Recent news on Tumor Necrosis Factor

Low Levels of Common Enzyme Key to Resistance in Ewing’s Sarcoma  -  25 May 2007
PressZoom (press release),The protein, called TRAIL ( tumor necrosis factor apoptosis-inducing ligand ),has generated tremendous interest among scientists looking for new therapies

Cytos Biotechnology reports results from a phase I/IIa study  -  25 May 2007
PipelineReview.com (press release),The inflammatory cytokine tumor necrosis factor alpha (TNF-α) hasbeen described as a key molecule in the pathogenesis of psoriasis.

New Analysis Of Data Shows Treatment With Abbott's HUMIRA ...  -  25 May 2007
Medical News Today (press release),It works by blocking tumor necrosis factor alpha (TNF-α), a protein that when produced in excess, plays a central role in the inflammatory responses of

Anti-Tumor Necrosis Factor Drug Doesn't Help Two Inflammatory Diseases  -  May 4, 2007
Medical News Today (press release),Two studies in the May 1, 2007, Annals of Internal Medicine find that infliximab, a widely used anti-tumor necrosis drug, has no benefit in patients

Proteasome Inhibitors Synergize with Tumor Necrosis Factor-Related ...  -  May 4, 2007
Journal of Clinical Endocrinology and Metabolism,Address all correspondence and requests for reprints to: Ruggero De Maria, Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di

Inhibition of the PI3K-Akt Signaling Pathway Reduces Tumor ...  -  May 1, 2007
Journal of Bone and Joint Surgery (subscription)The cytokine, tumor necrosis factor- (TNF-), is produced by macrophages in response to bacterial endotoxins and wear particles, and it increases osteoclast

Low Levels of Common Enzyme Key to Resistance in Ewing's Sarcoma  -  May 23, 2007
PharmaLive.com (press release),The protein, called TRAIL (tumor necrosis factor apoptosis-inducing ligand),has generated tremendous interest among scientists looking for new therapies

Targeted Genetics Completes Enrollment and Initial Dosing of ...  -  May 24, 2007
WM Experts (press release),The TNFR:Fc protein is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha), a key mediator of inflammation. "We are pleased with the rapid pace of

New Analysis of Data Shows Treatment With Abbott's HUMIRA(R ...  -  May 22, 2007
Earthtimes.orgIt works by blocking tumor necrosis factor alpha (TNF-alpha), a protein that when produced in excess, plays a central role in the inflammatory responses of

Aging Gracefully with the Chronic Disease – Rheumatoid Arthritis  -  May 15, 2007
SeniorJournal.com,Methotrexate and tumor necrosis factor (TNF) blockers are examples of DMARD that have been found to be helpful for many RA patients.

Celgene Drug Hits Goal in Psoriasis Trial  -  May 22, 2007
Reuters.uk,Celgene's product is designed to block a substance called tumor necrosis factor, or TNF, whose production by the body is linked to various inflammatory

Researchers Identify New Therapy for Patients with Crohn's Disease  -  May 3, 2007
DG NewsOne common therapy is a series of intravenous infusions of infliximab, which blocks tumor necrosis factor, an important cause of inflammation in Crohn's

Crippling at any age  -  Apr 26, 2007
SalemNews.com,Every two weeks, Abbie has to go to Children's Hospital for an infusion of Remicade, one of a new class of drugs known as tumor necrosis factor blockers.

Surgery for Congenital Heart Disease  -  May 2, 2007
The Journal of Thoracic and Cardiovascular Surgery...if a child produces a lot of tumor necrosis factor-, there may be a monoclonal antibody against tumor necrosis factor- that will be important for him.

New research from Cedars-Sinai Medical Center, Los Angeles, US ...  -  May 4, 2007
Therapeutics Daily (subscription) (press release),..."These mediators, including tumor necrosis factor, interleukins, and matrix metalloproteinases and transforming growth factor-beta are also prominent in

Treatment of Polymyalgia Rheumatica and Giant Cell Arteritis: Are ...  -  Apr 30, 2007
Annals of Internal MedicineThe evidence that tumor necrosis factor (TNF) plays a pathogenetic role is limited (12). The evidence is stronger for the involvement of other cytokines,

Infliximab May Not Benefit Patients With COPD  -  May 1, 2007
Medscape (subscription)..."Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-α is overexpressed

Researchers Identify New Therapy for Patients with Crohn’s Disease  -  May 1, 2007
Newswise (press release)One common therapy is a series of intravenous infusions of infliximab, which blocks tumor necrosis factor, an important cause of inflammation in Crohn’s

Infliximab Fails Test in Two Rheumatologic Diseases  -  Apr 30, 2007
MedPage Today,Explain that these studies tested infliximab (Remicade) a monoclonal antibody against tumor necrosis factor-alpha, and found it had no benefit and might

Scientists reveal how red wine kills cancer cells  -  May 10, 2007
Hindustan Times,Mayo and his team demonstrated that cancer cells treated with resveratrol died because they became sensitive to a compound called Tumor Necrosis Factor

Abbott's HUMIRA® (adalimumab) Receives Positive Opinion From ...  -  Apr 30, 2007
Medical News Today (press release),It works by blocking tumor necrosis factor alpha (TNF-α), a protein that when produced in excess, plays a central role in the inflammatory responses of many

Abbott's Humira (Adalimumab) Receives Positive Opinion from ...  -  Apr 27, 2007
PharmaLive.com (press release),It works by blocking tumor necrosis factor alpha (TNF-.), a protein that when produced in excess, plays a central role in the inflammatory responses of many

Data Show ENBREL Significantly Improved Nail Psoriasis in Patients ...  -  May 18, 2007
campus med,ENBREL acts by binding tumor necrosis factor (TNF), one of the dominant inflammatory cytokines or regulatory proteins that play an important role in both

Targeted Immune Modulators Advancing Autoimmune Disease Therapy  -  May 3, 2007
Business Wire (press release),While several of the current generation drugs achieve their primary effect through a similar mechanism - preventing tumor necrosis factor alpha (TNF-α),

Breastfeeding prevents type 2 diabetes mellitus: but, how and why?  -  May 8, 2007
Am J Clin Nutr (subscription),Human milk contains tumor necrosis factor (TNF-), interleukin (IL)-1, IL-6, transforming growth factor ß1 and ß2 (TGF-ß1 and TGF-ß2),

Don't tell these 4 that arthritis is an 'old folks' disease  -  May 6, 2007
Annapolis Capital,Other promising drugs are tumor necrosis factor inhibitors. They block the TNF hormone that is a conductor of inflammation throughout the body,

Full Text  -  May 3, 2007
Science Magazine (subscription)In contrast, no impairment in NF-B activation was detected after stimulation with tumor necrosis factor– (TNF-), which activates NF-B independently of the

Rituxan Phase II Data in Patients with Relapsing-Remitting ...  -  May 2, 2007
PipelineReview.com (press release),...with moderately-to-severely active rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor antagonist therapies.

Assessing Osteolysis with Use of High-Throughput Protein Chips  -  May 1, 2007
Journal of Bone and Joint Surgery (subscription)...primarily tumor necrosis factor- (TNF-), interleukin (IL)-1, and IL-6, with use of enzyme-linked immunosorbent assay and immunohistochemistry techniques

Abbott's HUMIRA(R) (Adalimumab) Receives Positive Opinion from ...  -  Apr 27, 2007
Earthtimes.org...in Crohn's disease) was a study of 299 patients with moderate to severe Crohn's disease who were new to anti-TNF (tumor necrosis factor) therapy.

Crippling at any age  -  26 Apr 2007
SalemNews.com,Every two weeks, Abbie has to go to Children's Hospital for an infusion of Remicade, one of a new class of drugs known as tumor necrosis factor blockers.

Pioneering research on sleeping sickness wins MERIAL Award for ...  -  26 Apr 2007
EurekAlert (press release),Since 1992, this Flemish researcher has been focusing his attention on the role that TNF (Tumor Necrosis Factor) plays in sleeping sickness.

Bristol-Myers Squibb Company Reports First Quarter 2007 Financial ...  -  26 Apr 2007
PR Newswire (press release),RA who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs, such as methotrexate or tumor necrosis factor antagonists.

Inflammation, Asthma, and Tumor Necrosis Factor-alpha  -  Apr 24, 2007
Medscape (subscription)Among the candidates identified as perhaps playing a role in refractory asthma is tumor necrosis factor-alpha (TNF-alpha), a pleiotropic inflammatory

Effects of Antioxidant Vitamins  -  Apr 24, 2007
Am J Pathology (subscription)Downstream consequences included increased tissue concentrations and secretion of tumor necrosis factor- and interleukin-1ß, increased expression of

The Host Inflammatory Response Promotes Liver Metastasis by ...  -  Apr 24, 2007
Am J Pathology (subscription)Kupffer cell-mediated release of tumor necrosis factor- and the up-regulation of vascular endothelial cell adhesion receptors, such as E-selectin.

Full Text  -  Apr 12, 2007
Science Magazine (subscription)Several studies have implicated the tumor necrosis factor superfamily of proinflammatory cytokines in lipid metabolism. Tumor necrosis factor was discovered

An Update on Transcription Factors in Asthma  -  Apr 23, 2007
Medscape (subscription)...induces activation of nuclear factor-kappaB (NF-kappaB) and Jun amino-terminal kinase signaling pathways in a tumor necrosis factor receptor-associated

FDA Approves Labeling Update for Orencia (abatacept) to Inhibit ...  -  Apr 25, 2007
PharmaLive.com (press release),...response to one or more disease-modifying, anti-rheumatic drugs (DMARDs), such as methotrexate (MTX) or tumor necrosis factor (TNF) antagonists.

Full Text  -  Apr 12, 2007
Science Magazine (subscription)We identified lymphotoxin (LT) and LIGHT, tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators

Imbalance of fatty acids linked to depression  -  Apr 18, 2007
Food Consumer,The inflammation-promoting compounds including tumor necrosis factor alpha and interleukin-6 have been associated with heart disease, type 2 diabetes,

Fatty acid tied to depression  -  Apr 17, 2007
ReutersThese compounds, which include tumor necrosis factor alpha and interleukin-6, are "all-purpose 'nasties' for aging," and have been tied to heart disease,

GenVec Announces New Research at AACR on Selectivity and Mechanism ...  -  Apr 17, 2007
PharmaLive.com (press release),GenVec researchers presented a poster entitled, "Selective delivery of tumor necrosis factor to disseminated tumors in the peritoneal cavity using targeted

A Newly Identified Immunosuppressive Protein in Rheumatoid Arthritis  -  Apr 7, 2007
MedIndia,Decoy receptor 3 (DcR3) is a newly identified member of the tumor necrosis factor receptor (TNFR) superfamily. A soluble protein, it is overexpressed in

Professor Marc Feldmann wins top lifetime achievement award  -  Apr 24, 2007
News-Medical.net,In 1991, Professor Feldmann and his colleagues found that all the different cytokines could be stopped by blocking one kind, Tumor Necrosis Factor (TNF)a.

Fatty acid tied to depression and inflammation  -  Apr 17, 2007
Scientific AmericanDepressed patients also had higher levels of tumor necrosis factor alpha, interleukin-6, and other inflammatory compounds. And as levels of depressive

In vitro Evaluation of Corrosion and Cytotoxicity of Orthodontic ...  -  Apr 23, 2007
Journal of Dental Research (subscription),NiSO 4 , nickel sulfate; SEM, standard error of the mean; WHO, World Health Organization; and TNF, tumor necrosis factor.

Immune system involved in lipid homeostasis  -  Apr 13, 2007
TheHeart.Org,T cells and liver cells that appears to regulate lipoprotein homeostasis, a process mediated by ligands in the tumor necrosis factor superfamily.

First approved prefilled autoinjector for rheumatoid arthritis and ...  -  Apr 4, 2007
CNW Telbec (Communiqués de presse),Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Rngl J Mrf 1997, 337:141-147.

CytImmune To Present At ASCO Phase I Clinical Trial of CYT-6091 to ...  -  Apr 4, 2007
PharmaLive.com (press release),CYT-6091 (Aurimune), CytImmune's lead drug compound, is recombinant human tumor necrosis factor alpha (TNF) bound to the surface of 27 nanometer pegylated

Carrington And Veterinary Products Laboratories Sign Three-Year ...  -  Apr 15, 2007
24-7PressRelease.com (press release)Acemannan stimulates macrophage to release Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1) and Interleukin-6 (IL-6), triggers an increase in natural

Callisto's Guanilib moves into clincial testing  -  Apr 5, 2007
Therapeutics Daily (subscription) (press release),...and confirm earlier evidence of down-regulation of interleukin-17, IL-23 and tumor necrosis factor, key cytokines that are known to be involved in

J&J, NYU charge Abbott with infringement  -  Apr 18, 2007
Chicago Sun-Times,The suit claims Abbott infringes on a 2006 patent received by Centocor and NYU covering antibodies and antibody fragments that bind Tumor Necrosis Factor,

Callisto Pharma Reveals Positive Data In Animal Models Of ...  -  Apr 5, 2007
Trading Markets,...significantly reduces gastrointestinal inflammation, and confirms earlier evidence of down-regulation of interleukin-17, IL-23, and tumor necrosis factor.

Abbott Files for Approval of Humira for Psoriasis  -  Apr 2, 2007
Reuters.uk,Humira is a fully human monoclonal antibody that works by blocking a protein known as tumor necrosis factor alpha, which plays a central role in the body's

J&J Net Income Falls 22 Percent After Acquisitions (Update5)  -  Apr 17, 2007
Bloomberg...and the university say Humira infringes on their patent covering antibodies against tumor necrosis factor, or TNF, which is linked to inflammation.

New Biomarker, Therapeutic Target for Melanoma ''Truly Exciting''  -  Apr 5, 2007
Cancerpage.com,NEW YORK APR 05, 2007 (Reuters Health) - A member of the tumor necrosis factor receptor superfamily, TROY, may represent both a biomarker and a therapeutic

Dietary Factors in the Modulation of Inflammatory Bowel Disease  -  Mar 28, 2007
Medscape (subscription)Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid induced colitic rats. J Nutr.

Carrington Provides Update On Its EquineVet™ Acemannan Advanced ...  -  Apr 17, 2007
PR Leap (press release),Acemannan acts on cells in the immune system that release Tumor Necrosis Factor (TNF), Interleukin-1 (IL-1), Interleukin-6 (IL-6), triggers an increase in

Abbott Opens New Biotechnology Manufacturing Facility In Puerto  -  Apr 16, 2007
Pharmaceutical Online (press release),It works by blocking tumor necrosis factor alpha (TNF-a), a protein that when produced in excess, plays a central role in the inflammatory responses of many

The Moose in the Room  -  Apr 16, 2007
Scientist,Centocor did $3.5 billion in sales last year, mostly on the success of its chief product, Remicade (infliximab), a tumor necrosis factor (TNF) inhibitor

ARIAD Files Patent Infringement Claim Against Amgen and Wyeth  -  Apr 15, 2007
ag-IP-news Agency,Enbrel is a tumor necrosis factor (TNF) blocker. Kineret is an interleukin-1 (IL-1) receptor antagonist. TNF and IL-1 are cytokines produced by the immune

Callisto Intends To Move Guanilib Into Clinical Trials In ...  -  Apr 7, 2007
Medical News Today (press release),...and confirm earlier evidence of down-regulation of interleukin-17 (IL-17), IL-23, and tumor necrosis factor (TNF), key cytokines that are known to be

Protein Kinase C (PKC) Regulates Ocular Inflammation and Apoptosis ...  -  Mar 27, 2007
Am J Pathology (subscription)At 6 hours, lipopolysaccharide-stimulated macrophages produced tumor necrosis factor- (TNF-) with nuclear factor B (NF-B )/p65 expression.

Billion dollar babies—biotech drugs as blockbusters  -  Apr 3, 2007
Nature.com (subscription),In the past few years, treatments for autoimmune disorders that target tumor necrosis factor (TNF-) have emerged as a major category for biotech companies.

The alcoholic lung: epidemiology, pathophysiology, and potential ...  -  Apr 11, 2007
AJP-Lung Physiology (subscription)Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-- and angiotensin II-induced

Genentech Announces First Quarter 2007 Results  -  Apr 12, 2007
PharmaLive.com (press release),...active rheumatoid arthritis who have had an inadequate response to previous treatment with one or more tumor necrosis factor (TNF) antagonist therapies.

Genentech Q1 Profit, Revenue Top Consensus; Sees FY07 EPS Growth ...  -  Apr 11, 2007
Trading Markets,...active rheumatoid arthritis who have had an inadequate response to previous treatment with one or more tumor necrosis factor antagonist therapies.

Abbott Laboratories opens new $450 million Puerto Rico plant  -  Apr 11, 2007
Worcester Telegram,Humira is a treatment for immune system disorders that acts by thwarting tumor necrosis factor, a warrior in the immune system that sometimes goes awry and

Protein May Be Key to Rheumatoid Arthritis  -  Mar 28, 2007
Atlanta Journal Constitution (subscription),DcR3 is a member of the large tumor necrosis factor receptor (TNFR) "super family," which has been identified in the last decade as important in the

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