Recent news on Rosiglitazone

Official advice on the safety of rosiglitazone  -  25 May 2007
Healthcare Republic (press release),The European Medicines Agency (EMEA) has advised that patients should not stop treatment with rosiglitazone, the diabetes drug, in response to a recent

The rosiglitazone aftermath: Legitimate concerns or hype?  -  25 May 2007
TheHeart.Org,Rosiglitazone is taken by about seven million people worldwide and brings in sales of more than $3 billion for GlaxoSmithKline. Analysts have warned that

Rosiglitazone (Avandia) Heart Attack Risk 'not Cause For Alarm ...  -  May 23, 2007
Medical News Today (press release),A study published in The New England Journal of Medicine suggests a link between taking rosiglitazone, used to treat Type 2 diabetes, and an increased risk

Ligand rosiglitazone for active ulcerative colitis  -  May 22, 2007
SpiritIndia,This study aimed to determine the effectiveness of the PPARy ligand rosiglitazone (Avandia®) in patients with UC. Researchers from the University of

Rosiglitazone Increases MI and CV Death?  -  May 21, 2007
Medscape (subscription)..."Because exposure of such patients to rosiglitazone is widespread, the public-health impact of an increase in cardiovascular risk could be substantial if

DDW: A Bit of Good News for Rosiglitazone (Avandia), With ...  -  May 21, 2007
MedPage Today,Explain that this study suggests that rosiglitazone (Avandia) - usually used to treat diabetes - may be an effective second-line therapy for ulcerative

Finding of Increased Heart Attack, Death in Diabetes Patients from ...  -  May 21, 2007
SeniorJournal.com,May 21, 2007 – Rosiglitazone, a drug widely used to treat type 2 diabetes, was found to significantly increase the risk of heart attacks and death from

Rosiglitazone increases MI and CV death in meta-analysis  -  May 21, 2007
TheHeart.Org,Cleveland, OH - A new meta-analysis has suggested that the diabetes drug rosiglitazone (Avandia, GlaxoSmithKline) may increase the risk of MI and

Meta-Analysis Links Rosiglitazone (Avandia) to Risk of Myocardial ...  -  May 21, 2007
MedPage Today,But the absolute number of rosiglitazone-associated events was small -- 86 MIs in the rosiglitazone patients versus 72 in the controls and 39 cardiovascular

Rosiglitazone and Cardiovascular Risk  -  May 21, 2007
New England Journal of Medicine (subscription),In this issue of the Journal, Nissen and Wolski 1 report the results of a meta-analysis of treatment trials of rosiglitazone, as compared either with other

Increased Risk of Fractures in Women Who Take Rosiglitazone  -  May 21, 2007
About - News & Issues,The ADOPT study originally was initiated to measure the effectiveness of three medications, rosiglitazone, metformin and glyburide on glycemic control,

New Prevention, Treatment Methods For Patients With Painful Bowel ...  -  May 23, 2007
Medical News Today (press release),This study aimed to determine the effectiveness of the PPARy ligand rosiglitazone (Avandia®) in patients with UC. Researchers from the University of

Cleveland Clinic Study Shows Commonly Used Diabetes Drug Increases ...  -  May 23, 2007
dLife.com,In an analysis of 42 trials, Steven Nissen, MD, found that use of the drug rosiglitazone (Avandia(TM)) raises patients' risk of heart attack and

American College of Cardiology, American Diabetes Association ...  -  May 24, 2007
SpiritIndia,The New England Journal of Medicine published an article entitled, "Effect of Rosiglitazone on the Risk of Myocardial Infarction and de ath from

Study Links Diabetes Drug To Heart Attack Risk And Death, FDA Alerts  -  May 22, 2007
Medical News Today,A recent US study has linked the diabetes type 2 drug rosiglitazone (brand name Avandia) to increased risk of heart attack and cardiovascular death and has

Diabetes pill may be deadly  -  May 22, 2007
Health24.com,The findings on Avandia (generic name rosiglitazone) will appear in the June 14 issue of the New England Journal of Medicine. The journal's editors released

Commonly Used Diabetes Drug Increases Risk Of Heart Attack  -  May 22, 2007
eMaxHealth.com,In an analysis of 42 trials, Steven Nissen, MD, found that use of the drug rosiglitazone (Avandia") raises patients' risk of heart attack and cardiovascular

Endocrinologists respond to Avandia report  -  May 23, 2007
SpiritIndia,Statement from the American Association of Clinical Endocrinologists regarding The New England Journal of Medicine article, “Effect of Rosiglitazone on the

Rosiglitazone May Lower Risk of Lung Cancer and Boost ...  -  May 15, 2007
About - News & Issues,The diabetes drugs, rosiglitazone (Avandia) and pioglitazone (Actos) have been shown to reduce the incidence of lung cancer in a study that appeared in the

Glaxo Diabetes Drug Tied to Heart Attacks  -  May 21, 2007
Smartmoney.comThe analysis also found the drug, known generically as rosiglitazone, increased the risk of death from cardiovascular causes that "had borderline

Diabetics reassured over US report  -  May 21, 2007
Channel 4 News,A study in the New England Journal Of Medicine (NEJM) found a link between the diabetes Type 2 drug rosiglitazone (Avandia) and a 43% increased risk of

'Thousands taking drugs for diabetes could be at greater risk of ...  -  May 21, 2007
Daily Mail,Patients and doctors have been warned to consider possible serious side effects linked to the drug Avandia, also known as rosiglitazone.

FDA Issues Safety Alert For Avandia  -  May 21, 2007
About - News & Issues,According to the study, Avandia (rosiglitazone) may lead to heart attacks and even death from cardiovascular causes. The study comes from the Cleveland

Diabetes Drug Avandia Boosts Heart Attack, Death Risk: Study  -  May 21, 2007
Forbes,The findings on Avandia (generic name rosiglitazone) will appear in the June 14 issue of the New England Journal of Medicine, but were released early on

Intensive Glucose Control in Elderly Adults  -  May 22, 2007
Journal of American Medical Association (subscription),1 He could have added that no studies have evaluated the effect of intensive control with rosiglitazone or the effect of this combination of antidiabetic

GSK rejects analysis of heart attack risk posed by Avandia  -  May 22, 2007
Pharma Times (subscription),...at 42 studies of Avandia (rosiglitazone) involving 15560 patients who received the drug and 12283 who were treated with placebos or other medicines.

Diabetes medicine is linked to heart ailments  -  May 22, 2007
Akron Beacon Journal,...``Because exposure of (diabetes) patients to rosiglitazone is widespread, the public health impact of an increase in cardiovascular risk could be

Glaxo tumbles on drug blamed for heart attacks  -  May 21, 2007
CNNMoney.comThe study of Avandia, also known as rosiglitazone, will be published this week in The New England Journal of Medicine. "Unfortunately, rosiglitazone appears

Glaxo's Avandia raises heart-death risk: study  -  May 21, 2007
Scientific AmericanThe news about Avandia, also known as rosiglitazone, triggered a freefall in GSK's shares, which closed off more than 5 percent on the London Stock Exchange

Safety of Diabetes Drug Questioned  -  May 22, 2007
Ivanhoe,Avandia, or rosiglitazone, is associated with an increased risk of heart attack and death. People with type two diabetes use Avandia to lower their blood

Drug for diabetes ‘puts patients at heart risk’  -  May 21, 2007
The Herald,Glaxo last night said a total of 241000 patients in the UK were on rosiglitazone. Of those about 155000 had Type 2 diabetes.

Glaxo's Avandia Raises Heart Disease Risk: Study  -  May 21, 2007
CNBC,The study of Avandia, also known as rosiglitazone, will be published this week in the New England Journal of Medicine. "Unfortunately, rosiglitazone appears

Leading diabetes drug 'raises risk of heart attack'  -  May 21, 2007
Independent,Unfortunately, rosiglitazone appears to increase, rather than decrease, the most serious complication of diabetes, heart disease."

Study raises concerns; Groups advise patients with diabetes to ...  -  May 22, 2007
PharmaLive.com (press release),Today the New England Journal of Medicine published an article entitled, "Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from

GSK hit by strong sterling but underlying growth is good  -  26 Apr 2007
Pharma Times (subscription),...and chronic obstructive pulmonary disease grew 11% to £835 million, while the type 2 diabetes drug Avandia (rosiglitazone) advanced 19% to £414 million.

Rosiglitazone does not adversely affect cardiac function in type 2 ...  -  Apr 16, 2007
TheHeart.Org,Glasgow, Scotland - The use of rosiglitazone (Avandia, GlaxoSmithKline) in type 2 diabetic patients with NYHA class 1-2 heart failure does not adversely

Nip diabetes in the bud  -  Apr 23, 2007
New Straits Times,The medication, rosiglitazone is a new thiazolidinedione (TZD), a class of oral anti-diabetic agents that, unlike most other medications, both treats the

Anti-diabetes drug slows progressive loss of sugar control in ...  -  Apr 20, 2007
exduco.net,The anti-diabetes drug, rosiglitazone, significantly slowed the increase of blood sugar levels in patients with recently diagnosed type 2 diabetes,

The Peroxisome Proliferator-Activated Receptor- Agonist ...  -  Apr 4, 2007
Journal of Clinical Endocrinology and Metabolism,Objective: The objective of the study was to determine whether rosiglitazone, a thiazolidinedione, inhibits bone formation.

STARR: Rosiglitazone shows trend toward reduced atherosclerosis ...  -  Mar 27, 2007
TheHeart.Org,New Orleans, LA - The thiazolidinedione antidiabetes drug rosiglitazone showed a trend toward a reduction in carotid intima media thickness (IMT) according

Diabetes Drugs Tied to Fractures in Women  -  Apr 17, 2007
Journal of American Medical Association (subscription),The action comes less than a month after a similar warning about excess fractures in women taking rosiglitazone (Avandia), another drug in the same class.

Research Suggests a Diabetes Medication May Be Good As Stroke ...  -  Apr 10, 2007
HealthNewsDigest.com,...(HealthNewsDigest.com) - HOUSTON — A diabetes medication named rosiglitazone may be good for reducing secondary stroke injury, too, according to a study to

Merck & Co's Janumet approved by the FDA  -  Apr 2, 2007
Pharma Times (subscription),...of oral diabetes medications, metformin or thiazolidinediones such as GlaxoSmithKline's Avandia (rosiglitazone) and Takeda/Lilly's Actos (pioglitazone).

Hope For Ending Pain, Infertility Of Endometriosis  -  Apr 5, 2007
eMaxHealth.com,That's why Lebovic and other UM Health System researchers are exploring the possible use of the diabetes medication called rosiglitazone as a treatment for

Hollis-Eden Pharmaceuticals Announces Filing of IND for Phase I ...  -  Mar 30, 2007
PipelineReview.com (press release),...test (OGTT) when compared to the control group, and at the end of the study was superior (p less than 0.003) to the active control (rosiglitazone).

Hollis-Eden Pharmaceuticals Announces Filing of IND for Phase I ...  -  Mar 29, 2007
Business Wire (press release),...and at the end of the study was superior (p<0.003) to the active control (rosiglitazone). In addition, HE3286 demonstrated a statistically significant

Oral medications to treat Type 2 diabetes  -  Apr 19, 2007
Chennai Online,Rosiglitazone (sold as Avandia by Glaxo Smith Kline), and Pioglitazone (sold in the name of Actos by Lilly/Takeda) are the two drugs available in this class

GTx Announces Ostarine(TM) Improved Insulin Resistance among ...  -  Apr 17, 2007
PipelineReview.com (press release),For example, in a one year study (the DREAM study), prediabetic patients taking rosiglitazone 8 mg evidenced a decline in fasting blood glucose of 9% from

Insulin Analogs or Premixed Insulin Analogs in Combination With ...  -  Apr 17, 2007
Medscape (subscription)Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-43. Abstract. Lebovitz HE, Austin MM, Blonde L,

Adding new diabetes drug may aid glycemic control  -  Apr 4, 2007
Scientific AmericanThe addition of exenatide to thiazolidinediones (TZDs), drugs such as rosiglitazone or pioglitazone, that increase cell response to insulin,

Exenatide in Combination Therapy: Small Study, Big Market, and ...  -  Apr 2, 2007
Annals of Internal Medicine...added to rosiglitazone (4 mg/d) or pioglitazone (30 mg/d) alone or in combination with metformin (79%) for 16 weeks to assess both efficacy and safety.

Exenatide Therapy for Type 2 Diabetes  -  Apr 2, 2007
Annals of Internal Medicine...biguanides (metformin), sulfonyureas (glipizide or glyburide), and thiazolidinediones (TZDs, such as rosiglitazone and pioglitazone).

Phynova - Significant progress in product pipeline  -  Apr 2, 2007
Oxfordshire Bioscience Network (press release),...rosiglitazone (GlaxoSmithKline´s Avandia), one of the current standard treatments for Type II diabetes, often associated with fatty liver disease.

Eli Lilly Advances Study of PPAR-alpha Agonist  -  Mar 28, 2007
Seeking Alpha,Despite the fervent interest in PPARs, the only PPAR modulators marketed in the US are the relatively PPAR-gamma-selective agonists, rosiglitazone and

Possible Rosiglitazone Risk for Women  -  Feb 22, 2007
Facts and Comparisons,...are advising health care professionals to consider fracture risk when treating female type 2 diabetes patients with rosiglitazone (Avandia).

Rosiglitazone Linked to Fracture Risk in Women  -  Feb 21, 2007
Medscape (subscription)February 21, 2007 — The risk for upper arm, hand, or foot fractures may be increased in women receiving rosiglitazone maleate vs metformin HCl or glyburide

Rosiglitazone linked to fracture risk in women  -  Feb 21, 2007
TheHeart.Org,The study's primary end point was to compare glycemic control achieved by rosiglitazone, metformin, and glyburide monotherapy.

Rosiglitazone (Avandia) Linked to Fractures in Women  -  Feb 21, 2007
MedPage Today,The FDA and drug company advised clinicians to carefully consider fracture risk before initiating rosiglitazone therapy. The company said that a review of

Diabetes Drug May Up Bone Fractures  -  Feb 23, 2007
WebMDDuring that time, women taking rosiglitazone were more likely to have bone fractures than women taking either metformin or glyburide.

NEJM lists benefits of GSK's Advair in COPD patients  -  Feb 22, 2007
Pharma Times (subscription),Meantime, GSK has informed doctors that long-term use of diabetes drug Avandia (rosiglitazone) has been linked to an increased incidence of fractures in

Effects of Chronic Rosiglitazone Therapy on Gene Expression in ...  -  Feb 6, 2007
Journal of Clinical Endocrinology and Metabolism,Objective: The aim of this study was to compare effects of therapeutic doses of rosiglitazone and metformin on expression of 50 genes in human adipose

GlaxoSmithKline Advises Health Officials on Avandia  -  Feb 21, 2007
PharmaLive.com (press release),Significantly more female patients who received rosiglitazone experienced fractures of the upper arm, hand, or foot, than did female patients who received

New oral drug for type 2 diabetes shows promise  -  Feb 16, 2007
Scientific AmericanPatients treated with rosiglitazone had a 1.3 percent decrease in HbA1c, with maximum reduction occurring at week 16. Patients who were not obese (body mass

Throwing drugs at diabetes: How not to do science  -  Jan 30, 2007
The Grand Rapids Press,In September, the media trumpeted a major study showing an expensive, brand-name drug, rosiglitazone (Avandia), prevented diabetes in people who were at

Canadian patients to benefit from renewal of CIHR/RX&D Health ...  -  Feb 8, 2007
CNW Telbec (Communiqués de presse),The results of the DREAM trial (Diabetes REduction Approaches with ramipril and rosiglitazone Medications), will provide a new strategy for preventing Type

Western drug ingredients found in proprietary Chinese medicine  -  Feb 6, 2007
Media Newswire (press release),Upon laboratory analysis, the product was found to have contained Western drug ingredients phenformin , rosiglitazone and glibenclamide .

Caution issued on Chinese medicine  -  Feb 5, 2007
News.gov.hk,The product contains phenformin, rosiglitazone and glibenclamide. Phenformin was used previously for the management of diabetes.

Weight-loss Supplement Shows Good And Bad Traits  -  Jan 31, 2007
Science Daily (press release)During the latter two weeks, some of the mice received daily injections of the anti-diabetes drug rosiglitazone. Rosiglitazone makes the body more sensitive

Canadian Patients to Benefit From Renewal of CIHR/Rx&D Health ...  -  Feb 8, 2007
Government of Canada Newsroom (press release),Dr. Hertzel Gerstein, from McMaster University, is testing the ability of ramipril and rosiglitazone to prevent Type 2 diabetes in over 5000 people from

Thiazolidinediones reduce need of post-PCI revascularization  -  Feb 7, 2007
Therapeutics Daily (subscription) (press release),NEW YORK (Reuters Health) - Pooled data from clinical trials involving more than 600 patients suggest that the thiazolidinediones (TZDs) rosiglitazone and

Biotech Day in Review: Allergan Expands Obesity Franchise  -  Feb 23, 2007
Seeking Alpha,GlaxoSmithKline [GSK] has begun telling doctors that rosiglitazone, a drug for type 2 diabetes, has increased the incidence of fractures in female patients.

Galvus Meets Not Inferior-to-Avandia Standard  -  Feb 16, 2007
MedPage Today,16 -- Galvus (vidagliptin), an investigational oral dipeptidyl peptidase IV-blocker (DPP-4) for type 2 diabetes, was as effective as Avandia (rosiglitazone)

Health Highlights: Feb. 22, 2007  -  Feb 22, 2007
Forbes,...warning doctors that long-term use of its diabetes drug Avandia (rosiglitazone) has been linked to an increased incidence of fractures in females.

New Recommendations for the Management of Diabetes and CVD  -  Feb 14, 2007
Medscape (subscription)Physical exercise, diet control, weight loss, metformin, and rosiglitazone have been demonstrated to reduce the progression of impaired glucose tolerance to

Pipeline paying dividends as GSK posts strong earnings rise  -  Feb 9, 2007
Pharma Times (subscription),Avandia (rosiglitazone) advanced 25% to £324 million, and the firm believes that its DREAM data, published in September which indicated that the drug can

Health Watch: Unwanted hair in women  -  Feb 8, 2007
Ithaca Journal,Medications reducing insulin resistance, such as metformin, pioglitazone and rosiglitazone also have a role. There are many other less common causes of

Metabolex Shows MBX-102/JNJ-39659100 Reduces Inflammation in ...  -  18 Jan 2007
PipelineReview.com (press release),Metabolex investigators, presenting at the Keystone Symposium in Keystone, Colo., compared the effect of MBX-102/JNJ-39659100, rosiglitazone and a vehicle

Slowing down type 2 diabetes  -  Jan 13, 2007
Malaysia Star,Results from the study showed that rosiglitazone slowed down the need for extra drug therapy by 60 months, while the delay when using metformin and

Emirates Diabetes Society Warns: Untreated diabetes can lead to ...  -  Jan 9, 2007
Al-Bawaba,This study demonstrated that initial treatment with rosiglitazone maleate reduced the risk of monotherapy failure in people with type 2 diabetes by 32

Hollis-Eden Pharmaceuticals Presents Data Demonstrating Discovery ...  -  Jan 16, 2007
Business Wire (press release),...tolerance test (OGTT) when compared to the control group and at the end of the study was superior (p<0.003) to the active control (rosiglitazone).

Endocrinology & Metabolism News, January 2007  -  Jan 5, 2007
Journal of Clinical Endocrinology and Metabolism,Among 4360 patients treated in a double-blind, randomized, controlled trial for a median 4 years, rosiglitazone was more effective in preventing failure of

The Year in Diabetes  -  Dec 22, 2006
MedPage Today,Avandia (rosiglitazone) prevents the onset of type 2 diabetes in a large proportion of high-risk patients, Canadian researchers reported in The Lancet and

The right balance drives the field of PPAR agonist R&D  -  Jan 15, 2007
PR Leap (press release),2007 | The commercial success of the two peroxisome proliferator-activated receptor (PPAR) gamma agonists pioglitazone and rosiglitazone from Takeda

The in Vitro Effects of Resistin on the Innate Immune Signaling ...  -  Jan 5, 2007
Journal of Clinical Endocrinology and Metabolism,Proinflammatory cytokine levels were increased in response to rhResistin (P < 0.001); this was attenuated by rosiglitazone (P < 0.01).

DES, statins, clopidogrel, and imaging dominate top heartwire ...  -  Dec 31, 2006
TheHeart.Org,Also in the top-read stories was A late summer's night DREAM: Rosiglitazone, but not ramipril, to prevent progression to diabetes, reported by heartwire at

TODAY ON PHARMALIVE.COM  -  Jan 5, 2007
PharmaLive.com (press release),...into the neurological markets (Pfizer with its statin Lipitor (atorvastatin) and GlaxoSmithKline with its PPAR-gamma agonist Avandia (rosiglitazone)).

New drug may make you put on weight  -  Jan 3, 2007
Electric New Paper,Researchers compared Avandia (known generically as rosiglitazone) to a pair of older medications for controlling blood sugar and found that Avandia does a

From girl bands to aerobics, Mac researchers studied it  -  Dec 27, 2006
Hamilton Spectator,...professor of medicine Dr. Hertzel Gerstein co-led the $25-million DREAM trial in 21 countries that showed the drug rosiglitazone used to treat diabetes

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...double-blind, 24-week trial, 214 patients with type 2 diabetes mellitus treated with thiazolidinediones (rosiglitazone or pioglitazone) for a minimum of

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