Recent news on Valproate

Epilepsy a Disease Like Any Other  -  25 May 2007
AllAfrica.com,Antiepileptic drugs like phenytoin, carbamazepine, sodium valproate, gabba pentin etc have to be taken for long, mostly for life in maintenance doses.

General Practitioners and Women Still Not Getting Valproate Message  -  May 11, 2007
Medscape (subscription)May 11, 2007 — In utero exposure to the anticonvulsant drug valproate increases the risk for poor cognitive outcomes and anatomical malformations compared

Epilepsy Drug Valproate Used During Pregnancy Linked To Lower IQ ...  -  May 8, 2007
Science Daily (press release)Science Daily — Children of women who took the epilepsy drug valproate during pregnancy appear to be at a greater risk for lower IQ, according to recent

AAN: In Utero Exposure to Valproate Lowers IQ  -  May 3, 2007
MedPage Today,BOSTON, May 3 -- Children whose mothers took valproate (Depakene) during pregnancy for control of epilepsy are at risk for significantly lower IQs than

Study: Valproate linked to kids' low IQ  -  May 3, 2007
United Press InternationalBOSTON, May 3 (UPI) -- The commonly prescribed anti-epileptic drug valproate should be avoided in pregnancy due to an apparent effect on a child's IQ,

ASK THE DOC  -  May 22, 2007
Glasgow Daily Record,His GP has tried lithium and valproate semi-sodium but he still has highs and lows and we are all suffering. A Manic depression (or bipolar disorder) is

Mum's epilepsy med linked to low IQ in kids  -  May 11, 2007
National Review of Medicine,The children of women who used the epilepsy drug valproate while pregnant are at greater risk for having low IQ. That's the finding of research presented at

New Medication Strategies for Comorbid Substance Use and Bipolar ...  -  May 18, 2007
Focus (subscription)A medication approaching this ideal is the GABA enhancer valproate. Adding atypical antipsychotic agents might not improve valproate's efficacy,

IQ results for children of mothers who took the epilepsy drugs ...  -  May 6, 2007
News-Medical.net,Children of women who took the epilepsy drug valproate during pregnancy appear to be at a greater risk for lower IQ, according to research presented at the

Lower IQ Found In Children Of Women Who Took Epilepsy Drug  -  May 5, 2007
eMaxHealth.com,Children of women who took the epilepsy drug valproate during pregnancy appear to be at a greater risk for lower IQ. The study looked at IQ results for 187

Epilepsy drug may lower children's IQ, study shows  -  May 4, 2007
Guardian Unlimited,Taking the drug valproate - which is already at the centre of a British court action after claims that it has damaged children - seems to double the chance

Epilepsy Drug Linked to Low IQ  -  May 3, 2007
WebMDMay 3, 2007 (Boston) -- Women of childbearing age should avoid taking the commonly prescribed epilepsy drug valproate because of a negative effect on their

Study finds more risks to unborn in epilepsy drug Depakote  -  May 4, 2007
Los Angeles Times,One in four women who took the widely used epilepsy drug valproate while pregnant gave birth to children who were mentally retarded, double the rate among

Popular epilepsy drug damages the unborn  -  May 7, 2007
News-Medical.net,The drug valproate, sold under the name Epilim in the UK, is made by drug company Sanofi-Synthelabo; it is currently at the centre of a British court case

Lower IQ for Children of Women who Took Epilepsy Drug  -  May 6, 2007
drkoop.com...(Ivanhoe Newswire) -- Women who took the epilepsy drug valproate while they were pregnant may have children with a lower IQ.

Children getting manic depression  -  May 16, 2007
Life Style Extra,Valproate can trigger excessive hair growth and, in adolescent girls, polycystic ovary syndrome, a leading cause of infertility.

Epilepsy Drug In Pregnancy Linked To Lower IQ And Mental Retardation  -  May 4, 2007
AHNBoston, MA (AHN) - A study has found that expectant mothers who took an epilepsy drug valproate during their pregnancy are at greater risk of bearing

Anti-Epileptic Drug Intake May Result In Children With Mental ...  -  May 5, 2007
MedIndia,In question is the drug valproate (already at the center of a British court action after claims that it has damaged children). Valproate seems to double the

Women Taking Antiepileptics Give Birth to Babies at Risk ...  -  May 4, 2007
DG NewsResults demonstrated that high rates of low birth weight (LBW) were found in newborns that were exposed to valproate, carbamazepine, phenytoin or

Epilepsy Drug Lowers Children's IQ  -  May 4, 2007
Dog Flu Diet and Diseases,Valproate is the name of the drug and according to researchers, 2-year-olds scored 12 points lower on intelligence quotients when their mothers took the

Dangerous tablets go missing  -  May 16, 2007
Cambridge Evening News,Police were called after a woman lost a box of 100 sodium valproate pills in Huntingdon. If taken in a large dosage, they can cause liver damage,

USPSYCH: New Definitions on Tap for Mixed Manias  -  Apr 26, 2007
Psychiatric Times,For bipolar disorder type I patients who are in a mixed manic or hypomanic state, she recommended valproate, aripiprazole (Abilify), risperidone (Risperdal)

Ask the Expert: Treatment Strategy for Co-occurring Bipolar ...  -  May 18, 2007
Focus (subscription)Emerging data suggest that valproate and carbamazepine, in addition to being appropriate mood stabilizers in bipolar disorder, are efficacious in treating

Birth defects linked to epilepsy drug  -  May 4, 2007
Bryan College Station Eagle,One in four women who took the epilepsy drug valproate while pregnant gave birth to children who were mentally retarded, double the rate among women who

Study links epilepsy drug to birth defects  -  May 3, 2007
St. Petersburg Times,HEALTH - One in four women who took the widely used epilepsy drug valproate while pregnant gave birth to children who were mentally retarded,

Epilepsy Drug Damages Unborn Babies  -  May 7, 2007
E Canada Now,The drug coming under fire here is known as Epilim or valproate and is made by the drug company Sanofi-Synthelabo. The drug is currently under fire in a

Effectiveness and Weight Effects of Open-Label Lamotrigine  -  May 23, 2007
Medscape (subscription)Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology. 2001;56:172-177. Abstract. Devinsky O, Vuong A,

Bipolar children - is the US overdiagnosing?  -  May 16, 2007
New Scientist (subscription),She was also taking the anti-convulsant Depakote (valproate) and the anti-psychotic Seroquel (quetiapine fumarate) to stabilise her mood.

New Data Shows Once a Day Lamictal XR is Effective in Treating ...  -  May 2, 2007
PharmaLive.com (press release),...for conversion to monotherapy in adults with partial seizures taking carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED.

Bipolar Spectrum Disorder May Be Underrecognized And Improperly ...  -  May 10, 2007
Medical News Today (press release),...eg, they were taking an antidepressant or other psychotropic medication in the absence of a mood stabilizing medication such as lithium, valproate,

Bipolar Spectrum Disorder Under-Recognized  -  May 9, 2007
Atlanta Journal Constitution (subscription),...or other psychotropic medication in the absence of a mood-stabilizing medication such as lithium, valproate, or carbamazepine, the study authors said.

Bipolar Spectrum Disorder Under-Recognized  -  May 9, 2007
HealthCentral.com,...or other psychotropic medication in the absence of a mood-stabilizing medication such as lithium, valproate, or carbamazepine, the study authors said.

Bipolar disorder  -  May 8, 2007
The Spokesman Review,Commonly prescribed medications include lithium, valproate and carbamazepine. Bipolar depression sometimes calls for the use of antidepressants (clozapine,

USPSYCH: New Definitions on Tap for Mixed Manias  -  26 Apr 2007
Psychiatric Times,For bipolar disorder type I patients who are in a mixed manic or hypomanic state, she recommended valproate, aripiprazole (Abilify), risperidone (Risperdal)

Research Finds Newer Drug For Partial Epilepsy Is Superior,But Old ...  -  Mar 29, 2007
Medical News Today (press release),A ground breaking clinical trial involving more than 2000 patients has compared newer drugs for epilepsy with carbamazepine and valproate, which have been

Talk therapy found best for bipolar patients  -  Apr 5, 2007
Portsmouth Herald News,...medications in patients with bipolar disorder. Antidepressants are used in some patients, along with mood stabilizers such as lithium or valproate.

Antidepressants not always best in bipolar  -  Mar 29, 2007
Earthtimes.orgIt is often treated with mood stabilizers such as lithium, valproate and carbamazepine, which reduce mania. Those with bipolar disorder may also be

Adjunctive Antidepressant Treatment for Bipolar Depression  -  Mar 28, 2007
New England Journal of Medicine (subscription),However, the study did not address the effectiveness of standard antidepressants used in conjunction with lithium or valproate; thus, its results may not be

Depression: What you need to know  -  Apr 7, 2007
Food Consumer,Both of these medications have gained wide acceptance in clinical practice, and valproate has been approved by the Food and Drug Administration for

Posttraumatic Parieto-Occipital Epilepsy  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)She was medicated with a regimen of sodium valproate, 1600 mg daily, and reevaluated after 6 months, but when drawing a three-dimensional figure she

April 2007 Big Pharma Litigation Update - Drugs Part II  -  Apr 12, 2007
Lawyers and Settlements,Washington, DC: The anti-epileptic drug, Depakote (valproate), marketed by Abbott Laboratories, is one of the most heavily prescribed medications for

Creating a Mouse Model of Bipolar Disorder  -  Apr 11, 2007
ScienceBlogsAdditionally, valproate (depakote) acts on on the circadian cycle by altering the expression of several circadian genes in the amygdala [Ogden et al.,

Trends in the Use of Psychotropic Drugs in Taiwan: A Population ...  -  Apr 5, 2007
Psychiatric Services (subscription)...including citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline), mood stabilizers (including lithium, carbamazepine, valproate, gabapentin,

Bipolar disorder can cause mood swings, out-of-control behavior  -  Apr 4, 2007
Casa Grande Valley Newspapers,Valproate and carbamazepine (anti-seizure medications) have also been used for some time to stabilize moods. A newer anti-seizure medication, lamotrigine,

Study Sheds Light On Medication Treatment Options For Bipolar Disorder  -  Apr 4, 2007
eMaxHealth.com,...between depression and mania, is usually treated with mood stabilizers such as lithium, valproate, carbamazepine or other medications that reduce mania.

Study backs therapy, not just pills, for bipolar illness  -  Apr 2, 2007
Pittsburgh Post Gazette,Antidepressants are used in some patients, along with mood stabilizers such as lithium or valproate. The two studies suggest researchers should investigate

Antidepros no bipolar help?  -  Mar 31, 2007
Health24.com,The standard of care for bipolar disorder is treatment with a mood stabiliser such as lithium, valproate, carbamazepine or other medications that reduce

Bipolar patients need new drugs  -  Mar 30, 2007
Baltimore Sun,Standard treatment consists of mood stabilizers such as lithium, valproate and carbamazepine. Antidepressants are often added to control severe depressive

Depression with dysphoria may need two drug types  -  Mar 29, 2007
Scientific AmericanThe subjects were treated with an SSRI plus an anticonvulsant (usually valproate) for 12 weeks. A variety of tests, including the Hamilton Depression Rating

Lithium and risk for Alzheimer's disease in elderly patients with ...  -  Mar 30, 2007
British Journal of Psychiatry (subscription),The use of antidepressants, benzodiazepines, antipsychotics, valproate, carbamazepine and other anticonvulsants did not differ with cognitive function (data

Study Sheds Light on Drug Treatment Options for Bipolar Disorder  -  Mar 29, 2007
DG NewsBipolar disorder is usually treated with mood stabilizers such as lithium, valproate, carbamazepine or other medications that reduce mania.

Antidepressants May Not Help Fight Bipolar Disorder  -  Mar 29, 2007
HealthCentral.com,The standard of care for bipolar disorder is treatment with a mood stabilizer such as lithium, valproate, carbamazepine or other medications that reduce

Study: Antidepressants Fail To Help Bipolar Depression  -  Mar 28, 2007
New York Sun,Standard treatment consists of mood stabilizers such as lithium, valproate, and carbamazepine. Antidepressants are often added to control severe depressive

Treatment of Bipolar Depression  -  Mar 28, 2007
New England Journal of Medicine (subscription),The primary goal of treatment is the prevention of these episodes with the use of mood stabilizers such as lithium, valproate, carbamazepine,

Antidepressants on top of mood stabilizers not helpful in most ...  -  Mar 28, 2007
BCM News,Mood stabilizers such as lithium, valproate, lamotrignine, carbamazepine or other medications are usually used in treatment to reduce mood swings,

Drug Choices for Different Seizures Get Clarification  -  Mar 23, 2007
MedPage Today,LIVERPOOL, England, March 23 -- Lamotrigine (Lamictal) should be the drug of choice for patients with partial-onset epileptic seizures while valproate

A Young Woman With ADHD, Bipolar Disorder, and a Heart Murmur  -  Mar 26, 2007
Medscape (subscription)Over the course of 1.5 years, she was treated with several trials of medications, including valproate sodium, buspirone, risperidone, and sertraline,

New Study Weighs Benefits of Epilepsy Drugs  -  Mar 22, 2007
Washington Post,THURSDAY, March 22 (HealthDay News) -- Valproate should be the drug of first choice for patients with generalized and unclassifiable epilepsy, new research

Research Finds Newer Drug For Partial Epilepsy Is Superior But Old ...  -  Mar 23, 2007
Medical News Today (press release),A ground breaking clinical trial involving more than 2000 patients has compared newer drugs for epilepsy with carbamazepine and valproate, which have been

Treatment-Resistant Bipolar Disorder  -  Mar 15, 2007
Focus (subscription)Established first-line treatments include lithium, valproate and second-generation antipsychotics (SGAs) in acute mania, and lithium and valproate as

Local hope for Alzheimer's patients  -  Mar 20, 2007
WOOD-TV,For the next two years, they'll test a drug called Valproate that could slow the progression of Alzheimer's. The memory program's Dr. Foley said he sees

Nigeria: Parkinson's Disease  -  Mar 26, 2007
AllAfrica.com,Drugs such as Haloperidol and Chlopromazine used to treat certain psychiatric disorders, Metoclopramide for the treatment of nausea and Valproate for the

Depakote linked to Serious Birth Defects and Death  -  Mar 8, 2007
Lawyers and Settlements,It is a compound of sodium valproate and valproic acid and is therefore sometimes referred to as valproate. It works by affecting chemicals in the body that

FDA Decision Encourages Lamictal Generics  -  Mar 8, 2007
MedIndia,...for conversion to monotherapy in adults with partial seizures who are receiving treatment with a single enzyme-inducing antiepileptic drug or valproate.

Lower Switch Rate in Depressed Patients With Bipolar II Than ...  -  Mar 15, 2007
Focus (subscription)Significantly more patients with bipolar I disorder than those with bipolar II disorder were taking valproate or atypical antipsychotics. Table 1.

Guideline Watch (November 2005): Practice Guideline for the ...  -  Mar 15, 2007
Focus (subscription)...was superior to divalproex or lithium alone in patients who had had an inadequate response to at least 2 weeks of lithium or valproate monotherapy (14).

Best First-Choice Drugs for Epilepsy ID'd  -  Mar 22, 2007
WebMD..."Valproate [the British term for valproic acid] is a much better drug at controlling generalized seizure than the others," Marson says.

Bibliography BIPOLAR DISORDER  -  Mar 15, 2007
Focus (subscription)...olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.

Another Walter Reed Scandal Cannabis for the Wounded  -  Mar 12, 2007
CounterPunch,Valproate may cause gastrointestinal problems, sedation, tremor and thrombocytopenia (low platelet levels in blood). It is teratogenic (induces mutations,

Serotonin Poisoning Is Easily Overlooked  -  Mar 6, 2007
The Ledger,...narcotic painkillers like fentanyl and tramadol; over-the-counter cough and cold remedies containing dextromethorphan; the anticonvulsant valproate;

Quality of Life in Bipolar Disorder: A Review of the Literature  -  Mar 15, 2007
Focus (subscription)A further study examined the effects of adding olanzapine to lithium or valproate in patients with BD (N=224) (69). Olanzapine cotherapy was associated with

Clozapine-Induced Cataplexy  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)She was on a regimen of sodium valproate, 1000mg/day, when clozapine was initiated and gradually hiked to 150mg/day. Though her symptoms decreased

Agitation in the Elderly  -  Feb 16, 2007
Psychiatric Times,Valproate may be as effective and a safer treatment for the behavioral complications of dementia, particularly of the Alzheimer's type.

Advances in the Treatment of Epilepsy and Other Important Research ...  -  Feb 2, 2007
Medscape (subscription)One patient with absence epilepsy had a seizure recurrence after 10 years of seizure freedom following a switch from one brand of generic valproate to

Defining the Boundaries of Childhood Bipolar Disorder  -  Jan 31, 2007
Am J Psychiatry (subscription)Scheffner D, Konig S, Rauterberg-Ruland I, Kochen W, Hofmann WJ, Unkelbach S: Fatal liver failure in 16 children with valproate therapy.

Affective Disorder and Personality Change in a Patient With ...  -  Jan 5, 2007
Psychosomatics (subscription)Lithium was discontinued; the edema resolved, and he was started on sodium valproate. As the valproate dose was titrated upward, his mood symptoms gradually

Advances in Treatment of Bipolar Disorder: Review of Psychiatry ...  -  Jan 3, 2007
Am J Psychiatry (subscription)Since 1994 with the approval of valproate for the treatment of acute mania, we have seen a rapid increase in assessments of multiple new medications and

INVEGA(TM) Approved By FDA As New Treatment For Schizophrenia  -  Dec 22, 2006
Medical News Today (press release),...in the treatment of bipolar mania either alone or in combination with a mood stabilizer (lithium or valproate) were: sleepiness, muscle stiffness,

Decoding Alzheimer's  -  Jan 3, 2007
BusinessWeekHis clinic is also running trials on Flurizan, antibodies from Wyeth/Elan and Eli Lilly, and the generic anti-seizure medicine Valproate.

INVEGA(TM) Approved By FDA As New Treatment For Schizophrenia  -  Dec 22, 2006
Medical News Today (press release),...in the treatment of bipolar mania either alone or in combination with a mood stabilizer (lithium or valproate) were: sleepiness, muscle stiffness,

No Weight Gain Seen in Patients on Investigative Antiepileptic ...  -  Dec 6, 2006
DG NewsSeveral antiepileptic drugs are known to be associated with weight gain, including valproate, carbamazepine, gabapentin, vigabatrin and pregabalin.

Coroner's findings into stabbing deaths  -  Dec 12, 2006
Advertiser Adelaide,He was non-compliant with his prescribed oral Sodium Valproate, hiding the tablets in his pocket. He also declined to take his nightly Haloperidol.

Influence of sub-syndromal symptoms after remission from manic or ...  -  Nov 30, 2006
British Journal of Psychiatry (subscription),Yatham, LN, Binder, C., Kusumakar,V., et al (2004) Risperidone plus lithium versus risperidone plus valproate in acute and continuation treatment of mania.

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)Therapeutic effect of valproate in mania. Am J Psychiatry 1981;138:256.[Medline]. Chouinard G. A double-blind controlled clinical trial of fluoxetine and

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