Recent news on Ritonavir

Medicines for the world's poor  -  May 23, 2007
Chicago Tribune,The company has shown little concern about making heat-stable lopinavir/ritonavir available in developing countries. In fact, its every step has been taken

Boehringer Ingelheim initiates international head-to-head HIV/AIDS ...  -  May 17, 2007
WebWire (press release),Patients will be randomised to receive 200 mg of Viramune® BID, 400 mg of Viramune® QD or 300 mg of atazanavir, boosted with 100 mg of ritonavir,

New option for highly pretreated patients with HIV  -  Apr 26, 2007
Healthcare RepublicTwo randomised studies, POWER 1 and 2, evaluated the safety and efficacy of darunavir in combination with low-dose ritonavir in treatment-experienced HIV-1

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  Apr 26, 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

Abbott drops price of its anti-AIDS medicines  -  Apr 30, 2007
ArabianBusiness.com,Kaletra/Aluvia (lopinavir/ritonavir) capsules and tablets are used in the treatment of HIV and AIDS. According to Abbott, the price reduction will apply to

Full Text  -  May 10, 2007
Science Magazine (subscription)AIDS advocates in particular have protested its plans to withdraw the registration of its new drugs, including a heat-stable form of lopinavir/ritonavir

Approvals: Herceptin, Reyataz, and Peg-Intron  -  May 21, 2007
Medscape (subscription)It can be used with ritonavir (Norvir, Abbot Laboratories, Inc) in patients who have previously received anti-HIV drugs, those who will be receiving

Thailand and Brazil look to co-operate on healthcare  -  May 21, 2007
Pharma Times (subscription),A couple of months earlier, Thailand had issued compulsory licences for Abbott Laboratories' AIDS drug Kaletra (opinavir/ritonavir) and

Boehringer Ingelheim Initiates International Head-to-Head HIV/AIDS ...  -  May 9, 2007
Juraforum.de,The ArTEN (Atazanavir/ritonavir on a background of Tenofovir andEmtricitabine (Truvada) versus Nevirapine) trial is a Phase IIIb,open-label, multinational,

Hetero sets up Russia venture  -  May 20, 2007
Business Standard,Hetero has 24 titles of ARV drugs, including the generic drug ritonavir, which are planned for production in Russia by Makiz Pharma.

World's premier law firm goes to bat for Abbott  -  Apr 26, 2007
Bangkok Post,Here, the use is clear _ Thailand will only use the licensed lopinavir/ritonavir within its national public health insurance schemes.

Health Canada approves Reyataz (atazanavir sulfate) 300 mg single ...  -  May 17, 2007
PharmaLive.com (press release),Taken once daily along with ritonavir and food as part of an anti-HIV drug regimen, the REYATAZ 300 mg single capsule formulation can replace two REYATAZ

Boehringer Ingelheim launches HIV drug trial  -  May 10, 2007
Forbes,...will compare the efficacy of Viramune with that of protease inhibitor treatment Atazanavir/Ritonavir, both in combination with HIV treatment Truvada.

Boehringer Ingelheim launches HIV drug trial  -  May 10, 2007
Hemscott,Viramune with that of protease inhibitor treatment Atazanavir/Ritonavir, both in combination with HIV treatment Truvada. krysia.diver@thomson.com kd/jr.

APS: Boehringer Ingelheim Initiates International Head-to-Head ...  -  May 9, 2007
ANP Pers Support,...of ritonavir, with a backbone regimen of tenofovir and emtricitabine (Truvada). Patients. BID or 400 mg QD after two weeks. Patients will be observed for a

Breaking Merck patent may drive investment away from Brazil  -  May 9, 2007
Pharmaceutical Business ReviewIn July 2005, Abbott agreed to keep the price of Kaletra (lopinavir/ritonavir), a top-selling protease inhibitor (PI), at current levels for the next six

Merck & Co horrified as Brazil breaks patent on AIDS drug  -  May 8, 2007
Pharma Times (subscription),...licences for Abbott Laboratories' AIDS drug Kaletra (opinavir/ritonavir) and Sanofi-Bristol-Myers Squibb's anti-clotting Plavix (clopidogrel).

Thailand put on USA's list of wrongdoers over patents  -  May 2, 2007
Pharma Times (subscription),...given its recent decision to issue compulsory licenses for Abbott Laboratories' AIDS drug Kaletra (opinavir/ritonavir) and Plavix (clopidogrel),

Africa: Q&A on Second-Line HIV/Aids Treatment  -  May 8, 2007
AllAfrica.com,The average price reduction for the seven formulations of the key second-line ARVs abacavir, didanosine, lopinavir/ritonavir, and tenofovir is 27% for low

No major metabolic differences between PI-based and NNRTI-based ...  -  Apr 29, 2007
Aidsmap,The treatments reflect what was in use during that period: nelfinavir (Viracept) was the most commonly used PI (61%), followed by ritonavir-boosted PIs

Pharmaceutical firm draws flak  -  Apr 26, 2007
Hindu,The Thai Government issued compulsory licence on lopinavir+ritonavir (generic name Kaletra) for the procurement of affordable generic drugs to protect the

New option for highly pretreated patients with HIV  -  26 Apr 2007
Healthcare RepublicTwo randomised studies, POWER 1 and 2, evaluated the safety and efficacy of darunavir in combination with low-dose ritonavir in treatment-experienced HIV-1

Abbott Offers Aluvia to Thailand in Return for Compulsory ...  -  26 Apr 2007
MedIndia,Abbott Laboratories said this week that it is willing to proceed with the registration of a heat stable version of lopinavir/ritonavir called Aluvia in

WHO welcomes decision by Abbott Labs to reduce price of lopinavir ...  -  Apr 12, 2007
News-Medical.net,In this context, WHO welcomes the decision of Abbott Laboratories to significantly reduce the price of lopinavir/ritonavir (LPV/r,

Abbott agrees with WHO to expand access to lopinavir / ritonavir  -  Apr 11, 2007
News-Medical.net,Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above the age of 2 years, in combination with other

Promising New Treatment For HIV - The Lancet  -  Apr 5, 2007
Medical News Today (press release),Patients in the control group were given an existing background combination therapy while others were given the background drugs plus darunavir-ritonavir

Price of AIDS drugs to go down  -  Apr 19, 2007
Joy Online,Organization has welcomed the decision of Abbott Laboratories to significantly reduce the price of an anti-retroviral drug, lopinavir/ritonavir (LPV/r).

TMC125 Can Be Used in Combination with Most Antiretrovirals  -  Apr 12, 2007
Drug Newswire (press release),Tipranavir/ritonavir, nevirapine and efavirenz reduced TMC125 exposures by 76%, 55% and 41% and should not be used in combination with TMC125.

New HIV drug shows promise  -  Apr 4, 2007
CBC North,In the study, researchers studied 100 people who took darunavir in combination with a low dose of an older protease inhibitor called ritonavir,

HIV: a new antiretroviral drug brings hope  -  Apr 12, 2007
Destination Santé,In fact darunavir has proven to be most effective when administered in combination with another commonly used antiretroviral drug, ritonavir.

Tibotec licenses darunavir to Aspen in Africa  -  Apr 4, 2007
Aidsmap,Darunavir boosted with ritonavir was licensed for use in treatment-experienced patients in the United States in June 2006 and in the European Union in March

Darunavir Effective in Resistant HIV  -  Apr 5, 2007
MedPage Today,In two parallel phase IIB randomized trials, darunavir, augmented by the protease inhibitor ritonavir, was better at reducing viral load than control drugs,

Darunavir looking promising as companion for agents in new HIV ...  -  Apr 4, 2007
Aidsmap,Further data from the POWER 1 & 2 studies of darunavir (Prezista) / ritonavir show that almost half of patients who received the new protease inhibitor with

Abbott Tries New Approach to Kaletra/Aluvia Pricing  -  Apr 12, 2007
Patent Baristas,Abbott and World Health Organization (WHO) Director-General, Margaret Chan, have agreed on a neew approach to provide Kaletra/Aluvia (lopinavir/ritonavir)

New drug for HIV 'shows promise'  -  Apr 4, 2007
BBC News,Darunavir was given by a Spanish team to patients with advanced HIV infection, in tandem with a low dose of the current antiretroviral ritonavir.

Hopes raised by new HIV treatment  -  Apr 5, 2007
InTheNews.co.uk,...drug ritonavir resulted in two-thirds of test subjects experiencing a tenfold reduction in HIV RNA levels – the genetic material that constitutes HIV.

A pharmaceutical step forward in the fight against HIV/AIDS  -  Apr 4, 2007
Ars Technica,The clinical study examined the use of a new protease-inhibitor drug called darunavir coupled with a lower dose of the existing ARV ritonavir.

Abbott announces Kaletra price cut for lower middle-income ...  -  Apr 10, 2007
Aidsmap,Abbott announced today that it will cut the price of Kaletra (lopinavir/ritonavir) in 40 lower middle-income countries to $1000 a year following discussions

New HIV treatment Darunavir Shows Promise  -  Apr 6, 2007
Insider Medicine,Patients were given darunavir plus ritonavir twice daily or an existing drug regimen. Both groups had advanced HIV infection and their existing combination

AIDS drug Prezista performs well in new study  -  Apr 5, 2007
ABC NewsThe researchers tracked 110 people given Prezista in combination with ritonavir and 120 people getting other protease inhibitors for about 11 months.

New antriretroviral drug shows promise  -  Apr 5, 2007
Gay.com UK,What's more, 45 percent of those taking darunavir-ritonavir reduced their HIV RNA concentrations to below 50 copies per milliliter of blood--the lowest

New hope in AIDS treatment, Spanish study highlights new drug  -  Apr 5, 2007
The Money Times,The drug was co-administered with Ritonavir, an antiretroviral agent, in trials conducted by researchers from the Barcelona hospital.

New HIV Drug Shows Promise  -  Apr 4, 2007
Ivanhoe,Spanish researchers find combining a new protease inhibitor called darunavir with a low dose of the existing antiretroviral drug ritonavir resulted in a

New antriretroviral drug shows promise  -  Apr 4, 2007
PlanetOut,What's more, 45 percent of those taking darunavir-ritonavir reduced their HIV RNA concentrations to below 50 copies per ml of blood--the lowest recordable

UN Health Agency Hails Move to Cut Price of Key HIV/aids Drug  -  Apr 11, 2007
NewsBlaze,The price of lopinavir/ritonavir (LPV/r, marketed as Kaletra/Aluvia) has been lowered by Abbott in some low and middle-income countries, where many HIV/AIDS

New AIDS drug Prezista performs well in new study  -  Apr 5, 2007
Today's Zaman,It is given along with a low dose of an older protease inhibitor called ritonavir. Prezista won approval from the US Food and Drug Administration last year,

Positive signs from new HIV drug ‎  -  Apr 4, 2007
PRESS TV,The drug is already licensed in the United States and the European Union (EU) for use with an existing drug, ritonavir.

More HIV drugs needed for children, doctors say  -  Apr 2, 2007
Chicago Sun-Times,FDA approval for a new pill version of its Kaletra liquid medicine for children, which combines the virus-fighting drugs lopinavir and ritonavir. AP.

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Burger D, Eggink A, Van der Ende J, et al. the pharmacokinetics of saquinavir in new tablet formulation + ritonavir (1000/100 mg twice daily) in

Guyana accessing key HIV drug cheaply from US-based company -Ramsammy  -  Apr 12, 2007
Stabroek News,According to information on the company's website Kaletra (lopinavir/ritonavir) is indicated for the treatment of HIV-1 infected adults and children above

Abbott sees dip in Q1 earnings  -  Apr 19, 2007
Pharma Times (subscription),...while the HIV protease inhibitor Kaletra (lopinavir/ritonavir) recorded revenues of $300 million, an increase of 7.2% over the same quarter last year.

Govt seeking new generic imports  -  Apr 18, 2007
Bangkok Post,A source said the Public Health Ministry was looking for generic drug producers of the new tablet form of the protease inhibitor lopinavir/ritonavir in

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal MedicineN(t)RTI = nucleotide reverse transcriptase inhibitor; NVP = nevirapine; PI = protease inhibitor; RTV = ritonavir; SQV = saquinavir; TDF = tenofovir;

Is there any clinical benefit to staying on a failing regimen?  -  Apr 12, 2007
Aidsmap,Regimens being used included NRTIs, NNRTIs, single protease inhibitors and ritonavir-boosted protease inhibitors. 43% of patients were receiving two

Thailand Mulls Offer for Low-Cost AIDS Drugs  -  Apr 12, 2007
Sci-Tech Today...in ending a dispute between Thailand and Abbott over the high price of Kaletra, which comprises the pharmaceutical ingredients lopinavir and ritonavir.

WHO welcomes Abbott's decision to reduce the price of second-line ...  -  Apr 11, 2007
IRNA,..."In this context, WHO welcomes the decision of Abbott Laboratories to significantly reduce the price of lopinavir/ritonavir (LPV/r,

Daily HIV/Aids Report  -  Apr 10, 2007
AllAfrica.com,Prezista will be prescribed in combination with the antiretroviral ritonavir, according to Business Day (Business Day, 4/5). A study published last week in

Thailand to consider AIDS drug offer  -  Apr 10, 2007
BusinessWeek...it had decided to offer its drug Kaletra, also known as lopinavir, and Aluvia, also known as ritonavir, at a reduced price in the developing world.

Abbott slashes the price of AIDS drug Kaletra and waits for ...  -  Apr 11, 2007
Pharma Times (subscription),...affordability and access while maintaining incentives to support developing new medicines" and has decided to offer Kaletra (lopinavir/ritonavir) to the

Aspen Pharmacare, Tibotec Enter Agreement To Distribute Protease ...  -  Apr 10, 2007
Kaiser network.org,Prezista will be prescribed in combination with the antiretroviral ritonavir, according to Business Day ( Business Day , 4/5). A study published last week

Tibotec and Aspen Collaborate on PREZISTA™ Access Plan for Africa  -  Apr 10, 2007
WebWire (press release),PREZISTA™, co-administered with ritonavir and with other antiretroviral agents (ARVs), is expected to be indicated for treatment-experienced patients,

Anti-HIV Medication PREZISTA™ (Darunavir) Receives Conditional ...  -  25 Feb 2007
Medical News Today (press release),A conditional marketing authorisation was granted to PREZISTA™, taken in combination with ritonavir and other antiretroviral medicinal products,

Gilead Sciences (GILD) Completes Phase II clinical trial of GS ...  -  Feb 23, 2007
StreetInsider.com (subscription),...with 100 mg of ritonavir, in combination with an optimized background antiretroviral regimen compared to a boosted comparator protease inhibitor regimen.

Be careful if using fosamprenavir/ritonavir for PEP, and did HCV ...  -  Jan 31, 2007
Aidsmap,Between January and March 2006 a total of 26 patients (22 for sexual exposure) were prescribed the fosamprenavir/ritonavir, Combivir regimen before a high

J&J unit's HIV drug Prezista gets conditional OK in Europe  -  Feb 19, 2007
Pharma Times (subscription),...is now authorised for use in all 27 EU member states when taken in combination with ritonavir and other antiretroviral medicinal products.

African-American Women Who Have Received HIV Treatment Are Sought ...  -  Feb 7, 2007
Medical News Today (press release),PREZISTA, co-administered with 100 mg ritonavir (PREZISTA/r) and with other antiretroviral agents, is indicated for the treatment of human immunodeficiency

Merck & Co., Inc. To Distribute ATRIPLA™ in Developing Countries  -  Feb 16, 2007
WebWire (press release),Liver enzymes should be monitored in patients with known or suspected hepatitis B or C and when ATRIPLA is administered with ritonavir or other medications

Thailand windfall awaits AIDS drug manufacturers  -  Jan 30, 2007
Daily News & Analysis,An estimated 20000 HIV-positive people have developed a resistance to the drug, and need the Lopinavir plus Ritonavir combination. YK Hamied, CEO, Cipla,

Officials at Boehringer Ingelheim discuss recent developments  -  Feb 8, 2007
Therapeutics Daily (subscription) (press release),Data demonstrate that at 24-weeks Aptivus, used with ritonavir (Aptivus/r) as part of combination antiretroviral therapy, achieved superior antiviral and

Pediatric studies lead to more information on drug labels  -  Feb 1, 2007
AAP News (subscription)Norvir (ritonavir) is another protease inhibitor used in combination with other drugs to treat HIV-infected pediatric patients.

Abbott's AIDS drug in a patent spot in India  -  Feb 20, 2007
Moneycontrol.com,Kaletra is a combination of lopinavir and ritonavir and is used in the second line treatment of AIDS. In addition to the soft-gel version, Kaletra is also

Data Published In AIDS Show Viramune (nevirapine) Achieves Durable ...  -  Feb 5, 2007
Medical News Today (press release),...nelfinavir (n=135), ritonavir (n=15), saquinavir (n=13), or indinavir or saquinavir in combination with low-dose ritonavir (n=19) prior to study entry.

Thailand Invokes WTO Rule To Sell Generics For HIV And Heart ...  -  Jan 30, 2007
Medical News Today,Kaletra (lopinavir) is a protease inhibitor antiretroviral drug and is given in combination with ritonavir as a multi-drug capsule to treat HIV/AIDS.

Thai License Upsets Drug Company; Government Ready To Talk  -  Feb 16, 2007
Intellectual Property Watch,On 26 January, the Thai government also announced a compulsory license, or government use, for Abbott’s HIV/AIDS drug, Kaletra (lopinavir/ritonavir),

It’s patent vs patient in AIDS fight  -  Feb 14, 2007
Economic Times,More recently, the Karnataka Network of Positive (KNP) and INP have opposed the grant of a patent for three of Abbott’s products — Ritonavir, Lopinavir and

Varning för olagligt erektionspreparat  -  Feb 14, 2007
Rundradion,If you are taking an HIV protease inhibitor (eg, ritonavir, saquinavir), do not take more than a 25 mg dose of sildenafil in a 48-hour period.

Abbott offers price cut to thwart Thai compulsory license on Kaletra  -  Feb 12, 2007
Aidsmap,Kaletra is a fixed dose protease inhibitor combination containing lopinavir and ritonavir, and is recommended by the World Health Organization as a

Exploiting natural HIV defence  -  Feb 9, 2007
BiopharmaReporter.com,Next came HIV protease inhibitors such as Roche's Invirase/Fortovase (saquinavir), Abbott Laboratories Norvir (ritonavir), Merck & Co's Crixivan (indinavir)

Minister's move ensures access to vital drugs  -  Feb 8, 2007
Nation Multimedia,...by Merck as Stocrin; lopinavir/ritonavir, produced by Abbott as Kaletra; and clopidogrel, produced by Sanofi-Aventis and Bristol Myers Squibb as Plavix.

Race factor in HIV therapy studied  -  Feb 6, 2007
United Press International...of Tibotec's drug PREZISTA (darunavir) tablets taken in combination with ritonavir and other anti-retroviral drugs over a 48-week treatment period.

WHO raps compulsory licensing plan  -  Feb 1, 2007
Bangkok Post,An estimated 20000 HIV-positive people have developed resistance to the drug, and need a combination of lopinavir and ritonavir, which is marketed as

Copycat heart drug in Thailand  -  Feb 2, 2007
LabTechnologist.com,Abbott's Kaletra (lopinavir/ritonavir), an HIV/AIDS drug, and Bristol-Myers Squibb and Sanofi-Aventis' Plavix (clopidogrel), an anti-clotting agent.

Asthma drug provides effective treatment for immune reconstitution ...  -  Jan 31, 2007
Aidsmap,Three weeks after initiating a nucleoside-sparing antiretroviral regimen consisting of saquinavir (Invirase) and Kaletra (lopinavir/ritonavir),

Thailand approves generic versions of two drugs  -  Jan 29, 2007
Bangkok Post,An estimated 20000 HIV-positive people have developed a resistance to the drug, and need the combination drugs of lopinavir and ritonavir, which is marketed

Data Published in AIDS Show Viramune(R) (nevirapine) Achieves ...  -  Jan 31, 2007
Earthtimes.org...nelfinavir (n=135), ritonavir (n=15),saquinavir (n=13), or indinavir or saquinavir in combination with low-doseritonavir (n=19) prior to study entry.

Pharma firms call on Thailand to talk, not issue licences  -  Jan 30, 2007
Pharma Times (subscription),...firms may freeze investment in Thailand in protest at his decision to import copycat versions of Kaletra (lopinavir/ritonavir) and Plavix (clopidogrel).

Outcry as Thailand allows generic version of protected drugs  -  Jan 29, 2007
Pharma Times (subscription),Kaletra (lopinavir/ritonavir), and Plavix (clopidogrel), the blockbuster anti-clotting agent sold by Sanofi-Aventis and Bristol-Myers Squibb.

Reality check for device-drug convergence  -  Feb 1, 2007
Nature.com (subscription),At one point, TransForm had worked on the Abbott Park, Illinois-based Abbott Laboratories anti-retroviral drug ritonavir. Originally in one crystal form,

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