Recent news on Temozolomide

Chemotherapy drug temozolomide shrinks brain tumors  -  May 22, 2007
News-Medical.net,Cancerous brain tumors appear to respond favorably to the drug temozolomide when used as primary chemotherapy after surgery, and the treatment appears to

Drug Shrinks Some Brain Tumors  -  May 22, 2007
Washington Post,TUESDAY, May 22 (HealthDay News) -- When used as primary chemotherapy after surgery, the drug temozolomide appears to help shrink some cancerous brain

Chemotherapy Drug Shrinks Brain Tumors  -  May 22, 2007
MedIndia,Cancerous brain tumors appear to respond favorably to the drug temozolomide when used as primary chemotherapy after surgery, and the treatment appears to

Bradmer announces 2007 first quarter operational and financial results  -  May 10, 2007
CNW Telbec (Communiqués de presse),The Phase III multi-center trial will compare Neuradiab as an adjuvant therapy to surgery, external beam radiation, and temozolomide to the current standard

Tapestry Pharmaceuticals Announces Phase II Clinical Program for ...  -  May 10, 2007
PipelineReview.com (press release),In addition to these Phase II studies, the Company will be initiating a Phase Ib/II study evaluating the combination of TPI 287 and temozolomide in primary

Cancer Research UK Responds to NICE Announcement on Temozolomide  -  Apr 11, 2007
PharmaLive.com (press release),...“Research on temozolomide suggests that it improves the two year survival rate for patients by 16 per cent. We can’t say how many lives have been cut

Fatal Reactivation of Hepatitis B with Temozolomide  -  Apr 11, 2007
New England Journal of Medicine (subscription),To the Editor: Encouraging results have led to the use of temozolomide as a first-line therapy for glioblastoma.

Tapestry Pharmaceuticals Presents Data on TPI at the AACR Annual ...  -  Apr 16, 2007
PipelineReview.com (press release),...--Increases the efficacy of temozolomide in glioblastoma In an orthotopic brain xenograft study using the U251 glioblastoma cell line, a combination of low

NICE overturns decision on Schering-Plough's brain cancer drug  -  Apr 12, 2007
Pharma Times (subscription),In a final appraisal document, NICE said it would recommend Schering-Plough's Temodal (temozolomide) for the treatment of newly-diagnosed glioblastoma

Myriad Genetics Initiates Phase 2 Clinical Trial of Azixa in ...  -  Mar 27, 2007
PipelineReview.com (press release),The trial will compare the survival of patients treated with Azixa to those treated with temozolomide or the combination of Azixa plus temozolomide.

Clinical Trials Update: April 4, 2007  -  Apr 4, 2007
Atlanta Journal Constitution (subscription),...low-grade brain tumors called gliomas can be stopped with the following combination of chemotherapy drugs: carboplatin, vincristine, and temozolomide.

Biotech Day In Review: Regeneron Up On AMD Data  -  Mar 28, 2007
Seeking Alpha,The trial has three arms: Azixa, temozolomide and a combination of Azixa plus temozolomide. Myriad dropped 48 cents to end at $34.58.

SP delivers again, beating forecasts  -  Apr 20, 2007
Pharma Times (subscription),Sales of Temodar (temozolomide), a treatment for certain types of brain tumours, rose 20% to $196 million as a result of continued use in Europe for

BTG signs agreement with Novacea and KuDOS for AQ4N  -  Apr 19, 2007
PharmaLive.com (press release),In November 2006, Novacea initiated a multi-centre Phase 1b/2a open-label clinical study of AQ4N in combination with radiotherapy and temozolomide in

Abbott Researchers Focus on New Cutting-Edge Approaches in the ...  -  Apr 13, 2007
PR Newswire (press release),3:55 pm, Room 404 AB] ABT-888 -- "The poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888 potentiates the antitumor activity of temozolomide in the

Bradmer hires Vice President Medical Affairs and opens Montreal office  -  Mar 29, 2007
Drug Newswire (press release),The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM tumors typically have infiltrating edges

Temozolomide Effective for Brain Tumor Treatment: Presented at ICACT  -  Feb 8, 2007
DG NewsPARIS, FRANCE -- February 8, 2007 -- The oral alkylating agent temozolomide (Temodar) has shown favorable results in a small study of adults with

'I'VE GOT TO SELL HOME TO PROLONG MY LIFE'  -  Feb 14, 2007
Ashfield Today,In advance of the final guidance being issued by NICE, the current policy of the PCT is not to fund Temozolomide, unless there are exceptional circumstances

Q4 2006 Genta Earnings Conference Call - Final  -  Feb 20, 2007
Insurance News Net,The first is a preliminary trial in combination with temozolomide, the most widely prescribed, but still unapproved drug in the US for melanoma,

Genta Incorporated Announces Fourth Quarter and Year End 2006 ...  -  Feb 15, 2007
Drug Newswire (press release),...(albumin-bound) (Abraxis BioScience, Inc.) plus Temodar(R) (temozolomide) Capsules (Schering-Plough Corporation) in patients with advanced melanoma.

Vical Initiates Pivotal Phase 3 Trial Of Allovectin-7(R) As First ...  -  Jan 6, 2007
Medical News Today (press release),Patients with metastatic melanoma often are treated off-label with drugs such as temozolomide, which has been approved by the FDA for the treatment of

AnGes MG, Vical to Start Phase III Clinical Trial of Allovectin ...  -  Jan 10, 2007
Japan Corporate News (press release),375 patients are taking part, 250 of them were given Allovectin-7 while the remaining 125 (the control group) were given decarbazine or temozolomide.

Cancer Research UK welcomes glioma drug ruling  -  Dec 22, 2006
Cancer Research UK - News & Resources,The number of patients with glioma - a form of brain tumour - who are eligible to receive temozolomide on the NHS has been increased following an appeal to

Safe Practice Guidelines for Oral Chemotherapy Found Gravely Lacking  -  Jan 12, 2007
MedPage Today,Cytoxan (cyclophosphamide), Iressa (gefitinib), Gleevec (imatinib), oral Rheumatrex (oral methotrexate), and Temodar (temozolomide).

Making Glioblastomas Starve - First Clinical Trials In The USA And ...  -  Dec 20, 2006
Medical News Today (press release),One of those drugs is the cancer-drug temozolomide. Professor Vajkoczy and his collaborators combined this drug with an anti-inflammatory inhibitor which

MNC pharma firms eyeing duty relief  -  Dec 27, 2006
Business Standard,Fulford (India), is another company that is trying for duty exemption for its anti-cancer drug Temozolomide, a medicine used in the treatment of brain tumor

EntreMed's Panzem(R) Demonstrates Antitumor Activity In Brain ...  -  Dec 24, 2006
Haber Sağlık,Previously, EntreMed has presented preclinical data showing that combination treatment with 2ME2 and Temodar(R) (temozolomide) resulted in a marked

Cancer Research UK welcomes glioma drug ruling  -  Dec 22, 2006
Cancer Research UK - News & Resources,The number of patients with glioma - a form of brain tumour - who are eligible to receive temozolomide on the NHS has been increased following an appeal to the ...

Vion Presents Data on VNP40101M for First Relapse of Acute Myeloid ...  -  Dec 14, 2006
DG NewsIn Poster #149-II, entitled "A Phase I Study of Cloretazine(R) and Temozolomide in Patients with Hematologic Malignancies", clinical data from this Phase I ...

Vion Presents Data on Cloretazine(R) (VNP40101M) at the 48th ...  -  Dec 11, 2006
PR Newswire (press release),...for this trial is expected to occur in the second quarter of 2007." In Poster #149-II, entitled "A Phase I Study of Cloretazine(R) and Temozolomide in Patients ...

Making Glioblastomas Starve - First Clinical Trials In The USA And ...  -  Dec 20, 2006
Medical News Today (press release),...shown that some drugs which are being used in conventional chemo-therapy have an anti-angiogenic effect." One of those drugs is the cancer-drug temozolomide. ...

EntreMed's Panzem(R) Demonstrates Antitumor Activity In Brain ...  -  Dec 24, 2006
Haber Sağlık,Previously, EntreMed has presented preclinical data showing that combination treatment with 2ME2 and Temodar(R) (temozolomide) resulted in a marked enhancement ...

Private UK biotech Pharminox signs $40m drug development deal with ...  -  Dec 11, 2006
PharmaLive.com (press release),In this role he was responsible for the discovery and early development of temozolomide, the market-leading treatment for malignant glioma, a common form of ...

UK's Pharminox signs $40 million deal with Schering-Plough  -  Dec 12, 2006
Pharma Times (subscription),...of the Cancer Research UK Experimental Cancer Chemotherapy Group, and was responsible for the discovery and early development of temozolomide for malignant ...

EntreMed's Panzem(R) Demonstrates Antitumor Activity in Brain ...  -  Dec 21, 2006
Yahoo! News (press release)Previously, EntreMed has presented preclinical data showing that combination treatment with 2ME2 and Temodar® (temozolomide) resulted in a marked enhancement ...

Nexavar in patients with advanced melanoma does not meet primary ...  -  Dec 6, 2006
Xagena.it,Two hundred seventy patients progressing after one previous systemic chemotherapeutic treatment ( with either Dacarbazine or Temozolomide ) were enrolled into ...

Mary McCarty: 13-year-old's battle with leukemia leaves lasting ...  -  Dec 9, 2006
Dayton Daily News (subscription),The time for a miracle is now. The Johnsons decided to include Leo in a Phase 1 trial of an experimental drug called temozolomide. ...

With cancer comes a lifetime of lessons  -  Dec 11, 2006
St. Petersburg Times,...comprising the trial drug talampanel along with the standard treatment of six weeks of radiation to the brain and the chemotherapy drug temodar (temozolomide). ...

Genta Initiates Pilot Clinical Trial Of Genasense(R) Plus Abraxane ...  -  Nov 30, 2006
Medical News Today (press release),...synergy when Genasense was combined with Abraxane(R) (paclitaxel protein-bound particles; Abraxis Oncology, Inc.) and Temodar(R) (temozolomide; Schering Plough ...

Genta Initiates Pilot Clinical Trial of Genasense(R) Plus Abraxane ...  -  Nov 29, 2006
Yahoo! News (press release)...synergy when Genasense was combined with Abraxane® (paclitaxel protein-bound particles; Abraxis Oncology, Inc.) and Temodar® (temozolomide; Schering Plough ...

Bradmer Meets with FDA on Initiation of Phase III Trial for ...  -  Dec 15, 2006
Yahoo! News (press release)...healthcare markets. The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM ...

Pharminox, Schering-Plough Enter Deal Worth Up To $40M  -  Dec 12, 2006
Therapeutics Daily (subscription) (press release),The deal is to find successor compounds to temozolomide (Temodal/Temodar), which Schering markets worldwide for malignant glioma. ...

Genta Initiates Pilot Clinical Trial of Genasense® Plus Abraxane ...  -  Nov 30, 2006
PipelineReview.com (press release),...paclitaxel protein-bound particles for injectable suspension) (albumin-bound) (Abraxis BioScience, Inc.) and Temodar® (temozolomide) Capsules (Schering-Plough ...

Onyx Plunges as Study Disappoints  -  Dec 4, 2006
TheStreet.comThe trial enrolled 270 patients whose disease progressed after previous treatments with either dacarbazine or temozolomide chemotherapies. ...

Onyx's Shares Drop On Top-Line Results Of Nexavar In Melanoma  -  Dec 4, 2006
BioWorld Online,...and placebo-controlled, and involved 270 patients that were progressing in disease after one previous treatment with either dacarbazine or temozolomide. ...

Onyx/Bayer: to pursue development of Nexavar despite study failure  -  Dec 5, 2006
Pharmaceutical Business Review...patients who had progressed after one prior chemotherapy regimen containing either the standard agent dacarbazine or Schering-Plough's Temodar (temozolomide). ...

Genta begins trial of Genasense  -  Nov 29, 2006
United Press International..."Our goal with this trial is to further evaluate the potential for Genasense to synergize with a taxane combined with temozolomide, drugs that are widely used ...

Protherics PLC announces GBP 38 million Fundraising  -  Dec 8, 2006
Genetic Engineering News (press release),Patients typically receive stereotactically guided radiotherapy and chemotherapy after surgery; temozolomide is the standard chemotherapeutic agent as it can ...

Genasense(R) Shown Active using Intermittent Dosing in Melanoma ...  09 Nov 2006
The use of Genasense plus Abraxane® (paclitaxel protein-bound particles; Abraxis Oncology, Inc.) and Temodar® (temozolomide; Schering Plough, Inc.) also ... -Yahoo! News (press release) Vion Pharmaceuticals to Host Conference Call to Discuss Third ...  09 Nov 2006
...trials of Cloretazine® (VNP40101M) as a single agent in pediatric brain tumors, small cell lung cancer, and in combination with temozolomide in hematologic ... -Yahoo! News (press release) Bradmer announces 2006 third quarter operational and financial ...  09 Nov 2006
...healthcare markets. The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM ... -Yahoo! News (press release) Andy’s appeal gears up  Oct 20, 2006
It was launched to raise £16,000 to pay for a course of the revolutionary Temozolomide drug for Corbridge father-of-three Andy Teasdale, who is suffering from ... -Hexham Courant, Schering-Plough Contracts with OncoMethylome Sciences for Use of ...  Oct 24, 2006
OncoMethylome’s assay will be used for MGMT methylation testing in multiple national and international clinical trials involving temozolomide in brain cancer ... -Genetic Engineering News (press release), Pharmacyclics Reports First Quarter Financial Results  Oct 26, 2006
...plus radiosurgery for treatment of brain metastases; -- Completed patient enrollment in a Phase 1 trial of Xcytrin plus Temodar(R) (temozolomide) for treatment ... -PR Newswire (press release), Novacea Initiates Phase 1/2 Trial of AQ4N in Glioblastoma ...  Nov 1, 2006
...that it has initiated a multicenter, Phase1b/2a open-label clinical trial of AQ4N (banoxantrone), in combination with radiotherapy and temozolomide, for safety ... -Market Wire (press release) Genentech Q3 2006 Earnings Call Transcript  Oct 10, 2006
...with Inotek on their ongoing Phase Ib trial investigating the PARP inhibitor as a potential treatment for malignant melanoma in combination with temozolomide. ... -Seeking Alpha, Tracon and Case Western University Enter Cancer Agreement  Oct 13, 2006
The patented therapy, which has been licensed to Tracon, has been studied in combination with the approved chemotherapeutic Temozolomide. ... -International News Service, Case Western Reserve University licenses methoxyamine to Tracon  Oct 13, 2006
The patented therapy, which has been licensed to TRACON, has been studied most intensively in combination with the approved chemotherapeutic Temozolomide. ... -EurekAlert (press release), Addition of Genasense® to DTIC-Dome® Improves Outcomes in ...  Oct 10, 2006
...therapeutic approaches. Recently, Temodar® (temozolomide) has supplanted DTIC as the standard palliative treatment. A randomized ... -Cancer Consultants (press release), Private UK Biotech Pharminox Signs $40 Million Drug Development ...  -  12 Dec 2006
PipelineReview.com (press release),In this role he was responsible for the discovery and early development of temozolomide, the market-leading treatment for malignant glioma, a common form of

UK's Pharminox signs $40 million deal with Schering-Plough  -  12 Dec 2006
Pharma Times (subscription),Temozolomide is licensed to Schering-Plough, which markets the drug as Temodal, and Mr Worrall said the Pharminox deal "reflects the high regard that

Nexavar in patients with advanced melanoma does not meet primary ...  -  Dec 6, 2006
Xagena.it,Two hundred seventy patients progressing after one previous systemic chemotherapeutic treatment ( with either Dacarbazine or Temozolomide ) were enrolled

Gliadel(R) Wafer Clinical Data Presented at Society for Neuro ...  -  Nov 21, 2006
PipelineReview.com (press release),Interim data from 35 patients with this aggressive brain tumor showed a median survival of 18.6 months when Gliadel Wafer and temozolomide are used in

Gliadel(R) Wafer Clinical Data Presented at Society for Neuro ...  -  Nov 20, 2006
Earthtimes.orgPneumocystis carinii prophylaxis was not required during concomitant treatment with radiotherapy and temozolomide. As of September 29, 2006,

With cancer comes a lifetime of lessons  -  Dec 11, 2006
St. Petersburg Times,...the trial drug talampanel along with the standard treatment of six weeks of radiation to the brain and the chemotherapy drug temodar (temozolomide).

Patients denied tumour treatment  -  Nov 20, 2006
ic Wales,His family wanted him to receive a new drug, temozolomide, already used in other countries. But even though his oncologist supported the use of the drug,

NEOPHARM (NEOL) Presents Data From Phase I Study of CINTREDEKIN ...  -  Nov 20, 2006
StreetInsider.com (subscription),...or without concurrent temozolomide following tumor resection appears to be safe and well-tolerated in patients with newly diagnosed malignant glioma.

Genta begins trial of Genasense  -  Nov 29, 2006
United Press International..."Our goal with this trial is to further evaluate the potential for Genasense to synergize with a taxane combined with temozolomide, drugs that are widely

Mary McCarty: 13-year-old's battle with leukemia leaves lasting ...  -  Dec 9, 2006
Dayton Daily News (subscription),The Johnsons decided to include Leo in a Phase 1 trial of an experimental drug called temozolomide. Before that, they set out on a family road trip — Leo's

NeoPharm Is Climbing On Phase I News  -  Nov 20, 2006
Trading Markets,...through Convection-Enhanced Delivery followed by external beam radiation therapy with or without concurrent temozolomide following tumor resection.

MGI Pharma: Tumor Patients Show Median Survival 18.6 Months  -  Nov 20, 2006
Therapeutics Daily (subscription) (press release),...brain tumors showed a median survival rate of 18.6 months when Gliadel Wafer and temozolomide are used in combination with surgery and radiotherapy.

Making Glioblastomas Starve - first Clinical Trials in the USA and ...  -  Dec 7, 2006
Juraforum.de,One of those drugs is the cancer-drug temozolomide. Professor Vajkoczy and his collaborators combined this drug with an anti-inflammatory inhibitor which

NEOPHARM Announces Presentation of Final Safety Data from Phase 1 ...  -  Nov 21, 2006
PipelineReview.com (press release),CED of CINTREDEKIN BESUDOTOX at the highest dose, 0.5 ug/mL, followed by EBRT with or without concurrent temozolomide was shown to be well-tolerated in

Onyx/Bayer: to pursue development of Nexavar despite study failure  -  Dec 5, 2006
Pharmaceutical Business Review...who had progressed after one prior chemotherapy regimen containing either the standard agent dacarbazine or Schering-Plough's Temodar (temozolomide).

Phase III Trial of Nexavar in Patients with Advanced Melanoma Does ...  -  Dec 5, 2006
PipelineReview.com (press release),Two hundred seventy patients progressing after one previous systemic chemotherapeutic treatment (with either dacarbazine (DTIC) or temozolomide) were

Onyx's Shares Drop On Top-Line Results Of Nexavar In Melanoma  -  Dec 4, 2006
BioWorld Online,...and placebo-controlled, and involved 270 patients that were progressing in disease after one previous treatment with either dacarbazine or temozolomide.

Onyx Plunges as Study Disappoints  -  Dec 4, 2006
TheStreet.comThe trial enrolled 270 patients whose disease progressed after previous treatments with either dacarbazine or temozolomide chemotherapies.

Bradmer Contracts With Prologue Research to Manage Multi-Center ...  -  Nov 29, 2006
PharmaLive.com (press release),The current standard of care for GBM patients is surgical resection followed by radiation and temozolomide. GBM tumors typically have infiltrating edges

Protherics PLC announces GBP 38 million Fundraising  -  Dec 8, 2006
Genetic Engineering News (press release),Patients typically receive stereotactically guided radiotherapy and chemotherapy after surgery; temozolomide is the standard chemotherapeutic agent as it

Vion Pharmaceuticals Reaches Midpoint Of Patient Accrual To ...  -  Nov 14, 2006
Medical News Today (press release),Additional trials of Cloretazine(R)(VNP40101M) as a single agent in pediatric brain tumors, small cell lung cancer, and in combination with temozolomide in

NEOPHARM's CINTREDEKIN BESUDOTOX Highlighted in Presentations at ...  -  Nov 13, 2006
Genetic Engineering News (press release),Results: CED of CINTREDEKIN BESUDOTOX (IL13-PE38QQR) Followed by Radiation Therapy Without and With Temozolomide in Newly Diagnosed Malignant Glioma.

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