Recent news on Tenofovir

Clinton Foundation announces new price cuts for tenofovir and ...  -  May 9, 2007
Aidsmap,A big reduction in price for tenofovir is one of the key features of the announcement. The generic manufacturers are now guaranteeing a ceiling price of

Tenofovir and Truvada licensed in South Africa  -  Apr 26, 2007
Aidsmap,Nearly 18 months after submission, an essential generic version of the anti-HIV drug tenofovir has finally been licensed in South Africa, along with a fixed

Boehringer Ingelheim initiates international head-to-head HIV/AIDS ...  -  May 17, 2007
WebWire (press release),Both agents will be combined with a background regimen including tenofovir and emtricitabine (Truvada®). The ArTEN trial will enroll 561 HIV-positive

South Africa: Nod for Aids Drugs is Cost Poser for State  -  Apr 25, 2007
AllAfrica.com,Viread contains tenofovir, while Truvada combines tenofovir with emtricitabine. Doctors and AIDS activists have for some time been calling for Viread and

Clinton Group Concludes AIDS Drugs Deal  -  May 9, 2007
Post ChronicleThe pill will have the drugs tenofovir, lamivudine and efavirenz. Clinton said the agreement was made in partnership with international drug purchase

Clinton clinches Aids deal  -  May 9, 2007
Health24.com,The agreement on the $1 once-a-day pills that combine the drugs efavirenz, lamivudine and tenofovir is 45 percent less than the current rate available for

Clinton brokers generic AIDS drug deal  -  May 8, 2007
Sydney Morning Herald,He said the pill combines the drugs Tenofovir and Lamivudine and Efavirenz. "The new cost for this treatment of $US339 ($A411.58) per patient per year

Bill Clinton Reaches Deal to Lower Cost of AIDS Drugs in ...  -  May 8, 2007
FOX NewsClinton also announced a reduced price for a once-daily first-line AIDS pill that combines the drugs tenofovir, lamivudine and efavirenz.

Clinton to the rescue again!  -  May 8, 2007
News-Medical.net,The plan is for the AIDS drugs tenofovir, lamivudine and efavirenz to be combined to make up the once-per-day AIDS pill which will cost $339 per patient per

Bill Clinton Brokers Generic AIDS Drug Deal  -  May 8, 2007
Medscape (subscription)Clinton also said a new once-daily pill combining tenofovir, lamivudine and efavirenz -- which is currently prohibitively expensive in developing countries

Bill Clinton Announces AIDS Drug Deals  -  May 8, 2007
Lompoc Record,...in part by securing lower prices for raw materials. The reduced-price, once-daily pill combines the drugs tenofovir, lamivudine and efavirenz.

Bill Clinton Announces Drug Agreements  -  May 8, 2007
Dog Flu Diet and Diseases,The AIDS drugs called tenofovir, lamivudine and efavirenz will be combined to make up the once-per-day AIDS pill. "Seven million people in the developing

Clinton Foundation deal to lower cost of AIDS drugs  -  May 8, 2007
WMC-TV,The reduced-price, once-daily pill combines the drugs tenofovir, lamivudine and efavirenz. The Clinton Foundation's activities are being financed by UNITAID

Boehringer Ingelheim Initiates International Head-to-Head HIV/AIDS ...  -  May 9, 2007
campus med,Both agents will be combined with a background regimen including tenofovir and emtricitabine (Truvada(R)). The ArTEN trial will enroll 561 HIV-positive

Boehringer Ingelheim Initiates International Head-to-Head HIV/AIDS ...  -  May 9, 2007
Juraforum.de,Both agents will becombined with a background regimen including tenofovir andemtricitabine (Truvada(R)). The ArTEN trial will enroll 561HIV-positive

Boehringer Ingelheim Initiates International Head-to-Head HIV/AIDS ...  -  May 9, 2007
PR-Inside.com (Pressemitteilung),The ArTEN (Atazanavir/ritonavir on a background of Tenofovir and Emtricitabine (Truvada) versus Nevirapine) trial is a Phase IIIb, open-label, multinational

Boehringer Ingelheim Initiates International Head-to-Head HIV/AIDS ...  -  May 9, 2007
Earthtimes.orgBothagents will be combined with a background regimen including tenofovir andemtricitabine (Truvada(R)). The ArTEN trial will enroll 561

Africa: Q&A on Second-Line HIV/Aids Treatment  -  May 8, 2007
AllAfrica.com,A. The key “next generation� first-line regimens include the same medicines as today’s leading first-line regimens except that tenofovir (TDF) or zidovudine

Second line of attack  -  May 21, 2007
Business Standard,...to manufacture and supply once-daily first-line drugs tenofovir, lamivudine and efavirenz at less than $1, as well as ARVs to 66 developing nations.

Approvals: Herceptin, Reyataz, and Peg-Intron  -  May 21, 2007
Medscape (subscription)Abbot Laboratories, Inc) in patients who have previously received anti-HIV drugs, those who will be receiving tenofovir disoproxil fumarate (Viread,

Aids drug awaits patent in India  -  May 20, 2007
Gulf Times,According to Alton, Viread (tenofovir disoproxil fumarate) is on its way to becoming the frontrunner drug across Europe for HIV/Aids due to its low toxicity

Health Canada approves Reyataz (atazanavir sulfate) 300 mg single ...  -  May 17, 2007
PharmaLive.com (press release),...patients who will be receiving tenofovir disoproxil fumarate, and patients who have never taken anti-HIV medicines that require SUSTIVA(R) (efavirenz)

Clinton challenges US control over Aids drug patents  -  May 9, 2007
Independent,They will combine the drugs Tenofovir, Lamivudine and Efavirenz. "This drug represents the best chance that science has to offer," Mr Clinton said.

Clinton announces new Aids drugs deal  -  May 10, 2007
InTheNews.co.uk,The pill combines the drugs tenofovir, lamivudine and efavirenz and is associated with improved treatment outcomes. Its new cost represents a 45 per cent

APS: Boehringer Ingelheim Initiates International Head-to-Head ...  -  May 9, 2007
ANP Pers Support,...of ritonavir, with a backbone regimen of tenofovir and emtricitabine (Truvada). Patients. BID or 400 mg QD after two weeks. Patients will be observed for a

Canadians being denied life-saving treatments  -  May 9, 2007
CNW Telbec (Communiqués de presse),..."Enter tenofovir, very effective with few side effects and toxicities, allowing HIV-positive people like me to live better lives.

South Africa: Unicef Commends Initiative to Reduce Prices on Aids ...  -  May 9, 2007
AllAfrica.com,...daily pill made available in the US in 2006 which is now considered the gold-standard treatment, combines the drugs tenofovir, lamivudine and efavirenz.

Breaking Merck patent may drive investment away from Brazil  -  May 9, 2007
Pharmaceutical Business ReviewThe same happened with Gilead's Viread (tenofovir), a high-selling NRTI and Roche/Pfizer's Viracept (nelfinavir), a PI that has been facing decreasing sales

Bill Clinton brokers deal for lower AIDS drug prices  -  May 9, 2007
ReutersHe said the pill combines the drugs Tenofovir and Lamivudine and Efavirenz. "This drug represents the best chance that science has to offer," said Clinton,

Clinton foundation deal lowers cost of Aids drugs  -  May 9, 2007
Ireland Online,The reduced-price, once-daily pill combines the drugs tenofovir, lamivudine and efavirenz. “Seven million people in the developing world are in need of

Deals will lower cost of AIDS drugs in some countries  -  May 9, 2007
Seattle Times,Clinton said the reduced-price, once-daily pill combines the drugs tenofovir, lamivudine and efavirenz. "Seven million people in the developing world are in

Clinton announces new deal on AIDS drugs  -  May 8, 2007
Boston Globe,The reduced-price, once-daily pill combines the drugs tenofovir, lamivudine, and efavirenz. Clinton said the new price of $339 per patient per year would be

UNICEF Lauds Price Slashing of 16 Aids Medicines in 66 Developing ...  -  May 9, 2007
NewsBlaze,...pill made available in the US in 2006 which is now considered the gold-standard treatment, combining the drugs tenofovir, lamivudine and efavirenz.

Clinton Group Makes Cheap AIDS Drug Deal  -  May 8, 2007
CBS News,The reduced-price, once-daily pill combines the drugs tenofovir, lamivudine and efavirenz. Clinton, seen at left during a conference earlier this month,

Clinton Foundation Strikes Deal for Lower-Cost Generic AIDS Drugs ...  -  May 9, 2007
Newsinferno.com,According to the Clinton Foundation, this drug, a combination of tenofovir, lamivudine, and efavirenz first launched in July of last year, offers “greater

Tenofovir and Truvada licensed in South Africa  -  26 Apr 2007
Aidsmap,Nearly 18 months after submission, an essential generic version of the anti-HIV drug tenofovir has finally been licensed in South Africa, along with a fixed

Further development of resistance infrequent in patients taking ...  -  Apr 11, 2007
Aidsmap,Maintaining tenofovir treatment after viral rebound and the emergence of the K65R tenofovir resistance mutation does not appear to result in the

Narrative Review: Antiretroviral Therapy to Prevent the Sexual ...  -  Apr 16, 2007
Annals of Internal MedicineData are available for the levels of intracellular phosphorylated forms of tenofovir, zidovudine, and lamivudine in mononuclear cells isolated from the male

Gilead shifts Irish ops  -  Apr 13, 2007
BiopharmaReporter.com,Major products for the company include Atripla (efavirenz, emtricitabine, tenofovir), the only once-daily single tablet regimen for HIV-1 infection,

d4T dose can be reduced without loss of effectiveness, meta ...  -  Apr 2, 2007
Aidsmap,After 48 weeks there were no differences in the rate of viral suppression, but patients receiving tenofovir or d4T 30mg experienced lipid improvements.

Pharma firms find US ally in patent row  -  Mar 27, 2007
Business Standard,The foundation has challenged the patent grant for Tenofovir in the United States Patent and Trademark Office (USPTO) on the same grounds as that of Indian

Queers Lose in Paris  -  Apr 5, 2007
Gay City NewsIt was his critique of the Family Health International's research trial of Gilead Sciences' Tenofovir in Cameroon that ultimately led to its cancellation.

Gilead Sciences: Rapid Growth Expected From New Products  -  Apr 3, 2007
Seeking Alpha,...including the strong uptake of Atripla (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg) following its launch in July 2006

Gilead's Atripla, Lower Costs Provide Lift To First Quarter  -  Apr 22, 2007
BioWorld Online,Truvada - the combo HIV drug pairing Gilead's Viread (tenofovir disoproxil fumarate) and Emtriva (emtricitabine), did especially well in Europe.

Gilead Sciences Announces First Quarter 2007 Financial Results  -  Apr 19, 2007
PharmaLive.com (press release),Sales of Viread(R) (tenofovir disoproxil fumarate) were $160.7 million in the first quarter of 2007, a 16 percent decrease from $191.8 million in the first

Inhibitex Acquires FermaVir for Over $19M  -  Apr 10, 2007
Genetic Engineering News (press release),...expected to produce a lead clinical candidate by end 2007; and Tenofovir, a nucleoside reverse transcriptase inhibitor for the treatment of HIV/AIDS.

Update on Opt-Out Testing and Initial Antiretroviral Therapy ...  -  Apr 2, 2007
Medscape (subscription)Moore R, Keruly J, Gallant J. Tenofovir and renal dysfunction in clinical practice. Program and abstracts of the 14th Conference on Retroviruses and

Billion dollar babies—biotech drugs as blockbusters  -  Apr 3, 2007
Nature.com (subscription),...emtricitabine and tenofovir), marketed jointly by Gilead of San Francisco and Bristol-Myers Squibb of New York and the human papilloma virus (HPV)

AbelsonTaylor Expands Account Services with Two New Hires  -  Apr 20, 2007
PharmaLive.com (press release),Dan Lathitham, 31, will manage the agency’s account for Gilead’s Truvada® (emtricitabine and tenofovir disoproxil fumarate) for the treatment of HIV.

Idenix Announces Data Presentations at the 2007 Digestive Disease ...  -  Apr 19, 2007
PharmaLive.com (press release),...will present "Absence of Pharmacokinetic Drug-Drug Interaction Between Telbivudine and Tenofovir" in a poster session beginning on Sunday, May 20,

Inhibitex Signs Definitive Agreement to Acquire FermaVir ...  -  Apr 10, 2007
PipelineReview.com (press release),Drs. de Clercq and Balzarini have co-invented multiple approved antivirals, including tenofovir, one of the most widely-used nucleoside reverse

Adverse effects of ARVs  -  Apr 1, 2007
ZimDaily,Tenofovir. A very potent drug against HIV, and in our setting, we recently started using it in combination with Lamivudine for patients who are co-infected

Atripla enters Kenyan market  -  27 Mar 2007
Africa Science News Service,Apola says Atripla is a fixed dose combination of efavirenz 600 mg (STOCRIN) and emtricitabine 200 mg + tenofovir 300 mg (TRUVADA).

Standard screening tests may not detect hidden hepatitis B virus ...  -  27 Mar 2007
Aidsmap,...with occult hepatitis B were taking antiretroviral drugs with anti-HBV activity, such as 3TC (Epivir), emtricitabine (Emtriva), or tenofovir (Viread).

PUBPAT Takes on Key HIV/AIDS Drug Patents  -  27 Mar 2007
ag-IP-news Agency,5922695, 5935946, 5977089 and 6043230, relate to the drug known generically as Tenofovir Disoproxil Fumarate (TDF), a key weapon in the battle against

CROI: Is tenofovir causing kidney problems?  -  Mar 13, 2007
Aidsmap,Tenofovir (Viread) has been associated with kidney (renal) toxicity in certain cases, although this has proven to be nearly always mild, rare,

Tenofovir-Ritonavir Combination Therapy Linked to Nephrotoxicity ...  -  Mar 5, 2007
DG NewsLOS ANGELES, CA -- March 5, 2007 -- Treatment of patients infected with HIV with regimens that contain tenofovir and ritonavir appear to be associated with

CROI: Tenofovir microbicide stops rectal infection in monkeys ...  -  Feb 27, 2007
Aidsmap,Two-thirds of monkeys treated with a tenofovir-containing rectal microbicide were protected from repeated rectal challenge with a pathogenic variety of SIV,

Two new medicines funded for people with HIV  -  Mar 14, 2007
Scoop.co.nz,Tenofovir (Viread) and emtricitabine (Emtriva) are comparatively new treatments that have similar actions to anti-HIV medicines that are already funded.

Pharmac's new HIV drugs too slow - Aids foundation  -  Mar 14, 2007
Stuff.co.nz,Tenofovir and emtricitabine were similar to drugs already funded by the drug agency, Mr Moodie said, but funding them was important because HIV could become

HIV drugs to be subsidised  -  Mar 15, 2007
New Zealand Herald,Tenofovir and Emtricitabine were similar to other subsidised drugs but funding them was important because HIV could become resistant to existing treatments.

New HIV meds funded after delay  -  Mar 14, 2007
Scoop.co.nz,The New Zealand AIDS Foundation is welcoming PHARMAC’s decision to fund two more anti-retroviral treatments for HIV from April 1, tenofovir (Viread) and

CROI: High rate of virologic failure on once-daily combination of ...  -  Mar 8, 2007
Aidsmap,Preliminary results from a prospective clinical trial of once-daily 3TC, tenofovir and nevirapine have shown a high rate of early virologic failure,

NRTIs Have Varying Effects on Serum Lipids and Body Fat: Presented ...  -  Feb 27, 2007
DG NewsTreatment in the other 2 arms consisted of lopinavir or efavirenz and lamiduvine plus one other NRTI (zidovudine, staduvine, or tenofovir).

How do ARVs work?  -  Mar 25, 2007
ZimDaily,...eg Efavirenz may be called Stocrin, Nevirapine Virimune, Tenofovir Viread, and Lopinavir/ritonavir may be called Kaletra (capsules) or Aluvia (tablets).

One pill a day for HIV patients  -  Mar 9, 2007
Chennai Online,The tablet contains Tenofovir 300 mg, Emtricitabine 200 mg and Efavirenz 600 mg, Health and Family Welfare Minister Anbumani Ramadoss said in a written

CROI: Kaletra less likely to cause fat loss than efavirenz when ...  -  Feb 27, 2007
Aidsmap,Nine per cent of tenofovir-treated patients developed lipoatrophy, a significantly lower proportion than the AZT recipients. When lipoatrophy incidence was

CROI: Is there a ceiling to CD4 recovery on virologically ...  -  Mar 13, 2007
Aidsmap,This lowered response was seen for tenofovir overall, not just for the combination of tenofovir and didanosine (Videx), which has been shown to blunt CD4

New HIV listings added to Pharmaceutical Schedule  -  Mar 14, 2007
Scoop.co.nz,Tenofovir disoproxil fumarate, emtricitabine and efavirenz versus fized-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patinets.

Avexa: trial success creates takeover speculation  -  Mar 22, 2007
Pharmaceutical Business ReviewFixed-dose combinations (FDCs) of NRTIs such as Gilead's Truvada (tenofovir/emtricitabine) and GSK's Combivir (lamivudine/zidovudine) are popular as they

HIV in India — The Challenges Ahead  -  Mar 21, 2007
New England Journal of Medicine (subscription),More expensive first-line medications (ie, tenofovir and emtricitabine) are not provided, nor are second-line medications and more expensive laboratory

CROI: high burden of side-effects from d4T leads to WHO dose ...  -  Mar 21, 2007
Aidsmap,Of note is the very low switch rate from tenofovir (Viread), which was used as part of the first-line regimen in Uganda.

CROI: Alendronate effectively treats bone loss in men and women ...  -  Feb 26, 2007
Aidsmap,About 65% were taking protease inhibitors and 38% were taking tenofovir (Viread), which has been linked with bone loss in some studies.

CROI: MSF reports good responses on PI-based second-line ART ...  -  Feb 27, 2007
Aidsmap,Tenofovir was used by 14.2%. The median patient follow-up time was 10.1 months — and all patients were still alive at the time of last evaluation.

CROI: HAART: Helpful or harmful to kidney function?  -  Mar 15, 2007
Aidsmap,After controlling for age, race, and gender, the following were found to predict GFR decline: hypertension, hyperlipidemia, proteinuria, use of tenofovir

HIV market: collaborative combinations  -  Mar 13, 2007
Pharmaceutical Business ReviewGSK's Combivir (lamivudine and zidovudine) or Gilead's Truvada (emtricitabine and tenofovir disoproxil fumarate) are potential candidates for such a

CROI: New NNRTI, TMC278, demonstrates sustained potency, better ...  -  Mar 2, 2007
Aidsmap,75mg, or 150mg) compared with open-label once-daily efavirenz (600mg), in combination with either AZT/3TC (Combivir) or tenofovir/FTC (Truvada),

CROI: Once daily Kaletra may be less effective when viral load ...  -  Mar 1, 2007
Aidsmap,All the patients received background therapy consisting of FTC with tenofovir or d4T extended release (approximately two-thirds received d4T).

Anti-HBV drug entecavir also active against HIV and promotes ...  -  Mar 1, 2007
Aidsmap,Further, two approved anti-HIV drugs -- emtricitabine (Emtriva) and tenofovir (Viread) – are also active against HBV, and are in clinical trials for this

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