Recent news on Troglitazone

Years Ago, Agency Was Warned of a Drug’s Risks  -  25 May 2007
Wilmington Morning Star,Referring to Avandia by its generic name, rosiglitazone, and to Rezulin as troglitazone, Dr. Buse wrote in the letter, “I do not believe that rosiglitazone

Analysis Associates Avandia With Greater Risk of Heart Attack  -  May 21, 2007
Diabetes Health (press release),In 2000, another glitazone, Rezulin (troglitazone), was removed from the market due to liver toxicity. Earlier this year, the Cochrane Library published a

Meta-Analysis Links Rosiglitazone (Avandia) to Risk of Myocardial ...  -  May 21, 2007
MedPage Today,A third drug in the same class, also known as peroxisome-proliferator-activated receptors or PPARs, troglitazone "was withdrawn from the market for rare,

Drug Safety Proposals and the Intrusion Of Federal Regulation into ...  -  May 11, 2007
American Enterprise Institute,3 (2001): 205-208; and DJ Graham et al., "Liver Enzyme Monitoring in Patients Treated with Troglitazone," Journal of the American Medical Association 286,

Diabetes Drugs Tied to Fractures in Women  -  Apr 17, 2007
Journal of American Medical Association (subscription),In 2000, Parke-Davis/Warner Lambert agreed to the FDA's request to withdraw its thiazolidinedione, called troglitazone (Rezulin), from the market because of

Effects of the Type 2 Diabetes-Associated PPARG P12A Polymorphism ...  -  Apr 4, 2007
Journal of Clinical Endocrinology and Metabolism,We also genotyped five other PPARG variants implicated in the response to troglitazone and assessed their effect on insulin sensitivity at 1 yr.

Oral medications to treat Type 2 diabetes  -  Apr 19, 2007
Chennai Online,Another drug Troglitazone (sold by Warner-Lambert as Rezulin) was recalled by the company due to its tendency to cause liver problems.

PDUFA Reauthorization — Drug Safety's Golden Moment of Opportunity?  -  Apr 13, 2007
New England Journal of Medicine (subscription),More recent events that have captured the public's attention include the market withdrawals of troglitazone, cerivastatin, and rofecoxib.

Eli Lilly Advances Study of PPAR-alpha Agonist  -  Mar 28, 2007
Seeking Alpha,The demise of the PPAR-gamma agonist, troglitazone, has been well documented. According to CDER, over 50 INDs have been filed for drugs designed as agonists

Lifestyle changes may reduce diabetes  -  Feb 12, 2007
Waterloo Record,Diabetes drugs included metformin, acarbose, glipizide and troglitazone; the weight-loss drug was orlistat. About 37 per cent of the participants developed

Exercise Pivotal In Preventing And Fighting Type II Diabetes  -  Feb 9, 2007
Science Daily (press release)Insulin-sensitizing Drug Cut Diabetes Risk (April 12, 2005) -- Researchers report that troglitazone lowered diabetes onset by 75 percent compared to placebo

The Role of Litigation in Defining Drug Risks  -  Jan 16, 2007
Journal of American Medical Association (subscription),However, in the case of troglitazone, an oral hypoglycemic found to cause liver failure, the company minimized its presentation of adverse effects by not

New medical research reported by Osaka University, Japan  -  Dec 28, 2006
Therapeutics Daily (subscription) (press release),Study 1: The thiazolidinedione drug troglitazone upregulates nitric oxide synthase expression in vascular endothelial cells.

Which is More Dangerous to Your Health—the Flu or the FDA?  -  Dec 21, 2006
Rutherford Institute,...cause harm include dexfenfluramine, a diet drug whose post-marketing data indicated an increased risk of pulmonary hypertension, and troglitazone, a diabetes ...

Dr. Reddy's Struggles for Homegrown Hit to Escape Rival Clones  -  Dec 5, 2006
BloombergHe came across an article about a molecule called troglitazone and decided he could make a better product. Troglitazone belonged ...

Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis ...  Oct 26, 2006
Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. According to a study from ... -Therapeutics Daily (subscription) (press release), Rosiglitazone, but Not Ramipril, Prevents Progression to Diabetes  Sep 19, 2006
...seen in DREAM was similar to that obtained by lifestyle interventions, as well as similar to that seen in 2 previous trials of troglitazone, a drug that has ... -Medscape (subscription)

Division of Endocrinology, Diabetes, and Metabolism, State ...  Sep 7, 2006
...org. Background: We have previously demonstrated an early and potent antiinflammatory effect of troglitazone and rosiglitazone. ... -Journal of Clinical Endocrinology and Metabolism

Dr. Reddy's Struggles for Homegrown Hit to Escape Rival Clones  -  Dec 5, 2006
BloombergTroglitazone belonged to a class of emerging drugs called insulin sensitizers. Insulin helps distribute sugar in the body. In type-2 diabetes,

Diabetes Drug Shows Promise Against Heart Attacks  -  Nov 14, 2006
U.S. News & World Report,Troglitazone, a drug in the same class as pioglitazone and sold as Rezulin, was withdrawn in March of 2000 after reports of liver failure.

Pioglitazone slows progression of carotid atherosclerosis vs ...  -  Nov 13, 2006
TheHeart.Org,...but there was no liver toxicity, which he said was reassuring, given the previous experience with troglitazone, which was withdrawn from the market.

Thiazolidinedione-derived novel therapeutic agents proposed for ...  Aug 16, 2006
..."Certain members of the TZD family of the peroxisome proliferator-activated receptor gamma (PPAR gamma) agonists, such as troglitazone and ciglitazone, exhibit ... -Therapeutics Daily (subscription)

Lifestyle Can Fend off Type 2 Diabetes Genetic Risk  Jul 20, 2006
To do this, they genotyped 3,548 men and women, including 585 people who were assigned to receive Rezulin (troglitazone) as part of the original Diabetes ... -MedPage Today

Minimizing Drug Toxicity  Jul 3, 2006
The Parke-Davis and Warner-Lambert antidiabetic drug troglitazone (Rezulin) was withdrawn from the market in 2000 after it, too, was found to cause severe ... -Chemical & Engineering News

David JA Jenkins , Andrea R Josse , Roxanne Labelle , Augustine ...  Jul 6, 2006
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis. Am J Gastroenterol 2001;96:519–25.[Medline]. ... -Am J Clin Nutr (subscription)



Brain cancer: Pioglitazone decreases the cells resistance to ...  Mar 21, 2006
The Cedars-Sinai researchers theorized that a diabetes drug called Troglitazone would limit the effects of the overexpressed proteins, reinstating the caspase ... - Xagena.it

New advertising code of conduct established in Vioxx withdrawal ...  Mar 9, 2006
Problems with drugs such as Sankyo and Parke-Davis' Rezulin (troglitazone) and Bayer's Baycol (cerivastatin) for example, have had little effect on the ... - Pharmaceutical Business Review

DATAMONITOR: New Advertising Code of Conduct Established in ...  Mar 10, 2006
Problems with drugs such as Rezulin (troglitazone) and Baycol (cerivastatin) for example, have had little effect on the blockbuster potential of competitor ... - PharmaLive.com



Researchers Break Chain Of Biochemical Events That Brain Cancer ...  Feb 6, 2006
The Cedars-Sinai researchers theorized that a diabetes drug called troglitazone would limit the effects of the overexpressed proteins, reinstating the caspase ... - Science Daily

This site is for informational purposes only--it does not offer medical advice or sell health products. If you need assistance, contact your physician or healthcare professional