Recent news on Retrovir

Carbon OKs action over prescriptions  -  25 May 2007
Allentown Morning Call,Also included are Myleran, used to treat forms of blood cancer; Navelbine, for treating cancer, specifically some lung cancers; Retrovir, for treating HIV

International panel issues new HIV/HCV co-infection guidelines  -  May 24, 2007
Aidsmap,Use of erythropoetin “should be encouraged� to manage anaemia, whilst AZT (Retrovir) “should be avoided.� Higher doses of pegylated interferon have been

I've done it. What now?  -  May 23, 2007
Health24.com,For occupational exposure A healthcare worker will usually receive a combination of AZT (retrovir) 200mg eight- hourly or 300mg 12-hourly and 3TC

HIV resistance mutations common but CXCR4 rare among untreated US ...  -  May 22, 2007
Aidsmap,Resistance to nevirapine (Viramune), delavirdine (Rescriptor), stavudine (Zerit), efavirenz (Sustiva), zidovudine (Retrovir), and nelfinavir (Viracept) were

First-trimester antiretrovirals a 'possible' risk for genital ...  -  27 Mar 2007
Aidsmap,...by multivariate analysis, only first-trimester AZT (zidovudine, Retrovir)use was a risk (odds ratio 10.68; 95% CI 2.11 to 54.13; p=.004).

CROI: high burden of side-effects from d4T leads to WHO dose ...  -  Mar 21, 2007
Aidsmap,Just under a quarter of the 2149 d4T-exposed patients switched treatment, compared to 13.2% of the 1433 AZT (zidovudine, Retrovir)-exposed patients.

Health-Care Workers Exposed To HIV On Job Need Preventive Treatment  -  Mar 5, 2007
Medical News Today (press release),...infected with HIV were reduced by about 81 percent among those who took zidovudine an anti-HIV drug also known as AZT or Retrovir after exposure.

CROI: New NNRTI, TMC278, demonstrates sustained potency, better ...  -  Mar 2, 2007
Aidsmap,In addition, in patients treated with Combivir, anaemia or neutropenia led to switches off zidovudine (AZT, Retrovir) in 6% of participants receiving TMC278

Single Patient Shows Baraclude May Be Linked to Risk for Resistant HIV  -  Feb 26, 2007
Medscape (subscription)The patient (male, aged 31 years) received combination zidovudine (Retrovir; GlaxoSmithKline), lamivudine, and nevirapine (Viramune; Boehringer Ingelheim)

Use of d4T is associated with buffalo hump  -  Feb 2, 2007
Aidsmap,...antiretroviral drugs (d4T and, to a lesser extent, AZT (zidovidine, Retrovir)), but relatively little is known about the exact causes of buffalo hump.

Exploiting natural HIV defence  -  Feb 9, 2007
BiopharmaReporter.com,When it was approved in 1987, it was marketed as Retrovir but came off patent in March 2006. The drug works through inhibiting reverse transcriptase - a

FDA Announces Tentative Approval of Triple Drug Fixed Dose Combination  -  Feb 6, 2007
PharmaLive.com (press release),The tablet contains lamivudine-zidovudine-nevirapine, the active ingredients in the widely used antiretroviral drugs Epivir (lamivudine), Retrovir

Post-Peripartum Use of Viramune Safe After Six-Month Wait  -  Jan 11, 2007
MedPage Today,In the United States, HIV-positive women typically receive Retrovir for prevention of mother-to-child viral transmission with intravenous doses during

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,...more quickly than resistance mutations to the nucleosides known as “thymidine analogues� – zidovudine (AZT, Retrovir) and stavudine (d4T, Zerit).

Emergence of resistance mutations: a comparison between drug classes  -  Dec 19, 2006
Aidsmap,...more quickly than resistance mutations to the nucleosides known as “thymidine analogues� – zidovudine (AZT, Retrovir) and stavudine (d4T, Zerit).

Triple nuke combination of AZT/3TC/tenofovir below current ...  -  Dec 17, 2006
Aidsmap,...safety and tolerability – of AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and tenofovir, dosed as Combivir twice daily and Viread once daily.

Advancements help in fight against AIDS  -  Dec 5, 2006
University Daily Kansan,1) Nucleoside Reverse Transcriptase Inhibitor (NRTIs) – The FDA approved azidothymidine (AZT), or Retrovir, to treat HIV-positive adults and children 3

New risk factors for severe liver toxicity identified in largest ...  Nov 3, 2006
...into mono- or dual therapy comprising a one of two nucleoside reverse transcriptase inhibitors (NRTIs) - including AZT (zidovudine, Retrovir), ddI (didanosine ... -Aidsmap, FDA Safety Changes: Retrovir and Cesamet  Aug 30, 2006
On May 10, the FDA approved safety labeling revisions for zidovudine (Retrovir tablets, capsules, and syrup made by GlaxoSmithKline) to warn of the potential ... -Medscape (subscription)

Recombinant human growth hormone reduces visceral fat in two ...  Sep 19, 2006
...case for subcutaneous fat loss (lipoatrophy), which has been strongly associated with d4T (stavudine, Zerit) and to a lesser extent, AZT (zidovudine, Retrovir ... -Aidsmap

Bacterial vaginosis and illness during pregnancy increase risk of ...  Aug 29, 2006
...earlier observations that in utero transmission is associated with higher viral loads and less than three weeks of AZT (zidovudine, Retrovir) prophylaxis for ... -Aidsmap

Advancements help in fight against AIDS  -  Dec 5, 2006
University Daily Kansan,1) Nucleoside Reverse Transcriptase Inhibitor (NRTIs) – The FDA approved azidothymidine (AZT), or Retrovir, to treat HIV-positive adults and children 3

Weight-based ribavirin dosing achieves high success rates in ...  -  Nov 21, 2006
Aidsmap,...to have a CD4 cell count of over 300 cells/mm 3 , were not allowed to take AZT (zidovudine, Retrovir) or ddI (diadosine, Videx) and were not cirrhotic.

Bacterial vaginosis and illness during pregnancy increase risk of ...  29 Aug 2006
...earlier observations that in utero transmission is associated with higher viral loads and less than three weeks of AZT (zidovudine, Retrovir) prophylaxis for ... -Aidsmap

GSK retracts AIDS drug Combivir's patent appeal  Aug 21, 2006
...said. The company had filed the patent application for Combivir, which is a combination of Epivir and Retrovir, nearly 8 years ago. ... -Business Standard

Business news in brief  Aug 22, 2006
...have to pay Glaxo a "reasonable royalty," the group said. Combivir is a combination of Glaxo's Epivir and Retrovir.- Bloomberg News. -Philadelphia Inquirer

IAC: Clinicians Urged to Consider HIV's Long-Term Complications  Aug 22, 2006
Another study, Gilead 934, compared the combination Emtriva (emtricitabine) and Viread with Epivir (lamivudine) and Retrovir (zidovudine). ... -MedPage Today

Study finds 4-drug treatment no better than 3 for HIV  Aug 14, 2006
Glaxo sells the first two under the brands Retrovir and Epivir, respectively, while Bristol-Myers Squibb Co. (BMY) sells the third under the brand Sustiva. ... -MarketWatch

Anti-Retroviral Therapy Continues to Elicit Debate  Aug 14, 2006
GlaxoSmith Kline in 2004. GlaxoSmithKline holds the patent for drugs such as Epivir, Retrovir and Combivir. But as various stakeholders ... -AllAfrica.com

Kaletra monotherapy as effective as triple therapy for at least 18 ...  Aug 17, 2006
They were randomised to receive treatment with Kaletra or efavirenz (Sustiva), both with AZT (zidovudine, Retrovir) and 3TC (lamivudine, Epivir). ... -Aidsmap

Updated HIV Treatment Guidelines Now Include Three GSK HIV ...  Aug 13, 2006
...to others. COMBIVIR is a combination tablet containing Epivir(R) (lamivudine, 3TC) and Retrovir(R) (zidovudine, AZT). INDICATION ... -International News Service

Efavirenz more durable than Kaletra over two years in treament ...  Aug 17, 2006
Participants in the triple-drug therapy groups also received 3TC (lamivudine, Epivir), plus their choice of AZT (zidovudine, Retrovir; 42%), d4T (stavudine ... -Aidsmap

Abacavir/3TC backbone proves most durable for children over five ...  Aug 16, 2006
...anti-HIV treatment regimen have better virological suppression and growth than children who take backbones comprising either AZT (zidovudine Retrovir) and 3TC ... -Aidsmap

Updated HIV Treatment Guidelines Now Include Three GSK HIV ...  Aug 13, 2006
...to others. COMBIVIR is a combination tablet containing Epivir® (lamivudine, 3TC) and Retrovir® (zidovudine, AZT). INDICATION COMBIVIR ... -Yahoo! News

Updated HIV Treatment Guidelines Now Include Three GSK HIV ...  Aug 14, 2006
...to others. COMBIVIR is a combination tablet containing Epivir(R) (lamivudine, 3TC) and Retrovir(R) (zidovudine, AZT). INDICATIO ... -Medical News Today

Updated HIV treatment guidelines now include three GSK HIV ...  Aug 14, 2006
...to others. Combivir is a combination tablet containing e pivir ® (lamivudine, 3TC) and retrovir ® (zidovudine, AZT). Combivir ... -WebWire

NRTI-sparing combination of ritonavir-boosted indinavir and ...  Aug 9, 2006
NRTIs, particularly d4T (stavudine, Zerit) and AZT (zidovudine, Retrovir) can cause loss of fat from under the skin or ‘lipoatrophy’. ... -Aidsmap

Gilead aims to speed AIDS drugs to poor  Aug 12, 2006
...eight agreements with African and Indian drug makers since 2001 to provide cheaper, generic versions of its HIV/AIDS treatments, Combivir, Retrovir and Epivir ... -News & Observer



Treatment simplification appears clinically safe in children with ...  May 11, 2006
The most commonly used nucleoside combinations were 3TC (lamivudine, Epivir) with AZT (zidovudine, Retrovir) or 3TC with d4T (stavudine, Zerit). ... - Aidsmap

Starting treatment with Kaletra involves greater risk of increased ...  Apr 24, 2006
Viread and 3TC (lamivudine, Epivir were significantly more likely to develop increased blood pressure than those taking AZT (zidovudine, Retrovir) and 3TC (p ... - Aidsmap

Aurobindo Pharma CB uses rare premium structure  Apr 23, 2006
...in early April and follows the expiry of GlaxoSmithKline’s patent on its capsule form of the same product which was marketed under the name of Retrovir. ... - FinanceAsia

Long-term study plays down risk of brain problems in HIV-positive ...  Apr 26, 2006
Treatment mainly consisted of monotherapy with AZT (zidovudine, Retrovir), ddI (didanosine, Videx) or ddC (zalcitabine, Hivid) although twelve patients had ... - Aidsmap

GSK turns to RFID to protect its AIDS drug  Apr 21, 2006
Among other GSK products flagged by the association as prone to adulteration, counterfeiting or diversion are Combivir, Epivir, Retrovir, Ziagen – all HIV ... - In-PharmaTechnologist.com





First-Time Generic Approvals: Glucotrol XL, Retrovir, Salagen  Apr 7, 2006
On March 27, the FDA approved a first-time generic formulation for zidovudine 100-mg capsules (made by Aurobindo Pharma Ltd; brand name Retrovir, made by ... - Medscape (subscription)

FDA OK's generic Retrovir for HIV  Mar 31, 2006
ROCKVILLE, Md., March 31 (UPI) -- The Food and Drug Administration said Friday it has approved generic Retrovir capsules to treat HIV. ... - United Press International

FDA Approves First Generic HIV/AIDS Drug in Capsule Form  Mar 31, 2006
...in Hyderabad, India, follows the expiration of GlaxoSmithKline’s patent on its capsule form of the product marketed under the tradename Retrovir. ... - FDA.gov

FDA Approves Generic Capsule Form of HIV/AIDS Drug  Apr 1, 2006
The approval of the capsule form of the drug, made by Aurobindo Pharma in India, follows the expiration of GlaxoSmithKline's patent on Retrovir, its brand name ... - HealthCentral.com

FDA Grants Aurobindo Approval for US Sale of Zidovudine Capsule  Apr 3, 2006
...tablet and oral solution form in September 2005 after the expiration of GlaxoSmithKline's patent on the drug, sold under the brand name Retrovir ( Kaiser Daily ... - Kaiser network.org

FDA Approves New Form Of Generic HIV/AIDS Drug  Mar 31, 2006
...said the approval follows the expiration of GlaxoSmithKline PLC's patent on the capsule form of the product, which is marketed under the tradename Retrovir. ... - Wall Street Journal (subscription)

FDA approves generic AZT for US sale  Apr 3, 2006
...approved for US sale. The US patent on AZT, sold under the brand name Retrovir, expired in September. Aurobindo Pharma's cheaper ... - The Advocate

Mauvais Genre' by Alain Buffard  Mar 31, 2006
They all decamp, to hoots and hollers from the audience, which makes its way out through a litter of empty boxes of Retrovir, an AIDS medicine. ... - New York Times

FDA Announces Tentative Approval for Generic Zidovudine, 100 mg ...  Mar 29, 2006
Hyderabad, India. This is a generic version of the already-approved Retrovir brand of the product manufactured by GlaxoSmithKline. The ... - PharmaLive.com

Study finds no link between brain-penetrating antiretroviral drugs ...  Mar 21, 2006
Previous studies have shown that these are AZT (zidovudine, Retrovir), d4T (stavudine, Zerit), 3TC (lamivudine, Epivir), abacavir (Ziagen), nevirapine (Viramune ... - Aidsmap

HAART failure rate halves in seven years  Mar 24, 2006
46% in 2002). The most common nucleoside backbone remained AZT (zidovudine, Retrovir) and lamivudine (3TC, Epivir) throughout the study period. ... - Aidsmap

Company Develops Better Tasting AIDS Solution to Help Treat Young ...  Mar 7, 2006
Zidovudine (Retrovir), an antiretroviral medication manufactured by both GSK (GlaxoSmithKline) and Cipla Pharmaceuticals, was the first drug approved to treat ... - Newsinferno.com



CROI News Feature: Experts divided over the future of treatment ...  Feb 9, 2006
77% of whom were women) received a HAART regimen comprising two nucleoside reverse transcriptase inhibitors (NRTIs) - AZT (zidovudine, Retrovir) and 3TC ... - Aidsmap,

CROI: AZT, 3TC and FTC achieve good concentrations in the female ...  Feb 17, 2006
The antiretroviral drugs AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and FTC (emtricitabine, Emtriva) rapidly achieve high concentrations in the ... - Aidsmap,

RFS Pharma Announces 2-Week Data from An NIH-Sponsored Phase 2 ...  Feb 14, 2006
...the K65R mutation show moderate to high cross resistance to the approved drugs, Hivid®, Videx®, Viread® and Epivir® and increased sensitivity to Retrovir ... - PharmaLive.com,

Multi-component drug delivery system: An emerging trend  Feb 8, 2006
Trizivir), lamivudine/zidovudine (Combivir), stavudine, d4T (Zerit), didanosine, ddI (Videx, Videx EC), zalcitabine, ddC (HIVID), and zidovudine, AZT (Retrovir ... - Express Pharma Pulse

Simplified treatment regimens show promise in HIV-infected ...  Feb 6, 2006
After switching, all of the children were taking 3TC (lamivudine, Epivir) and abacavir (Ziagen), along with either AZT (zidovudine, Retrovir) or d4T (stavudine ... - Aidsmap

One-pill HIV regimen outperforms gold standard  Jan 19, 2006
...of reducing HIV viral levels and increasing CD4-cell counts after one year of treatment that the gold-standard combination of Sustiva plus Retrovir and Epivir. ... - The Advocate

ICAAC: Switch from AZT or d4T to tenofovir may improve blood fat ...  Jan 13, 2006
Patients switching from anti-HIV drug regimens containing AZT (zidovudine, Retrovir) or d4T (stavudine, Zerit) may show better improvements in blood fat levels ... - Aidsmap

Health Beat  Jan 26, 2006
Journal of Medicine on January 19 shows that it is marginally better than another popular and older regimen that combines zidovudine (Retrovir/AZT), lamivudine ... - Bay Area Reporter

Most people given non-occupational PEP fully adhere to their ...  Jan 19, 2006
In 127 cases, triple antiretroviral therapy consisting of AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and nelfinavir (Viracept) was provided, with the ... - Aidsmap

John Beale  Jan 19, 2006
The only effective treatment for herpes and shingles, Zovirax, and Retrovir, the first treatment for HIV, both came out of this innovative enterprise. ... - Telegraph.co.uk

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