Recent news on Saquinavir

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal MedicineN(t)RTI = nucleotide reverse transcriptase inhibitor; NVP = nevirapine; PI = protease inhibitor; RTV = ritonavir; SQV = saquinavir; TDF = tenofovir;

Tibotec licenses darunavir to Aspen in Africa  -  Apr 4, 2007
Aidsmap,Roche, the manufacturer of saquinavir, is currently negotiating voluntary license and technology transfer deals with a number of African pharmaceutical

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Burger D, Eggink A, Van der Ende J, et al. the pharmacokinetics of saquinavir in new tablet formulation + ritonavir (1000/100 mg twice daily) in

Merck & Co., Inc. To Distribute ATRIPLA™ in Developing Countries  -  Feb 16, 2007
WebWire (press release),Saquinavir should not be used as the only protease inhibitor in combination with ATRIPLA. Coadministration of ATRIPLA and atazanavir is not recommended due

Data Published In AIDS Show Viramune (nevirapine) Achieves Durable ...  -  Feb 5, 2007
Medical News Today (press release),...nelfinavir (n=135), ritonavir (n=15), saquinavir (n=13), or indinavir or saquinavir in combination with low-dose ritonavir (n=19) prior to study entry.

Varning för olagligt erektionspreparat  -  Feb 14, 2007
Rundradion,If you are taking an HIV protease inhibitor (eg, ritonavir, saquinavir), do not take more than a 25 mg dose of sildenafil in a 48-hour period.

Exploiting natural HIV defence  -  Feb 9, 2007
BiopharmaReporter.com,Next came HIV protease inhibitors such as Roche's Invirase/Fortovase (saquinavir), Abbott Laboratories Norvir (ritonavir), Merck & Co's Crixivan (indinavir)

African-American Women Who Have Received HIV Treatment Are Sought ...  -  Feb 7, 2007
Medical News Today (press release),Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin,

(BPRW) AFRICAN-AMERICAN WOMEN WHO HAVE RECEIVED HIV TREATMENT ARE ...  -  Feb 6, 2007
Black PR Wire (press release),...rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin, simvastatin, or products containing St. John’s wort (Hypericum perforatum).

Use of d4T is associated with buffalo hump  -  Feb 2, 2007
Aidsmap,Univariate anaylsis revealed that buffalo hump was associated with longer duration of HIV infection (p = 0.0001), treatment with saquinavir (p = 0.001),

Asthma drug provides effective treatment for immune reconstitution ...  -  Jan 31, 2007
Aidsmap,Three weeks after initiating a nucleoside-sparing antiretroviral regimen consisting of saquinavir (Invirase) and Kaletra (lopinavir/ritonavir),

Roche Posts Outstanding Results for 2006  -  Feb 7, 2007
PharmaLive.com (press release),Combined sales of Invirase and Fortovase (saquinavir) increased 28% to 182 million Swiss francs. Growth is being fuelled by increasing uptake of the

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  Dec 26, 2006
Medscape (subscription)However, the MaxCmin 1 study with saquinavir/r vs indinavir/r was one of the first of these trials and found that saquinavir/r outperformed indinavir/r,

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...clarithromycin, and telithromycin -- HIV protease inhibitors (such as indinavir, nelfinavir, ritonavir, and saquinavir) -- the antidepressant nefazodone

Antiretroviral Therapy for HIV: New Data From HIV 8 in Glasgow  -  26 Dec 2006
Medscape (subscription)However, the MaxCmin 1 study with saquinavir/r vs indinavir/r was one of the first of these trials and found that saquinavir/r outperformed indinavir/r,

THE RIGHT TO A TRIAL  -  Dec 9, 2006
New Yorker,In 1994, saquinavir, the first anti-HIV protease inhibitor, was tested in clinical trials. In test-tube experiments, the compounds were remarkably potent in

Part IV facts  -  Dec 16, 2006
Sun-Sentinel.com,1995: First protease inhibitor, saquinavir, is approved in the United States, ushering in an era of highly active antiretroviral therapies (HAART),

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients ...  -  Dec 14, 2006
DG News...ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and telithromycin).

96-Week Data From Gilead’s Study 934 Comparing Viread ® and ...  -  Dec 15, 2006
Business Wire (press release),Saquinavir should not be used as the only protease inhibitor in combination with ATRIPLA. Coadministration of ATRIPLA and atazanavir is not recommended due

Roche - Initiatives in HIV/AIDS  -  Dec 4, 2006
PharmaLive.com (press release),Manufacturers in sub-Saharan Africa and the Least Developed Countries wishing to produce generic saquinavir for use in these countries will not be required

Roche Diagnostics Will Mark World AIDS Day  -  Dec 1, 2006
Inside INdiana Business (press release),Roche makes its HIV protease inhibitors – Invirase (saquinavir) and Viracept (nelfinavir) available at no profit prices for direct supplies from Roche Basel

Local version of new Aids drug planned  -  Nov 28, 2006
Bangkok Post,Other anti-Aids drugs the GPO expects to produce in the next two years include Indinavir, Saquinavir, ddI and Lopinavir, the GPO chief added.

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,GPO Director Mongkol Jivasantikarn told the Bangkok Post that the organisation plans to manufacture indinavir, saquinavir, lopinavir and ddI in the next two

Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor ...  -  Dec 21, 2006
Business Wire (press release),...clarithromycin, and telithromycin -- HIV protease inhibitors (such as indinavir, nelfinavir, ritonavir, and saquinavir) -- the antidepressant nefazodone

Antiretroviral Drug Resistance in Patients With HIV  Nov 6, 2006
By comparison, the 20%/80% cut-offs for other PIs are 1.2 FC/5.4 FC for tipranavir/r (TPV/r), 9.7 FC/56.1 FC for LPV/r, 7.1 FC/26.5 FC for saquinavir/r, and ... -Medscape (subscription) Roche gives Kenyan firms right for Aids drug  Oct 22, 2006
In the latest deal, both Cosmos and Universal have been given a voluntary licence by Roche to manufacture generic versions of Saquinavir, a second-line Aids ... -East African, Merck buys protease inhibitor from Ambrilia, may be potent booster ...  Oct 20, 2006
No cross-resistance to amprenavir, lopinavir, atazanavir, saquinavir, indinavir, and nelfinavir was observed for any viral mutants, but resistance mutations ... -Aidsmap, ARV drugs may also help fight malaria  Oct 10, 2006
They found that serum taken from people who were taking antiretroviral therapy - which included ritonavir-boosted saquinavir (Invirase) or lopinavir (Kaletra ... -SABC News, The Totally Frightful Issue: Horrific Inspiration  Oct 23, 2006
With long, funny names, they could have been drag queens or, maybe, a punk band: Lexiva, Invirase, Saquinavir, Agenerase, and, of course, who could forget The ... -Queerty, Antiretroviral Drugs: A Shot in the Arm to Fight Malaria?  Oct 12, 2006
The finding revealed that serum taken from people who were undergoing antiretroviral therapy, consisting of ritonavir-boosted saquinavir (Invirase) or ... -MedIndia, Aptivus®(tipranavir) Demonstrates Durable Response Through Nearly ...  Oct 15, 2006
...a group of ritonavir-boosted comparator protease inhibitors (PIs) that included lopinavir/r (Kaletra®), amprenavir/r (Agenerase®), saquinavir/r (Invirase ... -Medical News Today (press release), Briefs: Roche to help African companies produce drugs to fight HIV  Sep 22, 2006
...in Kenya — with the technical assistance necessary to produce saquinavir, the active ingredient in the Swiss-based pharmaceutical’s Invirase treatment. ... -Lincoln Journal Star

Antiretroviral Treatment Strategies for Adults  Sep 22, 2006
IAS-USA antiretroviral treatment guidelines [10] reflect this fact: 4 boosted PIs (atazanavir, fosamprenavir, lopinavir, and saquinavir) are recommended as ... -Medscape (subscription)

Chugai to Launch HIV Protease Inhibitor Invirase(R) Tablet 500mg ...  Sep 14, 2006
...today the launch of a new drug for HIV (Human Immunodeficiency Virus) infection, HIV Protease inhibitor Invirase® Tablet 500 mg (saquinavir mesilate), on ... -DG News

Kaiser Daily HIV/AIDS Report Highlights Recently Released Journal ...  Sep 19, 2006
Among the participants, 56 were treated with protease inhibitors -- indinavir, nelfinavir, ritonavir or saquinavir -- and 54 were treated with non-nucleoside ... -Medical News Today

Chugai to Launch HIV Protease Inhibitor INVIRASE(R) Tablet 500mg ...  Sep 13, 2006
...of a new drug for HIV (Human Immunodeficiency Virus) infection, HIV Protease inhibitor 'INVIRASE(R) Tablet 500 mg' (generic name: saquinavir mesilate), on ... -Japan Corporate News

Draft BHIVA treatment guidelines: respond by Monday September 4 th  Aug 30, 2006
Alternative boosted PI regimens recommended by BHIVA include boosted fosamprenavir, boosted saquinavir (Invirase and boosted atazanavir (Reyataz. ... -Aidsmap

Boosted saquinavir has similar potency, better lipid profile than ...  -  Nov 14, 2006
Aidsmap,Early results from a head-to-head comparison of boosted saquinavir with boosted lopinavir (Kaletra) suggest that the drugs achieve similar virological

Interim Analysis of New Study Suggests Boosted Saquinavir Mesylate ...  -  Nov 13, 2006
DG NewsInvirase is contraindicated in patients with clinically significant hypersensitivity to saquinavir or to any of the components contained in the capsule.

THE RIGHT TO A TRIAL  -  Dec 9, 2006
New Yorker,In 1994, saquinavir, the first anti-HIV protease inhibitor, was tested in clinical trials. In test-tube experiments, the compounds were remarkably potent in

Interim Analysis Of New Study Suggests Boosted INVIRASE(R) May ...  -  Nov 14, 2006
Medical News Today (press release),Encouraging results from an interim analysis of a new study suggest that the boosted protease inhibitor (PI/r) INVIRASE(R) 500 mg/r (saquinavir mesylate)

New Study Indicates Boosted Invirase 500 Patients Achieve Similar ...  -  Nov 13, 2006
campus med,A prospective study of efficacy and safety of once-daily saquinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors in treatment-naive Thai

- Study of Chronic-Phase Patients with Chronic Myelogenous ...  -  Dec 11, 2006
PR Newswire (press release),...ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and telithromycin).

Long-Term Data Show Aptivus(R) (tipranavir) Continues to ...  -  Nov 15, 2006
Drug Newswire (press release),...greater improvements in health-related quality of life (HRQOL) in comparison to treatment with lopinavir/r, amprenavir/r, saquinavir/r or indinavir/r.

Long-Term Data Show Aptivus(R) (tipranavir) Continues to ...  -  Nov 14, 2006
Earthtimes.org...or greater improvementsin health-related quality of life (HRQOL) in comparison to treatment withlopinavir/r, amprenavir/r, saquinavir/r or indinavir/r.

Roche - Initiatives in HIV/AIDS  -  Dec 4, 2006
PharmaLive.com (press release),Manufacturers in sub-Saharan Africa and the Least Developed Countries wishing to produce generic saquinavir for use in these countries will not be required

Roche Diagnostics Will Mark World AIDS Day  -  Dec 1, 2006
Inside INdiana Business (press release),Roche makes its HIV protease inhibitors – Invirase (saquinavir) and Viracept (nelfinavir) available at no profit prices for direct supplies from Roche Basel

Thailand to issue compulsory license for efavirenz  -  Nov 29, 2006
Aidsmap,GPO Director Mongkol Jivasantikarn told the Bangkok Post that the organisation plans to manufacture indinavir, saquinavir, lopinavir and ddI in the next two

Local version of new Aids drug planned  -  Nov 28, 2006
Bangkok Post,Other anti-Aids drugs the GPO expects to produce in the next two years include Indinavir, Saquinavir, ddI and Lopinavir, the GPO chief added.

24-week Results From Aptivus® (tipranavir) RESIST Studies ...  -  Nov 22, 2006
Medical News Today (press release),...comparator protease inhibitors that include lopinavir/r (Kaletra®), amprenavir/r (Agenerase®), saquinavir/r (Invirase®), and indinavir/r (Crixivan®).

Drug-Drug Interactions Clinically Manageable With PREZISTA(TM)  -  Nov 14, 2006
Drug Newswire (press release),...lopinavir/ritonavir, saquinavir/ritonavir, efavirenz, nevirapine, tenofovir disoproxil fumarate; antibiotics such as clarithromycin and ketoconazole;

Double Boosted Saquinavir/Lopinavir Shows Promise for Nucleoside ...  Aug 17, 2006
TORONTO, CANADA -- August 17, 2006 -- Double-boosted saquinavir (SQV)/lopinavir/ritonavir (LPV/r) appears to result in significant CD4 increases and viral load ... -DG News

Good Long-term Efficacy and Safety With Once-Daily Ritonavir ...  Aug 18, 2006
TORONTO, CANADA -- August 18, 2006 -- Once-daily saquinavir/ritonavir (SQV/r) based highly-active antiretroviral therapy (HAART) shows excellent long-term ... -DG News

Large analysis shows benefits of starting treatment with efavirenz  Aug 22, 2006
The boosted protease inhibitors included were amprenavir (Agenerase), lopinavir (Kaletra), saquinavir (Invirase / Fortovase) and indinavir (Crixivan): newer ... -Aidsmap

Roche AIDS drug may be pulled out of India  Aug 10, 2006
...the wholly-owned subsidiary of Swiss drug maker F Hoffmann-La Roche & Co (Roche), is likely to withdraw its anti-HIV AIDS drug Fortovase (Saquinavir) from the ... -Financial Express

Roche to put AIDS drug off Indian shelves  Aug 10, 2006
After withdrawing its HIV AIDS drug from Europe, Roche India is likely to discontinue manufacturing the Fortovase (Saquinavir) from the Indian market as well ... -Myiris.com

Analysis Provides Additional Data For PREZISTA™ (Darunavir) As ...  Aug 20, 2006
Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin ... -Medical News Today

Staccato study suggests that some CD4-guided treatment ...  Aug 7, 2006
Eighty per cent of the study’s participants were Thai, all of whom took ritonavir (Norvir)-boosted saquinavir (Invirase) along with two nucleoside reverse ... -Aidsmap

WHO issues paediatric HIV treatment guidelines for low-income ...  Aug 8, 2006
...should consist of ddI and abacavir unless abacavir was used in first-line treatment, plus either lopinavir/ritonavir (Kaletra), saquinavir/ritonavir (Invirase ... -Aidsmap

The Lancet Publishes 48-week Results From Tipranavir RESIST ...  Aug 8, 2006
...a group of ritonavir-boosted comparator protease inhibitors (PIs) that included lopinavir/r (Kaletra®), amprenavir/r (Agenerase®), saquinavir/r (Invirase ... -DG News

NRTI-sparing combination of ritonavir-boosted indinavir and ...  Aug 9, 2006
HIV treatment combinations using protease inhibitors that do not cause such serious metabolic changes such as atazanavir (Reyataz) or saquinavir (Invirase) may ... -Aidsmap

Acid-reducing agent increases saquinavir levels in HIV-negative ...  Jul 10, 2006
The stomach acid-reducing agent omeprazole (Losec) causes an 82% increase in the levels of saquinavir (Invirase) in the blood, when saquinavir is boosted with ... -Aidsmap

A Quarter Century of Battling HIV/AIDS  Jul 21, 2006
The year 1995 marked the beginning of another era, that of the protease inhibitors, the first of which was Invirase (saquinavir mesylate, SQV) from Roche ... -Drug Discovery & Development

Tibotec and J&J Cleared to Launch Aptivus Rival  Jun 29, 2006
The first approved protease inhibitor was Roche's Saquinavir (invirase), which was poorly absorbed by the digestive tract and rapidly metabolized by the liver. ... -International News Service

HIV - Updated Information On Aptivus® (tipranavir) Clinical Trial ...  Jul 9, 2006
...response based on resistance testing. The comparator PIs were lopinavir, indinavir, saquinavir and amprenavir. Patients in the RESIST ... -Medical News Today

FDA Approves Sprycel (Dasatinib) With Two Indications  Jun 29, 2006
...eg, ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, atazanavir, indinavir, nefazodone, nelfinavir, saquinavir, and telithromycin). ... -DG News

PREZISTA Receives US FDA Approval as Part of HIV Combination ...  Jun 23, 2006
Coadministration is not recommended with carbamazepine, phenobarbital, phenytoin, rifampin, lopinavir/ritonavir, saquinavir, lovastatin, pravastatin ... -Yahoo! News

Clinical Pharmacology of Antiretroviral Therapy -- New Data for ...  Jun 22, 2006
The PIs saquinavir (Invirase, Roche), nelfinavir (Viracept, Agouron Pharmaceuticals), ritonavir (Norvir, Abbott), lopinavir, and atazanavir (Reyataz, Bristol ... -Medscape (subscription)



International Approvals: Invirase and Remicade  May 15, 2006
May 15, 2006 — Health Canada has approved a 500-mg tablet formulation of saquinavir mesylate that significantly reduces the daily pill count for patients ... - Medscape (subscription)

HIV-positive people with higher viral load have increased risk of ...  Apr 23, 2006
Individuals who took unboosted saquinavir, a component of an antiretroviral regimen which would now be considered suboptimal, also had an increased risk of ... - Aidsmap

Roche Women Honored as 2006 TWIN Awardees  Apr 28, 2006
She led the FDA filings for the early AIDS drugs HIVID® (zalcitabine) and Invirase® (saquinavir mesylate), which positively affected the lives of countless ... - Yahoo! News





Wide variability in drug levels casts doubt on the practicality of ...  Mar 28, 2006
...active metabolite M8. ICVs for ritonavir (Norvir) were 34 and 43%, while for saquinavir (Invirase), they were 52 and 55%. The degree ... - Aidsmap

HAART failure rate halves in seven years  Mar 24, 2006
Compared with other single non-boosted protease inhibitors (PIs), regimens containing hard-gel saquinavir (Invirase) tended to be associated with a higher risk ... - Aidsmap

This site is for informational purposes only--it does not offer medical advice or sell health products. If you need assistance, contact your physician or healthcare professional