Recent news on Tacrolimus

Tacrolimus 0.03% Ointment Effective as Second-Line Treatment in ...  -  May 21, 2007
DG NewsVIENNA, AUSTRIA -- May 21, 2007 -- The immunosuppressant tacrolimus provides a safe and effective topical treatment when compared with the potent

Isotechnika announces interim three month data from Phase 2b ...  -  May 8, 2007
PipelineReview.com (press release),Within the first month post-transplant, kidney function showed improvement across all ISA247 dosing groups similar to that observed in the tacrolimus group.

Isotechnika Selected for Oral Presentation at the American ...  -  May 3, 2007
CNW Telbec (Communiqués de presse),Patients in all four treatment groups will have their doses adjusted in order to achieve pre-defined blood levels of either ISA247 or tacrolimus.

Advagraf(R) Now Approved Across Europe as a Once-Daily ...  -  Apr 29, 2007
PR Newswire UK (press release),One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients. Am J Transplant 2007;

Narrowband UV-B Treatment More Effective for Vitiligo Than ...  -  May 23, 2007
Medscape (subscription)Treatment options for vitiligo have included topical therapy with potent topical corticosteroids, calcipotriol, or tacrolimus; pseudocatalase therapy;

Advagraf(R) Now Approved Across Europe as a Once-Daily ...  -  Apr 29, 2007
Juraforum.de,London (ots/PRNewswire) - Astellas announced today that theEuropean Commission has approved the immunosuppressant Advagraf(R)(generic name: tacrolimus,

Medical Edge: Get pigmentation loss checked out  -  May 19, 2007
Bryan College Station Eagle,Alternatively, steroidlike immunomodulator creams, such as tacrolimus (Protopic) or pimecrolimus (Elidel), may be applied for similar effect.

Ziprasidone Syrup (Ziprasidone capsule) Information  -  May 18, 2007
American Chronicle,Amiodarone, dofetilide, dolasetron, droperidol, levomethadyl, mefloquine, moxifloxacin, pentamidine, pimozide, quinidine, sotalol, sparfloxacin, tacrolimus,

Developments In Stent Technology  -  May 17, 2007
Express Healthcare Management,Subsequently, everolimus, tacrolimus, zotanolimus and paclitaxel have been used on stents in clinical practice. These drugs are loaded on a polymer,

Atopic Dermatitis Often Precedes Asthma  -  May 16, 2007
ADVANCE for Physician Assistants,Driver sometimes prescribes pimecrolimus (Elidel) and tacrolimus (Protopic) for mild cases of atopic dermatitis. For more severe cases, she finds steroid

Astellas and Daiichi Sankyo figures fail to dazzle  -  May 16, 2007
Pharma Times (subscription),Growth was driven by sales of the immunosuppressant Prograf (tacrolimus), which was up 20.2% to 175.4 billion yen, although Harnal (tamsulosin) for benign

Business Browser  -  May 9, 2007
Edmonton Journal (subscription),Fewer incidences of some side-effects of tacrolimus, a widely used anti-rejection drug, occurred in patients who received ISA247, Yatscoff said.

Astellas submits antibiotic telavancin for EU approval  -  May 2, 2007
Pharma Times (subscription),European approval to market Advagraf, a once-daily version of its best-selling drug Prograf (tacrolimus) for use in kidney and liver transplants.

Advagraf® Now Approved Across Europe As A Once-daily ...  -  Apr 30, 2007
Medical News Today (press release),Astellas announced today that the European Commission has approved the immunosuppressant Advagraf® (generic name: tacrolimus, prolonged release) for

Sinclair Pharma plc : Les ventes d'Atopiclair atteignent 10 ...  -  Apr 30, 2007
Euronext (persbericht),In January 2006, the US Food and Drug Administration (FDA) approved updated labeling for two TIMs, pimecrolimus and tacrolimus. The new labeling includes a

ISHLT: In Cardiac Transplant, Switching Immunosuppessants Helps ...  -  Apr 26, 2007
MedPage Today,Weaning patients off calcineurin inhibitors such as tacrolimus (Prograf) and cyclosporine and on to sirolimus (Rapamune) improved renal function,

Renal transplantation in 1-5 year olds  -  Apr 26, 2007
News-Medical.net,The primary immunosuppressant therapy consisted of cyclosporine in 61% of the patients, tacrolimus in 39%, mycophenolate in 49% and azathioprine in 51%.

Renal transplantation in 1-5 year olds  -  26 Apr 2007
News-Medical.net,The primary immunosuppressant therapy consisted of cyclosporine in 61% of the patients, tacrolimus in 39%, mycophenolate in 49% and azathioprine in 51%.

Renal transplantation in children younger than 6 years old  -  26 Apr 2007
SpiritIndia,The primary immunosuppressant therapy consisted of cyclosporine in 61% of the patients, tacrolimus in 39%, mycophenolate in 49% and azathioprine in 51%.

Isotechnika's Independent Data Monitoring Committee Conducts ...  -  Apr 12, 2007
Drug Newswire (press release),Patients in all four treatment groups will have their doses adjusted in order to achieve pre- defined blood levels of either ISA247 or tacrolimus.

Isotechnika to Host Educational Symposium at the American ...  -  Apr 11, 2007
Juraforum.de,Patients in all four treatment groups will havetheir doses adjusted in order to achieve pre-defined blood levels ofeither ISA247 or tacrolimus.

Oral Lichen Planus Responds to Methotrexate, Pimecrolimus  -  Apr 18, 2007
Medscape (subscription)Clearing or greater than 75% improvement of OLP occurred in 52% receiving topical with/without intralesional corticosteroid, 48% receiving tacrolimus,

Case 12-2007 — A 56-Year-Old Woman with Renal Failure after Heart ...  -  Apr 18, 2007
New England Journal of Medicine (subscription),2 The risk is also increased by exposure to corticosteroids and the calcineurin-inhibitor agents (cyclosporine and tacrolimus). Hypertension occurs in 80%

Idenix Announces Data Presentations at the 2007 Digestive Disease ...  -  Apr 18, 2007
PR Newswire (press release),...that may affect renal function, such as cyclosporine or tacrolimus, renal function should be monitored both before and during treatment with TYZEKA.

Medical Edge -- Faded skin color does not always need treatment  -  Apr 13, 2007
Post-Bulletin,Alternatively, steroid-like immunomodulator creams, such as tacrolimus (Protopic) or pimecrolimus (Elidel), may be applied for similar effect.

Manhattan Pharmaceuticals Announces License Agreement and Expanded ...  -  Apr 5, 2007
Drug Newswire (press release),Recently, topical formulations of the immunosuppressive drugs tacrolimus and pimecrolimus have been introduced as anti-inflammatory agents.

Researchers Identify Risk Factors for Nocardia infection After ...  -  Apr 3, 2007
DG News3.2-235; P = .003), elevated median calcineurin inhibitor level (ie cyclosporine A, tacrolimus) in preceding 30 days OR was 5.8 (95% CI, 1.5-22;

New Cancer Practice Guidelines Recommend NOXAFIL(R) (Posaconazole ...  -  Apr 2, 2007
Drug Newswire (press release),...tacrolimus, or sirolimus and frequent monitoring of drug levels of these medications is necessary when taking them in combination with NOXAFIL.

Roche warns against switch in immunosuppressant regimen for heart ...  -  Feb 23, 2007
TheHeart.Org,No episodes of acute rejection developed in the eight patients who had continued on tacrolimus or cyclosporine. All patients had been maintained on

Majority of high-risk cornea grafts successful with systemic ...  -  Feb 14, 2007
OSN SuperSite (subscription),A majority of patients who received systemic tacrolimus underwent successful high-risk keratoplasty with grafts surviving at 2 years postop, according to

Tacrolimus Cream Appears Effective for Mild to Moderate Psoriasis ...  -  Feb 6, 2007
DG NewsWASHINGTON, DC -- February 6, 2007 -- Twice daily applications of tacrolimus cream 0.1% and 0.5% are safe and effective for the treatment of mild to

Efficacy and safety of inhaled tacrolimus in rat lung transplantation  -  Jan 31, 2007
The Journal of Thoracic and Cardiovascular SurgeryThe aim of this study was to investigate the efficacy and safety of inhaled tacrolimus for preventing acute rejection of rat lung allografts.

SEBIVO(R) (telbivudine) Recommended For Approval In European Union ...  -  Feb 24, 2007
Medical News Today (press release),...may affect renal function, such as cyclosporine or tacrolimus, renal function should be monitored both before and during treatment with telbivudine.

Committee for Medicinal Products for Human Use Summary of Positive ...  -  Feb 23, 2007
PharmaLive.com (press release),The active substance of Advagraf is Tacrolimus, a macrolide immunosuppressant medicinal product (ATC Code: L04AA05) that inhibits the activation of serine

EU panel backs Novartis' mock-up pandemic flu vaccine  -  Feb 23, 2007
MarketWatchAdvagraf (tacrolimus), from Astellas Pharma GmbH, intended for prevention and treatment of transplant rejection. EMEA review began on 1 March 2006,

FDA Approves New Dosing Recommendations For RAPAMUNE In High ...  -  Feb 3, 2007
Medical News Today (press release),In this and another study in de novo liver transplant recipients, the use of sirolimus in combination with cyclosporine or tacrolimus was associated with an

FDA Approves New Dosing Recommendations for Rapamune(R) (Sirolimus ...  -  Feb 2, 2007
DG NewsLiver Transplantation - Excess Mortality, Graft Loss, and Hepatic Artery Thrombosis (HAT): The use of sirolimus in combination with tacrolimus was

Mitsubishi/Tanabe merger may be first of many in Japan  -  Feb 5, 2007
Pharma Times (subscription),...although Astellas reported strong sales of the blood pressure lowerer Micardis (telmisartan) and the immunosuppressant Prograf (tacrolimus).

Cardiology Journal Editor Red-Faced Over Paclitaxel Error  -  Dec 27, 2006
MedPage Today,In fact, tacrolimus is an antiproliferative and immunosuppressant drug that belongs to an entirely different class of drugs than paclitaxel, a cancer drug

Rare skin condition treatable  -  Dec 28, 2006
Fort Worth Star Telegram,If they don't help, talk to your doctor about a cream or gel that contains pimecrolimus (Elidel) or tacrolimus (Protopic), drugs that can help with skin

100mg Vial  -  Jan 16, 2007
Pharmaceutical Processing,...concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus.

Hepatitis C Infection Raises Diabetes Risk After Liver Transplants  -  Jan 8, 2007
MedPage Today,8 -- Liver transplant recipients who are hepatitis C-virus (HCV) positive and receive Prograf (tacrolimus) as part of their immunosuppressant regimen are at

Risk Factors For Diabetes Following Liver Transplant  -  Jan 8, 2007
Science Daily (press release)The risk factors for developing NODM included HCV infection (especially when combined with the immunosuppressant tacrolimus), IFG prior to the transplant,

Source: Astellas Pharma US, Inc.  -  26 Dec 2006
Yahoo! News (press release)...be used concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus. ...

Study of Dasatinib or 800 Mg of Imatinib Mesylate Shows Patients ...  -  Dec 14, 2006
DG News...a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot ...

Promising Treatment For High Risk Kidney Recipients In First Year ...  -  Nov 24, 2006
Medical News Today (press release),Data from a 12-month, open-label study indicate that sirolimus-based therapy in combination with either tacrolimus (TAC) or cyclosporine (CsA) is efficacious ...

UBD's Institute Of Medicine To Hold Dermatology Lecture  -  Dec 8, 2006
Bru Direct,This trial with tacrolimus ointment and topical steroids is of great interest to explore the possibility of synergy while minimising the side effects, of ...

New agents show promise in management of atopic dermatitis  -  Dec 1, 2006
AAP News (subscription)The addition of calcineurin inhibitors tacrolimus and pimecrolimus to our therapeutic armamentarium in 2000-'01 was the first major advance in AD therapy in ...

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Medscape (subscription)Dose reductions and more frequent clinical monitoring of cyclosporine, tacrolimus, and sirolimus are recommended on initiation of posaconazole therapy because ...

Drug Takes Aim at Kidney Transplant Rejection  -  Nov 23, 2006
Ivanhoe,...involved about 450 high-risk patients who were randomly assigned to receive sirolimus (Rapamune) and the standard anti-rejection drug tacrolimus (TAC), or ...

Anacor Begins Phase 2b Study of AN0128 in Children  09 Nov 2006
Combinations of antibiotics, antihistamines, topical corticosteroids and topical immunomodulators (TIMs) such as picrolimus and tacrolimus are the current ... -Earthtimes.org Kepivance® Reduces Mucositis After Allogeneic Stem Cell ...  09 Nov 2006
...and cyclophosphamide regimen. GVHD prophylaxis was with 4 doses of methotrexate and cyclosporine or tacrolimus. Sixty-one patients ... -Cancer Consultants (press release), Drug Reduces Kidney-Transplant Rejection Rates  09 Nov 2006
..."Most studies, including this one, use cyclosporine-based immunosuppression, but tacrolimus is more commonly used by most centers today. ... -CBC News, Noxafil(R) (Posaconazole) Oral Suspension Approved in European ...  09 Nov 2006
...from cyclosporine has occurred when taken in combination with NOXAFIL and therefore reduction of the dose of drugs like cyclosporine, tacrolimus or sirolimus ... -Yahoo! News (press release) Data to Include Analyses on Diabetics, and Patients With Multiple ...  Nov 6, 2006
...for the Treatment of Chronic Total Occlusion: A Comparison of Serial Angiographic Follow-Up with Sirolimus, Paclitaxel, Zotarolimus and Tacrolimus-Eluting Stent ... -Yahoo! News (press release) How a face transplant is performed  Oct 25, 2006
He complained about the regime of drugs – tacrolimus/MMF/prednisone – to prevent rejection. Hallam said he felt like he had flu all the time. ... -Telegraph.co.uk, Idenix Pharmaceuticals Reports Third Quarter and Nine Month ...  Oct 27, 2006
...transplant recipient who has received or is receiving an immunosuppressant that may affect renal function, such as cyclosporine or tacrolimus, renal function ... -MSN Money Foro de Shell Security - Seguridad informática  Oct 26, 2006
...taclonex tors. Little evidence points to a defective microenvironment as. tacrolimus a cause of aplastic anemia. In patients with ... -Shell Security, Health Canada Endorsed Important Safety Information on CellCept ...  Oct 25, 2006
...received the standard immunosuppressive therapy for their centre, including CellCept, in combination with either cyclosporine or tacrolimus, and corticosteroids ... -DG News No need to fear it  Oct 28, 2006
On the face, creams containing tacrolimus or pimecrolimus are used. Several systemic drugs are useful in cases, which warrant therapy. ... -Hindu, Micromet Presents New Anti-IL-2 Antibody with Unique Mode of ...  Oct 25, 2006
...of marketed products including monoclonal antibodies (eg, Zenapax(R), Simulect(R)) as well as small molecule inhibitors (eg, rapamycin, cyclosporine, tacrolimus ... -PharmaLive.com (press release), Schering-Plough Announces FDA Approval of NOXAFIL(R) (Posaconazole ...  Oct 25, 2006
...from cyclosporine has occurred when taken in combination with NOXAFIL and therefore reduction of the dose of drugs like cyclosporine, tacrolimus, or sirolimus ... -Drug Newswire (press release), Micromet Presents New Anti-IL-2 Antibody with Unique Mode of ...  Oct 25, 2006
...of marketed products including monoclonal antibodies (eg, Zenapax®, Simulect®) as well as small molecule inhibitors (eg, rapamycin, cyclosporine, tacrolimus ... -Market Wire (press release) DSM accelerates anti-infective activity  Oct 19, 2006
...of 2007, will be mainly based on fermentation development competencies and will focus on big-name drugs such as Pravachol (pravastatin) and Prograf (tacrolimus ... -OutSourcing-Pharma.com, Schering-Plough Announces FDA Approval of NOXAFIL(R) (Posaconazole ...  Oct 23, 2006
...from cyclosporine has occurred when takenin combination with NOXAFIL and therefore reduction of the dose of drugs likecyclosporine, tacrolimus, or sirolimus ... -Earthtimes.org Nucryst Pharmaceuticals: hopes fade for allergic eczema treatment  Sep 22, 2006
Current treatments for AD include topical immunomodulators (TIMs) such as Astellas's Protopic (tacrolimus) and Novartis' Elidel (pimecrolimus), which had total ... -Pharmaceutical Business Review

New drug helps prevent heart transplant rejection.(Prograf from ...  Sep 23, 2006
Prograf (tacrolimus), available in capsule form and as an injectable, was previously approved for the prevention of graft rejection in people receiving liver ... -Therapeutics Daily (subscription)

European Union's CHMP Adopts Positive Opinion for NOXAFIL(R) ...  Sep 22, 2006
Dose reduction and more frequent clinical monitoring of cyclosporine, tacrolimus and sirolimus should be performed when NOXAFIL therapy is initiated. ... -PR Newswire

Alemtuzumab Induction Therapy  Sep 1, 2006
...was excellent. Maintenance immunosuppression was with tacrolimus (TAC), mycophenolate mofetil (MMF), and corticosteroids. One-year ... -Medscape (subscription)

Health Canada Endorsed Important Safety Information on Rapamune ...  Aug 25, 2006
...the investigational combination of drugs compared to patients receiving the usual standard therapy, which includes cyclosporine or tacrolimus, following kidney ... -DG News

Post-transplant Neurotoxicity: What Role do Calcineurin Inhibitors ...  Sep 13, 2006
It is well known that calcineurin inhibitors (CIs; cyclosporine and tacrolimus) may induce severe neurotoxicity even at therapeutic levels. ... -AJNR (subscription)

Clinical Trials in Kidney Transplantation  Sep 5, 2006
In experimental studies, FK778 in combination with either tacrolimus (TAC) or cyclosporine (CsA), resulted in prolongation of allograft survival as well as ... -Medscape (subscription)

STUDY SHOWS SPRYCEL(R) (DASATINIB) 100 MG ONCE A DAY PROVIDES ...  -  Dec 11, 2006
PR Newswire (press release),...a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot ...

UBD's Institute of Medicine to hold dermatology lecture  -  Dec 9, 2006
Borneo Bulletin,This trial with tacrolimus ointment and topical steroids is of great interest to explore the possibility of synergy while minimising the side effects of ...

Sirolimus-Based Therapy Results in 90% Graft Survival in High-Risk ...  -  Nov 20, 2006
DG NewsSirolimus-based anti-rejection therapy resulted in 90% graft survival after 1 year in high-risk patients, whether combined with tacrolimus or cyclosporine ...

Isotechnika Announces Initial Data From Phase IIb Kidney ...  -  Nov 16, 2006
Juraforum.de,...incidence of rejection episodes between the low (0.4 mg/kg twice daily) and mid (0.6 mg/kg twice daily) ISA247 dosing groups as in the tacrolimus control arm. ...

Promising Treatment For High Risk Kidney Recipients In First Year ...  -  Nov 24, 2006
Medical News Today (press release),Data from a 12-month, open-label study indicate that sirolimus-based therapy in combination with either tacrolimus (TAC) or cyclosporine (CsA) is efficacious ...

New agents show promise in management of atopic dermatitis  -  Dec 1, 2006
AAP News (subscription)The addition of calcineurin inhibitors tacrolimus and pimecrolimus to our therapeutic armamentarium in 2000-'01 was the first major advance in AD therapy in ...

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Medscape (subscription)Dose reductions and more frequent clinical monitoring of cyclosporine, tacrolimus, and sirolimus are recommended on initiation of posaconazole therapy because ...

Drug Takes Aim at Kidney Transplant Rejection  -  Nov 23, 2006
Ivanhoe,...involved about 450 high-risk patients who were randomly assigned to receive sirolimus (Rapamune) and the standard anti-rejection drug tacrolimus (TAC), or ...

Isotechnika "buy"  -  Nov 18, 2006
newratings.comWhile the secondary safety endpoints are not conclusive, the drug exhibited a healthy safety profile that could be comparable to tacrolimus, the analyst says. ...

New option for risky kidney transplants  -  Nov 21, 2006
United Press International...presented recently at the American Society of Nephrology Annual Meeting -- show that sirolimus-based therapy in combination with either tacrolimus (TAC) or ...

Dade Behring Launches Tacrolimus Test on Its Dimension(R), V-Twin ...  Jul 19, 2006
...(NASDAQ:DADE), the world's largest company solely dedicated to clinical diagnostics, today announced that it has launched the Tacrolimus test for use on its ... -Business Wire

Living his life to the full  Jul 14, 2006
...happen next.". Andy's doctor put him on tacrolimus, a drug that at the time was only being used for kidney and liver transplants. It ... -ic Liverpool

Medical Edge: Many remedies for common skin disorder  Jul 15, 2006
It is then washed off in the morning with a medicated shampoo. Two other new agents, pimecrolimus (Elidel) and tacrolimus (Protopic), are controversial. ... -Bryan College Station Eagle

Astellas Announces Application For The Immunosuppressant FK506 ...  Jul 5, 2006
...it has submitted an application for the market authorization for the immunosuppressant FK506 Modified Release Formulation (generic name: tacrolimus) to the ... -Medical News Today

Basilea Presents Compelling Clinical and Preclinical Data on Its ...  Jun 26, 2006
Ciclosporin and tacrolimus are frequently used and important immunosuppressant drugs in transplant medicine. BAL8557 had no significant ... -PrimeZone

Basilea Antifungal Therapy Posts Positive Data  Jun 28, 2006
Mycology meeting in Paris, show that BAL8557 had no significant impact on the pharmacokinetics of ciclosporin and a relatively modest effect on tacrolimus. ... -International News Service

Novartis's Elidel and Astellas's Protopic Were the Leading Branded ...  Jul 11, 2006
The two topical immunosuppressants pimecrolimus (Novartis's Elidel) and tacrolimus (Astellas's Protopic) are the leading branded products in this segment and ... -Genetic Engineering News

FDA Approves Sprycel (Dasatinib) With Two Indications  Jun 29, 2006
...a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot ... -DG News

Summer Health News: Safe, Effective Treatment for the Itching ...  Jun 22, 2006
The FDA has issued a public warning for both Elidel® (pimecrolimus) Cream and Protopic® (tacrolimus) Ointment, stating they should be used only after other ... -Yahoo! News

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