Recent news on Rosuvastatin

Rosuvastatin Shown To Be Safe And Well-tolerated Treatment For ...  -  May 12, 2007
Medical News Today (press release),A multinational clinical trial program, published in the journal "Cardiology" shows that rosuvastatin is well tolerated by a broad range of patients with

Rosuvastatin well tolerated by a broad range of patients with ...  -  May 9, 2007
News-Medical.net,The safety and tolerability of rosuvastatin were assessed using data from 16876 patients who received rosuvastatin 5-40 mg in a multinational phase

Heart patients in NZ ‘missing cholesterol goal  -  May 8, 2007
New Zealand Herald,Pharmac's clinical advisory committee had rejected funding Astra's rosuvastatin in 2005, finding there was "no overwhelming clinical need at that time",

Timing on meds is flexible  -  May 15, 2007
NorthJersey.com,Two other statins, atorvastatin (Lipitor) and rosuvastatin (Crestor), aren't broken down as readily, so you can take them any time.

Pharmac’s shameful legacy on statins  -  Apr 30, 2007
Scoop.co.nz,Australians have unlimited access to five statins, including the strongest, Rosuvastatin. New Zealanders have access to only three statins, two of which are

Heart patients in NZ `missing cholesterol goal'  -  May 8, 2007
Therapeutics Daily (subscription) (press release),..._ to press the Government to widen access to existing types of the cholesterol-lowering drugs and to pay for a new one made by Astra, rosuvastatin.

More heartache for statins.(Cholesterol)  -  May 8, 2007
Therapeutics Daily (subscription) (press release),A two-year study has shown that high doses of AstraZeneca's statin Crestor (rosuvastatin) slows--but does not reverse--atherosclerosis in people with

Isis Pharmaceuticals Updates Its Positive Phase 2 Data for ISIS ...  -  May 17, 2007
PR Newswire (press release),Patient 1 Patient 2 Patient 3 80 mg atorvastatin + Concurrent 10 mg ezetimibe + Lipid- 3.75 g 40 mg lowering 80 mg colesevelam + rosuvastatin + Therapies

Up And Down With Cholesterol Management  -  May 4, 2007
Medical News Today (press release),Combining the most potent HMG-CoA reductase inhibitor rosuvastatin and cholesterol absorption inhibitor (CAI) ezetimibe leads to > 70 % reduction of LDL

Germany next on AstraZeneca's hit list  -  Apr 30, 2007
DrugResearcher.com,Other products currently manufactured at the plant include Crestor (rosuvastatin) for the treatment of high cholesterol and Tenormin (atenolol) for high

Rosuvastatin vs placebo: Effects on progression of carotid ...  -  Apr 5, 2007
TheHeart.Org,The METEOR study tested the hypothesis that 40 mg of rosuvastatin daily would affect the progression of carotid intima medial thickness in patients at low

Effect of Rosuvastatin on Progression of Carotid Intima-Media ...  -  Mar 27, 2007
Journal of American Medical Association (subscription),The change in maximum CIMT for the 12 carotid sites was –0.0014 (95% CI, –0.0041 to 0.0014) mm/y for the rosuvastatin group vs 0.0131 (95% CI,

Rosuvastatin Treatment Prevents Progressive Kidney Inflammation ...  -  Mar 27, 2007
Am J Pathology (subscription)Chronic treatment with the hydrophilic rosuvastatin had renoprotective effects in terms of morphology and inflammation and prevented the changes in plasmin,

New Clinical Trial Shows CRESTOR(R) Significantly Slowed ...  -  Mar 29, 2007
PR Newswire (press release),METEOR and ASTEROID (AStudy To evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden) examined the effect of

Primary Prevention of Atherosclerotic Cardiovascular Disease The ...  -  Mar 27, 2007
Journal of American Medical Association (subscription),The study participants were randomly assigned to receive either 40 mg/d of rosuvastatin or placebo and were followed up for up to 2 years with serial

Cholesterol-lowering drug good for healthy people, study says  -  Apr 13, 2007
Therapeutics Daily (subscription) (press release),FOR YEARS THE DRUG ROSUVASTATIN (Crestor) has been used in lowering bad cholesterol levels in patients at high risk for heart problems.

Combination therapy may help high-risk patients reach cholesterol goal  -  Apr 2, 2007
Therapeutics Daily (subscription) (press release),The EXamination of Potential Lipid-modifying effects Of Rosuvastatin in combination with Ezetimibe versus Rosuvastatin alone (EXPLORER) study involved 469

Crestor Effective At Halting Early Atherosclerosis  -  Apr 4, 2007
Science Daily (press release)..."Rosuvastatin arrested the progression of thickened carotid arteries compared to a placebo," said John R. Crouse, MD, lead researcher and a professor of

AstraZeneca's 'big five' drive sales growth in first quarter  -  Apr 24, 2007
Pharma Times (subscription),The cholesterol-lowerer Crestor (rosuvastatin) put in another stellar performance rising 59% to $628 million, while gastrointestinal drug Nexium

Rosuvastatin acts rapidly in acute coronary syndrome  -  Jan 30, 2007
Therapeutics Daily (subscription) (press release),NEW YORK (Reuters Health) - The HMG-CoA reductase inhibitor rosuvastatin exerts rapid immunomodulatory effects on the level of T-cell activation in patients

Rosuvastatin slows hemodynamic progression of aortic stenosis  -  Jan 29, 2007
Therapeutics Daily (subscription) (press release),NEW YORK (Reuters Health) - The progression of asymptomatic aortic stenosis is slowed by treatment with rosuvastatin (Crestor), according to results of the

Statin given for lipid indication seen to slow aortic-stenosis ...  -  Jan 29, 2007
TheHeart.Org,Of Moura et al's 121 asymptomatic patients with "moderate to severe" aortic stenosis, the 61 with LDL cholesterol >130 mg/dL were started on rosuvastatin

All Sources Medscape MEDLINE Drug Reference  -  Feb 2, 2007
Medscape (subscription)...[11] The relative contribution of HDL-cholesterol elevation with high-dose rosuvastatin to the observed regression remains to be determined,

What is HDL?  -  Feb 7, 2007
Akron Beacon Journal,Statin drugs that lower LDL and raise HDL are atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin

Small increase in HDL may be big boost to health  -  Feb 7, 2007
Akron Beacon Journal,So for now, the key drugs to lower LDL and raise HDL are the statin drugs, such as atorvastatin (Lipitor), pravastatin (Pravachol) and rosuvastatin calcium

Statin Therapy Linked to Regression of Coronary Atherosclerosis  -  Feb 6, 2007
MedPage Today,...and ASTEROID (A Study to Evaluate the Effect of Rosuvastatin in Intravascular-Ultrasound Derived Indices of Coronary Atheroma Burden).

3000 jobs go as AstraZeneca faces up to future challenges - 02/02/2007  -  Feb 2, 2007
Pharma Times (subscription),The cholesterol-lowerer Crestor (rosuvastatin) put in another stellar performance rising 73% to $625 million, while gastrointestinal drug Nexium

Statins Can Slow Progression of Aortic Valve Disease  -  Jan 30, 2007
PR Newswire (press release),The RAAVE (Rosuvastatin Affecting Aortic Valve Endothelium to Slow the Progression of Aortic Stenosis) trial was conducted at the Hospital Pedro Hispano in

BNP substudy of HPS: Statins safe in heart failure  -  Jan 15, 2007
TheHeart.Org,They note that two such studies are underway with rosuvastatin (Crestor; AstraZeneca) to try to resolve these uncertainties: CORONA (Controlled Rosuvastatin

DES, statins, clopidogrel, and imaging dominate top heartwire ...  -  Dec 31, 2006
TheHeart.Org,One of the most popular stories of the year was ASTEROID lands with a bang: High-dose rosuvastatin regresses coronary atherosclerosis from the ACC 2006

Prescribing old statins could help save Pounds 85m  -  Dec 28, 2006
Therapeutics Daily (subscription) (press release),...with the older drugs simvastatin and pravastatin significantly cheaper than newer ones, such as atorvastatin (Lipitor) or rosuvastatin (Crestor).

Research and Markets: AstraZeneca Now Has Ten Products With Global ...  -  Jan 11, 2007
PharmaLive.com (press release),Crestor (rosuvastatin), a statin indicated to treat dyslipidaemia, which has posted strong year-on-year growth since its launch in 2003 in spite of safety

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...(d) p less than 0.05 vs. rosuvastatin 10 mg (e) p less than 0.05 vs. rosuvastatin 20 mg (f) p less than 0.05 vs. rosuvastatin 40 mg In a multicenter,

Beta-Agonists may cause thousands of asthma-related deaths each year  -  Jan 1, 2007
Health SentinelMeridia in the United States), the lipid lowering drug rosuvastatin (Crestor; made by AstraZeneca), and the acne drug isotretinoin (Roaccutane; Roche).

Study Shows Risk Of Acute Pancreatitis Low With Statins  -  Dec 29, 2006
Science Daily (press release)Circulation: Journal of the American Heart Association, (May 24, 2005), researchers said the cholesterol-lowering drug rosuvastatin (Crestor) was more .

Very high-intensity statin therapy shows promise for inducing ...  -  Dec 12, 2006
Xagena.it,Rosuvastatin ( Crestor ) is one of the most recently introduced statins and typically produces greater reductions in low-density lipoprotein cholesterol

Pfizer's value plummets $21 billion  -  Dec 5, 2006
Pharma Times (subscription),...was an "important positive" for AstraZeneca since it had been perceived as the biggest potential competitor to the latter's Crestor (rosuvastatin).

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...(d) p less than 0.05 vs. rosuvastatin 10 mg (e) p less than 0.05 vs. rosuvastatin 20 mg (f) p less than 0.05 vs. rosuvastatin 40 mg In a multicenter,

Statin users risk myocardial infarction by dropping treatment or ...  -  Dec 14, 2006
Xagena.it,...or Rosuvastatin ( Crestor ), rather than the first generation types, Pravastatin ( Pravachol ), Fluvastatin ( Lescol ) or Simvastatin ( Zocor ).

Statin Users Risk Heart Attacks By Dropping Treatment Or Taking ...  -  Dec 12, 2006
Medical News Today (press release),...to be using second generation statins ie atorvastatin or rosuvastatin, rather than the first generation types, pravastatin, fulvastatin or simvastatin.

Statin Users Risk Heart Attack by Dropping Drugs or Taking Low Doses  -  Dec 8, 2006
SeniorJournal.com,These patients were also relatively more likely to be using second generation statins ie atorvastatin or rosuvastatin, rather than the first generation

Cheaper drugs good news for patients  -  Dec 2, 2006
Sydney Morning Herald,About 700000 people with high blood cholesterol levels will be treated over the next four years with rosuvastatin calcium (Crestor) at a cost of $9.1

AstraZeneca Announces New Program that Offers Significant and ...  09 Nov 2006
...local pharmacy and immediately receive savings on AstraZeneca products, including NEXIUM® (esomeprazole), CRESTOR® (rosuvastatin), SEROQUEL® (quetiapine ... -Yahoo! News (press release) INEGY™ (ezetimibe/simvastatin) Is Superior To Crestor™ ...  Oct 20, 2006
INEGY™ (ezetimibe/simvastatin) provides significantly greater LDL ("bad") cholesterol (LDL-C) reduction compared with rosuvastatin (Crestor™) in patients ... -Medical News Today (press release), STATINS’ – THE GAME BEGINS  Oct 19, 2006
Currently available statins in the United States include lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin and rosuvastatin. ... -Patent Baristas, Schering-Plough's Inegy Superior to AstraZeneca's Crestor  Oct 18, 2006
The study, which provides the first comparative data for Inegy versus Crestor (rosuvastatin), was performed to assess the efficacy for LDL-cholesterol lowering ... -Therapeutics Daily (subscription) (press release), AstraZeneca: dropping another drug  Oct 27, 2006
AstraZeneca has not launched a new chemical entity - other than Exanta - since it debuted cholesterol-lowerer Crestor (rosuvastatin) in 2003. 'End Intelliext. -Pharmaceutical Business Review Crimson test for clues gets even better  Oct 13, 2006
A fascinating study using CRP readings hopes to prove that Crestor (rosuvastatin), a powerful statin, can indeed reduce inflammation in the coronary arteries ... -The Australian, High-Dose Statins and Atherosclerosis Regression  Oct 17, 2006
...the ASTEROID trial, Dr Nissen and colleagues 1 provide important information about the efficacy of intensive statin therapy with rosuvastatin on atherosclerosis ... -Journal of American Medical Association (subscription), High-Dose Statins and Atherosclerosis Regression  Oct 17, 2006
This study showed only that giving rosuvastatin at 40 mg/d on average produced plaque regressions, large reductions in LDL-C levels, and modest increases in HDL ... -Journal of American Medical Association (subscription), Rosuvastatin plus ezetimibe gets 80% of high-risk patients to LDL ...  Sep 11, 2006
Barcelona, Spain - The addition of ezetimibe (Zetia, Merck/Schering-Plough Pharmaceuticals) to statin therapy with rosuvastatin (Crestor, AstraZeneca) reduced ... -TheHeart.Org

Rosuvastatin plus diet in hypercholesterolemic adults unable to ...  Aug 27, 2006
...at The Cholesterol Center, Jewish Hospital, Cincinnati, was to assess the acceptability, effectiveness, and safety profile of Rosuvastatin ( Crestor ) 5 and 10 ... -Xagena.it

New EXPLORER Results Show Patients Achieved Dramatic Reductions in ...  Sep 6, 2006
LONDON, UK -- September 6, 2006 -- A combination treatment regimen of Crestor(TM) (rosuvastatin) 40 mg and ezetimibe 10 mg demonstrated a 46% reduction in ... -DG News

Combination statin therapy has the added benefit of reducing life ...  Sep 21, 2006
The new results show 46% reduction in C-reactive protein (CRP), a marker for inflammation, in patients treated with 40 mg of rosuvastatin and 10 mg ezetimibe. ... -Therapeutics Daily (subscription)

New EXPLORER Results Show Patients Achieved Dramatic Reductions in ...  Sep 6, 2006
LONDON, September 6 /CNW/ - A combination treatment regimen of CRESTOR(TM) (rosuvastatin) 40 mg and ezetimibe 10 mg demonstrated a 46% reduction in levels of C ... -CNW Telbec (Communiqués de presse)

Nieuwe resultaten EXPLORER tonen dramatische daling van C ...  Sep 6, 2006
5, 2006--A combination treatment regimen of CRESTOR(TM) (rosuvastatin) 40 mg and ezetimibe 10 mg demonstrated a 46% reduction in levels of C-reactive protein ... -Netherlands Corporate News (persbericht)

Statin Therapy Greatly Reduces Harmful Inflammation and ...  Sep 6, 2006
The new results show 46 percent reduction in C-reactive protein (CRP), a marker for inflammation, in patients treated with 40 mg of rosuvastatin and 10 mg ... -Newswise

INEGYT Is Superior To Simvastatin In Reducing Key Risk Markers Of ...  Sep 11, 2006
Lipid-Altering Efficacy and Safety of Ezetimibe/Simvastatin Versus Rosuvastatin in Patients with Primary Hypercholesterolemia - presentation at International ... -Medical News Today

Statins have an effect on inflammation as well as cholesterol  Sep 7, 2006
...cholesterol in five countries. They were given either a combination of ezetimibe and rosuvastatin or rosuvastatin on its own. Those on the ... -HealthandAge.com

Canadian Web Sites Selling Counterfeit Drug Products  Sep 1, 2006
...sodium), Nexium (esomeprazole), Hyzaar (losartan potassium/ hydrochlorothiazide), Zetia/Ezetrol (ezetimibe), Crestor (rosuvastatin calcium), Celebrex (celecoxib ... -Facts and Comparisons

What's the benefit of coenzyme Q10?  Aug 25, 2006
They include lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), and rosuvastatin (Crestor). ... -Belleville News-Democrat

AstraZeneca's Crestor overcomes safety concerns  Aug 27, 2006
While analysts don't expect Lipitor to relinquish its wide lead any time soon, Crestor, the chemical name of which is rosuvastatin calcium, has been steadily ... -The News Journal

Statin therapy also cuts inflammation  Sep 7, 2006
...says the study shows a 46-percent reduction in C-reactive protein, or CRP, a marker for inflammation, in patients treated with 40 mg of rosuvastatin and 10 mg ... -United Press International

Statins cut heart-risky inflammation  Sep 6, 2006
...percent decrease in so-called C-reactive protein (CRP), a known a marker for inflammation, when patients took a combination of 40 mg of rosuvastatin, sold as ... -United Press International

Very high-intensity statin therapy shows promise for inducing ...  -  12 Dec 2006
Xagena.it,Rosuvastatin ( Crestor ) is one of the most recently introduced statins and typically produces greater reductions in low-density lipoprotein cholesterol

Statin Users Risk Heart Attacks By Dropping Treatment Or Taking ...  -  12 Dec 2006
Medical News Today (press release),...to be using second generation statins ie atorvastatin or rosuvastatin, rather than the first generation types, pravastatin, fulvastatin or simvastatin.

Statin Users Risk Heart Attacks By Dropping Treatment or Taking ...  -  12 Dec 2006
eMaxHealth.com,...to be using second generation statins ie atorvastatin or rosuvastatin, rather than the first generation types, pravastatin, fulvastatin or simvastatin.

Substantial Regression of Atherosclerosis May Help Improve ...  -  Nov 15, 2006
CNW Telbec (Communiqués de presse),Earlier this year, initial results from ASTEROID (A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma

Pfizer's value plummets $21 billion  -  Dec 11, 2006
Pharma Times (subscription),...was an "important positive" for AstraZeneca since it had been perceived as the biggest potential competitor to the latter's Crestor (rosuvastatin).

Reduction in Volume of External Elastic Membrane of Artery Wall ...  -  Nov 17, 2006
DG NewsFor the study, patients were assigned to undergo a series of plaque imaging in response to treatment with rosuvastatin 40 mg/daily to determine if there was

Statin Users Risk Heart Attack by Dropping Drugs or Taking Low Doses  -  Dec 11, 2006
SeniorJournal.com,These patients were also relatively more likely to be using second generation statins ie atorvastatin or rosuvastatin, rather than the first generation

Cheaper drugs good news for patients  -  Dec 2, 2006
Sydney Morning Herald,About 700000 people with high blood cholesterol levels will be treated over the next four years with rosuvastatin calcium (Crestor) at a cost of $9.1

Heart drug could be life-saver  -  Nov 26, 2006
The West Australian,Crestor, or rosuvastatin, is a new cholesterol-lowering statin drug which is seen as having an advantage over similar drugs because it is effective in low

UAE Heart Network leads Dubai’s World Diabetes Day on Nov 27  -  Nov 16, 2006
Al-Bawaba,Statin treatment of rosuvastatin has been proved to lower LDL-cholesterol (LDL-C, or ‘bad’ cholesterol) and raise HDL-cholesterol (HDL-C,

English prescriptions are easier to read than Latin  -  Nov 15, 2006
Daily Press,...fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor) and simvastatin (Zocor) without complications.

Ben Hays Hi There Hi There  -  Nov 14, 2006
Digital Divide Network,...and less than the drugs phentermine the fingers and the rosuvastatin will not had alcoholic beverages a detailed explanation of cox 2 3 16 levitra

Rosuvastatin plus diet in hypercholesterolemic adults unable to ...  Aug 27, 2006
...at The Cholesterol Center, Jewish Hospital, Cincinnati, was to assess the acceptability, effectiveness, and safety profile of Rosuvastatin ( Crestor ) 5 and 10 ... -Xagena.it

Coronary artery disease: Rosuvastatin may reverse atherosclerosis  Aug 6, 2006
A two-year study demonstrated that Rosuvastatin ( Crestor ) reversed plaque build-up in the arteries of patients with evidence of coronary artery disease. ... -Xagena.it

AstraZeneca's Crestor overcomes safety concerns  Aug 27, 2006
While analysts don't expect Lipitor to relinquish its wide lead any time soon, Crestor, the chemical name of which is rosuvastatin calcium, has been steadily ... -The News Journal

Researchers from the United States report details of new studies ...  Aug 3, 2006
Study 1: Rosuvastatin 10 or 20 mg is an effective and safe therapeutic option for high-risk patients to achieve their lipid and apolipoprotein targets. ... -Therapeutics Daily (subscription)

What's the benefit of coenzyme Q10?  Aug 25, 2006
They include lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), and rosuvastatin (Crestor). ... -Belleville News-Democrat

Emergence of generic statins changing prescription patterns of ...  Jul 28, 2006
Crestor (rosuvastatin, AstraZeneca), on the other hand, the newest statin available to doctors, is gaining market share. ImpactRx ... -TheHeart.Org

Guidelines Seek to Standardize Care for Diseased Heart Valves  Aug 8, 2006
...may be answered by results from ongoing trials such as Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER), Simvastatin and ... -Journal of American Medical Association (subscription)

New data from the United States, United Kingdom and Netherlands ...  Aug 3, 2006
Rosuvastatin is an effective statin notable for liver selectivity and lack of significant metabolism.". Vanderbilt University researchers ... -Therapeutics Daily (subscription)

Feeling squeezed by statins  Aug 8, 2006
CYP3A4. Rosuvastatin (Crestor) and fluvastatin (Lescol) are broken down by a cousin of CYP3A4, which is less affected by grapefruit. ... -NorthJersey.com

Elan Reports Second Quarter 2006 Financial Results  Jul 31, 2006
...product containing the active pharmaceutical ingredients in Abbott's TriCor 145 (fenofibrate) and AstraZeneca's Crestor(R) (rosuvastatin calcium) products. ... -Business Wire

Elan says losses narrow in Q2  Aug 1, 2006
...an agreement to use Elan's formulation technologies in a new combination cholesterol-lowering product using AstraZeneca's Crestor (rosuvastatin) and Abbott ... -Pharma Times (subscription)

Oscient Paying Reliant $78M For Cholesterol Drug In US  Jul 25, 2006
...combination therapy of either TriCor or its next-generation version (known as ABT-335, now in Phase III trials) with Crestor (rosuvastatin), AstraZeneca's anti ... -BioWorld Online

Update - AZ shares dip despite hike in 2Q profits  Jul 28, 2006
...gastrointestinal drug Nexium (esomeprazole), Seroquel (quetiapine) for schizophrenia, cholesterol-lowerer Crestor (rosuvastatin), Arimidex (anastrozole for ... -Pharma Times (subscription)

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