthy man 1 ,2 ,3  -  Mar 7, 2007
Am J Clin Nutr (subscription),Selected plasma samples were spiked with reference standards of retinol, ß-apo-12'-carotenal, ß-apo-8'-carotenal, 13-cis-retinoic acid, all-trans-retinoic

How the products work  -  Mar 23, 2007
Malaysia Star,Other substitutes include arbutin (technically known as hydroquinone-beta-D-glucoside) and tretinoin (or all-trans retinoic acid).

The Body Perfect  -  Mar 22, 2007
Hamptons.com,Unlike prescription anti-wrinkle products, which usually contain fast acting, but harmful retinoic acid, Morning Glory products work more gradually,

Whole Body Regeneration From A Blood Vessel  -  Mar 5, 2007
Science Daily (press release)For molecular insights into regeneration, the researchers focused on retinoic acid (RA) signaling by examining the temporal expression of its receptor (RAR)

Whole body regeneration from a blood vessel  -  Mar 5, 2007
SpiritIndia,The unique Botrylloides whole body regeneration process could serve as a new in vivo model system for regeneration, suggesting that retinoic acid signaling

European Urology - Prognostic Value of CpG Island Hypermethylation ...  -  Mar 12, 2007
UroToday,CpG island hypermethylation at APC, retinoic acid receptor beta (RAR-beta), and PTGS2 discriminated with a sensitivity of 65–83% and a specificity of

A Key To Male Fertility  -  Mar 8, 2007
Medical News Today (press release),At the same time, the SHP protein controls the timing of the differentiation of the germ cells by inhibiting the metabolism of retinoic acids (see

Leukemia Drug Turns Mini-molecules Up, Cancer Genes Down  -  Mar 6, 2007
Medical News Today (press release),The drug is called all-trans-retinoic acid (ATRA) and it is considered the gold standard for treating the disease. The study showed that ATRA raises the

Ivrea Pharmaceuticals Announces Successful In Vitro Nail ...  -  Feb 5, 2007
Drug Newswire (press release),...to reduce the level of irritation associated with all trans retinoic acid (also called tretinoin) while uniquely maintaining efficacy in treating acne.

Testosterone on Time  -  Jan 31, 2007
Science Now,Moreover, they discovered that SHP plays a second role: reducing the production of retinoic acid to ensure the correct timing of sperm differentiation.

In one carcinogen, DMS researchers find a cancer cure  -  Jan 9, 2007
The Dartmouth,..."This appears to be due to the oncogenic protein repressing the function of the normal retinoic acid receptor pathway," Dmitrovsky said.

Utilization of DR1 as True RARE in Regulating the Ssm, a Novel ...  -  Jan 3, 2007
Journal of EndocrinologyThis gene, namely Ssm, recruits all three combinations of nuclear receptors in vitro but in vivo regulation is observed by trans-retinoic acid-activated

Vitamin A deficiency may turn dangerous  -  Jan 16, 2007
Newindpress (subscription),Retinol and retinoic acid (RA) are essential for embryonic development. During fetal development, RA functions in limb development and formation of the

Vitamin A and cancer link found  -  Jan 16, 2007
Guardian Unlimited,Laboratory tests showed that treatment with vitamin A, in the form of retinoic acid, turned the normally scaly lining of the oesophagus into a glandular

Aberrant innate immune response in lethal infection of macaques ...  -  Jan 17, 2007
Nature.com (subscription),An important pathway in activation of the antiviral response to influenza virus infection occurs through the activities of DDX58 (or retinoic-acid-inducible

What is Known About the Safety of Multivitamin-Multimineral ...  -  Jan 5, 2007
Am J Clin Nutr (subscription),Children exposed in utero to the anti-acne drug isotretinoin (13-cis-retinoic acid) have a pattern of congenital abnormalities known as the retinoic acid

HDAC inhibitors overcome first hurdle  -  Jan 4, 2007
Nature.com (subscription),Many trials with HDACs and retinoic acid—a differentiation agent—are also underway, as HDAC inhibitors seem able to restore the retinoic acid receptor

George Yang  -  Jan 11, 2007
Stanford University School of Medicine,Malladi P, Xu Y, Yang GP, Longaker MT "Functions of vitamin D, retinoic acid, and dexamethasone in mouse adipose-derived mesenchymal cells.

Arsenic Triggers Unique Mechanism in Rare Leukemia  -  Jan 3, 2007
eMaxHealth.com,15 and 17 that forms a fusion protein between two genes called promyelocytic leukemia protein (PML) and retinoic acid receptor alpha (RAR-alpha).

INNOVIVE Pharmaceuticals Acquires Exclusive North American Rights ...  -  Dec 10, 2006
Drug Newswire (press release),Tamibarotene was specifically designed to address challenges of APL resistance and the high rate of toxicity among patients treated with all-trans retinoic

The nuclear receptor hepatocyte nuclear factor 4 acts as a ...  -  Dec 18, 2006
Journal of Cell Biology (subscription)...hepatocyte nuclear factor 4 ; RAR , retinoic acid receptor ; RLE, rat lung endothelial; RXR , retinoid X receptor ; tRA, all-trans retinoic acid; WT,

Combination Treatment Highly Effective for Long-Term Survival in ...  -  Dec 12, 2006
DG News...[Presentation title: Long-Term Follow-Up Confirms the Benefit of All-Trans Retinoic Acid (ATRA) and Arsenic Trioxide (As2O3) as Front Line Therapy for Newly

CuraGen And TopoTarget Announce Expansion Of Belinostat (PXD101 ...  -  Dec 15, 2006
Medical News Today (press release),...with other active anti-cancer agents, including 5-FU, carboplatin, paclitaxel, cis-retinoic acid, azacitidine and Velcade(R) (bortezomib) for Injection.

New Data Demonstrate Clinical Activity of Vidaza(R) in Combination ...  -  Dec 11, 2006
PR Newswire (press release),Significant Clinical Activity of the Combination of Vidaza, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia (Abstract 160) Andres Soriano, MD,

Alternatives to Standard Chemotherapy Prolong Survival in Lymphoma ...  -  Dec 9, 2006
PR Newswire (press release),Since 1986, the innovative application of all-trans retinoic acid (ATRA) in APL treatment in China has dramatically improved the clinical outcome of

Whitening creams are ordered off the shelves  -  Dec 9, 2006
Nation Multimedia,The harmful substances included hydroquinone, retinoic acid and ammoniated mercury. These could cause severe skin irritation, white spots, incurable melasma

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
Earthtimes.orgSignificant Clinical Activity of the Combination of Azacitidine, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia: Results of a Phase I/II study

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
PR Newswire (press release),Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia: Results of a Phase I/II study Abstract ID: 160 Andres O. Soriano et al.

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