Recent news on Valproic Acid

Recall Of Two Valproic Acid Drugs, Depakene 500 Mg And Ratio ...  -  May 15, 2007
Medical News Today (press release),These products are being recalled and patients using Depakene 500 mg and ratio-VALPROIC ECC 500 mg (valproic acid) are advised to contact their physician or

Therapies for Myelodysplastic Syndrome Only Improve Survival in ...  -  May 23, 2007
DG NewsValproic acid treatment (n=76) was also associated with a longer survival time (48 vs. 29 months, P =.0325) in the overall group, but was particularly

Stop & Shop restricts sale of medicine  -  May 17, 2007
Providence Journal (subscription),The coroner’s report also found valproic acid, also known as Depakote; dextromethorphan, a cough suppressant in over-the-counter medicines;

AAN: In Utero Exposure to Valproate Lowers IQ  -  May 3, 2007
MedPage Today,The new findings emerged from on the same cohort of children, and suggest that valproate, or valproic acid, should be used only in women for whom no other

New Medication Strategies for Comorbid Substance Use and Bipolar ...  -  May 18, 2007
Focus (subscription)Elevated liver enzymes secondary to viral or alcoholic hepatitis can require dose reductions of valproic acid or carbamazepine.

Zidovudine Syrup (Zidovudine capsule) Information  -  May 18, 2007
American Chronicle,Aspirin, atovaquone, fluconazole, indomethacin, methadone, probenecid, trimethoprim, valproic acid: May increase serum concentration and potential toxicity

Neurodevelopment & the Environment: Are Vaccines to Blame for ...  -  Apr 28, 2007
American Chronicle,Another study found a few specific environmental factors including prenatal exposure to thalidomide, valproic acid, and rubella though they are likely to

Psychiatric Sequelae of Traumatic Brain Injury: A Case Report  -  May 2, 2007
Am J Psychiatry (subscription)Other treatment options for aggression include methylphenidate, cranial electrical stimulation, SSRIs, valproic acid, lithium, tricyclic antidepressants,

Is There a Role for Valproic Acid in the Treatment of Catatonia?  -  Apr 12, 2007
Journal of Neuropsychiatry (subscription)She was transferred to our institution for further evaluation and after several weeks with no improvement was placed on a regimen of valproic acid, 1000 mg,

Benham column: Some people a natural for good funerals  -  Apr 23, 2007
Bakersfield Californian (subscription),..."I am doing well with the drug (Valproic Acid). At this present time there are no other options for me, as I am excluded from all of the other trials due to

TopoTarget announces next Phase II clinical placebo controlled ...  -  Apr 24, 2007
PipelineReview.com (press release),TopoTarget A/S (CSE: TOPO) announced today that a Phase II clinical trial has been initiated, testing Avugane(TM), a topical valproic acid – an HDAC

TopoTarget Announces Next Phase II Clinical Placebo Controlled ...  -  Apr 24, 2007
PharmaLive.com (press release),...a Phase II clinical trial has been initiated, testing Avugane, a topical valproic acid - an HDAC inhibitor drug - in the treatment of acne vulgaris.

Psychosis Following Initiation of Zonisamide  -  Apr 2, 2007
Am J Psychiatry (subscription)Upon psychiatric admission, valproic acid was started for seizure control; primidone and vagal nerve stimulation continued. Ms. A received olanzapine,

Best First-Choice Drugs for Epilepsy ID'd  -  Mar 22, 2007
WebMDMarch 22, 2007 – Lamictal is the best first-choice drug for partial epilepsy, while valproic acid is the best first choice for generalized epilepsy,

COLORADO STATE’S ANIMAL CANCER CENTER INVESTIGATES PROMISING DRUG ...  -  Mar 7, 2007
Colorado State University (press release),An enzyme called histone deacetylase, which may reduce the sensitivity of cancer cells to chemotherapy, can be inhibited with valproic acid.

Rebecka Peebles  -  Mar 16, 2007
Stanford University School of Medicine,Tan V, Sahami AR, Peebles R, Shaw RJ "Abdominal migraine and treatment with intravenous valproic Acid." Psychosomatics 2006 Jul-Aug; 47: 4: 353-5 More

News and treatments briefs  -  Mar 21, 2007
NAPWA,A 2005 study had suggested that the anti-epilepsy drug valproic acid could stimulate HIV to leave viral reservoirs where it was out of the reach of

Developmental Neurobiology of Bipolar Disorder and Substance Use ...  -  Mar 21, 2007
Psychiatric Times,Those who were treated with lithium and psychosocial therapy in this study (compared with those treated with lithium, valproic acid, or psychosocial

Performance on a Virtual Reality Spatial Memory Navigation Task in ...  -  Feb 28, 2007
Am J Psychiatry (subscription)Those with bipolar depression had had therapeutic levels of lithium or valproic acid for at least 4 weeks at the time of testing.

Depakote linked to Serious Birth Defects and Death  -  Mar 8, 2007
Lawyers and Settlements,It is a compound of sodium valproate and valproic acid and is therefore sometimes referred to as valproate. It works by affecting chemicals in the body that

CSU Scientists Seek Dogs For Cancer Drug Test  -  Mar 7, 2007
cbs4denver.com,Dr. Douglas Thamm says a seizure medicine called valproic acid or depakote can help chemo drugs get deeper into cancer cells. The hope is to combine the

Schizophrenia and Co-Occurring Substance Use Disorder  -  Feb 28, 2007
Am J Psychiatry (subscription)Although a few studies have suggested that valproic acid may reduce alcohol use in patients with bipolar disorder, this agent has not been studied in

Treatment-Resistant Bipolar Disorder  -  Mar 15, 2007
Focus (subscription)Valproate (either divalproex sodium or generic valproic acid) is not FDA indicated for maintenance treatment in bipolar disorder, due to its lack of

Quality of Life in Bipolar Disorder: A Review of the Literature  -  Mar 15, 2007
Focus (subscription)Shi L, Tohen M, Breier A: Quality of life assessment in patients with bipolar disorder treated with olanzapine added to lithium or valproic acid.

Study debunks valproic acid as HIV cure  -  Feb 21, 2007
PlanetOut,Valproic acid is an anti-epilepsy drug that was recently found to also act against an enzyme that keeps HIV in a dormant mode inside cells.

Weymouth Couple Charged With Murder of Their Daughter  -  Feb 5, 2007
My Fox Boston,After an ongoing investigation, authorities determined that at the time of her death, Rebecca was being prescribed Clonidine for ADHD, and Valproic acid

Couple Charged In Daughter's Death  -  Feb 5, 2007
Boston Channel.com,...several medications at the time of her death -- Clonidine for attention deficit hyperactivity disorder, Valproic acid and Seroquel for bipolar disorder.

Characteristics of Psychotic Patients With Foreign Accent Syndrome  -  Feb 16, 2007
Journal of Neuropsychiatry (subscription)She initially showed poor response and ultimately required treatment with a regimen of valproic acid, 1500mg, olanzapine, 20mg, and lithium carbonate,

Fetal Heart-Cell Enzyme And Onset Of Heart Failure  -  Feb 23, 2007
Medical News Today (press release),HDAC inhibitors are already in trials for cancer and one, valproic acid, has been used for years to treat seizures. Most CHF medications are aimed at

Parents charged in daughter's death  -  Feb 5, 2007
Boston Globe,The medical examiner’s office determined the cause of the girl’s death as "intoxication due to the combined effects" of the drugs Clonidine, Valproic acid

Parents Charged In Death Of Daughter, 4  -  Feb 6, 2007
Boston Channel.com,Authorities said they found amounts of several prescription drugs in the girl's body, including Clonidine, Valproic acid, Dextromethorphan, Seroquel and

A Case of Mania Following the Use of Pramipexole  -  Jan 31, 2007
Am J Psychiatry (subscription)During the early illness course, she received several serotonin reuptake inhibitors alone or in combination with lithium, valproic acid, and carbamazepine

Psychiatrist Won't Practice Medicine After Girl's Death  -  Feb 7, 2007
Boston Channel.com,Valproic acid, also known as Depakote, Dextromethorphan, a cough suppressant, and Chlorpheniramine, an antihistamine, were also found in the girl's system,

Hull parents arrested in girl's poisoning death  -  Feb 5, 2007
Boston Globe,The medical examiner's office determined the girl died from "intoxication due to the combined effects" of the drugs clonidine, valproic acid (Depakote),

Fetal Heart-Cell Enzyme and Onset of Heart Failure  -  Feb 20, 2007
Newswise (press release)HDAC inhibitors are already in trials for cancer and one, valproic acid, has been used for years to treat seizures. Most CHF medications are aimed at

Couple arraigned in poisoning death of daughter  -  Feb 6, 2007
Boston Globe,The medical examiner's office determined the child died from intoxication due to the combined effect of Clonidine, valproic acid, dextronmethorphan,

Police: Parents killed 4-year-old in murder by meds  -  Feb 6, 2007
Boston Herald,Rebecca Riley was prescribed Clonidine for attention deficit hyperactivity disorder, or ADHD, and Valproic acid (Depakote) and Seroquel for bipolar

Doctor halts practice in probe of girl's overdose death  -  Feb 7, 2007
SouthCoastToday.com,The coroner's report also found Valproic Acid, also known as Depakote; Dextromethorphan, a cough suppressant in over-the-counter medicines;

Caution needed with children on psych meds  -  Feb 7, 2007
MetroWest Daily News,Prosecutors allege the couple overmedicated her with a combination of Clonidine; valproic acid, a mood stabilizer; Seroquel, an antipsychotic;

Rebecca’s Rx  -  Feb 7, 2007
Boston Herald,Depakote: Considered a mood stabilizer, it is the brand name for valproic acid. It is used alone or with other medications to treat certain types of

Girl fed fatal overdoses, court told  -  Feb 6, 2007
Boston Globe,The medical examiner's report indicates Rebecca died of intoxication caused by a combination of valproic acid, an antiseizure drug sometimes used in

Family’s troubled past emerges: Parents plead not guilty in ...  -  Feb 6, 2007
Boston Herald,According to authorities, Rebecca died of “intoxication due to the combined effects of Clonidine, Valproic acid (Depakote) and dextromethorphan and

Parents Charged With Daughter's ADHD Drug Overdose Death  -  Feb 6, 2007
FOX NewsThe coroner's report also found Valproic Acid, also known as Depakote, Dextromethorphan, a cough suppressant in over-the-counter medicines,

Parents charged in overdose death of 4-year-old  -  Feb 5, 2007
Boston Herald,The coroner’s report also found Valproic Acid, also known as Depakote, Dextromethorphan, a cough suppressant in over-the-counter medicines,

Analysis: Newer/older epilepsy drugs equal  -  Feb 5, 2007
Science Daily (press release)...than anti-epileptic drugs, no comparative study has demonstrated improved efficacy for any of these over carbamazepine, phenytoin, or valproic acid."

Agitation in the Elderly  -  Feb 16, 2007
Psychiatric Times,Sanborn WD, Bendfeldt F, Hamdy R (1995), Valproic acid for physically aggressive behavior in geriatric patients. Am J Geriatr Psychiatry 3(3):239-242.

Newer/older epilepsy drugs equal  -  Feb 5, 2007
Monsters and Critics.com,...than anti-epileptic drugs, no comparative study has demonstrated improved efficacy for any of these over carbamazepine, phenytoin, or valproic acid.'

Utah study gives boy future hope  -  Jan 8, 2007
The Casper Star Tribune,The breakthrough paved the way for researchers to investigate drugs such as valproic acid, a federally approved drug used to treat epilepsy,

Hopes For An AIDS Cure Remain Alive  -  Jan 8, 2007
The Ledger,In the study, Margolis' team added a common epilepsy drug, valproic acid, to the patients' standard mix of antiretroviral drugs.

Utah study gives Oregon boy with a rare disease hope  -  Jan 5, 2007
OregonLive.com,..."Valproic acid," Liam answers in his tiny voice. His parents let out a halfhearted cheer. The Russells are visibly beat from their trek from Portland, Ore.,

D-Pharm announces positive Phase IIb trial results for DP-b99 in ...  -  Jan 4, 2007
PipelineReview.com (press release),D-Pharm’s pipeline includes DP-VPA, a new chemical entity that is a modified and targeted version of valproic acid for epilepsy, bipolar disorder treatment

Epigenetic Drugs: Promising For Breast Cancer Treatment  -  Dec 25, 2006
Science Daily (press release)...been routinely employed for almost 30 years to treat non-malignant conditions: the antihypertensive hydralazine and the antiepileptic valproic acid.

Affective Disorder and Personality Change in a Patient With ...  -  Jan 5, 2007
Psychosomatics (subscription)Wroblewski BA, Joseph AB, Kupfer J, et al: Effectiveness of valproic acid on destructive and aggressive behaviours in patients with acquired brain injury.

A Utah Doctor gives a boy with a rare disease and his family hope  -  Dec 24, 2006
Salt Lake Tribune,The breakthrough paved the way for researchers to investigate drugs such as valproic acid, a federally approved drug used to treat epilepsy,

Valproic acid may help slow the progression of dementia  -  Dec 18, 2006
Xagena.it,Patients were randomized to receive either 250 milligrams of Valproic acid, or placebo, twice daily. Valproic acid ( Depakene ) is commonly used to prevent

Epigenetic Drugs: Promising For Breast Cancer Treatment  -  Dec 25, 2006
Science Daily (press release)...been routinely employed for almost 30 years to treat non-malignant conditions: the antihypertensive hydralazine and the antiepileptic valproic acid.

New Data Demonstrate Clinical Activity of Vidaza(R) in Combination ...  -  Dec 11, 2006
PR Newswire (press release),Significant Clinical Activity of the Combination of Vidaza, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia (Abstract 160) Andres Soriano, MD,

... Go to the Article  -  Dec 1, 2006
CancerWiseThe MD Anderson study involves the drug decitabine (Dacogen®), which has been shown to be effective in the treatment of MDS, and valproic acid (Depakene®),

Epigenetic drugs, promising for breast cancer treatment  -  Dec 21, 2006
innovations report,...been routinely employed for almost 30 years to treat non-malignant conditions: the antihypertensive hydralazine and the antiepileptic valproic acid.

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
Earthtimes.orgSignificant Clinical Activity of the Combination of Azacitidine, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia: Results of a Phase I/II study

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
PR Newswire (press release),...will be presented in oral sessions: * Significant Clinical Activity of the Combination of Azacitidine, Valproic Acid and All-Trans Retinoic Acid (ATRA)

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)This was when other anticonvulsants, such as carbamazepine (8, 9) and valproic acid (10), were starting to be studied in bipolar disorder.

New Data Demonstrate Clinical Activity of Vidaza in Combination ...  -  Dec 12, 2006
PharmaLive.com (press release),...delivered an oral presentation describing the interim results of a Phase 1/2 study evaluating Vidaza, a demethylating agent, and valproic acid,

Coroner's findings into stabbing deaths  -  Dec 12, 2006
Advertiser Adelaide,The results revealed a trace of Diazepam and Nordiazepam but no alcohol, cannabinoids, opiates, amphetamines, valproic acid, Olanzapine,

Radioimmunotherapy clears HIV-infected cells in mice  Nov 8, 2006
They also remark that the approach may be able to clear quiescent HIV-infected cells that have already been stimulated by valproic acid, an agent which has ... -Aidsmap, An Interaction Between Aspirin and Valproate: The Relevance of ...  Oct 30, 2006
Orr JM, Abbott FS, Farrell K, Ferguson S, Sheppard I, Godolphin W: Interaction between valproic acid and aspirin in epileptic children: serum protein binding ... -Am J Psychiatry (subscription) NARSAD Hosts 18th Annual New York Mental Health Symposium, Oct. ...  Oct 26, 2006
Dr. Bonaccorso will present her lab's finding that the mood stabilizer valproic acid and similar drugs can increase brain dopamine release and enhance the ... -PR Newswire (press release), Foro de Shell Security - Seguridad informática  Oct 27, 2006
...assays sugge valerian t profound functional loss of the hematopoieti valium progenitors, so much so that they are unresponsive even valproic acid to high ... -Shell Security, 300 Million Americans = 7.5 Million Carriers of Spinal Muscular ...  Oct 17, 2006
Currently the network is performing a phase II clinical trial to further evaluate a combined regimen of valproic acid and carnitine in children with SMA. ... -Earthtimes.org Cure For Autism Nowhere In Sight  Oct 23, 2006
...life," Diane Lento said. Medications like Prozac and Valproic acid can help treat repetitive behaviors and mood swings. In some kids ... -CBS 13, Scientists battle HIV dementia  Oct 16, 2006
Topping the candidates are the epilepsy drug valproic acid and lithium, a drug long used in manic-depression. Both inhibit an enzyme called GSK-3b. ... -Indianapolis Star, Valproic acid, a histone deacetylase inhibitor, enhances ...  Sep 12, 2006
On two anaplastic thyroid carcinoma cell lines (CAL-62 and ARO), we here show that valproic acid (VPA), a clinical available histone deacetylase inhibitor ... -Journal of Endocrinology

Unlocking The Mysteries Of Autism  Sep 22, 2006
...life," Diane Lento said. Medications like Prozac and Valproic acid can help treat repetitive behaviors and mood swings. In some kids ... -WCBS-TV New York

A place of answered prayers  Sep 16, 2006
...cure. He has been given more time by the use of the drug valproic acid, combined with the amino acid L-carnitine, said his mother. ... -Lancaster Newspapers

Major Depression and Manic-Depression - Any Difference?  Sep 18, 2006
...different. While major depression needs antidepressant, manic-depression requires a mood stabilizer such as lithium and valproic acid. ... -American Chronicle

Developmental Neurobiology of Bipolar Disorder and Substance Use ...  Aug 26, 2006
Those who were treated with lithium and psychosocial therapy in this study (compared with those treated with lithium, valproic acid, or psychosocial treatment ... -Psychiatric Times

Migraine Treatment And Prevention In Women  Sep 10, 2006
...be used. However, valproic acid, divalproex sodium and ergot derivatives should never be prescribed to pregnant patients. Early ... -Medical News Today

Obesity and Mental Disorders  Sep 12, 2006
...symptoms result in weight gain, including antidepressants such as paroxetine, antipsychotics such as olanzapine, and mood stabilizers such as valproic acid. ... -Journal of American Medical Association (subscription)

Licensing arrangement reached for HU antiepileptic drug  Sep 4, 2006
...metabolites). Valrocemide is a combination of a known antiepileptic drug, valproic acid, and a glycine derivative, glycinamide. ... -Jerusalem Post

Prevention Strategies Reviewed for Women With Migraines  Sep 6, 2006
...verapamil); selective serotonin reuptake inhibitors (paroxetine, fluoxetine); neuromodulators (divalproex sodium, valproic acid, gabapentin, topiramate ... -Medscape (subscription)

Botulinum Toxin Type A More Effective and Safer Than Divalproex ...  Sep 8, 2006
DVPX is approved in the USA for migraine prophylaxis and its primary metabolite, valproic acid, is the recommended first-line agent for migraine prophylaxis in ... -DG News

Myasthenia Gravis Disclosed by Lithium Carbonate  Sep 8, 2006
Lithium was discontinued. The patient was started on a regimen of valproic acid (1000 mg/day) for bipolar disorder and pyridostigmine for myasthenia gravis. ... -Journal of Neuropsychiatry (subscription)

Coroner's findings into stabbing deaths  -  12 Dec 2006
Advertiser Adelaide,The results revealed a trace of Diazepam and Nordiazepam but no alcohol, cannabinoids, opiates, amphetamines, valproic acid, Olanzapine,

New Data Demonstrate Clinical Activity of Vidaza(R) in Combination ...  -  Dec 11, 2006
PR Newswire (press release),Significant Clinical Activity of the Combination of Vidaza, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia (Abstract 160) Andres Soriano, MD,

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
Earthtimes.orgSignificant Clinical Activity of the Combination of Azacitidine, Valproic Acid and All-Trans Retinoic Acid (ATRA) in Leukemia: Results of a Phase I/II study

Clinical Data on Pharmion's Epigenetic Therapies in Higher-Risk ...  -  Dec 7, 2006
PR Newswire (press release),...will be presented in oral sessions: * Significant Clinical Activity of the Combination of Azacitidine, Valproic Acid and All-Trans Retinoic Acid (ATRA)

The Search for New Off-Label Indications for Antidepressant ...  -  Dec 6, 2006
Focus (subscription)This was when other anticonvulsants, such as carbamazepine (8, 9) and valproic acid (10), were starting to be studied in bipolar disorder.

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